Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001137429                                                           17    3301
NP_110411                                                              17    3301
XP_006715633                                                           17    3301
XP_006715632                                                           17    3301
NP_000856                                                              17    4312
NP_056507                                                              17    4312
NP_055523                                                              16    5631
NP_543009                                                              16    5631
NP_001009183                                                           16    5631
NP_001009182                                                           16    5631
NP_003607                                                              16    5631
NP_001161707                                                           16    5631
XP_006719769                                                           16    5631
NP_060570                                                              16    7355
NP_001165891                                                           16    7355
NP_001363                                                              16    7355
NP_001275759                                                           16    7355
NP_001275761                                                           16    7355
XP_006721530                                                           16    7355
XP_006721529                                                           16    7355
XP_006721528                                                           16    7355
XP_005270502                                                           16    7355
NP_060237                                                              15    9605
NP_570901                                                              15    9605
NP_001121685                                                           15    9605
NP_001121684                                                           15    9605
NP_653221                                                              15    9605
NP_001243316                                                           15    9605
NP_001243315                                                           15    9605
NP_001243314                                                           15    9605
NP_000788                                                              15    9605
NP_001003745                                                           15    9605
XP_006716662                                                           15    9605
XP_005246413                                                           15    9605
XP_005246412                                                           15    9605
XP_005270516                                                           15    9605
NP_689741                                                              15    9605
NP_001004461                                                           15    9605
>NP_001137429
          Length = 419

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LLAVLEMP 8
           LLAVL MP
Sbjct: 129 LLAVLNMP 136
>NP_110411
          Length = 419

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LLAVLEMP 8
           LLAVL MP
Sbjct: 129 LLAVLNMP 136
>XP_006715633
          Length = 419

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LLAVLEMP 8
           LLAVL MP
Sbjct: 129 LLAVLNMP 136
>XP_006715632
          Length = 419

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   LLAVLEMP 8
           LLAVL MP
Sbjct: 129 LLAVLNMP 136
>NP_000856
          Length = 365

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  LLAVLEMPL 9
          L+AVL MPL
Sbjct: 70 LVAVLVMPL 78
>NP_056507
          Length = 1932

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    LAVLEMPL 9
            +AVLE+PL
Sbjct: 1618 MAVLEVPL 1625
>NP_055523
          Length = 2209

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LLAVLEMPL 9
            L+AVLE P+
Sbjct: 2045 LIAVLECPV 2053
>NP_543009
          Length = 363

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LLAVLEMP 8
          LLA L+MP
Sbjct: 54 LLAALDMP 61
>NP_001009183
          Length = 250

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LLAVLEMPL 9
           LLA LE PL
Sbjct: 218 LLACLEKPL 226
>NP_001009182
          Length = 265

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LLAVLEMPL 9
           LLA LE PL
Sbjct: 203 LLACLEKPL 211
>NP_003607
          Length = 280

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LLAVLEMPL 9
           LLA LE PL
Sbjct: 218 LLACLEKPL 226
>NP_001161707
          Length = 2139

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LLAVLEMP 8
            L+AVLE P
Sbjct: 1865 LMAVLEFP 1872
>XP_006719769
          Length = 2209

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LLAVLEMPL 9
            L+AVLE P+
Sbjct: 2045 LIAVLECPV 2053
>NP_060570
          Length = 640

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LAVLEMPL 9
           LAVLE P+
Sbjct: 423 LAVLESPI 430
>NP_001165891
          Length = 621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LAVLEMPL 9
           LAVLE P+
Sbjct: 404 LAVLESPI 411
>NP_001363
          Length = 4486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LLAVLEMPL 9
            L AVLE PL
Sbjct: 2516 LQAVLEKPL 2524
>NP_001275759
          Length = 311

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LLAVLEMPL 9
          LLA LE P+
Sbjct: 9  LLATLEKPI 17
>NP_001275761
          Length = 268

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LLAVLEMPL 9
          LLA LE P+
Sbjct: 9  LLATLEKPI 17
>XP_006721530
          Length = 2746

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LLAVLEMPL 9
            L AVLE PL
Sbjct: 2516 LQAVLEKPL 2524
>XP_006721529
          Length = 2817

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LLAVLEMPL 9
            L AVLE PL
Sbjct: 2516 LQAVLEKPL 2524
>XP_006721528
          Length = 3869

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    LLAVLEMPL 9
            L AVLE PL
Sbjct: 2516 LQAVLEKPL 2524
>XP_005270502
          Length = 763

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LAVLEMPL 9
           L VLE+PL
Sbjct: 749 LKVLELPL 756
>NP_060237
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LLAVLEMP 8
           LLA+LE P
Sbjct: 101 LLALLESP 108
>NP_570901
          Length = 647

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LLAVLEMP 8
           LLA+LE P
Sbjct: 126 LLALLESP 133
>NP_001121685
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LLAVLEMP 8
          +LAV+E P
Sbjct: 88 MLAVMEQP 95
>NP_001121684
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LLAVLEMP 8
          +LAV+E P
Sbjct: 88 MLAVMEQP 95
>NP_653221
          Length = 335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LAVLEMP 8
           LAVL MP
Sbjct: 193 LAVLNMP 199
>NP_001243316
          Length = 335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LAVLEMP 8
           LAVL MP
Sbjct: 193 LAVLNMP 199
>NP_001243315
          Length = 335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LAVLEMP 8
           LAVL MP
Sbjct: 193 LAVLNMP 199
>NP_001243314
          Length = 339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LAVLEMP 8
           LAVL MP
Sbjct: 193 LAVLNMP 199
>NP_000788
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LLAVLEMPL 9
          LLA+L +PL
Sbjct: 82 LLALLVLPL 90
>NP_001003745
          Length = 314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LLAVLEMP 8
           L A+L+MP
Sbjct: 222 LFAILKMP 229
>XP_006716662
          Length = 596

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LLAVLEMP 8
           LLA+LE P
Sbjct: 126 LLALLESP 133
>XP_005246413
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LLAVLEMP 8
          +LAV+E P
Sbjct: 88 MLAVMEQP 95
>XP_005246412
          Length = 429

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LLAVLEMP 8
          +LAV+E P
Sbjct: 88 MLAVMEQP 95
>XP_005270516
          Length = 339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LAVLEMP 8
           LAVL MP
Sbjct: 193 LAVLNMP 199
>NP_689741
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LLAVLEMP 8
          +LAV+E P
Sbjct: 88 MLAVMEQP 95
>NP_001004461
          Length = 314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LLAVLEMP 8
           L A+L+MP
Sbjct: 222 LFAILKMP 229
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.150    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 483,219
Number of extensions: 592
Number of successful extensions: 38
Number of sequences better than 10000.0: 38
Number of HSP's gapped: 38
Number of HSP's successfully gapped: 38
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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