Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001155973                                                           20     509
NP_001020014                                                           20     509
NP_055903                                                              20     509
NP_055426                                                              17    2528
NP_002882                                                              17    2528
NP_722522                                                              17    2528
NP_001139120                                                           17    2528
XP_006720692                                                           17    2528
XP_006720691                                                           17    2528
XP_006720690                                                           17    2528
XP_005254635                                                           17    2528
XP_005248757                                                           17    2528
XP_006715468                                                           17    2528
XP_005248756                                                           17    2528
XP_006715467                                                           17    2528
NP_002145                                                              16    5631
NP_055031                                                              16    5631
NP_001136065                                                           16    5631
NP_001136066                                                           16    5631
NP_060907                                                              16    5631
NP_932095                                                              16    5631
XP_005252145                                                           16    5631
XP_006717237                                                           16    5631
XP_005252143                                                           16    5631
NP_006452                                                              16    7355
NP_001098714                                                           16    7355
NP_061927                                                              16    7355
XP_006722401                                                           16    7355
XP_006722400                                                           16    7355
XP_006722399                                                           16    7355
XP_006722398                                                           16    7355
XP_006717969                                                           16    7355
XP_005269977                                                           16    7355
XP_006717968                                                           16    7355
XP_006717967                                                           16    7355
XP_006717966                                                           16    7355
XP_006717965                                                           16    7355
XP_005251972                                                           16    7355
NP_002836                                                              16    7355
NP_663761                                                              16    7355
NP_054733                                                              15    9605
NP_004949                                                              15    9605
NP_775656                                                              15    9605
NP_002596                                                              15    9605
NP_005723                                                              15    9605
NP_001230066                                                           15    9605
NP_001034230                                                           15    9605
NP_112597                                                              15    9605
NP_001265719                                                           15    9605
NP_001265718                                                           15    9605
NP_114105                                                              15    9605
NP_066545                                                              15    9605
XP_006724601                                                           15    9605
XP_005260953                                                           15    9605
XP_006720630                                                           15    9605
XP_005254990                                                           15    9605
XP_005271745                                                           15    9605
XP_006718940                                                           15    9605
XP_006718936                                                           15    9605
XP_006713365                                                           15    9605
XP_006713364                                                           15    9605
XP_006713363                                                           15    9605
XP_005263496                                                           15    9605
XP_005263495                                                           15    9605
NP_001076439                                                           15    9605
>NP_001155973
          Length = 1833

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LETDQNQSD 9
            LET QNQSD
Sbjct: 1749 LETGQNQSD 1757
>NP_001020014
          Length = 1029

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LETDQNQSD 9
           LET QNQSD
Sbjct: 945 LETGQNQSD 953
>NP_055903
          Length = 1723

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    LETDQNQSD 9
            LET QNQSD
Sbjct: 1639 LETGQNQSD 1647
>NP_055426
          Length = 5596

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    ETDQNQS 8
            ETDQN+S
Sbjct: 4929 ETDQNES 4935
>NP_002882
          Length = 1273

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ETDQNQSD 9
           + DQNQSD
Sbjct: 843 DIDQNQSD 850
>NP_722522
          Length = 489

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ETDQNQSD 9
          + DQNQSD
Sbjct: 59 DIDQNQSD 66
>NP_001139120
          Length = 1257

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ETDQNQSD 9
           + DQNQSD
Sbjct: 827 DIDQNQSD 834
>XP_006720692
          Length = 1270

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ETDQNQSD 9
           + DQNQSD
Sbjct: 840 DIDQNQSD 847
>XP_006720691
          Length = 1182

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ETDQNQSD 9
           + DQNQSD
Sbjct: 827 DIDQNQSD 834
>XP_006720690
          Length = 1245

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ETDQNQSD 9
           + DQNQSD
Sbjct: 827 DIDQNQSD 834
>XP_005254635
          Length = 1280

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ETDQNQSD 9
           + DQNQSD
Sbjct: 827 DIDQNQSD 834
>XP_005248757
          Length = 3591

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    ETDQNQS 8
            ETDQN+S
Sbjct: 2924 ETDQNES 2930
>XP_006715468
          Length = 3744

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    ETDQNQS 8
            ETDQN+S
Sbjct: 3077 ETDQNES 3083
>XP_005248756
          Length = 3905

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    ETDQNQS 8
            ETDQN+S
Sbjct: 3238 ETDQNES 3244
>XP_006715467
          Length = 5550

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    ETDQNQS 8
            ETDQN+S
Sbjct: 4929 ETDQNES 4935
>NP_002145
          Length = 840

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LETDQNQSD 9
           +ETDQN  +
Sbjct: 510 METDQNAKE 518
>NP_055031
          Length = 414

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  LETDQNQS 8
          LE DQN S
Sbjct: 65 LEADQNDS 72
>NP_001136065
          Length = 414

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  LETDQNQS 8
          LE DQN S
Sbjct: 65 LEADQNDS 72
>NP_001136066
          Length = 314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  LETDQNQS 8
          LE DQN S
Sbjct: 65 LEADQNDS 72
>NP_060907
          Length = 484

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LETDQNQSD 9
           L+TDQN ++
Sbjct: 272 LDTDQNPAE 280
>NP_932095
          Length = 484

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LETDQNQSD 9
           L+TDQN ++
Sbjct: 272 LDTDQNPAE 280
>XP_005252145
          Length = 309

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LETDQNQSD 9
           L+TDQN ++
Sbjct: 97  LDTDQNPAE 105
>XP_006717237
          Length = 470

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LETDQNQSD 9
           L+TDQN ++
Sbjct: 272 LDTDQNPAE 280
>XP_005252143
          Length = 484

