Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_065681                                                              19     665
NP_066124                                                              19     665
XP_006717999                                                           19     665
NP_006390                                                              17    3301
NP_001273542                                                           16    5631
NP_073602                                                              16    5631
NP_001152763                                                           16    5631
NP_005793                                                              16    7355
NP_001034678                                                           16    7355
NP_612453                                                              16    7355
NP_001375                                                              16    7355
NP_001010854                                                           16    7355
XP_005267424                                                           16    7355
XP_006720122                                                           16    7355
XP_006720121                                                           16    7355
XP_005270616                                                           16    7355
NP_060954                                                              16    7355
NP_001191088                                                           15    9605
NP_001191089                                                           15    9605
NP_064511                                                              15    9605
NP_006333                                                              15    9605
NP_001139628                                                           15    9605
NP_002084                                                              15    9605
NP_001007535                                                           15    9605
NP_001275882                                                           15    9605
NP_065191                                                              15    9605
NP_001275884                                                           15    9605
NP_001275880                                                           15    9605
NP_001120936                                                           15    9605
NP_008818                                                              15    9605
NP_001185731                                                           15    9605
NP_001185730                                                           15    9605
NP_001091102                                                           15    9605
NP_003751                                                              15    9605
NP_112580                                                              15    9605
NP_001185732                                                           15    9605
XP_006723355                                                           15    9605
XP_006723354                                                           15    9605
XP_006723353                                                           15    9605
XP_006719148                                                           15    9605
XP_006719147                                                           15    9605
XP_005253442                                                           15    9605
XP_006717115                                                           15    9605
XP_006715967                                                           15    9605
XP_006715966                                                           15    9605
XP_006715965                                                           15    9605
XP_006715964                                                           15    9605
XP_006715963                                                           15    9605
XP_006715794                                                           15    9605
XP_006715793                                                           15    9605
XP_005262923                                                           15    9605
XP_005262922                                                           15    9605
XP_005262921                                                           15    9605
XP_005262920                                                           15    9605
XP_005262919                                                           15    9605
XP_005262918                                                           15    9605
XP_005247987                                                           15    9605
XP_006713918                                                           15    9605
XP_005247986                                                           15    9605
XP_005264496                                                           15    9605
XP_005264309                                                           15    9605
XP_005264308                                                           15    9605
XP_006712048                                                           15    9605
NP_001091105                                                           15    9605
NP_001004320                                                           15    9605
NP_001481                                                              15    9605
NP_001091103                                                           15    9605
NP_001091104                                                           15    9605
>NP_065681
          Length = 1072

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LELAASTPS 9
            L+LAASTPS
Sbjct: 1016 LDLAASTPS 1024
>NP_066124
          Length = 1114

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LELAASTPS 9
            L+LAASTPS
Sbjct: 1016 LDLAASTPS 1024
>XP_006717999
          Length = 1207

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    LELAASTPS 9
            L+LAASTPS
Sbjct: 1109 LDLAASTPS 1117
>NP_006390
          Length = 125

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   LAASTPS 9
           LAASTPS
Sbjct: 96  LAASTPS 102
>NP_001273542
          Length = 1086

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LELAASTPS 9
           LE+ A TPS
Sbjct: 680 LEMEAETPS 688
>NP_073602
          Length = 1067

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LELAASTPS 9
           LE+ A TPS
Sbjct: 661 LEMEAETPS 669
>NP_001152763
          Length = 981

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LELAASTPS 9
           LE+ A TPS
Sbjct: 575 LEMEAETPS 583
>NP_005793
          Length = 1045

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ELAASTPS 9
          ELAAS P+
Sbjct: 51 ELAASAPA 58
>NP_001034678
          Length = 261

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LELAASTPS 9
           LELA S+P+
Sbjct: 212 LELAESSPA 220
>NP_612453
          Length = 325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LELAASTPS 9
           LELA+ +PS
Sbjct: 179 LELASRSPS 187
>NP_001375
          Length = 489

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LELAASTPS 9
           LELA S+P+
Sbjct: 440 LELAESSPA 448
>NP_001010854
          Length = 843

