Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001269596                                                           18    1135
NP_001269595                                                           18    1135
XP_005253308                                                           18    1135
NP_003136                                                              17    2528
NP_000427                                                              17    3301
NP_071403                                                              17    3301
NP_073581                                                              17    4312
NP_003671                                                              16    5631
NP_056046                                                              16    5631
NP_612213                                                              16    5631
XP_006723231                                                           16    5631
XP_005258877                                                           16    5631
XP_005258876                                                           16    5631
XP_006718233                                                           16    5631
NP_054756                                                              16    5631
NP_001025169                                                           16    7355
NP_057264                                                              16    7355
NP_060142                                                              16    7355
NP_059138                                                              16    7355
NP_001265585                                                           16    7355
NP_001012527                                                           16    7355
NP_004166                                                              16    7355
XP_006720645                                                           16    7355
XP_005254546                                                           16    7355
XP_005254545                                                           16    7355
XP_005254544                                                           16    7355
XP_005254543                                                           16    7355
XP_005248368                                                           16    7355
XP_005263333                                                           16    7355
NP_001360                                                              15    9605
NP_001596                                                              15    9605
NP_998763                                                              15    9605
NP_060527                                                              15    9605
NP_877499                                                              15    9605
NP_001265398                                                           15    9605
NP_001265400                                                           15    9605
NP_001265399                                                           15    9605
NP_001265401                                                           15    9605
NP_055841                                                              15    9605
NP_659424                                                              15    9605
NP_001010898                                                           15    9605
NP_057594                                                              15    9605
NP_001193856                                                           15    9605
XP_006726853                                                           15    9605
XP_006723596                                                           15    9605
XP_006721216                                                           15    9605
XP_005268793                                                           15    9605
XP_005268792                                                           15    9605
XP_005268791                                                           15    9605
XP_005268789                                                           15    9605
XP_005268788                                                           15    9605
XP_006715067                                                           15    9605
XP_005248319                                                           15    9605
XP_006710706                                                           15    9605
NP_001956                                                              15    9605
>NP_001269596
          Length = 955

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   LLSIGVPLL 9
           LLS+G+PLL
Sbjct: 913 LLSLGLPLL 921
>NP_001269595
          Length = 976

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   LLSIGVPLL 9
           LLS+G+PLL
Sbjct: 934 LLSLGLPLL 942
>XP_005253308
          Length = 1012

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   LLSIGVPLL 9
           LLS+G+PLL
Sbjct: 970 LLSLGLPLL 978
>NP_003136
          Length = 183

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LLSIGVPLL 9
           L SIG+PLL
Sbjct: 158 LPSIGIPLL 166
>NP_000427
          Length = 520

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LSIGVPLL 9
           L IG+PLL
Sbjct: 321 LGIGIPLL 328
>NP_071403
          Length = 517

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LSIGVPLL 9
           L IG+PLL
Sbjct: 318 LGIGIPLL 325
>NP_073581
          Length = 468

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LSIGVPL 8
           LS+GVPL
Sbjct: 327 LSLGVPL 333
>NP_003671
          Length = 528

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LLSIGVPL 8
           L SIGVPL
Sbjct: 105 LESIGVPL 112
>NP_056046
          Length = 1436

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    LLSIGVPL 8
            LLS GVPL
Sbjct: 1314 LLSHGVPL 1321
>NP_612213
          Length = 409

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LLSIGVPLL 9
           L S+G+P+L
Sbjct: 331 LKSVGIPVL 339
>XP_006723231
          Length = 736

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLSIGVPLL 9
           L  +GVPLL
Sbjct: 149 LFLVGVPLL 157
>XP_005258877
          Length = 736

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLSIGVPLL 9
           L  +GVPLL
Sbjct: 149 LFLVGVPLL 157
>XP_005258876
          Length = 818

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLSIGVPLL 9
           L  +GVPLL
Sbjct: 231 LFLVGVPLL 239
>XP_006718233
          Length = 782

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LLSIGVPL 8
           LLS GVPL
Sbjct: 660 LLSHGVPL 667
>NP_054756
          Length = 736

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLSIGVPLL 9
           L  +GVPLL
Sbjct: 149 LFLVGVPLL 157
>NP_001025169
          Length = 340

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LSIGVPLL 9
           L++G+P+L
Sbjct: 280 LTLGIPML 287
>NP_057264
          Length = 530

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  LLSIGVP 7
          LLS+G+P
Sbjct: 60 LLSVGLP 66
>NP_060142
          Length = 1865

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    LLSIGVP 7
            LLS GVP
Sbjct: 1011 LLSFGVP 1017
>NP_059138
          Length = 1032

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSIGVPLL 9
           L +GVP+L
Sbjct: 828 LGLGVPML 835
>NP_001265585
          Length = 126

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2 LSIGVPL 8
         +SIGVP+
Sbjct: 1 MSIGVPI 7
>NP_001012527
          Length = 460

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  LLSIGVP 7
          LLS+G+P
Sbjct: 60 LLSVGLP 66
>NP_004166
          Length = 126

