Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_115803                                                              18    1135
NP_877435                                                              17    3301
NP_005874                                                              17    4312
XP_005276776                                                           17    4312
XP_005262564                                                           17    4312
XP_006722673                                                           17    4312
XP_006722672                                                           17    4312
XP_006722671                                                           17    4312
XP_006722670                                                           17    4312
XP_005259532                                                           17    4312
XP_006710324                                                           17    4312
XP_006726609                                                           16    5631
XP_006719787                                                           16    5631
XP_006710027                                                           16    5631
NP_115532                                                              16    7355
NP_076414                                                              16    7355
NP_001002259                                                           16    7355
NP_001193785                                                           16    7355
NP_055469                                                              16    7355
NP_110429                                                              16    7355
XP_006719211                                                           16    7355
XP_006719210                                                           16    7355
XP_006719209                                                           16    7355
XP_006719208                                                           16    7355
XP_006719207                                                           16    7355
XP_006719206                                                           16    7355
XP_006719205                                                           16    7355
XP_006719204                                                           16    7355
XP_006719203                                                           16    7355
XP_006719202                                                           16    7355
XP_006719201                                                           16    7355
XP_006719200                                                           16    7355
NP_001124537                                                           16    7355
NP_001124538                                                           16    7355
NP_000531                                                              15    9605
NP_001036188                                                           15    9605
NP_705838                                                              15    9605
NP_009041                                                              15    9605
NP_060724                                                              15    9605
NP_001129695                                                           15    9605
NP_940978                                                              15    9605
NP_060060                                                              15    9605
NP_001130008                                                           15    9605
NP_001124382                                                           15    9605
NP_056083                                                              15    9605
NP_001275923                                                           15    9605
NP_001275922                                                           15    9605
NP_001275921                                                           15    9605
NP_001275920                                                           15    9605
NP_001004326                                                           15    9605
NP_060900                                                              15    9605
NP_001275919                                                           15    9605
NP_001164171                                                           15    9605
XP_006723382                                                           15    9605
XP_006723381                                                           15    9605
XP_006723380                                                           15    9605
XP_006721298                                                           15    9605
XP_005256111                                                           15    9605
XP_005256110                                                           15    9605
XP_005256109                                                           15    9605
XP_006721297                                                           15    9605
XP_005256108                                                           15    9605
XP_005256106                                                           15    9605
XP_005268084                                                           15    9605
XP_005274066                                                           15    9605
XP_006714077                                                           15    9605
XP_005247302                                                           15    9605
XP_005273249                                                           15    9605
XP_005273248                                                           15    9605
XP_006710700                                                           15    9605
XP_006710699                                                           15    9605
XP_005244806                                                           15    9605
XP_006710697                                                           15    9605
XP_006710696                                                           15    9605
NP_003956                                                              15    9605
>NP_115803
          Length = 1156

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LLRSTLPLQ 9
           LLRS LPLQ
Sbjct: 679 LLRSPLPLQ 687
>NP_877435
          Length = 1102

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    LRSTLPLQ 9
            +R+TLPLQ
Sbjct: 1042 VRNTLPLQ 1049
>NP_005874
          Length = 2303

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LLRSTLP 7
            +LRSTLP
Sbjct: 2157 ILRSTLP 2163
>XP_005276776
          Length = 991

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LRSTLPLQ 9
           +RSTLPL+
Sbjct: 844 VRSTLPLR 851
>XP_005262564
          Length = 991

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LRSTLPLQ 9
           +RSTLPL+
Sbjct: 844 VRSTLPLR 851
>XP_006722673
          Length = 2302

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LLRSTLP 7
            +LRSTLP
Sbjct: 2156 ILRSTLP 2162
>XP_006722672
          Length = 2303

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LLRSTLP 7
            +LRSTLP
Sbjct: 2157 ILRSTLP 2163
>XP_006722671
          Length = 2303

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LLRSTLP 7
            +LRSTLP
Sbjct: 2157 ILRSTLP 2163
>XP_006722670
          Length = 2326

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LLRSTLP 7
            +LRSTLP
Sbjct: 2180 ILRSTLP 2186
>XP_005259532
          Length = 2327

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LLRSTLP 7
            +LRSTLP
Sbjct: 2181 ILRSTLP 2187
>XP_006710324
          Length = 943

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LRSTLPLQ 9
           +RSTLPL+
Sbjct: 796 VRSTLPLR 803
>XP_006726609
          Length = 2838

