Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              18    1935
XP_006716142                                                           18    1935
XP_005250088                                                           18    1935
XP_006716141                                                           18    1935
XP_005250085                                                           18    1935
XP_006716140                                                           18    1935
XP_005250084                                                           18    1935
XP_005250083                                                           18    1935
XP_005250082                                                           18    1935
NP_057407                                                              17    3301
NP_570711                                                              17    4312
NP_570712                                                              17    4312
NP_570714                                                              17    4312
NP_570713                                                              17    4312
NP_570716                                                              17    4312
NP_000235                                                              17    4312
NP_570715                                                              17    4312
NP_115525                                                              17    4312
XP_006718620                                                           17    4312
XP_005274059                                                           17    4312
XP_005274060                                                           17    4312
XP_005274058                                                           17    4312
NP_000341                                                              16    7355
NP_001034842                                                           16    7355
XP_006712080                                                           16    7355
XP_006712079                                                           16    7355
NP_079052                                                              15    9605
NP_001005407                                                           15    9605
NP_066921                                                              15    9605
NP_001030175                                                           15    9605
NP_056013                                                              15    9605
NP_001274365                                                           15    9605
XP_006721028                                                           15    9605
XP_006721027                                                           15    9605
XP_005255709                                                           15    9605
XP_006721026                                                           15    9605
XP_005254732                                                           15    9605
XP_005254731                                                           15    9605
XP_006720754                                                           15    9605
XP_005254729                                                           15    9605
XP_005254730                                                           15    9605
XP_005254728                                                           15    9605
XP_005254727                                                           15    9605
XP_005271814                                                           15    9605
XP_005271813                                                           15    9605
XP_006715738                                                           15    9605
XP_005271812                                                           15    9605
XP_005271810                                                           15    9605
XP_005271809                                                           15    9605
XP_005271808                                                           15    9605
XP_005271807                                                           15    9605
>NP_733751
          Length = 4911

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LHTDSLLIA 9
           L TDSLLIA
Sbjct: 596 LDTDSLLIA 604
>XP_006716142
          Length = 4927

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LHTDSLLIA 9
           L TDSLLIA
Sbjct: 597 LDTDSLLIA 605
>XP_005250088
          Length = 4928

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LHTDSLLIA 9
           L TDSLLIA
Sbjct: 597 LDTDSLLIA 605
>XP_006716141
          Length = 4959

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LHTDSLLIA 9
           L TDSLLIA
Sbjct: 597 LDTDSLLIA 605
>XP_005250085
          Length = 4979

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LHTDSLLIA 9
           L TDSLLIA
Sbjct: 597 LDTDSLLIA 605
>XP_006716140
          Length = 4982

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LHTDSLLIA 9
           L TDSLLIA
Sbjct: 597 LDTDSLLIA 605
>XP_005250084
          Length = 4982

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LHTDSLLIA 9
           L TDSLLIA
Sbjct: 597 LDTDSLLIA 605
>XP_005250083
          Length = 4982

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LHTDSLLIA 9
           L TDSLLIA
Sbjct: 596 LDTDSLLIA 604
>XP_005250082
          Length = 4983

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LHTDSLLIA 9
           L TDSLLIA
Sbjct: 597 LDTDSLLIA 605
>NP_057407
          Length = 1024

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LHTDSLL 7
           LHTD+LL
Sbjct: 645 LHTDTLL 651
>NP_570711
          Length = 610

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LHTDSL 6
           LHTDSL
Sbjct: 249 LHTDSL 254
>NP_570712
          Length = 615

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LHTDSL 6
           LHTDSL
Sbjct: 254 LHTDSL 259
>NP_570714
          Length = 615

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LHTDSL 6
           LHTDSL
Sbjct: 254 LHTDSL 259
>NP_570713
          Length = 615

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LHTDSL 6
           LHTDSL
Sbjct: 254 LHTDSL 259
>NP_570716
          Length = 615

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LHTDSL 6
           LHTDSL
Sbjct: 254 LHTDSL 259
>NP_000235
          Length = 615

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LHTDSL 6
           LHTDSL
Sbjct: 254 LHTDSL 259
>NP_570715
          Length = 615

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LHTDSL 6
           LHTDSL
Sbjct: 254 LHTDSL 259
>NP_115525
          Length = 359

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LHTDSL 6
           LHTDSL
Sbjct: 191 LHTDSL 196
>XP_006718620
          Length = 610

