Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              20     509
NP_001035957                                                           20     509
XP_006721991                                                           20     509
XP_006721990                                                           20     509
XP_006721989                                                           20     509
XP_005258041                                                           20     509
XP_006721988                                                           20     509
XP_006721987                                                           20     509
XP_006721986                                                           20     509
XP_005258040                                                           20     509
XP_006721985                                                           20     509
NP_001073981                                                           17    4312
XP_005270227                                                           17    4312
XP_005270226                                                           17    4312
XP_005270225                                                           17    4312
XP_005270224                                                           17    4312
XP_005270223                                                           17    4312
NP_777552                                                              16    5631
XP_006721747                                                           16    5631
XP_005257084                                                           16    5631
XP_006720523                                                           16    5631
NP_001013860                                                           16    7355
XP_006721205                                                           16    7355
XP_005255864                                                           16    7355
XP_006721204                                                           16    7355
XP_006721203                                                           16    7355
XP_006721202                                                           16    7355
XP_006721201                                                           16    7355
NP_002954                                                              15    9605
NP_065859                                                              15    9605
NP_065073                                                              15    9605
XP_006715582                                                           15    9605
XP_006711862                                                           15    9605
XP_005273271                                                           15    9605
XP_005273270                                                           15    9605
XP_005273269                                                           15    9605
XP_005273268                                                           15    9605
XP_005273266                                                           15    9605
XP_006711861                                                           15    9605
XP_005245488                                                           15    9605
XP_006711350                                                           15    9605
NP_055294                                                              15    9605
NP_005735                                                              15    9605
NP_789793                                                              15    9605
>NP_000258
          Length = 2818

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LKNNQADRS 9
           LKN QADRS
Sbjct: 612 LKNKQADRS 620
>NP_001035957
          Length = 2839

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LKNNQADRS 9
           LKN QADRS
Sbjct: 612 LKNKQADRS 620
>XP_006721991
          Length = 1632

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LKNNQADRS 9
           LKN QADRS
Sbjct: 622 LKNKQADRS 630
>XP_006721990
          Length = 2823

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LKNNQADRS 9
           LKN QADRS
Sbjct: 622 LKNKQADRS 630
>XP_006721989
          Length = 2823

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LKNNQADRS 9
           LKN QADRS
Sbjct: 622 LKNKQADRS 630
>XP_005258041
          Length = 2836

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LKNNQADRS 9
           LKN QADRS
Sbjct: 612 LKNKQADRS 620
>XP_006721988
          Length = 2846

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LKNNQADRS 9
           LKN QADRS
Sbjct: 622 LKNKQADRS 630
>XP_006721987
          Length = 2849

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LKNNQADRS 9
           LKN QADRS
Sbjct: 622 LKNKQADRS 630
>XP_006721986
          Length = 2854

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LKNNQADRS 9
           LKN QADRS
Sbjct: 609 LKNKQADRS 617
>XP_005258040
          Length = 2857

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LKNNQADRS 9
           LKN QADRS
Sbjct: 612 LKNKQADRS 620
>XP_006721985
          Length = 2867

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LKNNQADRS 9
           LKN QADRS
Sbjct: 622 LKNKQADRS 630
>NP_001073981
          Length = 974

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KNNQADRS 9
           +NNQA++S
Sbjct: 173 RNNQAEKS 180
>XP_005270227
          Length = 909

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KNNQADRS 9
           +NNQA++S
Sbjct: 173 RNNQAEKS 180
>XP_005270226
          Length = 927

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KNNQADRS 9
           +NNQA++S
Sbjct: 126 RNNQAEKS 133
>XP_005270225
          Length = 949

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KNNQADRS 9
           +NNQA++S
Sbjct: 173 RNNQAEKS 180
>XP_005270224
          Length = 949

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KNNQADRS 9
           +NNQA++S
Sbjct: 173 RNNQAEKS 180
>XP_005270223
          Length = 973

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KNNQADRS 9
           +NNQA++S
Sbjct: 173 RNNQAEKS 180
>NP_777552
          Length = 201