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LETDQNQSD 9
           L+TDQN ++
Sbjct: 272 LDTDQNPAE 280
>NP_006452
          Length = 1193

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LETDQNQSD 9
          LET Q++SD
Sbjct: 90 LETCQHESD 98
>NP_001098714
          Length = 1465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LETDQNQSD 9
           LET  NQ+D
Sbjct: 593 LETPLNQTD 601
>NP_061927
          Length = 835

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LETDQNQ 7
           LETD+N+
Sbjct: 706 LETDENR 712
>XP_006722401
          Length = 1432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LETDQNQSD 9
           LET  NQ+D
Sbjct: 531 LETPLNQTD 539
>XP_006722400
          Length = 1469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LETDQNQSD 9
           LET  NQ+D
Sbjct: 593 LETPLNQTD 601
>XP_006722399
          Length = 1477

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LETDQNQSD 9
           LET  NQ+D
Sbjct: 593 LETPLNQTD 601
>XP_006722398
          Length = 1494

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LETDQNQSD 9
           LET  NQ+D
Sbjct: 593 LETPLNQTD 601
>XP_006717969
          Length = 439

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LETDQNQ 7
           LETD+N+
Sbjct: 310 LETDENR 316
>XP_005269977
          Length = 555

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LETDQNQ 7
           LETD+N+
Sbjct: 426 LETDENR 432
>XP_006717968
          Length = 952

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LETDQNQ 7
           LETD+N+
Sbjct: 823 LETDENR 829
>XP_006717967
          Length = 952

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LETDQNQ 7
           LETD+N+
Sbjct: 823 LETDENR 829
>XP_006717966
          Length = 952

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LETDQNQ 7
           LETD+N+
Sbjct: 823 LETDENR 829
>XP_006717965
          Length = 958

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LETDQNQ 7
           LETD+N+
Sbjct: 829 LETDENR 835
>XP_005251972
          Length = 368

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  TDQNQSD 9
          TDQ QSD
Sbjct: 26 TDQAQSD 32
>NP_002836
          Length = 1452

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LETDQNQSD 9
           LET  NQ+D
Sbjct: 593 LETPLNQTD 601
>NP_663761
          Length = 525

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LETDQNQS 8
           LETDQ+ S
Sbjct: 193 LETDQSTS 200
>NP_054733
          Length = 2136

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LETDQN 6
           LETD+N
Sbjct: 493 LETDEN 498
>NP_004949
          Length = 2549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LETDQNQ 7
           L+T+QNQ
Sbjct: 872 LKTEQNQ 878
>NP_775656
          Length = 783

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ETDQNQ 7
           ETD+NQ
Sbjct: 650 ETDKNQ 655
>NP_002596
          Length = 829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ETDQNQ 7
           ETD+NQ
Sbjct: 696 ETDKNQ 701
>NP_005723
          Length = 1312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TDQNQS 8
           TD+NQS
Sbjct: 674 TDENQS 679
>NP_001230066
          Length = 757

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ETDQNQ 7
           ETD+NQ
Sbjct: 624 ETDKNQ 629
>NP_001034230
          Length = 2365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    TDQNQSD 9
            TDQ Q+D
Sbjct: 1721 TDQKQAD 1727
>NP_112597
          Length = 481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  ETDQNQSD 9
          +TD+NQ++
Sbjct: 5  DTDRNQTE 12
>NP_001265719
          Length = 285

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  LETDQNQSD 9
          LET   QSD
Sbjct: 89 LETGSRQSD 97
>NP_001265718
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LETDQNQSD 9
           LET   QSD
Sbjct: 149 LETGSRQSD 157
>NP_114105
          Length = 440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LETDQNQSD 9
           LET   QSD
Sbjct: 244 LETGSRQSD 252
>NP_066545
          Length = 196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  DQNQSD 9
          +QNQSD
Sbjct: 41 EQNQSD 46
>XP_006724601
          Length = 1020

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   LETDQN 6
           +ETDQN
Sbjct: 749 VETDQN 754
>XP_005260953
          Length = 161

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  DQNQSD 9
          +QNQSD
Sbjct: 6  EQNQSD 11
>XP_006720630
          Length = 582

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ETDQNQ 7
           ETD+NQ
Sbjct: 449 ETDKNQ 454
>XP_005254990
          Length = 639

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ETDQNQ 7
           ETD+NQ
Sbjct: 506 ETDKNQ 511
>XP_005271745
          Length = 176

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  ETDQNQSD 9
          +TD+NQ++
Sbjct: 5  DTDRNQTE 12
>XP_006718940
          Length = 263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ETDQNQSD 9
           ETD +Q D
Sbjct: 93  ETDSDQQD 100
>XP_006718936
          Length = 292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ETDQNQSD 9
           ETD +Q D
Sbjct: 122 ETDSDQQD 129
>XP_006713365
          Length = 367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LETDQNQSD 9
           LET   QSD
Sbjct: 171 LETGSRQSD 179
>XP_006713364
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LETDQNQSD 9
           LET   QSD
Sbjct: 249 LETGSRQSD 257
>XP_006713363
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LETDQNQSD 9
           LET   QSD
Sbjct: 251 LETGSRQSD 259
>XP_005263496
          Length = 2322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LETDQNQ 7
           L+T+QNQ
Sbjct: 645 LKTEQNQ 651
>XP_005263495
          Length = 2549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   LETDQNQ 7
           L+T+QNQ
Sbjct: 872 LKTEQNQ 878
>NP_001076439
          Length = 292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ETDQNQSD 9
           ETD +Q D
Sbjct: 122 ETDSDQQD 129
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.287    0.110    0.268 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 592,841
Number of extensions: 1212
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.8 bits)
S2: 28 (15.4 bits)

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