Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001265354                                                           17    4312
NP_001265352                                                           17    4312
NP_620137                                                              17    4312
NP_443124                                                              17    4312
NP_004831                                                              17    4312
NP_001139504                                                           17    4312
XP_006724854                                                           17    4312
XP_005262556                                                           17    4312
XP_006713065                                                           17    4312
XP_005264953                                                           17    4312
XP_006713064                                                           17    4312
XP_006713063                                                           17    4312
XP_006713062                                                           17    4312
XP_006713061                                                           17    4312
XP_006713060                                                           17    4312
XP_006713059                                                           17    4312
XP_006713058                                                           17    4312
XP_006713057                                                           17    4312
NP_955379                                                              17    4312
NP_001070248                                                           17    4312
NP_660337                                                              16    7355
XP_006720926                                                           16    7355
XP_006720925                                                           16    7355
XP_006720924                                                           16    7355
XP_006720923                                                           16    7355
XP_005255218                                                           16    7355
XP_005255217                                                           16    7355
XP_005248494                                                           16    7355
NP_001229864                                                           15    9605
NP_005451                                                              15    9605
NP_008850                                                              15    9605
NP_002965                                                              15    9605
XP_006714801                                                           15    9605
XP_006714800                                                           15    9605
XP_006714799                                                           15    9605
XP_006714798                                                           15    9605
XP_006714797                                                           15    9605
XP_005272195                                                           15    9605
XP_005272196                                                           15    9605
>NP_001265354
          Length = 1774

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LGSLSAANT 9
           LGSLSA  T
Sbjct: 247 LGSLSAVTT 255
>NP_001265352
          Length = 306

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LGSLSAANT 9
           LGSLSA  T
Sbjct: 247 LGSLSAVTT 255
>NP_620137
          Length = 810

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   SLSAANT 9
           SLSAANT
Sbjct: 517 SLSAANT 523
>NP_443124
          Length = 2459

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LGSLSAANT 9
           LGSLSA  T
Sbjct: 932 LGSLSAVTT 940
>NP_004831
          Length = 776

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   SLSAANT 9
           SLSAANT
Sbjct: 124 SLSAANT 130
>NP_001139504
          Length = 777

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   SLSAANT 9
           SLSAANT
Sbjct: 484 SLSAANT 490
>XP_006724854
          Length = 695

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3  SLSAANT 9
          SLSAANT
Sbjct: 43 SLSAANT 49
>XP_005262556
          Length = 727

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   SLSAANT 9
           SLSAANT
Sbjct: 124 SLSAANT 130
>XP_006713065
          Length = 709

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LGSLSAAN 8
           +GSLS+AN
Sbjct: 354 IGSLSSAN 361
>XP_005264953
          Length = 713

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LGSLSAAN 8
           +GSLS+AN
Sbjct: 354 IGSLSSAN 361
>XP_006713064
          Length = 1115

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LGSLSAAN 8
           +GSLS+AN
Sbjct: 354 IGSLSSAN 361
>XP_006713063
          Length = 1125

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LGSLSAAN 8
           +GSLS+AN
Sbjct: 354 IGSLSSAN 361
>XP_006713062
          Length = 1158

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LGSLSAAN 8
           +GSLS+AN
Sbjct: 354 IGSLSSAN 361
>XP_006713061
          Length = 1162

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LGSLSAAN 8
           +GSLS+AN
Sbjct: 354 IGSLSSAN 361
>XP_006713060
          Length = 1162

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LGSLSAAN 8
           +GSLS+AN
Sbjct: 354 IGSLSSAN 361
>XP_006713059
          Length = 1172

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LGSLSAAN 8
           +GSLS+AN
Sbjct: 354 IGSLSSAN 361
>XP_006713058
          Length = 1172

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LGSLSAAN 8
           +GSLS+AN
Sbjct: 354 IGSLSSAN 361
>XP_006713057
          Length = 1172

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LGSLSAAN 8
           +GSLS+AN
Sbjct: 354 IGSLSSAN 361
>NP_955379
          Length = 712

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LGSLSAAN 8
           +GSLS+AN
Sbjct: 354 IGSLSSAN 361
>NP_001070248
          Length = 991

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LGSLSAANT 9
           LGSLSA  T
Sbjct: 932 LGSLSAVTT 940
>NP_660337
          Length = 1748

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  GSLSAAN 8
          GS+SAAN
Sbjct: 47 GSVSAAN 53
>XP_006720926
          Length = 1383

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  GSLSAAN 8
          GS+SAAN
Sbjct: 47 GSVSAAN 53
>XP_006720925
          Length = 1674

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  GSLSAAN 8
          GS+SAAN
Sbjct: 47 GSVSAAN 53
>XP_006720924
          Length = 1679

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  GSLSAAN 8
          GS+SAAN
Sbjct: 47 GSVSAAN 53
>XP_006720923
          Length = 1738

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  GSLSAAN 8
          GS+SAAN
Sbjct: 47 GSVSAAN 53
>XP_005255218
          Length = 1750

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  GSLSAAN 8
          GS+SAAN
Sbjct: 47 GSVSAAN 53
>XP_005255217
          Length = 1751

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  GSLSAAN 8
          GS+SAAN
Sbjct: 47 GSVSAAN 53
>XP_005248494
          Length = 398

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LGSLSAANT 9
           LGSL  +NT
Sbjct: 347 LGSLCTSNT 355
>NP_001229864
          Length = 603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LGSLSAAN 8
           LGSLSA++
Sbjct: 232 LGSLSASS 239
>NP_005451
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LGSLSAAN 8
           LGSLSA++
Sbjct: 598 LGSLSASS 605
>NP_008850
          Length = 390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1 LGSLSAANT 9
         + SLS ANT
Sbjct: 1 MNSLSEANT 9
>NP_002965
          Length = 390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1 LGSLSAANT 9
         + SLS ANT
Sbjct: 1 MNSLSEANT 9
>XP_006714801
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LGSLSAAN 8
           LGSLSA++
Sbjct: 238 LGSLSASS 245
>XP_006714800
          Length = 609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LGSLSAAN 8
           LGSLSA++
Sbjct: 238 LGSLSASS 245
>XP_006714799
          Length = 669

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LGSLSAAN 8
           LGSLSA++
Sbjct: 298 LGSLSASS 305
>XP_006714798
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LGSLSAAN 8
           LGSLSA++
Sbjct: 598 LGSLSASS 605
>XP_006714797
          Length = 969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LGSLSAAN 8
           LGSLSA++
Sbjct: 598 LGSLSASS 605
>XP_005272195
          Length = 969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LGSLSAAN 8
           LGSLSA++
Sbjct: 598 LGSLSASS 605
>XP_005272196
          Length = 969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   LGSLSAAN 8
           LGSLSA++
Sbjct: 598 LGSLSASS 605
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.297    0.110    0.264 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 335,445
Number of extensions: 461
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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