Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001243000                                                           17    3301
XP_005257603                                                           17    3301
XP_006722058                                                           17    3301
XP_005257602                                                           17    3301
NP_001137357                                                           17    4312
NP_001137358                                                           17    4312
NP_001231921                                                           17    4312
NP_001231919                                                           17    4312
NP_002471                                                              17    4312
XP_005268950                                                           17    4312
XP_005268949                                                           17    4312
XP_005268948                                                           17    4312
XP_005268946                                                           17    4312
XP_005268944                                                           17    4312
XP_005268945                                                           17    4312
XP_005268943                                                           17    4312
XP_005268942                                                           17    4312
NP_758954                                                              16    5631
NP_001245140                                                           16    5631
NP_689496                                                              16    5631
NP_001166109                                                           16    5631
XP_005266021                                                           16    5631
XP_006714968                                                           16    5631
XP_005266020                                                           16    5631
NP_000660                                                              16    7355
NP_115956                                                              16    7355
NP_004221                                                              16    7355
XP_006722999                                                           16    7355
NP_001254537                                                           15    9605
NP_006580                                                              15    9605
NP_937995                                                              15    9605
XP_005276798                                                           15    9605
XP_006726273                                                           15    9605
XP_005276797                                                           15    9605
XP_006726272                                                           15    9605
XP_005276795                                                           15    9605
XP_005244905                                                           15    9605
XP_006711190                                                           15    9605
XP_005244904                                                           15    9605
XP_006711189                                                           15    9605
XP_005244902                                                           15    9605
>NP_001243000
          Length = 5207

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    RSSSSLRT 9
            RSSS+LRT
Sbjct: 2109 RSSSALRT 2116
>XP_005257603
          Length = 5256

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    RSSSSLRT 9
            RSSS+LRT
Sbjct: 2158 RSSSALRT 2165
>XP_006722058
          Length = 5256

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    RSSSSLRT 9
            RSSS+LRT
Sbjct: 2158 RSSSALRT 2165
>XP_005257602
          Length = 5256

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2    RSSSSLRT 9
            RSSS+LRT
Sbjct: 2158 RSSSALRT 2165
>NP_001137357
          Length = 1030

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   RSSSSLRT 9
           R SSSLRT
Sbjct: 517 RDSSSLRT 524
>NP_001137358
          Length = 943

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   RSSSSLRT 9
           R SSSLRT
Sbjct: 430 RDSSSLRT 437
>NP_001231921
          Length = 974

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   RSSSSLRT 9
           R SSSLRT
Sbjct: 517 RDSSSLRT 524
>NP_001231919
          Length = 995

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   RSSSSLRT 9
           R SSSLRT
Sbjct: 517 RDSSSLRT 524
>NP_002471
          Length = 1030

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   RSSSSLRT 9
           R SSSLRT
Sbjct: 517 RDSSSLRT 524
>XP_005268950
          Length = 931

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   RSSSSLRT 9
           R SSSLRT
Sbjct: 517 RDSSSLRT 524
>XP_005268949
          Length = 987

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   RSSSSLRT 9
           R SSSLRT
Sbjct: 517 RDSSSLRT 524
>XP_005268948
          Length = 990

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   RSSSSLRT 9
           R SSSLRT
Sbjct: 517 RDSSSLRT 524
>XP_005268946
          Length = 999

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   RSSSSLRT 9
           R SSSLRT
Sbjct: 517 RDSSSLRT 524
>XP_005268944
          Length = 1005

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   RSSSSLRT 9
           R SSSLRT
Sbjct: 517 RDSSSLRT 524
>XP_005268945
          Length = 1005

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   RSSSSLRT 9
           R SSSLRT
Sbjct: 517 RDSSSLRT 524
>XP_005268943
          Length = 1034

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   RSSSSLRT 9
           R SSSLRT
Sbjct: 517 RDSSSLRT 524
>XP_005268942
          Length = 1046

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   RSSSSLRT 9
           R SSSLRT
Sbjct: 517 RDSSSLRT 524
>NP_758954
          Length = 292

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RSSSSLR 8
           RSSSSLR
Sbjct: 200 RSSSSLR 206
>NP_001245140
          Length = 280

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RSSSSLR 8
           RSSSSLR
Sbjct: 188 RSSSSLR 194
>NP_689496
          Length = 867

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RSSSSLR 8
           RSSSSLR
Sbjct: 146 RSSSSLR 152
>NP_001166109
          Length = 900

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RSSSSLR 8
           RSSSSLR
Sbjct: 179 RSSSSLR 185
>XP_005266021
          Length = 786

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RSSSSLR 8
           RSSSSLR
Sbjct: 179 RSSSSLR 185
>XP_006714968
          Length = 804

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RSSSSLR 8
           RSSSSLR
Sbjct: 179 RSSSSLR 185
>XP_005266020
          Length = 835

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   RSSSSLR 8
           RSSSSLR
Sbjct: 179 RSSSSLR 185
>NP_000660
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LRSSSSLRT 9
           LRS  S+RT
Sbjct: 363 LRSGKSIRT 371
>NP_115956
          Length = 430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LRSSSSLR 8
           +RS+SSLR
Sbjct: 423 MRSASSLR 430
>NP_004221
          Length = 353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LRSSSSL 7
           LRSSSSL
Sbjct: 328 LRSSSSL 334
>XP_006722999
          Length = 353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LRSSSSL 7
           LRSSSSL
Sbjct: 328 LRSSSSL 334
>NP_001254537
          Length = 650

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LRSSSSLR 8
           L SSSSLR
Sbjct: 615 LSSSSSLR 622
>NP_006580
          Length = 668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LRSSSSLR 8
           L SSSSLR
Sbjct: 633 LSSSSSLR 640
>NP_937995
          Length = 572

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LRSSSSLR 8
           L SSSSLR
Sbjct: 537 LSSSSSLR 544
>XP_005276798
          Length = 397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LRSSSSLR 8
           L SSSSLR
Sbjct: 362 LSSSSSLR 369
>XP_006726273
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LRSSSSLR 8
           L SSSSLR
Sbjct: 452 LSSSSSLR 459
>XP_005276797
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LRSSSSLR 8
           L SSSSLR
Sbjct: 538 LSSSSSLR 545
>XP_006726272
          Length = 592

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LRSSSSLR 8
           L SSSSLR
Sbjct: 557 LSSSSSLR 564
>XP_005276795
          Length = 669

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LRSSSSLR 8
           L SSSSLR
Sbjct: 634 LSSSSSLR 641
>XP_005244905
          Length = 397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LRSSSSLR 8
           L SSSSLR
Sbjct: 362 LSSSSSLR 369
>XP_006711190
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LRSSSSLR 8
           L SSSSLR
Sbjct: 452 LSSSSSLR 459
>XP_005244904
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LRSSSSLR 8
           L SSSSLR
Sbjct: 538 LSSSSSLR 545
>XP_006711189
          Length = 592

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LRSSSSLR 8
           L SSSSLR
Sbjct: 557 LSSSSSLR 564
>XP_005244902
          Length = 669

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LRSSSSLR 8
           L SSSSLR
Sbjct: 634 LSSSSSLR 641
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.304    0.108    0.235 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 323,150
Number of extensions: 357
Number of successful extensions: 41
Number of sequences better than 10000.0: 41
Number of HSP's gapped: 41
Number of HSP's successfully gapped: 41
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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