Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              19     869
NP_001263689                                                           19     869
NP_001119584                                                           19     869
NP_001119586                                                           19     869
NP_001263625                                                           19     869
NP_001119590                                                           19     869
NP_001263690                                                           19     869
NP_001119585                                                           19     869
NP_001263624                                                           19     869
NP_001119588                                                           19     869
NP_001119587                                                           19     869
NP_001119589                                                           19     869
NP_001263627                                                           19     869
NP_001263628                                                           19     869
NP_001263626                                                           19     869
NP_001073929                                                           17    3301
XP_006713676                                                           17    3301
XP_005247478                                                           17    3301
NP_001269714                                                           17    4312
NP_060476                                                              17    4312
NP_001269711                                                           17    4312
NP_004648                                                              16    5631
NP_060719                                                              16    7355
NP_001258968                                                           16    7355
NP_001011649                                                           16    7355
NP_877963                                                              16    7355
NP_002651                                                              16    7355
NP_473371                                                              16    7355
NP_001274141                                                           16    7355
NP_001271230                                                           16    7355
NP_002410                                                              16    7355
NP_001271231                                                           16    7355
NP_061155                                                              16    7355
NP_065867                                                              16    7355
NP_001116291                                                           16    7355
XP_003403542                                                           16    7355
XP_005260495                                                           16    7355
XP_006717248                                                           16    7355
XP_006717247                                                           16    7355
XP_006717246                                                           16    7355
XP_006717245                                                           16    7355
XP_006717244                                                           16    7355
XP_006717243                                                           16    7355
XP_006717242                                                           16    7355
XP_006715810                                                           16    7355
XP_006715809                                                           16    7355
XP_006712095                                                           16    7355
XP_006712094                                                           16    7355
XP_006712093                                                           16    7355
XP_005264429                                                           16    7355
XP_005246008                                                           16    7355
XP_005246007                                                           16    7355
XP_003403793                                                           16    7355
NP_060022                                                              16    7355
NP_001229267                                                           16    7355
NP_705838                                                              15    9605
NP_671732                                                              15    9605
NP_001275682                                                           15    9605
NP_653259                                                              15    9605
NP_005487                                                              15    9605
NP_001002800                                                           15    9605
XP_005262426                                                           15    9605
XP_005262425                                                           15    9605
XP_006713522                                                           15    9605
XP_005246216                                                           15    9605
XP_006711947                                                           15    9605
XP_005273219                                                           15    9605
XP_006711444                                                           15    9605
NP_006203                                                              15    9605
>NP_000537
          Length = 393

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LRRNSFEVR 9
           L RNSFEVR
Sbjct: 265 LGRNSFEVR 273
>NP_001263689
          Length = 354

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LRRNSFEVR 9
           L RNSFEVR
Sbjct: 226 LGRNSFEVR 234
>NP_001119584
          Length = 393

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LRRNSFEVR 9
           L RNSFEVR
Sbjct: 265 LGRNSFEVR 273
>NP_001119586
          Length = 341

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LRRNSFEVR 9
           L RNSFEVR
Sbjct: 265 LGRNSFEVR 273
>NP_001263625
          Length = 302

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LRRNSFEVR 9
           L RNSFEVR
Sbjct: 226 LGRNSFEVR 234
>NP_001119590
          Length = 354

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LRRNSFEVR 9
           L RNSFEVR
Sbjct: 226 LGRNSFEVR 234
>NP_001263690
          Length = 354

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LRRNSFEVR 9
           L RNSFEVR
Sbjct: 226 LGRNSFEVR 234
>NP_001119585
          Length = 346

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LRRNSFEVR 9
           L RNSFEVR
Sbjct: 265 LGRNSFEVR 273
>NP_001263624
          Length = 307

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LRRNSFEVR 9
           L RNSFEVR
Sbjct: 226 LGRNSFEVR 234
>NP_001119588
          Length = 209

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LRRNSFEVR 9
           L RNSFEVR
Sbjct: 133 LGRNSFEVR 141
>NP_001119587
          Length = 261

