Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              20     509
XP_006718908                                                           20     509
XP_005271621                                                           20     509
XP_006718907                                                           20     509
XP_006718906                                                           20     509
XP_005271619                                                           20     509
XP_005271618                                                           20     509
NP_055722                                                              19     869
NP_001192244                                                           17    2528
NP_078912                                                              17    2528
NP_001092010                                                           16    5631
NP_001159970                                                           16    5631
NP_006656                                                              16    5631
NP_001273206                                                           16    5631
NP_001073936                                                           16    5631
NP_659441                                                              16    5631
NP_001273207                                                           16    5631
NP_001273208                                                           16    5631
NP_006313                                                              16    5631
NP_057323                                                              16    5631
XP_006725181                                                           16    5631
XP_006725180                                                           16    5631
XP_005256732                                                           16    5631
XP_005254804                                                           16    5631
XP_006720791                                                           16    5631
XP_005254803                                                           16    5631
XP_005254800                                                           16    5631
XP_005254799                                                           16    5631
XP_005268350                                                           16    5631
XP_006716362                                                           16    5631
XP_006716361                                                           16    5631
NP_003913                                                              16    5631
NP_077288                                                              16    7355
NP_001120652                                                           16    7355
NP_000251                                                              16    7355
NP_060338                                                              16    7355
NP_001041                                                              16    7355
NP_056175                                                              16    7355
NP_001193968                                                           16    7355
NP_001193965                                                           16    7355
NP_060321                                                              16    7355
XP_006720655                                                           16    7355
XP_006720654                                                           16    7355
XP_006720653                                                           16    7355
XP_006720652                                                           16    7355
XP_005254573                                                           16    7355
XP_006719656                                                           16    7355
XP_005271664                                                           16    7355
XP_006718929                                                           16    7355
XP_005271663                                                           16    7355
XP_005271662                                                           16    7355
XP_005271661                                                           16    7355
XP_005271660                                                           16    7355
XP_006718624                                                           16    7355
XP_005274069                                                           16    7355
XP_006718623                                                           16    7355
XP_006718622                                                           16    7355
XP_006718621                                                           16    7355
NP_056078                                                              15    9605
NP_001167587                                                           15    9605
NP_001167588                                                           15    9605
NP_001116295                                                           15    9605
XP_005254315                                                           15    9605
XP_005254314                                                           15    9605
XP_006720509                                                           15    9605
XP_005254313                                                           15    9605
XP_005254312                                                           15    9605
XP_005245315                                                           15    9605
XP_006711447                                                           15    9605
XP_005245314                                                           15    9605
NP_065840                                                              15    9605
NP_001128522                                                           15    9605
NP_002637                                                              15    9605
>NP_000042
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LRDVIYTFI 9
            LRDVIYT I
Sbjct: 1465 LRDVIYTLI 1473
>XP_006718908
          Length = 1708

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LRDVIYTFI 9
           LRDVIYT I
Sbjct: 117 LRDVIYTLI 125
>XP_005271621
          Length = 2708

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LRDVIYTFI 9
            LRDVIYT I
Sbjct: 1117 LRDVIYTLI 1125
>XP_006718907
          Length = 3050

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LRDVIYTFI 9
            LRDVIYT I
Sbjct: 1459 LRDVIYTLI 1467
>XP_006718906
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LRDVIYTFI 9
            LRDVIYT I
Sbjct: 1465 LRDVIYTLI 1473
>XP_005271619
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LRDVIYTFI 9
            LRDVIYT I
Sbjct: 1465 LRDVIYTLI 1473
>XP_005271618
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LRDVIYTFI 9
            LRDVIYT I
Sbjct: 1465 LRDVIYTLI 1473
>NP_055722
          Length = 1578

 Score = 18.9 bits (37), Expect =   869
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    LRDVIYTF 8
            LRDV+YT+
Sbjct: 1524 LRDVVYTY 1531
>NP_001192244
          Length = 459

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LRDVIYTFI 9
           +RDVIY ++
Sbjct: 220 IRDVIYPYV 228
>NP_078912
          Length = 459

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LRDVIYTFI 9
           +RDVIY ++
Sbjct: 220 IRDVIYPYV 228
>NP_001092010
          Length = 543

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DVIYTF 8
           DV+YTF
Sbjct: 171 DVLYTF 176
>NP_001159970
          Length = 469

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DVIYTF 8
           DV+YTF
Sbjct: 171 DVLYTF 176
>NP_006656
          Length = 543

