Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245200                                                           20     509
NP_000240                                                              20     509
XP_005265218                                                           20     509
NP_005460                                                              18    1935
XP_005260297                                                           18    1935
XP_005260296                                                           18    1935
NP_055590                                                              17    2528
NP_001007468                                                           17    2528
NP_001245256                                                           17    2528
NP_001245255                                                           17    2528
NP_001245254                                                           17    2528
XP_006724453                                                           17    2528
XP_005261930                                                           17    2528
XP_006724452                                                           17    2528
XP_005261929                                                           17    2528
XP_005261928                                                           17    2528
XP_005261927                                                           17    2528
XP_006724451                                                           17    2528
XP_005261926                                                           17    2528
XP_005261925                                                           17    2528
NP_003642                                                              17    3301
XP_006724816                                                           16    5631
XP_006724815                                                           16    5631
XP_006724814                                                           16    5631
XP_005262462                                                           16    5631
NP_001122326                                                           16    7355
NP_001122324                                                           16    7355
NP_001122325                                                           16    7355
NP_056992                                                              16    7355
NP_004167                                                              16    7355
NP_001005291                                                           16    7355
NP_115867                                                              16    7355
NP_071402                                                              16    7355
XP_006721633                                                           16    7355
XP_005256829                                                           16    7355
XP_005255530                                                           16    7355
XP_006716086                                                           16    7355
XP_005250465                                                           16    7355
XP_005250464                                                           16    7355
XP_005250463                                                           16    7355
XP_005250462                                                           16    7355
NP_115820                                                              15    9605
NP_001184008                                                           15    9605
NP_001541                                                              15    9605
NP_001007246                                                           15    9605
NP_001184009                                                           15    9605
NP_001258927                                                           15    9605
NP_004569                                                              15    9605
NP_059523                                                              15    9605
NP_003209                                                              15    9605
NP_064551                                                              15    9605
NP_036379                                                              15    9605
NP_001182531                                                           15    9605
NP_036380                                                              15    9605
NP_001107859                                                           15    9605
NP_006755                                                              15    9605
NP_872412                                                              15    9605
NP_115606                                                              15    9605
XP_006726481                                                           15    9605
XP_006719700                                                           15    9605
XP_005269242                                                           15    9605
XP_006719699                                                           15    9605
XP_005269241                                                           15    9605
XP_005251349                                                           15    9605
XP_005251348                                                           15    9605
XP_006714573                                                           15    9605
XP_006714269                                                           15    9605
XP_006713765                                                           15    9605
>NP_001245200
          Length = 687

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  LNRIAAGEV 9
          +NRIAAGEV
Sbjct: 16 VNRIAAGEV 24
>NP_000240
          Length = 756

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  LNRIAAGEV 9
          +NRIAAGEV
Sbjct: 16 VNRIAAGEV 24
>XP_005265218
          Length = 687

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  LNRIAAGEV 9
          +NRIAAGEV
Sbjct: 16 VNRIAAGEV 24
>NP_005460
          Length = 319

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LNRIAAGEV 9
           LNRIAA EV
Sbjct: 175 LNRIAAQEV 183
>XP_005260297
          Length = 254

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LNRIAAGEV 9
           LNRIAA EV
Sbjct: 175 LNRIAAQEV 183
>XP_005260296
          Length = 266

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LNRIAAGEV 9
           LNRIAA EV
Sbjct: 122 LNRIAAQEV 130
>NP_055590
          Length = 1211

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LNRIAAG 7
           LNRIAAG
Sbjct: 929 LNRIAAG 935
>NP_001007468
          Length = 1242

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LNRIAAG 7
           LNRIAAG
Sbjct: 960 LNRIAAG 966
>NP_001245256
          Length = 1148

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LNRIAAG 7
           LNRIAAG
Sbjct: 866 LNRIAAG 872
>NP_001245255
          Length = 1160

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LNRIAAG 7
           LNRIAAG
Sbjct: 878 LNRIAAG 884
>NP_001245254
          Length = 1187

