Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245202                                                           21     229
NP_001245200                                                           21     229
NP_001161091                                                           21     229
NP_000240                                                              21     229
NP_001161090                                                           21     229
NP_001161089                                                           21     229
NP_001245203                                                           21     229
XP_005265221                                                           21     229
XP_005265220                                                           21     229
XP_005265218                                                           21     229
NP_878918                                                              18    1935
NP_055995                                                              18    1935
XP_006720147                                                           18    1935
XP_005267517                                                           18    1935
XP_005267516                                                           18    1935
XP_005267515                                                           18    1935
XP_005267514                                                           18    1935
XP_005267513                                                           18    1935
XP_005267512                                                           18    1935
XP_005267511                                                           18    1935
NP_057345                                                              17    4312
NP_001180538                                                           17    4312
NP_079089                                                              17    4312
NP_001180539                                                           17    4312
XP_005257482                                                           17    4312
XP_005271280                                                           17    4312
XP_006710968                                                           17    4312
NP_001180540                                                           17    4312
NP_055498                                                              16    5631
NP_001136082                                                           16    5631
XP_006721669                                                           16    5631
NP_001257997                                                           16    7355
NP_660089                                                              16    7355
NP_055785                                                              16    7355
NP_054797                                                              16    7355
NP_001191443                                                           16    7355
NP_001191446                                                           16    7355
NP_001191445                                                           16    7355
XP_006716610                                                           16    7355
XP_005245027                                                           16    7355
NP_037453                                                              15    9605
NP_079375                                                              15    9605
NP_002620                                                              15    9605
NP_060647                                                              15    9605
NP_001005210                                                           15    9605
NP_689753                                                              15    9605
NP_001156736                                                           15    9605
NP_001025062                                                           15    9605
NP_001171922                                                           15    9605
XP_006721642                                                           15    9605
XP_006721641                                                           15    9605
XP_006721640                                                           15    9605
XP_006719914                                                           15    9605
XP_005266530                                                           15    9605
XP_006719913                                                           15    9605
XP_006719912                                                           15    9605
XP_006719911                                                           15    9605
XP_006719910                                                           15    9605
XP_006719909                                                           15    9605
XP_006714086                                                           15    9605
XP_006714085                                                           15    9605
XP_006714084                                                           15    9605
NP_112567                                                              15    9605
>NP_001245202
          Length = 515

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  LHEESIMER 9
          LHEESI+ER
Sbjct: 76 LHEESILER 84
>NP_001245200
          Length = 687

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LHEESIMER 9
           LHEESI+ER
Sbjct: 317 LHEESILER 325
>NP_001161091
          Length = 515

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  LHEESIMER 9
          LHEESI+ER
Sbjct: 76 LHEESILER 84
>NP_000240
          Length = 756

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LHEESIMER 9
           LHEESI+ER
Sbjct: 317 LHEESILER 325
>NP_001161090
          Length = 515

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  LHEESIMER 9
          LHEESI+ER
Sbjct: 76 LHEESILER 84
>NP_001161089
          Length = 658

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LHEESIMER 9
           LHEESI+ER
Sbjct: 219 LHEESILER 227
>NP_001245203
          Length = 515

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  LHEESIMER 9
          LHEESI+ER
Sbjct: 76 LHEESILER 84
>XP_005265221
          Length = 515

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  LHEESIMER 9
          LHEESI+ER
Sbjct: 76 LHEESILER 84
>XP_005265220
          Length = 515

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1  LHEESIMER 9
          LHEESI+ER
Sbjct: 76 LHEESILER 84
>XP_005265218
          Length = 687

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   LHEESIMER 9
           LHEESI+ER
Sbjct: 248 LHEESILER 256
>NP_878918
          Length = 6907

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LHEESIMER 9
            L EESIME+
Sbjct: 1098 LQEESIMEK 1106
>NP_055995
          Length = 6885

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LHEESIMER 9
            L EESIME+
Sbjct: 1098 LQEESIMEK 1106
>XP_006720147
          Length = 4788

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LHEESIMER 9
            L EESIME+
Sbjct: 1098 LQEESIMEK 1106
>XP_005267517
          Length = 6883

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LHEESIMER 9
            L EESIME+
Sbjct: 1098 LQEESIMEK 1106
>XP_005267516
          Length = 6884

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LHEESIMER 9
            L EESIME+
Sbjct: 1098 LQEESIMEK 1106
>XP_005267515
          Length = 6899

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LHEESIMER 9
            L EESIME+
Sbjct: 1098 LQEESIMEK 1106
>XP_005267514
          Length = 6908

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LHEESIMER 9
            L EESIME+
Sbjct: 1098 LQEESIMEK 1106
>XP_005267513
          Length = 6921

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LHEESIMER 9
            L EESIME+
Sbjct: 1098 LQEESIMEK 1106
>XP_005267512
          Length = 6922

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LHEESIMER 9
            L EESIME+
Sbjct: 1098 LQEESIMEK 1106
>XP_005267511
          Length = 6922

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LHEESIMER 9
            L EESIME+
Sbjct: 1098 LQEESIMEK 1106
>NP_057345
          Length = 453

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   HEESIM 7
           HEESIM
Sbjct: 115 HEESIM 120
>NP_001180538
          Length = 398

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   HEESIM 7
           HEESIM
Sbjct: 115 HEESIM 120
>NP_079089
          Length = 612

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LHEESIMER 9
           LH++SIM++
Sbjct: 242 LHQKSIMKK 250
>NP_001180539
          Length = 396