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LHTDSL 6
           LHTDSL
Sbjct: 249 LHTDSL 254
>XP_005274059
          Length = 610

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LHTDSL 6
           LHTDSL
Sbjct: 249 LHTDSL 254
>XP_005274060
          Length = 610

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LHTDSL 6
           LHTDSL
Sbjct: 249 LHTDSL 254
>XP_005274058
          Length = 610

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LHTDSL 6
           LHTDSL
Sbjct: 249 LHTDSL 254
>NP_000341
          Length = 2273

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    HTDSLLI 8
            H DSLLI
Sbjct: 2225 HKDSLLI 2231
>NP_001034842
          Length = 1958

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LHTDSLLI 8
            LH DS+L+
Sbjct: 1247 LHNDSVLL 1254
>XP_006712080
          Length = 924

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LHTDSLLI 8
           LH DS+L+
Sbjct: 213 LHNDSVLL 220
>XP_006712079
          Length = 1683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LHTDSLLI 8
            LH DS+L+
Sbjct: 1005 LHNDSVLL 1012
>NP_079052
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    LHTDSL 6
            LHTD+L
Sbjct: 1293 LHTDAL 1298
>NP_001005407
          Length = 2347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    LHTDSL 6
            +HTDSL
Sbjct: 2013 VHTDSL 2018
>NP_066921
          Length = 2353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    LHTDSL 6
            +HTDSL
Sbjct: 2019 VHTDSL 2024
>NP_001030175
          Length = 225

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  LHTDSL 6
          LHTDS+
Sbjct: 27 LHTDSV 32
>NP_056013
          Length = 1261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LHTDSL 6
           LHTD+L
Sbjct: 638 LHTDNL 643
>NP_001274365
          Length = 1271

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LHTDSL 6
           LHTD+L
Sbjct: 695 LHTDNL 700
>XP_006721028
          Length = 2336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    LHTDSL 6
            +HTDSL
Sbjct: 2002 VHTDSL 2007
>XP_006721027
          Length = 2342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    LHTDSL 6
            +HTDSL
Sbjct: 2008 VHTDSL 2013
>XP_005255709
          Length = 2347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    LHTDSL 6
            +HTDSL
Sbjct: 2013 VHTDSL 2018
>XP_006721026
          Length = 2358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    LHTDSL 6
            +HTDSL
Sbjct: 2024 VHTDSL 2029
>XP_005254732
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    LHTDSL 6
            LHTD+L
Sbjct: 1293 LHTDAL 1298
>XP_005254731
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    LHTDSL 6
            LHTD+L
Sbjct: 1293 LHTDAL 1298
>XP_006720754
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    LHTDSL 6
            LHTD+L
Sbjct: 1293 LHTDAL 1298
>XP_005254729
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    LHTDSL 6
            LHTD+L
Sbjct: 1293 LHTDAL 1298
>XP_005254730
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    LHTDSL 6
            LHTD+L
Sbjct: 1293 LHTDAL 1298
>XP_005254728
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    LHTDSL 6
            LHTD+L
Sbjct: 1293 LHTDAL 1298
>XP_005254727
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    LHTDSL 6
            LHTD+L
Sbjct: 1293 LHTDAL 1298
>XP_005271814
          Length = 1047

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LHTDSL 6
           LHTD+L
Sbjct: 424 LHTDNL 429
>XP_005271813
          Length = 1214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LHTDSL 6
           LHTD+L
Sbjct: 638 LHTDNL 643
>XP_006715738
          Length = 1229

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LHTDSL 6
           LHTD+L
Sbjct: 653 LHTDNL 658
>XP_005271812
          Length = 1245

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LHTDSL 6
           LHTD+L
Sbjct: 710 LHTDNL 715
>XP_005271810
          Length = 1276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LHTDSL 6
           LHTD+L
Sbjct: 653 LHTDNL 658
>XP_005271809
          Length = 1286

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LHTDSL 6
           LHTD+L
Sbjct: 710 LHTDNL 715
>XP_005271808
          Length = 1318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LHTDSL 6
           LHTD+L
Sbjct: 695 LHTDNL 700
>XP_005271807
          Length = 1333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LHTDSL 6
           LHTD+L
Sbjct: 710 LHTDNL 715
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.327    0.138    0.372 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 593,638
Number of extensions: 798
Number of successful extensions: 51
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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