Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              17    2528
NP_671714                                                              17    2528
XP_006715890                                                           17    2528
XP_005250160                                                           17    2528
XP_005250159                                                           17    2528
NP_055495                                                              17    3301
XP_006722261                                                           17    3301
XP_005258130                                                           17    3301
NP_001106677                                                           17    4312
NP_001275635                                                           16    7355
NP_000868                                                              16    7355
NP_477352                                                              16    7355
NP_065987                                                              16    7355
NP_002641                                                              16    7355
NP_006050                                                              16    7355
NP_005039                                                              16    7355
XP_005261692                                                           16    7355
XP_005261691                                                           16    7355
XP_005263991                                                           16    7355
XP_005263989                                                           16    7355
XP_005263990                                                           16    7355
XP_005263988                                                           16    7355
XP_005263987                                                           16    7355
XP_005263986                                                           16    7355
NP_001264156                                                           15    9605
NP_003658                                                              15    9605
NP_001264155                                                           15    9605
NP_055537                                                              15    9605
NP_001273374                                                           15    9605
NP_001269323                                                           15    9605
NP_006639                                                              15    9605
XP_006717302                                                           15    9605
XP_005252201                                                           15    9605
XP_005252200                                                           15    9605
XP_006717301                                                           15    9605
XP_005252199                                                           15    9605
XP_005252198                                                           15    9605
XP_005252197                                                           15    9605
XP_006717300                                                           15    9605
XP_005252196                                                           15    9605
XP_005252195                                                           15    9605
XP_005252194                                                           15    9605
XP_006715343                                                           15    9605
XP_006715342                                                           15    9605
XP_006715341                                                           15    9605
XP_006715340                                                           15    9605
XP_006715339                                                           15    9605
XP_006715338                                                           15    9605
>NP_005742
          Length = 3907

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LGISELESQ 9
            L ISELESQ
Sbjct: 2606 LRISELESQ 2614
>NP_671714
          Length = 3899

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LGISELESQ 9
            L ISELESQ
Sbjct: 2598 LRISELESQ 2606
>XP_006715890
          Length = 3860

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LGISELESQ 9
            L ISELESQ
Sbjct: 2559 LRISELESQ 2567
>XP_005250160
          Length = 3939

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LGISELESQ 9
            L ISELESQ
Sbjct: 2638 LRISELESQ 2646
>XP_005250159
          Length = 3952

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LGISELESQ 9
            L ISELESQ
Sbjct: 2651 LRISELESQ 2659
>NP_055495
          Length = 2235

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LGISELESQ 9
            LGI+ELE Q
Sbjct: 1927 LGIAELELQ 1935
>XP_006722261
          Length = 2092

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LGISELESQ 9
            LGI+ELE Q
Sbjct: 1784 LGIAELELQ 1792
>XP_005258130
          Length = 2234

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LGISELESQ 9
            LGI+ELE Q
Sbjct: 1926 LGIAELELQ 1934
>NP_001106677
          Length = 74

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2 GISELES 8
         G+SELES
Sbjct: 3 GVSELES 9
>NP_001275635
          Length = 538

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LGISELESQ 9
           L ISE+ES+
Sbjct: 296 LNISEIESR 304
>NP_000868
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LGISELESQ 9
           L ISE+ES+
Sbjct: 296 LNISEIESR 304
>NP_477352
          Length = 2102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    GISELESQ 9
            G+SELE +
Sbjct: 1813 GVSELEKE 1820
>NP_065987
          Length = 600

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LGISELE 7
           LGIS+LE
Sbjct: 591 LGISDLE 597
>NP_002641
          Length = 854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GISELESQ 9
           G+SELE +
Sbjct: 565 GVSELEKE 572
>NP_006050
          Length = 1575

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    GISELESQ 9
            G+SE+E Q
Sbjct: 1463 GLSEMEQQ 1470
>NP_005039
          Length = 550

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LGISELES 8
           +G+ ELES
Sbjct: 205 IGVKELES 212
>XP_005261692
          Length = 1854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    GISELESQ 9
            G+SELE +
Sbjct: 1565 GVSELEKE 1572
>XP_005261691
          Length = 2099