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   HEESIM 7
           HEESIM
Sbjct: 115 HEESIM 120
>XP_005257482
          Length = 386

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  HEESIM 7
          HEESIM
Sbjct: 48 HEESIM 53
>XP_005271280
          Length = 566

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LHEESIMER 9
           LH++SIM++
Sbjct: 242 LHQKSIMKK 250
>XP_006710968
          Length = 579

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   LHEESIMER 9
           LH++SIM++
Sbjct: 242 LHQKSIMKK 250
>NP_001180540
          Length = 351

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   HEESIM 7
           HEESIM
Sbjct: 115 HEESIM 120
>NP_055498
          Length = 1036

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LHEESIMER 9
           L EE++MER
Sbjct: 813 LPEETLMER 821
>NP_001136082
          Length = 1036

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LHEESIMER 9
           L EE++MER
Sbjct: 813 LPEETLMER 821
>XP_006721669
          Length = 1009

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LHEESIMER 9
           L EE++MER
Sbjct: 786 LPEETLMER 794
>NP_001257997
          Length = 87

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  LHEESIMER 9
          LH +S+M++
Sbjct: 61 LHRQSLMQK 69
>NP_660089
          Length = 96

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  LHEESIMER 9
          LH +S+M++
Sbjct: 70 LHRQSLMQK 78
>NP_055785
          Length = 792

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LHEESIMER 9
           +HE  I+ER
Sbjct: 709 IHEGDILER 717
>NP_054797
          Length = 178

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LHEESIMER 9
           LH  ++MER
Sbjct: 116 LHRRTMMER 124
>NP_001191443
          Length = 714

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LHEESIMER 9
           +HE  I+ER
Sbjct: 631 IHEGDILER 639
>NP_001191446
          Length = 752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LHEESIMER 9
           +HE  I+ER
Sbjct: 669 IHEGDILER 677
>NP_001191445
          Length = 748

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LHEESIMER 9
           +HE  I+ER
Sbjct: 665 IHEGDILER 673
>XP_006716610
          Length = 154

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LHEESIMER 9
           LH  ++MER
Sbjct: 92  LHRRTMMER 100
>XP_005245027
          Length = 794

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LHEESIMER 9
           +HE  I+ER
Sbjct: 709 IHEGDILER 717
>NP_037453
          Length = 465

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LHEESIMER 9
           LH+ S+M+R
Sbjct: 346 LHKYSLMKR 354
>NP_079375
          Length = 1217

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   HEESIMER 9
           H+E++M+R
Sbjct: 737 HKEALMKR 744
>NP_002620
          Length = 254

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LHEESIME 8
           L EE+IME
Sbjct: 200 LSEEAIME 207
>NP_060647
          Length = 1770

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EESIMER 9
            +ES+MER
Sbjct: 1424 KESVMER 1430
>NP_001005210
          Length = 341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   LHEESIME 8
           LH  S+ME
Sbjct: 139 LHNNSLME 146
>NP_689753
          Length = 684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HEESIME 8
           H+E++ME
Sbjct: 352 HKEAVME 358
>NP_001156736
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  HEESIME 8
          H+E IME
Sbjct: 4  HQECIME 10
>NP_001025062
          Length = 254

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LHEESIME 8
           L EE+IME
Sbjct: 200 LSEEAIME 207
>NP_001171922
          Length = 1619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LHEESIMER 9
           + E+SIME+
Sbjct: 93  IKEDSIMEK 101
>XP_006721642
          Length = 979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   HEESIMER 9
           H+E++M+R
Sbjct: 737 HKEALMKR 744
>XP_006721641
          Length = 1140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   HEESIMER 9
           H+E++M+R
Sbjct: 737 HKEALMKR 744
>XP_006721640
          Length = 1174

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   HEESIMER 9
           H+E++M+R
Sbjct: 694 HKEALMKR 701
>XP_006719914
          Length = 1639

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LHEESIMER 9
           + E+SIME+
Sbjct: 113 IKEDSIMEK 121
>XP_005266530
          Length = 1643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LHEESIMER 9
           + E+SIME+
Sbjct: 113 IKEDSIMEK 121
>XP_006719913
          Length = 1650

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LHEESIMER 9
           + E+SIME+
Sbjct: 113 IKEDSIMEK 121
>XP_006719912
          Length = 1672

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LHEESIMER 9
           + E+SIME+
Sbjct: 93  IKEDSIMEK 101
>XP_006719911
          Length = 1688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LHEESIMER 9
           + E+SIME+
Sbjct: 113 IKEDSIMEK 121
>XP_006719910
          Length = 1692

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LHEESIMER 9
           + E+SIME+
Sbjct: 113 IKEDSIMEK 121
>XP_006719909
          Length = 1692

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LHEESIMER 9
           + E+SIME+
Sbjct: 113 IKEDSIMEK 121
>XP_006714086
          Length = 1690

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EESIMER 9
            +ES+MER
Sbjct: 1344 KESVMER 1350
>XP_006714085
          Length = 1690

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EESIMER 9
            +ES+MER
Sbjct: 1344 KESVMER 1350
>XP_006714084
          Length = 1753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    EESIMER 9
            +ES+MER
Sbjct: 1424 KESVMER 1430
>NP_112567
          Length = 1623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LHEESIMER 9
           + E+SIME+
Sbjct: 93  IKEDSIMEK 101
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.127    0.323 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 568,317
Number of extensions: 903
Number of successful extensions: 63
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 63
Number of HSP's successfully gapped: 63
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package