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LRRNSFEVR 9
           L RNSFEVR
Sbjct: 133 LGRNSFEVR 141
>NP_001119589
          Length = 214

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LRRNSFEVR 9
           L RNSFEVR
Sbjct: 133 LGRNSFEVR 141
>NP_001263627
          Length = 182

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LRRNSFEVR 9
           L RNSFEVR
Sbjct: 106 LGRNSFEVR 114
>NP_001263628
          Length = 187

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LRRNSFEVR 9
           L RNSFEVR
Sbjct: 106 LGRNSFEVR 114
>NP_001263626
          Length = 234

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LRRNSFEVR 9
           L RNSFEVR
Sbjct: 106 LGRNSFEVR 114
>NP_001073929
          Length = 560

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LRRNSFEV 8
           L+RN FEV
Sbjct: 172 LKRNQFEV 179
>XP_006713676
          Length = 560

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LRRNSFEV 8
           L+RN FEV
Sbjct: 172 LKRNQFEV 179
>XP_005247478
          Length = 560

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LRRNSFEV 8
           L+RN FEV
Sbjct: 172 LKRNQFEV 179
>NP_001269714
          Length = 376

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LRRNSFEVR 9
           L RN FEVR
Sbjct: 150 LFRNRFEVR 158
>NP_060476
          Length = 421

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LRRNSFEVR 9
           L RN FEVR
Sbjct: 150 LFRNRFEVR 158
>NP_001269711
          Length = 307

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  LRRNSFEVR 9
          L RN FEVR
Sbjct: 36 LFRNRFEVR 44
>NP_004648
          Length = 425

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LRRNSFEV 8
           LRRN F+V
Sbjct: 150 LRRNHFKV 157
>NP_060719
          Length = 1893

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RNSFEVR 9
           RNSFE R
Sbjct: 285 RNSFEER 291
>NP_001258968
          Length = 1663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RNSFEVR 9
           RNSFE R
Sbjct: 285 RNSFEER 291
>NP_001011649
          Length = 1814

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RNSFEVR 9
           RNSFE R
Sbjct: 285 RNSFEER 291
>NP_877963
          Length = 1290

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LRRNSFEVR 9
           LR N FE+R
Sbjct: 644 LRCNEFEMR 652
>NP_002651
          Length = 1291

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LRRNSFEVR 9
           LR N FE+R
Sbjct: 644 LRCNEFEMR 652
>NP_473371
          Length = 330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LRRNSFEV 8
          +RRN+F V
Sbjct: 59 MRRNAFSV 66
>NP_001274141
          Length = 929

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RNSFEVR 9
           RNS++VR
Sbjct: 342 RNSYDVR 348
>NP_001271230
          Length = 1087

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RRNSFEV 8
            RRN+FE+
Sbjct: 1015 RRNTFEL 1021
>NP_002410
          Length = 847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RRNSFEV 8
           RRN FEV
Sbjct: 513 RRNVFEV 519
>NP_001271231
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RRNSFEV 8
            RRN+FE+
Sbjct: 1014 RRNTFEL 1020
>NP_061155
          Length = 1124

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RRNSFEV 8
            RRN+FE+
Sbjct: 1052 RRNTFEL 1058
>NP_065867
          Length = 1029

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RNSFEVR 9
           RNS++VR
Sbjct: 442 RNSYDVR 448
>NP_001116291
          Length = 1028

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RNSFEVR 9
           RNS++VR
Sbjct: 442 RNSYDVR 448
>XP_003403542
          Length = 846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RRNSFEV 8
           R+NSFE+
Sbjct: 517 RKNSFEL 523
>XP_005260495
          Length = 1330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LRRNSFEVR 9
           LR N FE+R
Sbjct: 644 LRCNEFEMR 652
>XP_006717248
          Length = 1664

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RNSFEVR 9
           RNSFE R
Sbjct: 285 RNSFEER 291
>XP_006717247
          Length = 1670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RNSFEVR 9
           RNSFE R
Sbjct: 285 RNSFEER 291
>XP_006717246
          Length = 1820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RNSFEVR 9
           RNSFE R
Sbjct: 285 RNSFEER 291
>XP_006717245
          Length = 1861