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    GISELESQ 9
            G+SELE +
Sbjct: 1810 GVSELEKE 1817
>XP_005263991
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LGISELESQ 9
           L ISE+ES+
Sbjct: 296 LNISEIESR 304
>XP_005263989
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LGISELESQ 9
           L ISE+ES+
Sbjct: 296 LNISEIESR 304
>XP_005263990
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LGISELESQ 9
           L ISE+ES+
Sbjct: 296 LNISEIESR 304
>XP_005263988
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LGISELESQ 9
           L ISE+ES+
Sbjct: 296 LNISEIESR 304
>XP_005263987
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LGISELESQ 9
           L ISE+ES+
Sbjct: 296 LNISEIESR 304
>XP_005263986
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LGISELESQ 9
           L ISE+ES+
Sbjct: 296 LNISEIESR 304
>NP_001264156
          Length = 835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LGISELES 8
          LG+SEL S
Sbjct: 55 LGLSELPS 62
>NP_003658
          Length = 907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LGISELES 8
          LG+SEL S
Sbjct: 55 LGLSELPS 62
>NP_001264155
          Length = 883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LGISELES 8
          LG+SEL S
Sbjct: 55 LGLSELPS 62
>NP_055537
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GISELES 8
           G+S+LES
Sbjct: 895 GVSDLES 901
>NP_001273374
          Length = 1047

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GISELES 8
           G+S+LES
Sbjct: 874 GVSDLES 880
>NP_001269323
          Length = 2297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ISELESQ 9
            ISEL+SQ
Sbjct: 1945 ISELQSQ 1951
>NP_006639
          Length = 2217

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ISELESQ 9
            ISEL+SQ
Sbjct: 1908 ISELQSQ 1914
>XP_006717302
          Length = 2148

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ISELESQ 9
            ISEL+SQ
Sbjct: 1908 ISELQSQ 1914
>XP_005252201
          Length = 2185

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ISELESQ 9
            ISEL+SQ
Sbjct: 1908 ISELQSQ 1914
>XP_005252200
          Length = 2208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ISELESQ 9
            ISEL+SQ
Sbjct: 1856 ISELQSQ 1862
>XP_006717301
          Length = 2212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ISELESQ 9
            ISEL+SQ
Sbjct: 1908 ISELQSQ 1914
>XP_005252199
          Length = 2215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ISELESQ 9
            ISEL+SQ
Sbjct: 1863 ISELQSQ 1869
>XP_005252198
          Length = 2217

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ISELESQ 9
            ISEL+SQ
Sbjct: 1908 ISELQSQ 1914
>XP_005252197
          Length = 2224

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ISELESQ 9
            ISEL+SQ
Sbjct: 1908 ISELQSQ 1914
>XP_006717300
          Length = 2227

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ISELESQ 9
            ISEL+SQ
Sbjct: 1908 ISELQSQ 1914
>XP_005252196
          Length = 2242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ISELESQ 9
            ISEL+SQ
Sbjct: 1908 ISELQSQ 1914
>XP_005252195
          Length = 2259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ISELESQ 9
            ISEL+SQ
Sbjct: 1907 ISELQSQ 1913
>XP_005252194
          Length = 2260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    ISELESQ 9
            ISEL+SQ
Sbjct: 1908 ISELQSQ 1914
>XP_006715343
          Length = 1018

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GISELES 8
           G+S+LES
Sbjct: 845 GVSDLES 851
>XP_006715342
          Length = 1018

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GISELES 8
           G+S+LES
Sbjct: 845 GVSDLES 851
>XP_006715341
          Length = 1018

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GISELES 8
           G+S+LES
Sbjct: 845 GVSDLES 851
>XP_006715340
          Length = 1018

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GISELES 8
           G+S+LES
Sbjct: 845 GVSDLES 851
>XP_006715339
          Length = 1030

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GISELES 8
           G+S+LES
Sbjct: 857 GVSDLES 863
>XP_006715338
          Length = 1052

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GISELES 8
           G+S+LES
Sbjct: 879 GVSDLES 885
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.298    0.125    0.288 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 494,650
Number of extensions: 885
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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