Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004382                                                              18    1935
NP_055723                                                              17    4312
NP_857595                                                              17    4312
NP_056259                                                              17    4312
NP_001191387                                                           16    5631
NP_683760                                                              16    5631
NP_001155130                                                           16    5631
NP_001155131                                                           16    5631
NP_001155132                                                           16    5631
NP_001155128                                                           16    5631
NP_001155129                                                           16    5631
NP_001123644                                                           16    5631
NP_001123645                                                           16    5631
NP_005366                                                              16    5631
NP_061117                                                              16    5631
XP_005266503                                                           16    5631
XP_005266502                                                           16    5631
XP_006715558                                                           16    5631
NP_060527                                                              16    7355
NP_003493                                                              16    7355
NP_851393                                                              16    7355
NP_001001665                                                           16    7355
NP_001188505                                                           16    7355
NP_065093                                                              16    7355
XP_005255667                                                           16    7355
XP_005255666                                                           16    7355
XP_005255665                                                           16    7355
XP_005255664                                                           16    7355
XP_006712546                                                           16    7355
NP_000008                                                              15    9605
NP_733828                                                              15    9605
NP_057258                                                              15    9605
NP_057133                                                              15    9605
NP_689749                                                              15    9605
NP_001273689                                                           15    9605
NP_061917                                                              15    9605
NP_851782                                                              15    9605
NP_001107592                                                           15    9605
XP_005267778                                                           15    9605
XP_005252094                                                           15    9605
XP_006717200                                                           15    9605
XP_005252092                                                           15    9605
XP_005262782                                                           15    9605
XP_006714141                                                           15    9605
XP_005262780                                                           15    9605
XP_005262779                                                           15    9605
XP_005264958                                                           15    9605
XP_005264957                                                           15    9605
XP_006712663                                                           15    9605
XP_006712662                                                           15    9605
XP_006712661                                                           15    9605
XP_006712660                                                           15    9605
NP_006373                                                              15    9605
>NP_004382
          Length = 501

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1  LLVIAGYL 8
          L+VIAGYL
Sbjct: 12 LVVIAGYL 19
>NP_055723
          Length = 538

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LLVIAGYLP 9
           L+V+A Y+P
Sbjct: 342 LIVVATYIP 350
>NP_857595
          Length = 514

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IAGYLP 9
           +AGYLP
Sbjct: 347 VAGYLP 352
>NP_056259
          Length = 300

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VIAGYLP 9
           +IAG+LP
Sbjct: 247 IIAGFLP 253
>NP_001191387
          Length = 417

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LLVIAGYL 8
          LLV+ GYL
Sbjct: 16 LLVLLGYL 23
>NP_683760
          Length = 417

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LLVIAGYL 8
          LLV+ GYL
Sbjct: 16 LLVLLGYL 23
>NP_001155130
          Length = 745

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  VIAGYLP 9
          VIA YLP
Sbjct: 65 VIANYLP 71
>NP_001155131
          Length = 603

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  VIAGYLP 9
          VIA YLP
Sbjct: 65 VIANYLP 71
>NP_001155132
          Length = 605

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  VIAGYLP 9
          VIA YLP
Sbjct: 65 VIANYLP 71
>NP_001155128
          Length = 758

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  VIAGYLP 9
          VIA YLP
Sbjct: 65 VIANYLP 71
>NP_001155129
          Length = 555

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  VIAGYLP 9
          VIA YLP
Sbjct: 65 VIANYLP 71
>NP_001123644
          Length = 637

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  VIAGYLP 9
          VIA YLP
Sbjct: 65 VIANYLP 71
>NP_001123645
          Length = 761

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  VIAGYLP 9
          VIA YLP
Sbjct: 65 VIANYLP 71
>NP_005366
          Length = 640

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  VIAGYLP 9
          VIA YLP
Sbjct: 65 VIANYLP 71
>NP_061117
          Length = 423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LLVIAGYL 8
          LLV+ GYL
Sbjct: 16 LLVLLGYL 23
>XP_005266503
          Length = 328

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LLVIAGYL 8
          LLV+ GYL
Sbjct: 16 LLVLLGYL 23
>XP_005266502
          Length = 423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LLVIAGYL 8
          LLV+ GYL
Sbjct: 16 LLVLLGYL 23
>XP_006715558
          Length = 449

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  VIAGYLP 9
          VIA YLP
Sbjct: 65 VIANYLP 71
>NP_060527
          Length = 289

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LLVIAGYLP 9
           L+ I+G++P
Sbjct: 263 LITISGFIP 271
>NP_003493
          Length = 862

