Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              18    1135
NP_001263689                                                           18    1135
NP_001119584                                                           18    1135
NP_001119586                                                           18    1135
NP_001263625                                                           18    1135
NP_001119590                                                           18    1135
NP_001263690                                                           18    1135
NP_001119585                                                           18    1135
NP_001263624                                                           18    1135
NP_001119588                                                           18    1135
NP_001119587                                                           18    1135
NP_001119589                                                           18    1135
NP_001263627                                                           18    1135
NP_001263628                                                           18    1135
NP_001263626                                                           18    1135
NP_004648                                                              18    1935
NP_001073929                                                           17    3301
XP_006713676                                                           17    3301
XP_005247478                                                           17    3301
NP_006429                                                              16    5631
NP_036364                                                              16    5631
XP_005257299                                                           16    5631
NP_473371                                                              16    7355
NP_001271230                                                           16    7355
NP_001177188                                                           16    7355
NP_002410                                                              16    7355
NP_001271231                                                           16    7355
NP_061155                                                              16    7355
XP_003403542                                                           16    7355
XP_006715810                                                           16    7355
XP_006715809                                                           16    7355
XP_005247328                                                           16    7355
XP_003403793                                                           16    7355
NP_705838                                                              15    9605
NP_671732                                                              15    9605
NP_001158307                                                           15    9605
NP_061952                                                              15    9605
NP_853514                                                              15    9605
NP_001275682                                                           15    9605
NP_005487                                                              15    9605
NP_001002800                                                           15    9605
XP_005258568                                                           15    9605
XP_006713522                                                           15    9605
XP_006712095                                                           15    9605
XP_006712094                                                           15    9605
XP_006712093                                                           15    9605
XP_005264429                                                           15    9605
XP_005246216                                                           15    9605
XP_006711947                                                           15    9605
XP_005273219                                                           15    9605
XP_006711444                                                           15    9605
NP_006203                                                              15    9605
NP_789781                                                              15    9605
NP_060022                                                              15    9605
NP_001229267                                                           15    9605
>NP_000537
          Length = 393

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LLRRNSFEV 9
           LL RNSFEV
Sbjct: 264 LLGRNSFEV 272
>NP_001263689
          Length = 354

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LLRRNSFEV 9
           LL RNSFEV
Sbjct: 225 LLGRNSFEV 233
>NP_001119584
          Length = 393

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LLRRNSFEV 9
           LL RNSFEV
Sbjct: 264 LLGRNSFEV 272
>NP_001119586
          Length = 341

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LLRRNSFEV 9
           LL RNSFEV
Sbjct: 264 LLGRNSFEV 272
>NP_001263625
          Length = 302

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LLRRNSFEV 9
           LL RNSFEV
Sbjct: 225 LLGRNSFEV 233
>NP_001119590
          Length = 354

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LLRRNSFEV 9
           LL RNSFEV
Sbjct: 225 LLGRNSFEV 233
>NP_001263690
          Length = 354

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LLRRNSFEV 9
           LL RNSFEV
Sbjct: 225 LLGRNSFEV 233
>NP_001119585
          Length = 346

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LLRRNSFEV 9
           LL RNSFEV
Sbjct: 264 LLGRNSFEV 272
>NP_001263624
          Length = 307

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LLRRNSFEV 9
           LL RNSFEV
Sbjct: 225 LLGRNSFEV 233
>NP_001119588
          Length = 209

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LLRRNSFEV 9
           LL RNSFEV
Sbjct: 132 LLGRNSFEV 140
>NP_001119587
          Length = 261

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LLRRNSFEV 9
           LL RNSFEV
Sbjct: 132 LLGRNSFEV 140
>NP_001119589
          Length = 214

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LLRRNSFEV 9
           LL RNSFEV
Sbjct: 132 LLGRNSFEV 140
>NP_001263627
          Length = 182

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LLRRNSFEV 9
           LL RNSFEV
Sbjct: 105 LLGRNSFEV 113
>NP_001263628
          Length = 187

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LLRRNSFEV 9
           LL RNSFEV
Sbjct: 105 LLGRNSFEV 113
>NP_001263626
          Length = 234

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LLRRNSFEV 9
           LL RNSFEV
Sbjct: 105 LLGRNSFEV 113
>NP_004648
          Length = 425

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LLRRNSFEV 9
           LLRRN F+V
Sbjct: 149 LLRRNHFKV 157
>NP_001073929
          Length = 560

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LRRNSFEV 9
           L+RN FEV
Sbjct: 172 LKRNQFEV 179
>XP_006713676
          Length = 560

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LRRNSFEV 9
           L+RN FEV
Sbjct: 172 LKRNQFEV 179
>XP_005247478
          Length = 560

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LRRNSFEV 9
           L+RN FEV
Sbjct: 172 LKRNQFEV 179
>NP_006429
          Length = 277

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  LLRRNSF 7
          LLRRN F
Sbjct: 7  LLRRNQF 13
>NP_036364
          Length = 390