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2 LSIGVPL 8
         +SIGVP+
Sbjct: 1 MSIGVPI 7
>XP_006720645
          Length = 1060

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    LLSIGVP 7
            LLS GVP
Sbjct: 1011 LLSFGVP 1017
>XP_005254546
          Length = 1443

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LLSIGVP 7
           LLS GVP
Sbjct: 569 LLSFGVP 575
>XP_005254545
          Length = 1864

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    LLSIGVP 7
            LLS GVP
Sbjct: 1011 LLSFGVP 1017
>XP_005254544
          Length = 1884

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    LLSIGVP 7
            LLS GVP
Sbjct: 1011 LLSFGVP 1017
>XP_005254543
          Length = 1885

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    LLSIGVP 7
            LLS GVP
Sbjct: 1011 LLSFGVP 1017
>XP_005248368
          Length = 243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  LLSIGVP 7
          LLS+G+P
Sbjct: 60 LLSVGLP 66
>XP_005263333
          Length = 358

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LSIGVPLL 9
           L++G+P+L
Sbjct: 280 LTLGIPML 287
>NP_001360
          Length = 4624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LSIGVPLL 9
            LS+G PLL
Sbjct: 3641 LSLGRPLL 3648
>NP_001596
          Length = 968

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LLSIGVPL 8
           ++SIGVP+
Sbjct: 696 VVSIGVPV 703
>NP_998763
          Length = 600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LLSIGVPL 8
          L+S+G PL
Sbjct: 45 LMSLGCPL 52
>NP_060527
          Length = 289

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LLSIGVPL 8
           L+ IG+PL
Sbjct: 107 LMVIGIPL 114
>NP_877499
          Length = 730

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LLSIGVPL 8
           L+ IG+PL
Sbjct: 107 LMVIGIPL 114
>NP_001265398
          Length = 1675

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LLSIGVPL 8
            +LSIG+P+
Sbjct: 1469 VLSIGLPV 1476
>NP_001265400
          Length = 1688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LLSIGVPL 8
            +LSIG+P+
Sbjct: 1440 VLSIGLPV 1447
>NP_001265399
          Length = 1711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LLSIGVPL 8
            +LSIG+P+
Sbjct: 1463 VLSIGLPV 1470
>NP_001265401
          Length = 1645

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LLSIGVPL 8
            +LSIG+P+
Sbjct: 1397 VLSIGLPV 1404
>NP_055841
          Length = 1717

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LLSIGVPL 8
            +LSIG+P+
Sbjct: 1469 VLSIGLPV 1476
>NP_659424
          Length = 202

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SIGVPLL 9
           +IGVPL+
Sbjct: 150 TIGVPLI 156
>NP_001010898
          Length = 727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LLSIGVPL 8
           L+ IG+PL
Sbjct: 106 LIIIGIPL 113
>NP_057594
          Length = 453

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LLSIGVP 7
           LLS GVP
Sbjct: 408 LLSYGVP 414
>NP_001193856
          Length = 4707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LSIGVPLL 9
            LS+G PLL
Sbjct: 3723 LSLGRPLL 3730
>XP_006726853
          Length = 707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  LLSIGVP 7
          LLS+G+P
Sbjct: 75 LLSLGLP 81
>XP_006723596
          Length = 707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  LLSIGVP 7
          LLS+G+P
Sbjct: 75 LLSLGLP 81
>XP_006721216
          Length = 877

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LLSIGVPL 8
           ++SIGVP+
Sbjct: 696 VVSIGVPV 703
>XP_005268793
          Length = 1162

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   LLSIGVPL 8
           +LSIG+P+
Sbjct: 914 VLSIGLPV 921
>XP_005268792
          Length = 1646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LLSIGVPL 8
            +LSIG+P+
Sbjct: 1398 VLSIGLPV 1405
>XP_005268791
          Length = 1646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LLSIGVPL 8
            +LSIG+P+
Sbjct: 1398 VLSIGLPV 1405
>XP_005268789
          Length = 1712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LLSIGVPL 8
            +LSIG+P+
Sbjct: 1464 VLSIGLPV 1471
>XP_005268788
          Length = 1718

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LLSIGVPL 8
            +LSIG+P+
Sbjct: 1470 VLSIGLPV 1477
>XP_006715067
          Length = 4707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LSIGVPLL 9
            LS+G PLL
Sbjct: 3723 LSLGRPLL 3730
>XP_005248319
          Length = 4609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LSIGVPLL 9
            LS+G PLL
Sbjct: 3626 LSLGRPLL 3633
>XP_006710706
          Length = 727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LLSIGVPL 8
           L+ IG+PL
Sbjct: 106 LIIIGIPL 113
>NP_001956
          Length = 589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LLSIGVP 7
           LLS+G P
Sbjct: 313 LLSVGAP 319
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.160    0.443 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 635,897
Number of extensions: 1058
Number of successful extensions: 55
Number of sequences better than 10000.0: 55
Number of HSP's gapped: 55
Number of HSP's successfully gapped: 55
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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