Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055365                                                              19     869
NP_060811                                                              17    4312
NP_001265460                                                           17    4312
NP_001265462                                                           17    4312
NP_001265461                                                           17    4312
NP_037509                                                              17    4312
NP_001158067                                                           17    4312
XP_006725075                                                           17    4312
XP_006725074                                                           17    4312
XP_006725073                                                           17    4312
XP_005267103                                                           17    4312
XP_006715573                                                           17    4312
XP_006715572                                                           17    4312
NP_054859                                                              16    5631
NP_001120679                                                           16    5631
XP_006712620                                                           16    5631
XP_005246688                                                           16    5631
XP_005246689                                                           16    5631
NP_006098                                                              16    7355
NP_057508                                                              16    7355
XP_005257512                                                           16    7355
XP_006722006                                                           16    7355
XP_005257511                                                           16    7355
XP_005257509                                                           16    7355
XP_005257508                                                           16    7355
XP_005257507                                                           16    7355
XP_005257506                                                           16    7355
XP_005257505                                                           16    7355
NP_001360                                                              15    9605
NP_001361                                                              15    9605
NP_078849                                                              15    9605
XP_005248319                                                           15    9605
XP_006712019                                                           15    9605
>NP_055365
          Length = 1032

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   LQYSQSLI 8
           LQYSQSLI
Sbjct: 407 LQYSQSLI 414
>NP_060811
          Length = 678

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LQYSQSLIA 9
           LQY+++L+A
Sbjct: 624 LQYTENLVA 632
>NP_001265460
          Length = 631

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LQYSQSLIA 9
           LQY+++L+A
Sbjct: 577 LQYTENLVA 585
>NP_001265462
          Length = 605

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LQYSQSLIA 9
           LQY+++L+A
Sbjct: 551 LQYTENLVA 559
>NP_001265461
          Length = 552

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LQYSQSLIA 9
           LQY+++L+A
Sbjct: 498 LQYTENLVA 506
>NP_037509
          Length = 778

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LQYSQSLIA 9
           LQY++SL++
Sbjct: 342 LQYNESLVS 350
>NP_001158067
          Length = 1036

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LQYSQSLIA 9
           LQY++SL++
Sbjct: 600 LQYNESLVS 608
>XP_006725075
          Length = 552

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LQYSQSLIA 9
           LQY+++L+A
Sbjct: 498 LQYTENLVA 506
>XP_006725074
          Length = 678

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LQYSQSLIA 9
           LQY+++L+A
Sbjct: 624 LQYTENLVA 632
>XP_006725073
          Length = 688

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LQYSQSLIA 9
           LQY+++L+A
Sbjct: 634 LQYTENLVA 642
>XP_005267103
          Length = 552

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LQYSQSLIA 9
           LQY+++L+A
Sbjct: 498 LQYTENLVA 506
>XP_006715573
          Length = 678

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LQYSQSLIA 9
           LQY+++L+A
Sbjct: 624 LQYTENLVA 632
>XP_006715572
          Length = 688

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LQYSQSLIA 9
           LQY+++L+A
Sbjct: 634 LQYTENLVA 642
>NP_054859
          Length = 954

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LQYSQSLIA 9
           + YSQ LIA
Sbjct: 347 ISYSQDLIA 355
>NP_001120679
          Length = 954

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LQYSQSLIA 9
           + YSQ LIA
Sbjct: 347 ISYSQDLIA 355
>XP_006712620
          Length = 932

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LQYSQSLIA 9
           + YSQ LIA
Sbjct: 347 ISYSQDLIA 355
>XP_005246688
          Length = 954

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LQYSQSLIA 9
           + YSQ LIA
Sbjct: 347 ISYSQDLIA 355
>XP_005246689
          Length = 954

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LQYSQSLIA 9
           + YSQ LIA
Sbjct: 347 ISYSQDLIA 355
>NP_006098
          Length = 432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LQYSQSLIA 9
          L+Y QSL+A
Sbjct: 86 LRYLQSLLA 94
>NP_057508
          Length = 432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LQYSQSLIA 9
          L+Y QSL+A
Sbjct: 86 LRYLQSLLA 94
>XP_005257512
          Length = 387

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LQYSQSLIA 9
          L+Y QSL+A
Sbjct: 86 LRYLQSLLA 94
>XP_006722006
          Length = 413

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LQYSQSLIA 9
          L+Y QSL+A
Sbjct: 10 LRYLQSLLA 18
>XP_005257511
          Length = 422

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LQYSQSLIA 9
          L+Y QSL+A
Sbjct: 86 LRYLQSLLA 94
>XP_005257509
          Length = 442

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LQYSQSLIA 9
          L+Y QSL+A
Sbjct: 86 LRYLQSLLA 94
>XP_005257508
          Length = 469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LQYSQSLIA 9
          L+Y QSL+A
Sbjct: 86 LRYLQSLLA 94
>XP_005257507
          Length = 469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LQYSQSLIA 9
          L+Y QSL+A
Sbjct: 86 LRYLQSLLA 94
>XP_005257506
          Length = 472

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LQYSQSLIA 9
          L+Y QSL+A
Sbjct: 86 LRYLQSLLA 94
>XP_005257505
          Length = 489

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LQYSQSLIA 9
          L+Y QSL+A
Sbjct: 86 LRYLQSLLA 94
>NP_001360
          Length = 4624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LQYSQSLIA 9
            LQY QSL A
Sbjct: 4299 LQYIQSLPA 4307
>NP_001361
          Length = 4158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    QYSQSLI 8
            QY QSLI
Sbjct: 3012 QYRQSLI 3018
>NP_078849
          Length = 441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LQYSQSLI 8
          L+Y QSL+
Sbjct: 92 LEYQQSLL 99
>XP_005248319
          Length = 4609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LQYSQSLIA 9
            LQY QSL A
Sbjct: 4284 LQYIQSLPA 4292
>XP_006712019
          Length = 4158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    QYSQSLI 8
            QY QSLI
Sbjct: 3012 QYRQSLI 3018
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.125    0.296 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 370,150
Number of extensions: 404
Number of successful extensions: 33
Number of sequences better than 10000.0: 33
Number of HSP's gapped: 33
Number of HSP's successfully gapped: 33
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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