Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055365                                                              17    3301
NP_061152                                                              17    4312
NP_891847                                                              17    4312
XP_006716112                                                           17    4312
XP_005250550                                                           17    4312
NP_597677                                                              16    5631
NP_056199                                                              16    5631
XP_005248340                                                           16    5631
XP_005248339                                                           16    5631
XP_005248337                                                           16    5631
XP_006714531                                                           16    5631
XP_006714530                                                           16    5631
NP_000123                                                              16    7355
NP_001013859                                                           16    7355
NP_001184033                                                           16    7355
NP_001013858                                                           16    7355
NP_005924                                                              16    7355
NP_003541                                                              16    7355
NP_057427                                                              16    7355
NP_006551                                                              16    7355
NP_941989                                                              16    7355
NP_001020767                                                           16    7355
XP_006718194                                                           16    7355
XP_006718193                                                           16    7355
XP_006718192                                                           16    7355
XP_006718191                                                           16    7355
XP_006718190                                                           16    7355
XP_005252813                                                           16    7355
XP_005252812                                                           16    7355
XP_006718189                                                           16    7355
XP_006718188                                                           16    7355
XP_006718187                                                           16    7355
XP_005252811                                                           16    7355
XP_006718186                                                           16    7355
XP_006718185                                                           16    7355
XP_005249935                                                           16    7355
XP_005249934                                                           16    7355
XP_006715851                                                           16    7355
XP_005249933                                                           16    7355
NP_079184                                                              15    9605
NP_001161413                                                           15    9605
NP_001138462                                                           15    9605
NP_001099129                                                           15    9605
NP_056052                                                              15    9605
XP_005254738                                                           15    9605
XP_005254737                                                           15    9605
XP_006710416                                                           15    9605
XP_006710415                                                           15    9605
XP_005270511                                                           15    9605
>NP_055365
          Length = 1032

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   EKNSAVL 9
           EKNSAVL
Sbjct: 219 EKNSAVL 225
>NP_061152
          Length = 1858

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSEKNSAVL 9
           L E+NSA+L
Sbjct: 824 LEEENSAIL 832
>NP_891847
          Length = 1858

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSEKNSAVL 9
           L E+NSA+L
Sbjct: 824 LEEENSAIL 832
>XP_006716112
          Length = 1816

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSEKNSAVL 9
           L E+NSA+L
Sbjct: 824 LEEENSAIL 832
>XP_005250550
          Length = 1858

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LSEKNSAVL 9
           L E+NSA+L
Sbjct: 824 LEEENSAIL 832
>NP_597677
          Length = 2804

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    LSEKNSAV 8
            LS+KNS+V
Sbjct: 2220 LSDKNSSV 2227
>NP_056199
          Length = 2697

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    LSEKNSAV 8
            LS+KNS+V
Sbjct: 2220 LSDKNSSV 2227
>XP_005248340
          Length = 2265

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    LSEKNSAV 8
            LS+KNS+V
Sbjct: 1681 LSDKNSSV 1688
>XP_005248339
          Length = 2584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    LSEKNSAV 8
            LS+KNS+V
Sbjct: 2000 LSDKNSSV 2007
>XP_005248337
          Length = 2698

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    LSEKNSAV 8
            LS+KNS+V
Sbjct: 2220 LSDKNSSV 2227
>XP_006714531
          Length = 2738

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    LSEKNSAV 8
            LS+KNS+V
Sbjct: 2154 LSDKNSSV 2161
>XP_006714530
          Length = 2755

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    LSEKNSAV 8
            LS+KNS+V
Sbjct: 2220 LSDKNSSV 2227
>NP_000123
          Length = 2351

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LSEKNSAVL 9
            LSEKN  V+
Sbjct: 1163 LSEKNKVVV 1171
>NP_001013859
          Length = 718

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSEKNSAV 8
           L +KNSAV
Sbjct: 348 LKDKNSAV 355
>NP_001184033
          Length = 3972

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SEKNSAVL 9
           S++NSA+L
Sbjct: 183 SDRNSAIL 190
>NP_001013858
          Length = 718

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSEKNSAV 8
           L +KNSAV
Sbjct: 348 LKDKNSAV 355
>NP_005924
          Length = 3969

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SEKNSAVL 9
           S++NSA+L
Sbjct: 183 SDRNSAIL 190
>NP_003541
          Length = 718

