Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              20     299
XP_006718907                                                           20     299
XP_006718906                                                           20     299
XP_005271619                                                           20     299
XP_005271618                                                           20     299
NP_597677                                                              17    3301
NP_056199                                                              17    3301
XP_005248340                                                           17    3301
XP_005248339                                                           17    3301
XP_005248337                                                           17    3301
XP_006714531                                                           17    3301
XP_006714530                                                           17    3301
NP_001690                                                              17    4312
NP_001265528                                                           17    4312
NP_068713                                                              17    4312
NP_113584                                                              17    4312
NP_001032852                                                           17    4312
XP_005262029                                                           17    4312
XP_005262028                                                           17    4312
XP_005262026                                                           17    4312
XP_006724637                                                           17    4312
XP_005262025                                                           17    4312
XP_005262024                                                           17    4312
XP_005262023                                                           17    4312
XP_005262022                                                           17    4312
XP_006715638                                                           17    4312
XP_005267216                                                           17    4312
NP_115521                                                              17    4312
NP_976241                                                              16    5631
NP_998754                                                              16    5631
XP_005246837                                                           16    5631
XP_005246836                                                           16    5631
XP_006712758                                                           16    5631
XP_005246834                                                           16    5631
NP_663314                                                              16    7355
NP_055271                                                              16    7355
NP_001186421                                                           16    7355
NP_954657                                                              16    7355
NP_000215                                                              16    7355
NP_001171434                                                           16    7355
NP_060839                                                              16    7355
NP_001138680                                                           16    7355
NP_002422                                                              16    7355
XP_005267745                                                           16    7355
XP_005267744                                                           16    7355
XP_006717830                                                           16    7355
XP_005269759                                                           16    7355
NP_008986                                                              15    9605
NP_060873                                                              15    9605
NP_001277134                                                           15    9605
NP_001277133                                                           15    9605
NP_001167448                                                           15    9605
NP_060110                                                              15    9605
NP_061836                                                              15    9605
NP_387505                                                              15    9605
NP_001193856                                                           15    9605
XP_005261051                                                           15    9605
XP_006717660                                                           15    9605
XP_006715203                                                           15    9605
XP_006715202                                                           15    9605
XP_006715201                                                           15    9605
XP_006715200                                                           15    9605
XP_005249275                                                           15    9605
XP_006715199                                                           15    9605
XP_006715067                                                           15    9605
>NP_000042
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LIKLMADIC 9
           LI+LMADIC
Sbjct: 345 LIELMADIC 353
>XP_006718907
          Length = 3050

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LIKLMADIC 9
           LI+LMADIC
Sbjct: 345 LIELMADIC 353
>XP_006718906
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LIKLMADIC 9
           LI+LMADIC
Sbjct: 345 LIELMADIC 353
>XP_005271619
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LIKLMADIC 9
           LI+LMADIC
Sbjct: 345 LIELMADIC 353
>XP_005271618
          Length = 3056

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LIKLMADIC 9
           LI+LMADIC
Sbjct: 345 LIELMADIC 353
>NP_597677
          Length = 2804

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LIKLMADIC 9
            +IK++ DIC
Sbjct: 1868 VIKILRDIC 1876
>NP_056199
          Length = 2697

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LIKLMADIC 9
            +IK++ DIC
Sbjct: 1868 VIKILRDIC 1876
>XP_005248340
          Length = 2265

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LIKLMADIC 9
            +IK++ DIC
Sbjct: 1329 VIKILRDIC 1337
>XP_005248339
          Length = 2584

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LIKLMADIC 9
            +IK++ DIC
Sbjct: 1648 VIKILRDIC 1656
>XP_005248337
          Length = 2698

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LIKLMADIC 9
            +IK++ DIC
Sbjct: 1868 VIKILRDIC 1876
>XP_006714531
          Length = 2738

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LIKLMADIC 9
            +IK++ DIC
Sbjct: 1802 VIKILRDIC 1810
>XP_006714530
          Length = 2755

