Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              18    1935
NP_001075109                                                           18    1935
NP_001127923                                                           17    2528
NP_001127922                                                           17    2528
NP_690877                                                              17    2528
NP_057531                                                              17    2528
NP_000360                                                              17    2528
XP_005268094                                                           17    2528
XP_005249832                                                           17    2528
XP_006715803                                                           17    2528
XP_006715802                                                           17    2528
XP_006715801                                                           17    2528
NP_620687                                                              17    4312
NP_852111                                                              17    4312
NP_000136                                                              17    4312
NP_008880                                                              16    5631
NP_001258963                                                           16    5631
NP_001120868                                                           16    5631
NP_001265305                                                           16    5631
NP_001265310                                                           16    5631
NP_001265299                                                           16    5631
NP_001265302                                                           16    5631
NP_001265301                                                           16    5631
NP_001265303                                                           16    5631
NP_001265304                                                           16    5631
NP_005365                                                              16    5631
NP_001265300                                                           16    5631
XP_006722914                                                           16    5631
XP_006721977                                                           16    5631
XP_006721976                                                           16    5631
XP_006721975                                                           16    5631
NP_065386                                                              16    7355
NP_060606                                                              16    7355
NP_001193775                                                           16    7355
NP_001136018                                                           16    7355
NP_361013                                                              16    7355
NP_002842                                                              16    7355
NP_001193767                                                           16    7355
XP_005268986                                                           16    7355
XP_006716139                                                           16    7355
XP_005250576                                                           16    7355
NP_001193768                                                           16    7355
NP_001128302                                                           15    9605
NP_060121                                                              15    9605
NP_004987                                                              15    9605
NP_001128303                                                           15    9605
NP_001128304                                                           15    9605
NP_071431                                                              15    9605
NP_653259                                                              15    9605
XP_005262426                                                           15    9605
XP_005262425                                                           15    9605
XP_006720948                                                           15    9605
XP_006720947                                                           15    9605
XP_005255386                                                           15    9605
XP_005255385                                                           15    9605
XP_005255384                                                           15    9605
XP_005267096                                                           15    9605
XP_006715570                                                           15    9605
>NP_008835
          Length = 4128

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LLYITVRNA 9
           LL ITVRNA
Sbjct: 669 LLSITVRNA 677
>NP_001075109
          Length = 4097

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LLYITVRNA 9
           LL ITVRNA
Sbjct: 669 LLSITVRNA 677
>NP_001127923
          Length = 321

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LLYITVRNA 9
           ++Y+T+RNA
Sbjct: 255 IMYMTLRNA 263
>NP_001127922
          Length = 435

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LLYITVRNA 9
           ++Y+T+RNA
Sbjct: 357 IMYMTLRNA 365
>NP_690877
          Length = 423

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LLYITVRNA 9
           ++Y+T+RNA
Sbjct: 357 IMYMTLRNA 365
>NP_057531
          Length = 540

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LLYITVRNA 9
           ++Y+T RNA
Sbjct: 309 MMYLTTRNA 317
>NP_000360
          Length = 764

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LYITVRN 8
           +YITVRN
Sbjct: 604 IYITVRN 610
>XP_005268094
          Length = 764

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LYITVRN 8
           +YITVRN
Sbjct: 604 IYITVRN 610
>XP_005249832
          Length = 428

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LLYITVRNA 9
           ++Y+T RNA
Sbjct: 197 MMYLTTRNA 205
>XP_006715803
          Length = 540

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LLYITVRNA 9
           ++Y+T RNA
Sbjct: 309 MMYLTTRNA 317
>XP_006715802
          Length = 540

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LLYITVRNA 9
           ++Y+T RNA
Sbjct: 309 MMYLTTRNA 317
>XP_006715801
          Length = 540

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LLYITVRNA 9
           ++Y+T RNA
Sbjct: 309 MMYLTTRNA 317
>NP_620687
          Length = 1224

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   YITVRNA 9
           YI+VRNA
Sbjct: 785 YISVRNA 791
>NP_852111
          Length = 669

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LYITVRN 8
           +Y+TVRN
Sbjct: 526 IYLTVRN 532
>NP_000136
          Length = 695

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LYITVRN 8
           +Y+TVRN
Sbjct: 552 IYLTVRN 558
>NP_008880
          Length = 593

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LLYITVRN 8
           LLYI +RN
Sbjct: 408 LLYILLRN 415
>NP_001258963
          Length = 604

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LLYITVRN 8
           LLYI +RN
Sbjct: 419 LLYILLRN 426
>NP_001120868
          Length = 590

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LLYITVRN 8
           LLYI +RN
Sbjct: 405 LLYILLRN 412
>NP_001265305
          Length = 569

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LLYITVRNA 9
           ++Y+T +NA
Sbjct: 338 MMYLTTKNA 346
>NP_001265310
          Length = 552

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LLYITVRNA 9
           ++Y+T +NA
Sbjct: 321 MMYLTTKNA 329
>NP_001265299
          Length = 597

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LLYITVRNA 9
           ++Y+T +NA
Sbjct: 366 MMYLTTKNA 374
>NP_001265302
          Length = 541