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IAGYLP 9
           I+GYLP
Sbjct: 234 ISGYLP 239
>NP_851393
          Length = 826

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IAGYLP 9
           I+GYLP
Sbjct: 234 ISGYLP 239
>NP_001001665
          Length = 372

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LVIAGYL 8
           LVI GYL
Sbjct: 256 LVIGGYL 262
>NP_001188505
          Length = 295

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4 IAGYLP 9
         +AGYLP
Sbjct: 1 MAGYLP 6
>NP_065093
          Length = 295

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4 IAGYLP 9
         +AGYLP
Sbjct: 1 MAGYLP 6
>XP_005255667
          Length = 473

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IAGYLP 9
           I+GYLP
Sbjct: 283 ISGYLP 288
>XP_005255666
          Length = 862

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IAGYLP 9
           I+GYLP
Sbjct: 234 ISGYLP 239
>XP_005255665
          Length = 875

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IAGYLP 9
           I+GYLP
Sbjct: 283 ISGYLP 288
>XP_005255664
          Length = 911

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IAGYLP 9
           I+GYLP
Sbjct: 283 ISGYLP 288
>XP_006712546
          Length = 447

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LVIAGYL 8
           LVI GYL
Sbjct: 331 LVIGGYL 337
>NP_000008
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LVIAGYL 8
           LVIAG+L
Sbjct: 400 LVIAGHL 406
>NP_733828
          Length = 1322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    LLVIAGYL 8
            LL++ GY+
Sbjct: 1160 LLILCGYI 1167
>NP_057258
          Length = 595

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LVIAGY 7
           LV+AGY
Sbjct: 465 LVVAGY 470
>NP_057133
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  LVIAGY 7
          LV+AGY
Sbjct: 76 LVVAGY 81
>NP_689749
          Length = 1462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   IAGYLP 9
           +AGY+P
Sbjct: 489 VAGYVP 494
>NP_001273689
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LVIAGY 7
           LV+AGY
Sbjct: 387 LVVAGY 392
>NP_061917
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  LLVIAGY 7
          LLV AGY
Sbjct: 33 LLVAAGY 39
>NP_851782
          Length = 1283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    LLVIAGYL 8
            LL++ GY+
Sbjct: 1121 LLILCGYI 1128
>NP_001107592
          Length = 811

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LLVIAGYL 8
           +LV+ GY+
Sbjct: 302 ILVVCGYI 309
>XP_005267778
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  LVIAGY 7
          LV+AGY
Sbjct: 76 LVVAGY 81
>XP_005252094
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LVIAGY 7
           LV+AGY
Sbjct: 387 LVVAGY 392
>XP_006717200
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LVIAGY 7
           LV+AGY
Sbjct: 387 LVVAGY 392
>XP_005252092
          Length = 595

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LVIAGY 7
           LV+AGY
Sbjct: 465 LVVAGY 470
>XP_005262782
          Length = 1216

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    LLVIAGYL 8
            LL++ GY+
Sbjct: 1054 LLILCGYI 1061
>XP_006714141
          Length = 1259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    LLVIAGYL 8
            LL++ GY+
Sbjct: 1097 LLILCGYI 1104
>XP_005262780
          Length = 1307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    LLVIAGYL 8
            LL++ GY+
Sbjct: 1145 LLILCGYI 1152
>XP_005262779
          Length = 1314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    LLVIAGYL 8
            LL++ GY+
Sbjct: 1152 LLILCGYI 1159
>XP_005264958
          Length = 1462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   IAGYLP 9
           +AGY+P
Sbjct: 532 VAGYVP 537
>XP_005264957
          Length = 1505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   IAGYLP 9
           +AGY+P
Sbjct: 532 VAGYVP 537
>XP_006712663
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  LLVIAGY 7
          LLV AGY
Sbjct: 89 LLVAAGY 95
>XP_006712662
          Length = 425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  LLVIAGY 7
          LLV AGY
Sbjct: 89 LLVAAGY 95
>XP_006712661
          Length = 692

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  LLVIAGY 7
          LLV AGY
Sbjct: 89 LLVAAGY 95
>XP_006712660
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  LLVIAGY 7
          LLV AGY
Sbjct: 89 LLVAAGY 95
>NP_006373
          Length = 752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LVIAGYLP 9
           L IAG+LP
Sbjct: 710 LHIAGHLP 717
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.333    0.162    0.485 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 452,811
Number of extensions: 549
Number of successful extensions: 53
Number of sequences better than 10000.0: 53
Number of HSP's gapped: 53
Number of HSP's successfully gapped: 53
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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