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   DVIYTF 8
           DV+YTF
Sbjct: 171 DVLYTF 176
>NP_001273206
          Length = 897

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LRDVIYTF 8
           +RD++Y F
Sbjct: 241 VRDILYVF 248
>NP_001073936
          Length = 1848

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RDVIYTF 8
           +DVIYT+
Sbjct: 121 QDVIYTY 127
>NP_659441
          Length = 787

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DVIYTFI 9
           DVIY F+
Sbjct: 568 DVIYAFV 574
>NP_001273207
          Length = 824

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LRDVIYTF 8
           +RD++Y F
Sbjct: 251 VRDILYVF 258
>NP_001273208
          Length = 439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LRDVIYTF 8
           +RD++Y F
Sbjct: 251 VRDILYVF 258
>NP_006313
          Length = 907

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LRDVIYTF 8
           +RD++Y F
Sbjct: 251 VRDILYVF 258
>NP_057323
          Length = 3530

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RDVIYTFI 9
            R++IYT+I
Sbjct: 1248 RNLIYTYI 1255
>XP_006725181
          Length = 681

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DVIYTFI 9
           DVIY F+
Sbjct: 462 DVIYAFV 468
>XP_006725180
          Length = 774

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DVIYTFI 9
           DVIY F+
Sbjct: 568 DVIYAFV 574
>XP_005256732
          Length = 3531

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RDVIYTFI 9
            R++IYT+I
Sbjct: 1248 RNLIYTYI 1255
>XP_005254804
          Length = 4796

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LRDVIY 6
           LRDVIY
Sbjct: 985 LRDVIY 990
>XP_006720791
          Length = 4853

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LRDVIY 6
            LRDVIY
Sbjct: 1050 LRDVIY 1055
>XP_005254803
          Length = 4854

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LRDVIY 6
            LRDVIY
Sbjct: 1050 LRDVIY 1055
>XP_005254800
          Length = 4861

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LRDVIY 6
            LRDVIY
Sbjct: 1050 LRDVIY 1055
>XP_005254799
          Length = 4861

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LRDVIY 6
            LRDVIY
Sbjct: 1050 LRDVIY 1055
>XP_005268350
          Length = 818

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LRDVIYTF 8
           +RD++Y F
Sbjct: 251 VRDILYVF 258
>XP_006716362
          Length = 681

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DVIYTFI 9
           DVIY F+
Sbjct: 462 DVIYAFV 468
>XP_006716361
          Length = 774

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   DVIYTFI 9
           DVIY F+
Sbjct: 568 DVIYAFV 574
>NP_003913
          Length = 4861

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    LRDVIY 6
            LRDVIY
Sbjct: 1050 LRDVIY 1055
>NP_077288
          Length = 1256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  DVIYTFI 9
          DV+YT++
Sbjct: 76 DVVYTWV 82
>NP_001120652
          Length = 2175

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    LRDVIYTFI 9
            +RD++ TF+
Sbjct: 1552 IRDLVVTFL 1560
>NP_000251
          Length = 2215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    LRDVIYTFI 9
            +RD++ TF+
Sbjct: 1590 IRDLVVTFL 1598
>NP_060338
          Length = 705

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RDVIYTFI 9
           R+VIYT +
Sbjct: 493 REVIYTLL 500
>NP_001041
          Length = 369

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VIYTFI 9
           +IYTFI
Sbjct: 209 IIYTFI 214
>NP_056175
          Length = 1042

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LRDVIYTF 8
           L DV+YT+
Sbjct: 966 LMDVVYTW 973
>NP_001193968
          Length = 262

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  LRDVIYTFI 9
          LRDV+Y  +
Sbjct: 47 LRDVLYELL 55
>NP_001193965
          Length = 286

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  LRDVIYTFI 9
          LRDV+Y  +
Sbjct: 47 LRDVLYELL 55
>NP_060321
          Length = 323

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RDVIYTF 8
           RD+IY F
Sbjct: 145 RDLIYAF 151
>XP_006720655
          Length = 304

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RDVIYTF 8
           RD+IY F
Sbjct: 126 RDLIYAF 132
>XP_006720654
          Length = 309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RDVIYTF 8
           RD+IY F
Sbjct: 145 RDLIYAF 151
>XP_006720653
          Length = 310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RDVIYTF 8
           RD+IY F
Sbjct: 145 RDLIYAF 151
>XP_006720652
          Length = 311

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RDVIYTF 8
           RD+IY F
Sbjct: 145 RDLIYAF 151
>XP_005254573
          Length = 322

