Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_958441                                                              19     869
NP_958439                                                              19     869
NP_958440                                                              19     869
NP_005219                                                              19     869
NP_874358                                                              17    2528
NP_598004                                                              17    3301
NP_542407                                                              16    5631
NP_001269042                                                           16    5631
NP_001269041                                                           16    5631
NP_003926                                                              16    5631
XP_006724415                                                           16    5631
XP_005261871                                                           16    5631
XP_005261870                                                           16    5631
XP_006724414                                                           16    5631
XP_005261868                                                           16    5631
XP_006724413                                                           16    5631
XP_006724412                                                           16    5631
XP_006723607                                                           16    5631
XP_005260724                                                           16    5631
NP_001192222                                                           16    7355
NP_001192223                                                           16    7355
NP_000712                                                              16    7355
NP_000709                                                              16    7355
NP_001230741                                                           16    7355
NP_001120694                                                           15    9605
NP_075461                                                              15    9605
NP_001120693                                                           15    9605
NP_000059                                                              15    9605
NP_001167551                                                           15    9605
NP_001129203                                                           15    9605
NP_036411                                                              15    9605
NP_078921                                                              15    9605
NP_071926                                                              15    9605
XP_005273701                                                           15    9605
XP_006716464                                                           15    9605
XP_006716463                                                           15    9605
XP_006716462                                                           15    9605
XP_005265922                                                           15    9605
XP_005265921                                                           15    9605
XP_005265919                                                           15    9605
XP_006714900                                                           15    9605
XP_005265917                                                           15    9605
XP_005268557                                                           15    9605
XP_005268556                                                           15    9605
XP_006714855                                                           15    9605
XP_006714854                                                           15    9605
XP_005268555                                                           15    9605
XP_005268554                                                           15    9605
NP_001004759                                                           15    9605
>NP_958441
          Length = 705

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  LIALNTVEQ 9
          LIALNTVE+
Sbjct: 90 LIALNTVER 98
>NP_958439
          Length = 628

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  LIALNTVEQ 9
          LIALNTVE+
Sbjct: 90 LIALNTVER 98
>NP_958440
          Length = 405

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  LIALNTVEQ 9
          LIALNTVE+
Sbjct: 90 LIALNTVER 98
>NP_005219
          Length = 1210

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  LIALNTVEQ 9
          LIALNTVE+
Sbjct: 90 LIALNTVER 98
>NP_874358
          Length = 631

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LIALNTVEQ 9
           L+A+NTV+Q
Sbjct: 435 LVAVNTVKQ 443
>NP_598004
          Length = 545

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   IALNTVEQ 9
           +ALNTVE+
Sbjct: 277 LALNTVEE 284
>NP_542407
          Length = 425

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LIALNTVEQ 9
           +IALNT+++
Sbjct: 199 VIALNTIKE 207
>NP_001269042
          Length = 862

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IALNTVE 8
           +ALNTVE
Sbjct: 299 LALNTVE 305
>NP_001269041
          Length = 862

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IALNTVE 8
           +ALNTVE
Sbjct: 299 LALNTVE 305
>NP_003926
          Length = 862

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IALNTVE 8
           +ALNTVE
Sbjct: 299 LALNTVE 305
>XP_006724415
          Length = 707

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IALNTVE 8
           +ALNTVE
Sbjct: 299 LALNTVE 305
>XP_005261871
          Length = 708

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IALNTVE 8
           +ALNTVE
Sbjct: 299 LALNTVE 305
>XP_005261870
          Length = 726

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IALNTVE 8
           +ALNTVE
Sbjct: 163 LALNTVE 169
>XP_006724414
          Length = 730

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IALNTVE 8
           +ALNTVE
Sbjct: 299 LALNTVE 305
>XP_005261868
          Length = 862

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IALNTVE 8
           +ALNTVE
Sbjct: 299 LALNTVE 305
>XP_006724413
          Length = 862

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IALNTVE 8
           +ALNTVE
Sbjct: 299 LALNTVE 305
>XP_006724412
          Length = 862

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IALNTVE 8
           +ALNTVE
Sbjct: 299 LALNTVE 305
>XP_006723607
          Length = 447

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LIALNTVEQ 9
           +IALNT+++
Sbjct: 199 VIALNTIKE 207
>XP_005260724
          Length = 448