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LLYITVRNA 9
           ++Y+T +NA
Sbjct: 310 MMYLTTKNA 318
>NP_001265301
          Length = 576

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LLYITVRNA 9
           ++Y+T +NA
Sbjct: 345 MMYLTTKNA 353
>NP_001265303
          Length = 413

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LLYITVRNA 9
           ++Y+T +NA
Sbjct: 182 MMYLTTKNA 190
>NP_001265304
          Length = 541

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LLYITVRNA 9
           ++Y+T +NA
Sbjct: 310 MMYLTTKNA 318
>NP_005365
          Length = 552

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LLYITVRNA 9
           ++Y+T +NA
Sbjct: 321 MMYLTTKNA 329
>NP_001265300
          Length = 541

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LLYITVRNA 9
           ++Y+T +NA
Sbjct: 310 MMYLTTKNA 318
>XP_006722914
          Length = 566

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LLYITVRN 8
           LLYI +RN
Sbjct: 381 LLYILLRN 388
>XP_006721977
          Length = 535

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LLYITVRNA 9
           ++Y+T +NA
Sbjct: 304 MMYLTTKNA 312
>XP_006721976
          Length = 546

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LLYITVRNA 9
           ++Y+T +NA
Sbjct: 315 MMYLTTKNA 323
>XP_006721975
          Length = 563

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LLYITVRNA 9
           ++Y+T +NA
Sbjct: 332 MMYLTTKNA 340
>NP_065386
          Length = 179

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LLYITVRNA 9
           LL++++RNA
Sbjct: 169 LLFMSLRNA 177
>NP_060606
          Length = 3477

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LYITVRNA 9
            LY+ V+NA
Sbjct: 3130 LYLAVKNA 3137
>NP_001193775
          Length = 1892

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LYITVRNA 9
            LY+ V+NA
Sbjct: 1545 LYLAVKNA 1552
>NP_001136018
          Length = 1076

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YITVRNA 9
           ++TVRNA
Sbjct: 917 HVTVRNA 923
>NP_361013
          Length = 1076

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YITVRNA 9
           ++TVRNA
Sbjct: 917 HVTVRNA 923
>NP_002842
          Length = 2315

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    LLYITVRN 8
            L Y TVRN
Sbjct: 1862 LAYYTVRN 1869
>NP_001193767
          Length = 1455

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    LLYITVRN 8
            L Y TVRN
Sbjct: 1002 LAYYTVRN 1009
>XP_005268986
          Length = 179

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LLYITVRNA 9
           LL++++RNA
Sbjct: 169 LLFMSLRNA 177
>XP_006716139
          Length = 1869

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    LLYITVRN 8
            L Y TVRN
Sbjct: 1416 LAYYTVRN 1423
>XP_005250576
          Length = 2308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    LLYITVRN 8
            L Y TVRN
Sbjct: 1855 LAYYTVRN 1862
>NP_001193768
          Length = 1448

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    LLYITVRN 8
            L Y TVRN
Sbjct: 995  LAYYTVRN 1002
>NP_001128302
          Length = 1196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LYITVR 7
           LY+TVR
Sbjct: 530 LYVTVR 535
>NP_060121
          Length = 1196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LYITVR 7
           LY+TVR
Sbjct: 530 LYVTVR 535
>NP_004987
          Length = 1531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ITVRNA 9
           ITVRNA
Sbjct: 644 ITVRNA 649
>NP_001128303
          Length = 1196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LYITVR 7
           LY+TVR
Sbjct: 530 LYVTVR 535
>NP_001128304
          Length = 1053

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LYITVR 7
           LY+TVR
Sbjct: 530 LYVTVR 535
>NP_071431
          Length = 371

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LLYITVRN 8
           +LY ++RN
Sbjct: 94  ILYFSIRN 101
>NP_653259
          Length = 2073

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LLYITVRN 8
            LLY+ +RN
Sbjct: 1504 LLYLLMRN 1511
>XP_005262426
          Length = 2055

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LLYITVRN 8
            LLY+ +RN
Sbjct: 1486 LLYLLMRN 1493
>XP_005262425
          Length = 2086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LLYITVRN 8
            LLY+ +RN
Sbjct: 1517 LLYLLMRN 1524
>XP_006720948
          Length = 1401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ITVRNA 9
           ITVRNA
Sbjct: 514 ITVRNA 519
>XP_006720947
          Length = 1466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ITVRNA 9
           ITVRNA
Sbjct: 644 ITVRNA 649
>XP_005255386
          Length = 1472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ITVRNA 9
           ITVRNA
Sbjct: 644 ITVRNA 649
>XP_005255385
          Length = 1485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ITVRNA 9
           ITVRNA
Sbjct: 598 ITVRNA 603
>XP_005255384
          Length = 1489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ITVRNA 9
           ITVRNA
Sbjct: 602 ITVRNA 607
>XP_005267096
          Length = 1168

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LYITVR 7
           LY+TVR
Sbjct: 530 LYVTVR 535
>XP_006715570
          Length = 1179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LYITVR 7
           LY+TVR
Sbjct: 530 LYVTVR 535
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.335    0.145    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 372,509
Number of extensions: 584
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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