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RNSFEVR 9
           RNSFE R
Sbjct: 285 RNSFEER 291
>XP_006717244
          Length = 1867

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RNSFEVR 9
           RNSFE R
Sbjct: 285 RNSFEER 291
>XP_006717243
          Length = 1889

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RNSFEVR 9
           RNSFE R
Sbjct: 275 RNSFEER 281
>XP_006717242
          Length = 1898

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RNSFEVR 9
           RNSFE R
Sbjct: 284 RNSFEER 290
>XP_006715810
          Length = 1105

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RRNSFEV 8
            RRN+FE+
Sbjct: 1033 RRNTFEL 1039
>XP_006715809
          Length = 1142

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    RRNSFEV 8
            RRN+FE+
Sbjct: 1070 RRNTFEL 1076
>XP_006712095
          Length = 849

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LRRNSFEVR 9
           LRRNS+ ++
Sbjct: 241 LRRNSYGIQ 249
>XP_006712094
          Length = 1067

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LRRNSFEVR 9
           LRRNS+ ++
Sbjct: 241 LRRNSYGIQ 249
>XP_006712093
          Length = 1460

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LRRNSFEVR 9
           LRRNS+ ++
Sbjct: 241 LRRNSYGIQ 249
>XP_005264429
          Length = 1472

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LRRNSFEVR 9
           LRRNS+ ++
Sbjct: 241 LRRNSYGIQ 249
>XP_005246008
          Length = 984

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RNSFEVR 9
           RNS++VR
Sbjct: 442 RNSYDVR 448
>XP_005246007
          Length = 985

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RNSFEVR 9
           RNS++VR
Sbjct: 442 RNSYDVR 448
>XP_003403793
          Length = 846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RRNSFEV 8
           R+NSFE+
Sbjct: 517 RKNSFEL 523
>NP_060022
          Length = 1458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LRRNSFEVR 9
           LRRNS+ ++
Sbjct: 241 LRRNSYGIQ 249
>NP_001229267
          Length = 1453

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LRRNSFEVR 9
           LRRNS+ ++
Sbjct: 241 LRRNSYGIQ 249
>NP_705838
          Length = 4069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RRNSFE 7
           +RNSFE
Sbjct: 152 KRNSFE 157
>NP_671732
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  LRRNSFEV 8
          +RRN+F +
Sbjct: 56 MRRNAFSI 63
>NP_001275682
          Length = 1263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    LRRNSFEV 8
            LR N FE+
Sbjct: 1226 LRNNMFEI 1233
>NP_653259
          Length = 2073

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   LRRNSFEVR 9
           +RR++FE++
Sbjct: 235 MRRHAFELK 243
>NP_005487
          Length = 1288

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    LRRNSFEV 8
            LR N FE+
Sbjct: 1251 LRNNMFEI 1258
>NP_001002800
          Length = 1288

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    LRRNSFEV 8
            LR N FE+
Sbjct: 1251 LRNNMFEI 1258
>XP_005262426
          Length = 2055

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   LRRNSFEVR 9
           +RR++FE++
Sbjct: 204 MRRHAFELK 212
>XP_005262425
          Length = 2086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   LRRNSFEVR 9
           +RR++FE++
Sbjct: 235 MRRHAFELK 243
>XP_006713522
          Length = 1210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    LRRNSFEV 8
            LR N FE+
Sbjct: 1173 LRNNMFEI 1180
>XP_005246216
          Length = 429

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  RRNSFE 7
          RRN+FE
Sbjct: 59 RRNNFE 64
>XP_006711947
          Length = 441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  RRNSFE 7
          RRN+FE
Sbjct: 59 RRNNFE 64
>XP_005273219
          Length = 263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LRRNSF 6
           +RRNSF
Sbjct: 220 MRRNSF 225
>XP_006711444
          Length = 407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LRRNSF 6
           +RRNSF
Sbjct: 364 MRRNSF 369
>NP_006203
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LRRNSF 6
           +RRNSF
Sbjct: 462 MRRNSF 467
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.335    0.142    0.383 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 489,361
Number of extensions: 1169
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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