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LLRRNSFEV 9
           LLRR +F+V
Sbjct: 145 LLRRRNFKV 153
>XP_005257299
          Length = 225

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LLRRNSFEV 9
           LLRR +F+V
Sbjct: 145 LLRRRNFKV 153
>NP_473371
          Length = 330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LRRNSFEV 9
          +RRN+F V
Sbjct: 59 MRRNAFSV 66
>NP_001271230
          Length = 1087

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RRNSFEV 9
            RRN+FE+
Sbjct: 1015 RRNTFEL 1021
>NP_001177188
          Length = 180

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  LLRRNSF 7
          LLR NSF
Sbjct: 5  LLRENSF 11
>NP_002410
          Length = 847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RRNSFEV 9
           RRN FEV
Sbjct: 513 RRNVFEV 519
>NP_001271231
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RRNSFEV 9
            RRN+FE+
Sbjct: 1014 RRNTFEL 1020
>NP_061155
          Length = 1124

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RRNSFEV 9
            RRN+FE+
Sbjct: 1052 RRNTFEL 1058
>XP_003403542
          Length = 846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RRNSFEV 9
           R+NSFE+
Sbjct: 517 RKNSFEL 523
>XP_006715810
          Length = 1105

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RRNSFEV 9
            RRN+FE+
Sbjct: 1033 RRNTFEL 1039
>XP_006715809
          Length = 1142

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    RRNSFEV 9
            RRN+FE+
Sbjct: 1070 RRNTFEL 1076
>XP_005247328
          Length = 165

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  LLRRNSF 7
          LLR NSF
Sbjct: 5  LLRENSF 11
>XP_003403793
          Length = 846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RRNSFEV 9
           R+NSFE+
Sbjct: 517 RKNSFEL 523
>NP_705838
          Length = 4069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   RRNSFE 8
           +RNSFE
Sbjct: 152 KRNSFE 157
>NP_671732
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  LRRNSFEV 9
          +RRN+F +
Sbjct: 56 MRRNAFSI 63
>NP_001158307
          Length = 865

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   LLRRNSFE 8
           +LR N FE
Sbjct: 266 ILRENDFE 273
>NP_061952
          Length = 865

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   LLRRNSFE 8
           +LR N FE
Sbjct: 266 ILRENDFE 273
>NP_853514
          Length = 1732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    LLRRNSF 7
            LLRRN++
Sbjct: 1012 LLRRNTY 1018
>NP_001275682
          Length = 1263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    LRRNSFEV 9
            LR N FE+
Sbjct: 1226 LRNNMFEI 1233
>NP_005487
          Length = 1288

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    LRRNSFEV 9
            LR N FE+
Sbjct: 1251 LRNNMFEI 1258
>NP_001002800
          Length = 1288

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    LRRNSFEV 9
            LR N FE+
Sbjct: 1251 LRNNMFEI 1258
>XP_005258568
          Length = 1029

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LLRRNSFE 8
           +LR+NS E
Sbjct: 822 ILRKNSLE 829
>XP_006713522
          Length = 1210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    LRRNSFEV 9
            LR N FE+
Sbjct: 1173 LRNNMFEI 1180
>XP_006712095
          Length = 849

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LRRNSFEV 9
           LRRNS+ +
Sbjct: 241 LRRNSYGI 248
>XP_006712094
          Length = 1067

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LRRNSFEV 9
           LRRNS+ +
Sbjct: 241 LRRNSYGI 248
>XP_006712093
          Length = 1460

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LRRNSFEV 9
           LRRNS+ +
Sbjct: 241 LRRNSYGI 248
>XP_005264429
          Length = 1472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LRRNSFEV 9
           LRRNS+ +
Sbjct: 241 LRRNSYGI 248
>XP_005246216
          Length = 429

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  RRNSFE 8
          RRN+FE
Sbjct: 59 RRNNFE 64
>XP_006711947
          Length = 441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  RRNSFE 8
          RRN+FE
Sbjct: 59 RRNNFE 64
>XP_005273219
          Length = 263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LRRNSF 7
           +RRNSF
Sbjct: 220 MRRNSF 225
>XP_006711444
          Length = 407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LRRNSF 7
           +RRNSF
Sbjct: 364 MRRNSF 369
>NP_006203
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LRRNSF 7
           +RRNSF
Sbjct: 462 MRRNSF 467
>NP_789781
          Length = 1048

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LLRRNSFE 8
           +LR+NS E
Sbjct: 822 ILRKNSLE 829
>NP_060022
          Length = 1458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LRRNSFEV 9
           LRRNS+ +
Sbjct: 241 LRRNSYGI 248
>NP_001229267
          Length = 1453

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LRRNSFEV 9
           LRRNS+ +
Sbjct: 241 LRRNSYGI 248
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.334    0.145    0.382 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 483,662
Number of extensions: 835
Number of successful extensions: 55
Number of sequences better than 10000.0: 55
Number of HSP's gapped: 55
Number of HSP's successfully gapped: 55
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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