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSEKNSAV 8
           L +KNSAV
Sbjct: 348 LKDKNSAV 355
>NP_057427
          Length = 3114

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SEKNSAVL 9
           S KNSA+L
Sbjct: 821 SPKNSAIL 828
>NP_006551
          Length = 482

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SEKNSAV 8
           SEKN+AV
Sbjct: 99  SEKNNAV 105
>NP_941989
          Length = 483

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SEKNSAV 8
           SEKN+AV
Sbjct: 99  SEKNNAV 105
>NP_001020767
          Length = 486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SEKNSAV 8
           SEKN+AV
Sbjct: 99  SEKNNAV 105
>XP_006718194
          Length = 487

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SEKNSAV 8
           SEKN+AV
Sbjct: 99  SEKNNAV 105
>XP_006718193
          Length = 487

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SEKNSAV 8
           SEKN+AV
Sbjct: 99  SEKNNAV 105
>XP_006718192
          Length = 487

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SEKNSAV 8
           SEKN+AV
Sbjct: 99  SEKNNAV 105
>XP_006718191
          Length = 487

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SEKNSAV 8
           SEKN+AV
Sbjct: 99  SEKNNAV 105
>XP_006718190
          Length = 513

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SEKNSAV 8
           SEKN+AV
Sbjct: 126 SEKNNAV 132
>XP_005252813
          Length = 514

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SEKNSAV 8
           SEKN+AV
Sbjct: 126 SEKNNAV 132
>XP_005252812
          Length = 519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SEKNSAV 8
           SEKN+AV
Sbjct: 135 SEKNNAV 141
>XP_006718189
          Length = 519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SEKNSAV 8
           SEKN+AV
Sbjct: 135 SEKNNAV 141
>XP_006718188
          Length = 522

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SEKNSAV 8
           SEKN+AV
Sbjct: 135 SEKNNAV 141
>XP_006718187
          Length = 522

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SEKNSAV 8
           SEKN+AV
Sbjct: 135 SEKNNAV 141
>XP_005252811
          Length = 523

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SEKNSAV 8
           SEKN+AV
Sbjct: 135 SEKNNAV 141
>XP_006718186
          Length = 523

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SEKNSAV 8
           SEKN+AV
Sbjct: 135 SEKNNAV 141
>XP_006718185
          Length = 523

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SEKNSAV 8
           SEKN+AV
Sbjct: 135 SEKNNAV 141
>XP_005249935
          Length = 671

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSEKNSAV 8
           L +KNSAV
Sbjct: 301 LKDKNSAV 308
>XP_005249934
          Length = 671

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSEKNSAV 8
           L +KNSAV
Sbjct: 301 LKDKNSAV 308
>XP_006715851
          Length = 718

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSEKNSAV 8
           L +KNSAV
Sbjct: 348 LKDKNSAV 355
>XP_005249933
          Length = 718

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LSEKNSAV 8
           L +KNSAV
Sbjct: 348 LKDKNSAV 355
>NP_079184
          Length = 626

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  LSEKNS 6
          LSEKNS
Sbjct: 70 LSEKNS 75
>NP_001161413
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  LSEKNS 6
          LSEKNS
Sbjct: 6  LSEKNS 11
>NP_001138462
          Length = 1742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LSEKNSAVL 9
            LSE  SAVL
Sbjct: 1197 LSEDQSAVL 1205
>NP_001099129
          Length = 624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   EKNSAVL 9
           EKN AVL
Sbjct: 539 EKNEAVL 545
>NP_056052
          Length = 1354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LSEKNS 6
           LSEKNS
Sbjct: 768 LSEKNS 773
>XP_005254738
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  LSEKNS 6
          LSEKNS
Sbjct: 70 LSEKNS 75
>XP_005254737
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  LSEKNS 6
          LSEKNS
Sbjct: 6  LSEKNS 11
>XP_006710416
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   EKNSAVL 9
           EKN AVL
Sbjct: 219 EKNEAVL 225
>XP_006710415
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   EKNSAVL 9
           EKN AVL
Sbjct: 219 EKNEAVL 225
>XP_005270511
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   EKNSAVL 9
           EKN AVL
Sbjct: 219 EKNEAVL 225
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.295    0.112    0.244 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 429,074
Number of extensions: 437
Number of successful extensions: 49
Number of sequences better than 10000.0: 49
Number of HSP's gapped: 49
Number of HSP's successfully gapped: 49
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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