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LNRIAAG 7
           LNRIAAG
Sbjct: 905 LNRIAAG 911
>XP_006724453
          Length = 1160

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LNRIAAG 7
           LNRIAAG
Sbjct: 878 LNRIAAG 884
>XP_005261930
          Length = 1189

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LNRIAAG 7
           LNRIAAG
Sbjct: 878 LNRIAAG 884
>XP_006724452
          Length = 1189

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LNRIAAG 7
           LNRIAAG
Sbjct: 878 LNRIAAG 884
>XP_005261929
          Length = 1240

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LNRIAAG 7
           LNRIAAG
Sbjct: 929 LNRIAAG 935
>XP_005261928
          Length = 1247

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LNRIAAG 7
           LNRIAAG
Sbjct: 936 LNRIAAG 942
>XP_005261927
          Length = 1247

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LNRIAAG 7
           LNRIAAG
Sbjct: 936 LNRIAAG 942
>XP_006724451
          Length = 1271

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LNRIAAG 7
           LNRIAAG
Sbjct: 960 LNRIAAG 966
>XP_005261926
          Length = 1271

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LNRIAAG 7
           LNRIAAG
Sbjct: 960 LNRIAAG 966
>XP_005261925
          Length = 1271

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   LNRIAAG 7
           LNRIAAG
Sbjct: 960 LNRIAAG 966
>NP_003642
          Length = 372

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRIAAGEV 9
           NRI AGE+
Sbjct: 257 NRIQAGEI 264
>XP_006724816
          Length = 1105

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  LNRIAAGE 8
          LNR  AGE
Sbjct: 6  LNRFCAGE 13
>XP_006724815
          Length = 1105

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  LNRIAAGE 8
          LNR  AGE
Sbjct: 6  LNRFCAGE 13
>XP_006724814
          Length = 1116

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  LNRIAAGE 8
          LNR  AGE
Sbjct: 6  LNRFCAGE 13
>XP_005262462
          Length = 1129

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  LNRIAAGE 8
          LNR  AGE
Sbjct: 6  LNRFCAGE 13
>NP_001122326
          Length = 871

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRIAAGEV 9
           NRI+ GEV
Sbjct: 651 NRISHGEV 658
>NP_001122324
          Length = 875

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRIAAGEV 9
           NRI+ GEV
Sbjct: 651 NRISHGEV 658
>NP_001122325
          Length = 872

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRIAAGEV 9
           NRI+ GEV
Sbjct: 652 NRISHGEV 659
>NP_056992
          Length = 876

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRIAAGEV 9
           NRI+ GEV
Sbjct: 652 NRISHGEV 659
>NP_004167
          Length = 1147

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LNRIAAG 7
           +NR+AAG
Sbjct: 305 INRLAAG 311
>NP_001005291
          Length = 1177

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LNRIAAG 7
           +NR+AAG
Sbjct: 335 INRLAAG 341
>NP_115867
          Length = 380

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   NRIAAGEV 9
           NR+A G+V
Sbjct: 243 NRVAEGQV 250
>NP_071402
          Length = 317

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  LNRIAAGE 8
          LNR+  GE
Sbjct: 47 LNRVVGGE 54
>XP_006721633
          Length = 1123

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LNRIAAG 7
           +NR+AAG
Sbjct: 281 INRLAAG 287
>XP_005256829
          Length = 1145

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LNRIAAG 7
           +NR+AAG
Sbjct: 303 INRLAAG 309
>XP_005255530
          Length = 317

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  LNRIAAGE 8
          LNR+  GE
Sbjct: 47 LNRVVGGE 54
>XP_006716086
          Length = 649

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRIAAGEV 9
           NRI+ GEV
Sbjct: 425 NRISHGEV 432
>XP_005250465
          Length = 878

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRIAAGEV 9
           NRI+ GEV
Sbjct: 658 NRISHGEV 665
>XP_005250464
          Length = 879