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    LIKLMADIC 9
            +IK++ DIC
Sbjct: 1868 VIKILRDIC 1876
>NP_001690
          Length = 885

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LIKLMADI 8
           L+K MADI
Sbjct: 640 LVKFMADI 647
>NP_001265528
          Length = 626

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LIKLMADI 8
           L+K MADI
Sbjct: 381 LVKFMADI 388
>NP_068713
          Length = 894

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LIKLMADI 8
           L+K MADI
Sbjct: 649 LVKFMADI 656
>NP_113584
          Length = 4374

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LIKLMADIC 9
           +IKL+ +IC
Sbjct: 681 IIKLLEEIC 689
>NP_001032852
          Length = 1125

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LIKLMADIC 9
           +IKL+ +IC
Sbjct: 778 IIKLITEIC 786
>XP_005262029
          Length = 4240

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LIKLMADIC 9
           +IKL+ +IC
Sbjct: 681 IIKLLEEIC 689
>XP_005262028
          Length = 4341

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LIKLMADIC 9
           +IKL+ +IC
Sbjct: 681 IIKLLEEIC 689
>XP_005262026
          Length = 4359

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LIKLMADIC 9
           +IKL+ +IC
Sbjct: 681 IIKLLEEIC 689
>XP_006724637
          Length = 4365

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LIKLMADIC 9
           +IKL+ +IC
Sbjct: 681 IIKLLEEIC 689
>XP_005262025
          Length = 4373

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LIKLMADIC 9
           +IKL+ +IC
Sbjct: 681 IIKLLEEIC 689
>XP_005262024
          Length = 4374

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LIKLMADIC 9
           +IKL+ +IC
Sbjct: 681 IIKLLEEIC 689
>XP_005262023
          Length = 4374

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LIKLMADIC 9
           +IKL+ +IC
Sbjct: 681 IIKLLEEIC 689
>XP_005262022
          Length = 4374

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LIKLMADIC 9
           +IKL+ +IC
Sbjct: 681 IIKLLEEIC 689
>XP_006715638
          Length = 745

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KLMADIC 9
           KLM D+C
Sbjct: 641 KLMRDVC 647
>XP_005267216
          Length = 745

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KLMADIC 9
           KLM D+C
Sbjct: 641 KLMRDVC 647
>NP_115521
          Length = 745

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   KLMADIC 9
           KLM D+C
Sbjct: 641 KLMRDVC 647
>NP_976241
          Length = 644

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LMADIC 9
          LMAD+C
Sbjct: 89 LMADLC 94
>NP_998754
          Length = 1250

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LMADIC 9
          LMAD+C
Sbjct: 89 LMADLC 94
>XP_005246837
          Length = 1277

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LMADIC 9
          LMAD+C
Sbjct: 89 LMADLC 94
>XP_005246836
          Length = 1302

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LMADIC 9
          LMAD+C
Sbjct: 89 LMADLC 94
>XP_006712758
          Length = 1302

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LMADIC 9
          LMAD+C
Sbjct: 89 LMADLC 94
>XP_005246834
          Length = 1302

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LMADIC 9
          LMAD+C
Sbjct: 89 LMADLC 94
>NP_663314
          Length = 458

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   KLMADIC 9
           KL++D+C
Sbjct: 210 KLLSDLC 216
>NP_055271
          Length = 469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   KLMADIC 9
           KL++D+C
Sbjct: 221 KLLSDLC 227
>NP_001186421
          Length = 455

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   KLMADIC 9
           KL++D+C
Sbjct: 207 KLLSDLC 213
>NP_954657
          Length = 430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LIKLMADI 8
           L K+MADI
Sbjct: 245 LAKIMADI 252
>NP_000215
          Length = 430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LIKLMADI 8
           L K+MADI
Sbjct: 245 LAKIMADI 252
>NP_001171434
          Length = 267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  IKLMADIC 9
          +KLM ++C
Sbjct: 19 LKLMVNVC 26
>NP_060839
          Length = 529