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LLRSTLP 7
            LLR+TLP
Sbjct: 2095 LLRTTLP 2101
>XP_006719787
          Length = 2838

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LLRSTLP 7
            LLR+TLP
Sbjct: 2095 LLRTTLP 2101
>XP_006710027
          Length = 2837

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LLRSTLP 7
            LLR+TLP
Sbjct: 2094 LLRTTLP 2100
>NP_115532
          Length = 960

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LRSTLP 7
           LRSTLP
Sbjct: 449 LRSTLP 454
>NP_076414
          Length = 1077

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LRSTLP 7
           LRSTLP
Sbjct: 449 LRSTLP 454
>NP_001002259
          Length = 1127

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LRSTLP 7
           LRSTLP
Sbjct: 449 LRSTLP 454
>NP_001193785
          Length = 905

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LRSTLP 7
           LRSTLP
Sbjct: 449 LRSTLP 454
>NP_055469
          Length = 442

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   RSTLPL 8
           RSTLPL
Sbjct: 273 RSTLPL 278
>NP_110429
          Length = 453

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LRSTLPLQ 9
          LR+T+P Q
Sbjct: 44 LRATIPFQ 51
>XP_006719211
          Length = 794

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LRSTLP 7
           LRSTLP
Sbjct: 116 LRSTLP 121
>XP_006719210
          Length = 940

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LRSTLP 7
           LRSTLP
Sbjct: 449 LRSTLP 454
>XP_006719209
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LRSTLP 7
           LRSTLP
Sbjct: 449 LRSTLP 454
>XP_006719208
          Length = 961

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LRSTLP 7
           LRSTLP
Sbjct: 449 LRSTLP 454
>XP_006719207
          Length = 1043

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LRSTLP 7
           LRSTLP
Sbjct: 449 LRSTLP 454
>XP_006719206
          Length = 1046

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LRSTLP 7
           LRSTLP
Sbjct: 368 LRSTLP 373
>XP_006719205
          Length = 1057

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LRSTLP 7
           LRSTLP
Sbjct: 449 LRSTLP 454
>XP_006719204
          Length = 1078

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LRSTLP 7
           LRSTLP
Sbjct: 449 LRSTLP 454
>XP_006719203
          Length = 1091

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LRSTLP 7
           LRSTLP
Sbjct: 449 LRSTLP 454
>XP_006719202
          Length = 1092

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LRSTLP 7
           LRSTLP
Sbjct: 449 LRSTLP 454
>XP_006719201
          Length = 1106

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LRSTLP 7
           LRSTLP
Sbjct: 449 LRSTLP 454
>XP_006719200
          Length = 1126

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LRSTLP 7
           LRSTLP
Sbjct: 449 LRSTLP 454
>NP_001124537
          Length = 210

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  STLPLQ 9
          STLPLQ
Sbjct: 15 STLPLQ 20
>NP_001124538
          Length = 210

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  STLPLQ 9
          STLPLQ
Sbjct: 15 STLPLQ 20
>NP_000531
          Length = 5038

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LLRSTLPLQ 9
            +LRS +PL+
Sbjct: 2456 ILRSLVPLE 2464
>NP_001036188
          Length = 5033

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LLRSTLPLQ 9
            +LRS +PL+
Sbjct: 2456 ILRSLVPLE 2464
>NP_705838
          Length = 4069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LLRSTLPLQ 9
            L+R  LPL+
Sbjct: 1856 LMRENLPLE 1864
>NP_009041
          Length = 2627

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LLRSTLP 7
           LLRS LP
Sbjct: 917 LLRSVLP 923
>NP_060724
          Length = 495

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LLRSTLP 7
           LLR TLP
Sbjct: 417 LLRPTLP 423
>NP_001129695
          Length = 553

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LLRSTLP 7
           LLR TLP
Sbjct: 475 LLRPTLP 481
>NP_940978
          Length = 2045

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LLRSTLPL 8
            +LRST+P+
Sbjct: 1940 VLRSTVPV 1947
>NP_060060
          Length = 977

