Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_113655                                                              18    1935
NP_005890                                                              18    1935
NP_114068                                                              18    1935
NP_114064                                                              18    1935
NP_001245356                                                           18    1935
NP_001245355                                                           18    1935
NP_001245357                                                           18    1935
XP_006721966                                                           18    1935
XP_006714863                                                           18    1935
XP_006714862                                                           18    1935
XP_005268578                                                           18    1935
NP_001866                                                              17    3301
NP_110424                                                              17    3301
NP_001116105                                                           17    3301
XP_005262687                                                           17    3301
XP_006712171                                                           17    3301
NP_001136087                                                           17    4312
NP_001136086                                                           17    4312
NP_065112                                                              17    4312
NP_001275939                                                           17    4312
XP_005264285                                                           17    4312
XP_006712034                                                           17    4312
XP_005264284                                                           17    4312
XP_005264283                                                           17    4312
XP_005264282                                                           17    4312
NP_001136088                                                           17    4312
NP_056067                                                              17    4312
NP_001185797                                                           16    5631
NP_005177                                                              16    5631
NP_001185798                                                           16    5631
NP_001167558                                                           16    5631
NP_858045                                                              16    5631
NP_006525                                                              16    5631
NP_001167559                                                           16    5631
NP_689914                                                              16    5631
NP_001231                                                              16    5631
XP_006718761                                                           16    5631
NP_005623                                                              16    7355
NP_877439                                                              16    7355
NP_001957                                                              16    7355
NP_653292                                                              16    7355
XP_005255575                                                           16    7355
XP_005255574                                                           16    7355
XP_005255573                                                           16    7355
XP_006720998                                                           16    7355
XP_005255571                                                           16    7355
XP_006720997                                                           16    7355
XP_006720996                                                           16    7355
XP_006720995                                                           16    7355
XP_006720994                                                           16    7355
NP_057653                                                              15    9605
NP_005987                                                              15    9605
NP_001010874                                                           15    9605
NP_848611                                                              15    9605
NP_001186867                                                           15    9605
NP_872393                                                              15    9605
XP_006722810                                                           15    9605
XP_005272530                                                           15    9605
XP_006722809                                                           15    9605
XP_005265722                                                           15    9605
XP_005265721                                                           15    9605
XP_005265720                                                           15    9605
XP_005265719                                                           15    9605
XP_006712515                                                           15    9605
XP_006712514                                                           15    9605
XP_006712513                                                           15    9605
XP_006712512                                                           15    9605
XP_006712511                                                           15    9605
XP_006712510                                                           15    9605
XP_006712509                                                           15    9605
XP_005246533                                                           15    9605
XP_006712508                                                           15    9605
NP_115893                                                              15    9605
NP_940936                                                              15    9605
>NP_113655
          Length = 959

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LRMRNPVV 8
           +R+RNPVV
Sbjct: 221 VRLRNPVV 228
>NP_005890
          Length = 966

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LRMRNPVVG 9
           L++R PVVG
Sbjct: 257 LKLRRPVVG 265
>NP_114068
          Length = 966

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LRMRNPVVG 9
           L++R PVVG
Sbjct: 257 LKLRRPVVG 265
>NP_114064
          Length = 966

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LRMRNPVVG 9
           L++R PVVG
Sbjct: 257 LKLRRPVVG 265
>NP_001245356
          Length = 896

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LRMRNPVV 8
           +R+RNPVV
Sbjct: 221 VRLRNPVV 228
>NP_001245355
          Length = 945

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LRMRNPVV 8
           +R+RNPVV
Sbjct: 221 VRLRNPVV 228
>NP_001245357
          Length = 983

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LRMRNPVV 8
           +R+RNPVV
Sbjct: 245 VRLRNPVV 252
>XP_006721966
          Length = 896

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LRMRNPVVG 9
           L++R PVVG
Sbjct: 257 LKLRRPVVG 265
>XP_006714863
          Length = 921

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LRMRNPVV 8
           +R+RNPVV
Sbjct: 183 VRLRNPVV 190
>XP_006714862
          Length = 956

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LRMRNPVV 8
           +R+RNPVV
Sbjct: 221 VRLRNPVV 228
>XP_005268578
          Length = 959

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LRMRNPVV 8
           +R+RNPVV
Sbjct: 221 VRLRNPVV 228
>NP_001866
          Length = 1500