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   RDVIYTF 8
           RD+IY F
Sbjct: 145 RDLIYAF 151
>XP_006719656
          Length = 1179

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  DVIYTFI 9
          DV+YT++
Sbjct: 76 DVVYTWV 82
>XP_005271664
          Length = 732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RDVIYTFI 9
           R+VIYT +
Sbjct: 493 REVIYTLL 500
>XP_006718929
          Length = 756

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RDVIYTFI 9
           R+VIYT +
Sbjct: 493 REVIYTLL 500
>XP_005271663
          Length = 774

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RDVIYTFI 9
           R+VIYT +
Sbjct: 493 REVIYTLL 500
>XP_005271662
          Length = 777

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RDVIYTFI 9
           R+VIYT +
Sbjct: 493 REVIYTLL 500
>XP_005271661
          Length = 777

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RDVIYTFI 9
           R+VIYT +
Sbjct: 493 REVIYTLL 500
>XP_005271660
          Length = 777

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RDVIYTFI 9
           R+VIYT +
Sbjct: 493 REVIYTLL 500
>XP_006718624
          Length = 2177

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    LRDVIYTFI 9
            +RD++ TF+
Sbjct: 1552 IRDLVVTFL 1560
>XP_005274069
          Length = 2176

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    LRDVIYTFI 9
            +RD++ TF+
Sbjct: 1552 IRDLVVTFL 1560
>XP_006718623
          Length = 2189

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    LRDVIYTFI 9
            +RD++ TF+
Sbjct: 1552 IRDLVVTFL 1560
>XP_006718622
          Length = 2190

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    LRDVIYTFI 9
            +RD++ TF+
Sbjct: 1552 IRDLVVTFL 1560
>XP_006718621
          Length = 2225

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    LRDVIYTFI 9
            +RD++ TF+
Sbjct: 1588 IRDLVVTFL 1596
>NP_056078
          Length = 3036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 7/9 (77%)

Query: 1    LRDVIYTFI 9
            + D++YT +
Sbjct: 2230 IHDILYTIV 2238
>NP_001167587
          Length = 3037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 7/9 (77%)

Query: 1    LRDVIYTFI 9
            + D++YT +
Sbjct: 2230 IHDILYTIV 2238
>NP_001167588
          Length = 2400

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 7/9 (77%)

Query: 1    LRDVIYTFI 9
            + D++YT +
Sbjct: 1594 IHDILYTIV 1602
>NP_001116295
          Length = 526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   LRDVIYTF 8
           LRD +Y F
Sbjct: 395 LRDSVYIF 402
>XP_005254315
          Length = 2576

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 7/9 (77%)

Query: 1    LRDVIYTFI 9
            + D++YT +
Sbjct: 2230 IHDILYTIV 2238
>XP_005254314
          Length = 2605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 7/9 (77%)

Query: 1    LRDVIYTFI 9
            + D++YT +
Sbjct: 2230 IHDILYTIV 2238
>XP_006720509
          Length = 2646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 7/9 (77%)

Query: 1    LRDVIYTFI 9
            + D++YT +
Sbjct: 2230 IHDILYTIV 2238
>XP_005254313
          Length = 3057

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 7/9 (77%)

Query: 1    LRDVIYTFI 9
            + D++YT +
Sbjct: 2230 IHDILYTIV 2238
>XP_005254312
          Length = 3058

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 7/9 (77%)

Query: 1    LRDVIYTFI 9
            + D++YT +
Sbjct: 2230 IHDILYTIV 2238
>XP_005245315
          Length = 1607

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3    DVIYTF 8
            D++YTF
Sbjct: 1441 DLVYTF 1446
>XP_006711447
          Length = 1634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3    DVIYTF 8
            D++YTF
Sbjct: 1468 DLVYTF 1473
>XP_005245314
          Length = 1634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3    DVIYTF 8
            D++YTF
Sbjct: 1468 DLVYTF 1473
>NP_065840
          Length = 1163

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LRDVIYTF 8
           ++DV+Y F
Sbjct: 671 IKDVLYEF 678
>NP_001128522
          Length = 1179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LRDVIYTF 8
           ++DV+Y F
Sbjct: 687 IKDVLYEF 694
>NP_002637
          Length = 1634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3    DVIYTF 8
            D++YTF
Sbjct: 1468 DLVYTF 1473
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.349    0.166    0.488 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 489,523
Number of extensions: 778
Number of successful extensions: 73
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.7 bits)
S2: 28 (15.4 bits)

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