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRIAAGEV 9
           NRI+ GEV
Sbjct: 659 NRISHGEV 666
>XP_005250463
          Length = 882

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRIAAGEV 9
           NRI+ GEV
Sbjct: 658 NRISHGEV 665
>XP_005250462
          Length = 883

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NRIAAGEV 9
           NRI+ GEV
Sbjct: 659 NRISHGEV 666
>NP_115820
          Length = 1834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LNRIAAGEV 9
            LN+  AGEV
Sbjct: 1384 LNQTPAGEV 1392
>NP_001184008
          Length = 401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RIAAGE 8
           RIAAGE
Sbjct: 233 RIAAGE 238
>NP_001541
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RIAAGE 8
           RIAAGE
Sbjct: 283 RIAAGE 288
>NP_001007246
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RIAAGE 8
           RIAAGE
Sbjct: 283 RIAAGE 288
>NP_001184009
          Length = 401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RIAAGE 8
           RIAAGE
Sbjct: 233 RIAAGE 238
>NP_001258927
          Length = 113

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LNRIAAGEV 9
          LN+I +GE+
Sbjct: 70 LNKIESGEL 78
>NP_004569
          Length = 218

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LNRIAAGEV 9
           LN+I +GE+
Sbjct: 175 LNKIESGEL 183
>NP_059523
          Length = 439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LNRIAAGE 8
           L RIAAG+
Sbjct: 129 LTRIAAGK 136
>NP_003209
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LNRIAAGE 8
           L RIAAG+
Sbjct: 129 LTRIAAGK 136
>NP_064551
          Length = 725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RIAAGE 8
           RIAAGE
Sbjct: 361 RIAAGE 366
>NP_036379
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LNRIAAG 7
           LNR AAG
Sbjct: 247 LNRTAAG 253
>NP_001182531
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LNRIAAG 7
           LNR AAG
Sbjct: 180 LNRTAAG 186
>NP_036380
          Length = 448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LNRIAAG 7
           LNR AAG
Sbjct: 298 LNRTAAG 304
>NP_001107859
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LNRIAAGEV 9
           +NRIA+G +
Sbjct: 184 VNRIASGVI 192
>NP_006755
          Length = 506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RIAAGE 8
           RIAAGE
Sbjct: 341 RIAAGE 346
>NP_872412
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LNRIAAGEV 9
           +NRIA+G +
Sbjct: 187 VNRIASGVI 195
>NP_115606
          Length = 603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LNRIAAGE 8
           L R+AAG+
Sbjct: 460 LERVAAGQ 467
>XP_006726481
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  NRIAAG 7
          NR+AAG
Sbjct: 25 NRVAAG 30
>XP_006719700
          Length = 468

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LNRIAAGE 8
           L R+AAG+
Sbjct: 460 LERVAAGQ 467
>XP_005269242
          Length = 508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LNRIAAGE 8
           L R+AAG+
Sbjct: 460 LERVAAGQ 467
>XP_006719699
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LNRIAAGE 8
           L R+AAG+
Sbjct: 373 LERVAAGQ 380
>XP_005269241
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LNRIAAGE 8
           L R+AAG+
Sbjct: 460 LERVAAGQ 467
>XP_005251349
          Length = 449

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LNRIAAGE 8
           L RIAAG+
Sbjct: 129 LTRIAAGK 136
>XP_005251348
          Length = 469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LNRIAAGE 8
           L RIAAG+
Sbjct: 129 LTRIAAGK 136
>XP_006714573
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  NRIAAG 7
          NR+AAG
Sbjct: 25 NRVAAG 30
>XP_006714269
          Length = 387

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LNRIAAGEV 9
           +NRIA+G +
Sbjct: 153 VNRIASGVI 161
>XP_006713765
          Length = 616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RIAAGE 8
           RIAAGE
Sbjct: 252 RIAAGE 257
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.136    0.349 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 414,860
Number of extensions: 542
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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