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LRMRNPVVG 9
           L M NP++G
Sbjct: 94  LTMANPIIG 102
>NP_110424
          Length = 323

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LRMRNPVV 8
           L+MRNP +
Sbjct: 144 LKMRNPAI 151
>NP_001116105
          Length = 1506

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LRMRNPVVG 9
           L M NP++G
Sbjct: 100 LTMANPIIG 108
>XP_005262687
          Length = 323

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LRMRNPVV 8
           L+MRNP +
Sbjct: 144 LKMRNPAI 151
>XP_006712171
          Length = 323

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LRMRNPVV 8
           L+MRNP +
Sbjct: 144 LKMRNPAI 151
>NP_001136087
          Length = 1160

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RMRNPVV 8
           R RNPVV
Sbjct: 928 RFRNPVV 934
>NP_001136086
          Length = 1196

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RMRNPVV 8
           R RNPVV
Sbjct: 964 RFRNPVV 970
>NP_065112
          Length = 630

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RMRNPVVG 9
           R+R+PV+G
Sbjct: 151 RLRHPVLG 158
>NP_001275939
          Length = 590

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RMRNPVVG 9
           R+R+PV+G
Sbjct: 151 RLRHPVLG 158
>XP_005264285
          Length = 949

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RMRNPVV 8
           R RNPVV
Sbjct: 717 RFRNPVV 723
>XP_006712034
          Length = 1195

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RMRNPVV 8
           R RNPVV
Sbjct: 963 RFRNPVV 969
>XP_005264284
          Length = 1196

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RMRNPVV 8
           R RNPVV
Sbjct: 964 RFRNPVV 970
>XP_005264283
          Length = 1231

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    RMRNPVV 8
            R RNPVV
Sbjct: 999  RFRNPVV 1005
>XP_005264282
          Length = 1231

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    RMRNPVV 8
            R RNPVV
Sbjct: 999  RFRNPVV 1005
>NP_001136088
          Length = 1160

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RMRNPVV 8
           R RNPVV
Sbjct: 928 RFRNPVV 934
>NP_056067
          Length = 1231

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    RMRNPVV 8
            R RNPVV
Sbjct: 999  RFRNPVV 1005
>NP_001185797
          Length = 714

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LRMRNP 6
           +RMRNP
Sbjct: 292 IRMRNP 297
>NP_005177
          Length = 714

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LRMRNP 6
           +RMRNP
Sbjct: 292 IRMRNP 297
>NP_001185798
          Length = 714

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LRMRNP 6
           +RMRNP
Sbjct: 292 IRMRNP 297
>NP_001167558
          Length = 1423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    LRMRNPVVG 9
            L+M NP  G
Sbjct: 1193 LKMENPTAG 1201
>NP_858045
          Length = 1424

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    LRMRNPVVG 9
            L+M NP  G
Sbjct: 1193 LKMENPTAG 1201
>NP_006525
          Length = 1420

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    LRMRNPVVG 9
            L+M NP  G
Sbjct: 1193 LKMENPTAG 1201
>NP_001167559
          Length = 1415

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    LRMRNPVVG 9
            L+M NP  G
Sbjct: 1188 LKMENPTAG 1196
>NP_689914
          Length = 5058

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  RMRNPVV 8
          R+RNPV+
Sbjct: 19 RLRNPVL 25
>NP_001231
          Length = 726

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LRMRNPVVG 9
           L+MR PV G
Sbjct: 460 LKMRIPVAG 468
>XP_006718761
          Length = 714

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LRMRNP 6
           +RMRNP
Sbjct: 292 IRMRNP 297
>NP_005623
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LRMRNP 6
           LR+RNP
Sbjct: 733 LRLRNP 738
>NP_877439
          Length = 852

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RMRNPV 7
           RM+NPV
Sbjct: 816 RMKNPV 821
>NP_001957
          Length = 723

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LRMRNPVV 8
          +R+RNP V
Sbjct: 14 IRLRNPPV 21
>NP_653292
          Length = 719

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LRMRNP 6
           LR+RNP
Sbjct: 279 LRLRNP 284
>XP_005255575
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LRMRNP 6
           LR+RNP
Sbjct: 733 LRLRNP 738
>XP_005255574
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LRMRNP 6
           LR+RNP
Sbjct: 733 LRLRNP 738
>XP_005255573
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LRMRNP 6
           LR+RNP
Sbjct: 733 LRLRNP 738
>XP_006720998
          Length = 1098