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LIKLMADIC 9
           L+++MA IC
Sbjct: 330 LMRMMARIC 338
>NP_001138680
          Length = 467

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LIKLMADIC 9
           L+++MA IC
Sbjct: 330 LMRMMARIC 338
>NP_002422
          Length = 309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  IKLMADIC 9
          +KLM ++C
Sbjct: 19 LKLMVNVC 26
>XP_005267745
          Length = 278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  IKLMADIC 9
          +KLM ++C
Sbjct: 19 LKLMVNVC 26
>XP_005267744
          Length = 309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  IKLMADIC 9
          +KLM ++C
Sbjct: 19 LKLMVNVC 26
>XP_006717830
          Length = 283

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  KLMADIC 9
          KL++D+C
Sbjct: 35 KLLSDLC 41
>XP_005269759
          Length = 283

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  KLMADIC 9
          KL++D+C
Sbjct: 35 KLLSDLC 41
>NP_008986
          Length = 1390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   LIKLMADIC 9
           L+K + D+C
Sbjct: 875 LVKSLEDLC 883
>NP_060873
          Length = 582

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LIKLMADI 8
           + KLMAD+
Sbjct: 118 IAKLMADV 125
>NP_001277134
          Length = 510

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  LIKLMADI 8
          + KLMAD+
Sbjct: 46 IAKLMADV 53
>NP_001277133
          Length = 544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LIKLMADI 8
           + KLMAD+
Sbjct: 118 IAKLMADV 125
>NP_001167448
          Length = 1365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   IKLMADIC 9
           +KL  D+C
Sbjct: 228 LKLSTDVC 235
>NP_060110
          Length = 1371

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   IKLMADIC 9
           +KL  D+C
Sbjct: 228 LKLSTDVC 235
>NP_061836
          Length = 2320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    IKLMADI 8
            IKLM+D+
Sbjct: 1640 IKLMSDV 1646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    IKLMADI 8
            IKLM+D+
Sbjct: 1939 IKLMSDV 1945
>NP_387505
          Length = 2269

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    IKLMADI 8
            IKLM+D+
Sbjct: 1640 IKLMSDV 1646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    IKLMADI 8
            IKLM+D+
Sbjct: 1939 IKLMSDV 1945
>NP_001193856
          Length = 4707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LIKLMADIC 9
           L+K ++D+C
Sbjct: 924 LLKKISDLC 932
>XP_005261051
          Length = 2242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    IKLMADI 8
            IKLM+D+
Sbjct: 1562 IKLMSDV 1568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    IKLMADI 8
            IKLM+D+
Sbjct: 1861 IKLMSDV 1867
>XP_006717660
          Length = 1369

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   LIKLMADIC 9
           L+K + D+C
Sbjct: 854 LVKSLEDLC 862
>XP_006715203
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   IKLMADIC 9
           +KL  D+C
Sbjct: 228 LKLSTDVC 235
>XP_006715202
          Length = 966

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   IKLMADIC 9
           +KL  D+C
Sbjct: 228 LKLSTDVC 235
>XP_006715201
          Length = 1375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   IKLMADIC 9
           +KL  D+C
Sbjct: 228 LKLSTDVC 235
>XP_006715200
          Length = 1419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   IKLMADIC 9
           +KL  D+C
Sbjct: 228 LKLSTDVC 235
>XP_005249275
          Length = 1421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   IKLMADIC 9
           +KL  D+C
Sbjct: 228 LKLSTDVC 235
>XP_006715199
          Length = 1425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   IKLMADIC 9
           +KL  D+C
Sbjct: 228 LKLSTDVC 235
>XP_006715067
          Length = 4707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   LIKLMADIC 9
           L+K ++D+C
Sbjct: 924 LLKKISDLC 932
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.345    0.153    0.474 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 386,042
Number of extensions: 694
Number of successful extensions: 68
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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