Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              19     869
NP_001075109                                                           19     869
NP_001093320                                                           17    4312
NP_001093260                                                           17    4312
NP_001094101                                                           17    4312
NP_055105                                                              17    4312
XP_006717089                                                           17    4312
XP_006717088                                                           17    4312
NP_001008781                                                           16    5631
XP_006718827                                                           16    5631
NP_037498                                                              16    7355
NP_001128649                                                           16    7355
NP_001128647                                                           16    7355
NP_690869                                                              16    7355
XP_006719300                                                           16    7355
XP_006719299                                                           16    7355
XP_005268701                                                           16    7355
NP_001128648                                                           16    7355
NP_003728                                                              15    9605
NP_079446                                                              15    9605
NP_079146                                                              15    9605
NP_542415                                                              15    9605
NP_542416                                                              15    9605
NP_542414                                                              15    9605
NP_006255                                                              15    9605
NP_001348                                                              15    9605
NP_689481                                                              15    9605
NP_620711                                                              15    9605
NP_057305                                                              15    9605
NP_057396                                                              15    9605
NP_006323                                                              15    9605
XP_005253264                                                           15    9605
XP_005268514                                                           15    9605
XP_005263224                                                           15    9605
XP_005247007                                                           15    9605
NP_001129115                                                           15    9605
NP_001129116                                                           15    9605
>NP_008835
          Length = 4128

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LITPLQAV 8
            LITPLQAV
Sbjct: 2790 LITPLQAV 2797
>NP_001075109
          Length = 4097

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    LITPLQAV 8
            LITPLQAV
Sbjct: 2790 LITPLQAV 2797
>NP_001093320
          Length = 479

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LITPLQA 7
           L+TPLQA
Sbjct: 429 LLTPLQA 435
>NP_001093260
          Length = 479

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LITPLQA 7
           L+TPLQA
Sbjct: 429 LLTPLQA 435
>NP_001094101
          Length = 481

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LITPLQA 7
           L+TPLQA
Sbjct: 431 LLTPLQA 437
>NP_055105
          Length = 1098

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ITPLQAVD 9
           ITP+QAV+
Sbjct: 508 ITPVQAVN 515
>XP_006717089
          Length = 653

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  ITPLQAVD 9
          ITP+QAV+
Sbjct: 63 ITPVQAVN 70
>XP_006717088
          Length = 1024

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ITPLQAVD 9
           ITP+QAV+
Sbjct: 434 ITPVQAVN 441
>NP_001008781
          Length = 4557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LITPLQAVD 9
            L+T +QA+D
Sbjct: 2618 LVTQVQAID 2626

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LITPLQAVD 9
            L+T +QAVD
Sbjct: 3149 LLTRVQAVD 3157
>XP_006718827
          Length = 3479

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LITPLQAVD 9
            L+T +QA+D
Sbjct: 1508 LVTQVQAID 1516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    LITPLQAVD 9
            L+T +QAVD
Sbjct: 2039 LLTRVQAVD 2047
>NP_037498
          Length = 822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ITPLQAV 8
           +TP+QAV
Sbjct: 659 VTPVQAV 665
>NP_001128649
          Length = 571

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TPLQAVD 9
           TPL AVD
Sbjct: 160 TPLTAVD 166
>NP_001128647
          Length = 667

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TPLQAVD 9
           TPL AVD
Sbjct: 256 TPLTAVD 262
>NP_690869
          Length = 660

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TPLQAVD 9
           TPL AVD
Sbjct: 249 TPLTAVD 255
>XP_006719300
          Length = 571

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TPLQAVD 9
           TPL AVD
Sbjct: 160 TPLTAVD 166
>XP_006719299
          Length = 660

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TPLQAVD 9
           TPL AVD
Sbjct: 249 TPLTAVD 255
>XP_005268701
          Length = 667

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TPLQAVD 9
           TPL AVD
Sbjct: 256 TPLTAVD 262
>NP_001128648
          Length = 660

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   TPLQAVD 9
           TPL AVD
Sbjct: 249 TPLTAVD 255
>NP_003728
          Length = 3298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LITPLQAVD 9
            L+T LQA D
Sbjct: 1235 LVTTLQAKD 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LITPLQAVD 9
            L+T L A+D
Sbjct: 2724 LVTTLHAID 2732
>NP_079446
          Length = 979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LITPLQAV 8
           L+TP+Q +
Sbjct: 166 LVTPIQRI 173
>NP_079146
          Length = 1606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   LITPLQAV 8
           L+TP+Q +
Sbjct: 166 LVTPIQRI 173
>NP_542415
          Length = 2294

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    LITPLQA 7
            L+TPLQ+
Sbjct: 1409 LLTPLQS 1415
>NP_542416
          Length = 2490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    LITPLQA 7
            L+TPLQ+
Sbjct: 1605 LLTPLQS 1611
>NP_542414
          Length = 2485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    LITPLQA 7
            L+TPLQ+
Sbjct: 1600 LLTPLQS 1606
>NP_006255
          Length = 2466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    LITPLQA 7
            L+TPLQ+
Sbjct: 1581 LLTPLQS 1587
>NP_001348
          Length = 1270

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    LITPLQ 6
            L+TPLQ
Sbjct: 1061 LVTPLQ 1066
>NP_689481
          Length = 475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LITPLQAV 8
           L+TP+Q V
Sbjct: 468 LLTPVQTV 475
>NP_620711
          Length = 737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ITPLQA 7
           +TPLQA
Sbjct: 258 VTPLQA 263
>NP_057305
          Length = 460

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ITPLQAVD 9
           I P QAVD
Sbjct: 216 IEPAQAVD 223
>NP_057396
          Length = 641

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   ITPLQAV 8
           +TPLQA+
Sbjct: 327 LTPLQAM 333
>NP_006323
          Length = 250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  TPLQAVD 9
          +PLQA+D
Sbjct: 27 SPLQALD 33
>XP_005253264
          Length = 3443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    LITPLQAVD 9
            L+T LQA D
Sbjct: 1380 LVTTLQAKD 1388

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LITPLQAVD 9
            L+T L A+D
Sbjct: 2869 LVTTLHAID 2877
>XP_005268514
          Length = 317

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  ITPLQAVD 9
          I P QAVD
Sbjct: 73 IEPAQAVD 80
>XP_005263224
          Length = 2491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    LITPLQA 7
            L+TPLQ+
Sbjct: 1606 LLTPLQS 1612
>XP_005247007
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ITPLQA 7
           +TPLQA
Sbjct: 258 VTPLQA 263
>NP_001129115
          Length = 467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ITPLQAVD 9
           I P QAVD
Sbjct: 223 IEPAQAVD 230
>NP_001129116
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   ITPLQAVD 9
           I P QAVD
Sbjct: 159 IEPAQAVD 166
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.141    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 541,817
Number of extensions: 767
Number of successful extensions: 41
Number of sequences better than 10000.0: 37
Number of HSP's gapped: 41
Number of HSP's successfully gapped: 41
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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