Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_056161                                                              18    1482
XP_006720156                                                           18    1482
NP_000360                                                              18    1935
XP_005268094                                                           18    1935
NP_852111                                                              17    3301
NP_000136                                                              17    3301
NP_000278                                                              17    4312
NP_005497                                                              17    4312
NP_001191184                                                           17    4312
XP_005249237                                                           17    4312
NP_000224                                                              16    5631
NP_004572                                                              16    5631
NP_878256                                                              16    5631
XP_005276467                                                           16    5631
XP_005268017                                                           16    5631
XP_005268016                                                           16    5631
XP_005264366                                                           16    5631
XP_006712078                                                           16    5631
NP_057332                                                              16    7355
NP_006085                                                              16    7355
NP_001157743                                                           16    7355
NP_872584                                                              16    7355
NP_001136069                                                           16    7355
XP_005266305                                                           16    7355
XP_005266304                                                           16    7355
XP_006718488                                                           16    7355
XP_005273432                                                           16    7355
XP_005273431                                                           16    7355
NP_006822                                                              16    7355
NP_076411                                                              16    7355
NP_001005280                                                           15    9605
NP_001177418                                                           15    9605
NP_874362                                                              15    9605
NP_001177637                                                           15    9605
>NP_056161
          Length = 2539

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LLLITSVDL 9
           LLLITS DL
Sbjct: 581 LLLITSADL 589
>XP_006720156
          Length = 2497

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LLLITSVDL 9
           LLLITS DL
Sbjct: 581 LLLITSADL 589
>NP_000360
          Length = 764

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LLLITSVDL 9
           LLLI SVDL
Sbjct: 467 LLLIASVDL 475
>XP_005268094
          Length = 764

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LLLITSVDL 9
           LLLI SVDL
Sbjct: 467 LLLIASVDL 475
>NP_852111
          Length = 669

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LLLITSVDL 9
           LLLI SVD+
Sbjct: 389 LLLIASVDI 397
>NP_000136
          Length = 695

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LLLITSVDL 9
           LLLI SVD+
Sbjct: 415 LLLIASVDI 423
>NP_000278
          Length = 980

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LLLITSVDL 9
           +LL+T+VDL
Sbjct: 525 VLLLTAVDL 533
>NP_005497
          Length = 478

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  LLLITSVDL 9
          LLL+TSV L
Sbjct: 15 LLLVTSVTL 23
>NP_001191184
          Length = 335

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  LLLITSVDL 9
          LLL+TSV L
Sbjct: 15 LLLVTSVTL 23
>XP_005249237
          Length = 892

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LLLITSVDL 9
           +LL+T+VDL
Sbjct: 437 VLLLTAVDL 445
>NP_000224
          Length = 699

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LLLITSVD 8
           LLLI SVD
Sbjct: 412 LLLIASVD 419
>NP_004572
          Length = 567

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LLLITSVDL 9
           LLL+T +DL
Sbjct: 462 LLLVTHLDL 470
>NP_878256
          Length = 567

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LLLITSVDL 9
           LLL+T +DL
Sbjct: 462 LLLVTHLDL 470
>XP_005276467
          Length = 97

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  LLLITSVDL 9
          L L+TSVDL
Sbjct: 52 LHLLTSVDL 60
>XP_005268017
          Length = 297

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LLLITSVDL 9
           LLL+T +DL
Sbjct: 192 LLLVTHLDL 200
>XP_005268016
          Length = 297

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LLLITSVDL 9
           LLL+T +DL
Sbjct: 192 LLLVTHLDL 200
>XP_005264366
          Length = 380

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LLLITSVD 8
           LLLI SVD
Sbjct: 93  LLLIASVD 100
>XP_006712078
          Length = 389

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LLLITSVD 8
           LLLI SVD
Sbjct: 102 LLLIASVD 109
>NP_057332
          Length = 1901

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    LLITSVDL 9
            LLIT++D+
Sbjct: 1810 LLITNIDM 1817
>NP_006085
          Length = 1091

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    LLITSVD 8
            LL+TSVD
Sbjct: 1007 LLLTSVD 1013
>NP_001157743
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LLITSVD 8
           LL+TSVD
Sbjct: 933 LLLTSVD 939
>NP_872584
          Length = 1528

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    LLITSVD 8
            LL+TSVD
Sbjct: 1444 LLLTSVD 1450
>NP_001136069
          Length = 361

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LLITSVDL 9
           +++TSVDL
Sbjct: 323 IVVTSVDL 330
>XP_005266305
          Length = 1856

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    LLITSVDL 9
            LLIT++D+
Sbjct: 1765 LLITNIDM 1772
>XP_005266304
          Length = 1873

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    LLITSVDL 9
            LLIT++D+
Sbjct: 1782 LLITNIDM 1789
>XP_006718488
          Length = 425

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LLITSVDL 9
           +++TSVDL
Sbjct: 387 IVVTSVDL 394
>XP_005273432
          Length = 1125

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    LLITSVD 8
            LL+TSVD
Sbjct: 1041 LLLTSVD 1047
>XP_005273431
          Length = 1528

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    LLITSVD 8
            LL+TSVD
Sbjct: 1444 LLLTSVD 1450
>NP_006822
          Length = 425

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LLITSVDL 9
           +++TSVDL
Sbjct: 387 IVVTSVDL 394
>NP_076411
          Length = 317

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LLLITSVDL 9
           LLL+TSV L
Sbjct: 133 LLLVTSVFL 141
>NP_001005280
          Length = 316

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LLLITSVDL 9
          ++ +TSVDL
Sbjct: 45 IVTVTSVDL 53
>NP_001177418
          Length = 24

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LLLITSVDL 9
          LLLI  +DL
Sbjct: 10 LLLIREIDL 18
>NP_874362
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LLLITSVDL 9
           +LLI  VDL
Sbjct: 342 MLLIAGVDL 350
>NP_001177637
          Length = 24

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LLLITSVDL 9
          LLLI  +DL
Sbjct: 10 LLLIREIDL 18
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.153    0.367 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 361,963
Number of extensions: 427
Number of successful extensions: 34
Number of sequences better than 10000.0: 34
Number of HSP's gapped: 34
Number of HSP's successfully gapped: 34
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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