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LIALNTVEQ 9
           +IALNT+++
Sbjct: 199 VIALNTIKE 207
>NP_001192222
          Length = 2313

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LIALNTV 7
            +IALNTV
Sbjct: 1487 MIALNTV 1493
>NP_001192223
          Length = 2251

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LIALNTV 7
            +IALNTV
Sbjct: 1468 MIALNTV 1474
>NP_000712
          Length = 2270

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LIALNTV 7
            +IALNTV
Sbjct: 1487 MIALNTV 1493
>NP_000709
          Length = 2339

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LIALNTV 7
            +IALNTV
Sbjct: 1480 MIALNTV 1486
>NP_001230741
          Length = 2237

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LIALNTV 7
            +IALNTV
Sbjct: 1480 MIALNTV 1486
>NP_001120694
          Length = 2506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    LIALNTV 7
            +IALNT+
Sbjct: 1574 MIALNTI 1580
>NP_075461
          Length = 2512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    LIALNTV 7
            +IALNT+
Sbjct: 1578 MIALNTI 1584
>NP_001120693
          Length = 2261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    LIALNTV 7
            +IALNT+
Sbjct: 1575 MIALNTI 1581
>NP_000059
          Length = 2266

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    LIALNTV 7
            +IALNT+
Sbjct: 1578 MIALNTI 1584
>NP_001167551
          Length = 2263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    LIALNTV 7
            +IALNT+
Sbjct: 1575 MIALNTI 1581
>NP_001129203
          Length = 153

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IALNTVEQ 9
           ++LN++EQ
Sbjct: 129 VSLNSIEQ 136
>NP_036411
          Length = 294

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IALNTVEQ 9
           I LN++EQ
Sbjct: 246 IVLNSIEQ 253
>NP_078921
          Length = 229

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IALNTVEQ 9
           ++LN++EQ
Sbjct: 205 VSLNSIEQ 212
>NP_071926
          Length = 1544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ALNTVE 8
           ALNTVE
Sbjct: 148 ALNTVE 153
>XP_005273701
          Length = 183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IALNTVEQ 9
           ++LN++EQ
Sbjct: 159 VSLNSIEQ 166
>XP_006716464
          Length = 183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IALNTVEQ 9
           ++LN++EQ
Sbjct: 159 VSLNSIEQ 166
>XP_006716463
          Length = 230

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IALNTVEQ 9
           ++LN++EQ
Sbjct: 210 VSLNSIEQ 217
>XP_006716462
          Length = 234

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IALNTVEQ 9
           ++LN++EQ
Sbjct: 210 VSLNSIEQ 217
>XP_005265922
          Length = 232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IALNTVEQ 9
           I LN++EQ
Sbjct: 184 IVLNSIEQ 191
>XP_005265921
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IALNTVEQ 9
           I LN++EQ
Sbjct: 209 IVLNSIEQ 216
>XP_005265919
          Length = 310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IALNTVEQ 9
           I LN++EQ
Sbjct: 262 IVLNSIEQ 269
>XP_006714900
          Length = 319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IALNTVEQ 9
           I LN++EQ
Sbjct: 271 IVLNSIEQ 278
>XP_005265917
          Length = 335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IALNTVEQ 9
           I LN++EQ
Sbjct: 287 IVLNSIEQ 294
>XP_005268557
          Length = 934

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ALNTVE 8
           ALNTVE
Sbjct: 148 ALNTVE 153
>XP_005268556
          Length = 1466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  ALNTVE 8
          ALNTVE
Sbjct: 70 ALNTVE 75
>XP_006714855
          Length = 1473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ALNTVE 8
           ALNTVE
Sbjct: 148 ALNTVE 153
>XP_006714854
          Length = 1486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ALNTVE 8
           ALNTVE
Sbjct: 148 ALNTVE 153
>XP_005268555
          Length = 1524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ALNTVE 8
           ALNTVE
Sbjct: 148 ALNTVE 153
>XP_005268554
          Length = 1531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ALNTVE 8
           ALNTVE
Sbjct: 148 ALNTVE 153
>NP_001004759
          Length = 354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LIALNTV 7
           L+A+NTV
Sbjct: 189 LVAINTV 195
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.130    0.307 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 298,541
Number of extensions: 285
Number of successful extensions: 49
Number of sequences better than 10000.0: 49
Number of HSP's gapped: 49
Number of HSP's successfully gapped: 49
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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