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LRMRNP 6
           LR+RNP
Sbjct: 801 LRLRNP 806
>XP_005255571
          Length = 1112

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LRMRNP 6
           LR+RNP
Sbjct: 759 LRLRNP 764
>XP_006720997
          Length = 1124

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LRMRNP 6
           LR+RNP
Sbjct: 771 LRLRNP 776
>XP_006720996
          Length = 1153

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LRMRNP 6
           LR+RNP
Sbjct: 800 LRLRNP 805
>XP_006720995
          Length = 1154

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LRMRNP 6
           LR+RNP
Sbjct: 801 LRLRNP 806
>XP_006720994
          Length = 1154

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LRMRNP 6
           LR+RNP
Sbjct: 801 LRLRNP 806
>NP_057653
          Length = 743

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LRMRNPVV 8
          L MR+PV+
Sbjct: 3  LSMRDPVI 10
>NP_005987
          Length = 723

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LRMRNPVV 8
          L MR+PV+
Sbjct: 3  LSMRDPVI 10
>NP_001010874
          Length = 363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RMRNPVV 8
           R+R+PVV
Sbjct: 177 RLRHPVV 183
>NP_848611
          Length = 746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RMRNPVV 8
           R+RNP V
Sbjct: 576 RVRNPTV 582
>NP_001186867
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MRNPVVG 9
           +R+PV+G
Sbjct: 285 LRHPVIG 291
>NP_872393
          Length = 3234

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RMRNPVVG 9
            R R+P+VG
Sbjct: 1250 RGRSPIVG 1257
>XP_006722810
          Length = 499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LRMRNPVVG 9
           LR++NP  G
Sbjct: 459 LRLKNPQEG 467
>XP_005272530
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LRMRNPVVG 9
           LR++NP  G
Sbjct: 465 LRLKNPQEG 473
>XP_006722809
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LRMRNPVVG 9
           LR++NP  G
Sbjct: 484 LRLKNPQEG 492
>XP_005265722
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RMRNPVV 8
           R+R+PVV
Sbjct: 177 RLRHPVV 183
>XP_005265721
          Length = 318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RMRNPVV 8
           R+R+PVV
Sbjct: 177 RLRHPVV 183
>XP_005265720
          Length = 326

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RMRNPVV 8
           R+R+PVV
Sbjct: 177 RLRHPVV 183
>XP_005265719
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RMRNPVV 8
           R+R+PVV
Sbjct: 162 RLRHPVV 168
>XP_006712515
          Length = 3232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RMRNPVVG 9
            R R+P+VG
Sbjct: 1248 RGRSPIVG 1255
>XP_006712514
          Length = 2496

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RMRNPVVG 9
            R R+P+VG
Sbjct: 1253 RGRSPIVG 1260
>XP_006712513
          Length = 3220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RMRNPVVG 9
            R R+P+VG
Sbjct: 1149 RGRSPIVG 1156
>XP_006712512
          Length = 3237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RMRNPVVG 9
            R R+P+VG
Sbjct: 1253 RGRSPIVG 1260
>XP_006712511
          Length = 3256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RMRNPVVG 9
            R R+P+VG
Sbjct: 1253 RGRSPIVG 1260
>XP_006712510
          Length = 3305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RMRNPVVG 9
            R R+P+VG
Sbjct: 1253 RGRSPIVG 1260
>XP_006712509
          Length = 3319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RMRNPVVG 9
            R R+P+VG
Sbjct: 1248 RGRSPIVG 1255
>XP_005246533
          Length = 3323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RMRNPVVG 9
            R R+P+VG
Sbjct: 1253 RGRSPIVG 1260
>XP_006712508
          Length = 3324

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RMRNPVVG 9
            R R+P+VG
Sbjct: 1253 RGRSPIVG 1260
>NP_115893
          Length = 3258

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RMRNPVVG 9
            R R+P+VG
Sbjct: 1255 RGRSPIVG 1262
>NP_940936
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LRMRNPVVG 9
           LR++NP  G
Sbjct: 465 LRLKNPQEG 473
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.148    0.449 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 684,611
Number of extensions: 950
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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