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LRSTLPLQ 9
          ++STLPL+
Sbjct: 17 IQSTLPLK 24
>NP_001130008
          Length = 616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LRSTLPLQ 9
           L STLPL+
Sbjct: 532 LSSTLPLR 539
>NP_001124382
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   LRSTLPLQ 9
           LRS  PLQ
Sbjct: 329 LRSNTPLQ 336
>NP_056083
          Length = 2243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RSTLPLQ 9
           R+T+PLQ
Sbjct: 952 RATVPLQ 958
>NP_001275923
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LLRSTLPLQ 9
           +L+ST PL+
Sbjct: 211 VLKSTFPLK 219
>NP_001275922
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LLRSTLPLQ 9
           +L+ST PL+
Sbjct: 211 VLKSTFPLK 219
>NP_001275921
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LLRSTLPLQ 9
           +L+ST PL+
Sbjct: 211 VLKSTFPLK 219
>NP_001275920
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LLRSTLPLQ 9
           +L+ST PL+
Sbjct: 488 VLKSTFPLK 496
>NP_001004326
          Length = 349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LRSTLPL 8
          LR+T+PL
Sbjct: 69 LRATIPL 75
>NP_060900
          Length = 658

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LLRSTLPLQ 9
           +L+ST PL+
Sbjct: 503 VLKSTFPLK 511
>NP_001275919
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LLRSTLPLQ 9
           +L+ST PL+
Sbjct: 557 VLKSTFPLK 565
>NP_001164171
          Length = 781

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LRSTLPLQ 9
           L STLPL+
Sbjct: 697 LSSTLPLR 704
>XP_006723382
          Length = 5027

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LLRSTLPLQ 9
            +LRS +PL+
Sbjct: 2456 ILRSLVPLE 2464
>XP_006723381
          Length = 5031

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LLRSTLPLQ 9
            +LRS +PL+
Sbjct: 2455 ILRSLVPLE 2463
>XP_006723380
          Length = 5032

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LLRSTLPLQ 9
            +LRS +PL+
Sbjct: 2456 ILRSLVPLE 2464
>XP_006721298
          Length = 448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LLRSTLPLQ 9
           +L+ST PL+
Sbjct: 293 VLKSTFPLK 301
>XP_005256111
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LLRSTLPLQ 9
           +L+ST PL+
Sbjct: 367 VLKSTFPLK 375
>XP_005256110
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LLRSTLPLQ 9
           +L+ST PL+
Sbjct: 367 VLKSTFPLK 375
>XP_005256109
          Length = 554

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LLRSTLPLQ 9
           +L+ST PL+
Sbjct: 399 VLKSTFPLK 407
>XP_006721297
          Length = 615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LLRSTLPLQ 9
           +L+ST PL+
Sbjct: 460 VLKSTFPLK 468
>XP_005256108
          Length = 624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LLRSTLPLQ 9
           +L+ST PL+
Sbjct: 469 VLKSTFPLK 477
>XP_005256106
          Length = 675

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LLRSTLPLQ 9
           +L+ST PL+
Sbjct: 520 VLKSTFPLK 528
>XP_005268084
          Length = 2627

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LLRSTLP 7
           LLRS LP
Sbjct: 917 LLRSVLP 923
>XP_005274066
          Length = 349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LRSTLPL 8
          LR+T+PL
Sbjct: 69 LRATIPL 75
>XP_006714077
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LRSTLPLQ 9
           L STLPL+
Sbjct: 822 LSSTLPLR 829
>XP_005247302
          Length = 2248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RSTLPLQ 9
           R+T+PLQ
Sbjct: 957 RATVPLQ 963
>XP_005273249
          Length = 432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LLRSTLP 7
           LLR TLP
Sbjct: 354 LLRPTLP 360
>XP_005273248
          Length = 554

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   LLRSTLP 7
           LLR TLP
Sbjct: 476 LLRPTLP 482
>XP_006710700
          Length = 1479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LLRSTLPL 8
            +LRST+P+
Sbjct: 1374 VLRSTVPV 1381
>XP_006710699
          Length = 1766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LLRSTLPL 8
            +LRST+P+
Sbjct: 1661 VLRSTVPV 1668
>XP_005244806
          Length = 2049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LLRSTLPL 8
            +LRST+P+
Sbjct: 1944 VLRSTVPV 1951
>XP_006710697
          Length = 2053

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LLRSTLPL 8
            +LRST+P+
Sbjct: 1948 VLRSTVPV 1955
>XP_006710696
          Length = 2057

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    LLRSTLPL 8
            +LRST+P+
Sbjct: 1952 VLRSTVPV 1959
>NP_003956
          Length = 344

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   LRSTLPLQ 9
           LRS  PLQ
Sbjct: 317 LRSNTPLQ 324
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.141    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 560,822
Number of extensions: 835
Number of successful extensions: 75
Number of sequences better than 10000.0: 75
Number of HSP's gapped: 75
Number of HSP's successfully gapped: 75
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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