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LKNNQADRS 9
          +K+NQ DR+
Sbjct: 78 IKDNQKDRT 86
>XP_006721747
          Length = 198

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LKNNQADRS 9
          +K+NQ DR+
Sbjct: 75 IKDNQKDRT 83
>XP_005257084
          Length = 209

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LKNNQADRS 9
           +K+NQ DR+
Sbjct: 115 IKDNQKDRT 123
>XP_006720523
          Length = 519

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LKNNQAD 7
           ++NNQAD
Sbjct: 453 IENNQAD 459
>NP_001013860
          Length = 1435

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LKNNQAD 7
           L+NN+AD
Sbjct: 700 LRNNRAD 706
>XP_006721205
          Length = 1441

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LKNNQAD 7
           L+NN+AD
Sbjct: 700 LRNNRAD 706
>XP_005255864
          Length = 1372

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LKNNQAD 7
           L+NN+AD
Sbjct: 664 LRNNRAD 670
>XP_006721204
          Length = 1405

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LKNNQAD 7
           L+NN+AD
Sbjct: 664 LRNNRAD 670
>XP_006721203
          Length = 1408

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LKNNQAD 7
           L+NN+AD
Sbjct: 700 LRNNRAD 706
>XP_006721202
          Length = 1424

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LKNNQAD 7
           L+NN+AD
Sbjct: 700 LRNNRAD 706
>XP_006721201
          Length = 1430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LKNNQAD 7
           L+NN+AD
Sbjct: 700 LRNNRAD 706
>NP_002954
          Length = 101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1 LKNNQADRS 9
         + N QA+RS
Sbjct: 1 MSNTQAERS 9
>NP_065859
          Length = 1722

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LKNNQADRS 9
           L+N Q+D+S
Sbjct: 114 LQNGQSDQS 122
>NP_065073
          Length = 2177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LKNNQADR 8
           LKN +AD+
Sbjct: 663 LKNQEADQ 670
>XP_006715582
          Length = 2106

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LKNNQADR 8
           LKN +AD+
Sbjct: 592 LKNQEADQ 599
>XP_006711862
          Length = 1704

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LKNNQADRS 9
           L+N Q+D+S
Sbjct: 114 LQNGQSDQS 122
>XP_005273271
          Length = 1722

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LKNNQADRS 9
           L+N Q+D+S
Sbjct: 114 LQNGQSDQS 122
>XP_005273270
          Length = 1722

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LKNNQADRS 9
           L+N Q+D+S
Sbjct: 114 LQNGQSDQS 122
>XP_005273269
          Length = 1722

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LKNNQADRS 9
           L+N Q+D+S
Sbjct: 114 LQNGQSDQS 122
>XP_005273268
          Length = 1722

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LKNNQADRS 9
           L+N Q+D+S
Sbjct: 114 LQNGQSDQS 122
>XP_005273266
          Length = 1722

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LKNNQADRS 9
           L+N Q+D+S
Sbjct: 114 LQNGQSDQS 122
>XP_006711861
          Length = 1722

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LKNNQADRS 9
           L+N Q+D+S
Sbjct: 114 LQNGQSDQS 122
>XP_005245488
          Length = 101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1 LKNNQADRS 9
         + N QA+RS
Sbjct: 1 MSNTQAERS 9
>XP_006711350
          Length = 101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1 LKNNQADRS 9
         + N QA+RS
Sbjct: 1 MSNTQAERS 9
>NP_055294
          Length = 470

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  LKNNQADR 8
          +KNNQ ++
Sbjct: 58 IKNNQTEK 65
>NP_005735
          Length = 557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KNNQAD 7
           +NNQAD
Sbjct: 492 ENNQAD 497
>NP_789793
          Length = 101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1 LKNNQADRS 9
         + N QA+RS
Sbjct: 1 MSNTQAERS 9
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.299    0.113    0.283 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 596,026
Number of extensions: 1130
Number of successful extensions: 44
Number of sequences better than 10000.0: 44
Number of HSP's gapped: 44
Number of HSP's successfully gapped: 44
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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