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LELAASTPS 9
           LEL AS+P+
Sbjct: 825 LELEASSPA 833
>XP_005267424
          Length = 656

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LELAASTPS 9
           LEL AS+P+
Sbjct: 638 LELEASSPA 646
>XP_006720122
          Length = 820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LELAASTPS 9
           LEL AS+P+
Sbjct: 802 LELEASSPA 810
>XP_006720121
          Length = 851

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LELAASTPS 9
           LEL AS+P+
Sbjct: 833 LELEASSPA 841
>XP_005270616
          Length = 413

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LELAASTPS 9
           LELA S+P+
Sbjct: 364 LELAESSPA 372
>NP_060954
          Length = 550

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LELAASTP 8
           L+LAAS P
Sbjct: 258 LQLAASVP 265
>NP_001191088
          Length = 654

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  LAASTP 8
          LAASTP
Sbjct: 44 LAASTP 49
>NP_001191089
          Length = 618

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  LAASTP 8
          LAASTP
Sbjct: 8  LAASTP 13
>NP_064511
          Length = 654

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  LAASTP 8
          LAASTP
Sbjct: 44 LAASTP 49
>NP_006333
          Length = 838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LELAASTPS 9
           ++LAA TP+
Sbjct: 475 VQLAAETPT 483
>NP_001139628
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LELAASTPS 9
           ++ AASTP+
Sbjct: 384 IQAAASTPT 392
>NP_002084
          Length = 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LELAASTPS 9
           ++ AASTP+
Sbjct: 397 IQAAASTPT 405
>NP_001007535
          Length = 242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  LAASTP 8
          LAASTP
Sbjct: 28 LAASTP 33
>NP_001275882
          Length = 824

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LELAASTP 8
           LEL AS+P
Sbjct: 806 LELEASSP 813
>NP_065191
          Length = 858

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LELAASTP 8
           LEL AS+P
Sbjct: 840 LELEASSP 847
>NP_001275884
          Length = 504

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LELAASTP 8
           LEL AS+P
Sbjct: 486 LELEASSP 493
>NP_001275880
          Length = 882

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LELAASTP 8
           LEL AS+P
Sbjct: 864 LELEASSP 871
>NP_001120936
          Length = 3925

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    AASTPS 9
            AASTPS
Sbjct: 3657 AASTPS 3662
>NP_008818
          Length = 494

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AASTPS 9
           AASTPS
Sbjct: 311 AASTPS 316
>NP_001185731
          Length = 1591

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LAASTP 8
           LAASTP
Sbjct: 210 LAASTP 215
>NP_001185730
          Length = 1621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LAASTP 8
           LAASTP
Sbjct: 203 LAASTP 208
>NP_001091102
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  LELAASTPS 9
          LELA   PS
Sbjct: 46 LELAGENPS 54
>NP_003751
          Length = 1585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LAASTP 8
           LAASTP
Sbjct: 204 LAASTP 209
>NP_112580
          Length = 233

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  LAASTPS 9
          LAAS+PS
Sbjct: 29 LAASSPS 35
>NP_001185732
          Length = 515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LAASTP 8
           LAASTP
Sbjct: 215 LAASTP 220
>XP_006723355
          Length = 618

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  LAASTP 8
          LAASTP
Sbjct: 8  LAASTP 13
>XP_006723354
          Length = 654

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  LAASTP 8
          LAASTP
Sbjct: 44 LAASTP 49
>XP_006723353
          Length = 716

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LAASTP 8
           LAASTP
Sbjct: 106 LAASTP 111
>XP_006719148
          Length = 251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AASTPS 9
           AASTPS
Sbjct: 205 AASTPS 210
>XP_006719147
          Length = 290

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AASTPS 9
           AASTPS
Sbjct: 205 AASTPS 210
>XP_005253442
          Length = 314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AASTPS 9
           AASTPS
Sbjct: 205 AASTPS 210
>XP_006717115
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  LELAASTPS 9
          LELA   PS
Sbjct: 46 LELAGENPS 54
>XP_006715967
          Length = 674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LELAASTP 8
           L LAA TP
Sbjct: 250 LNLAAQTP 257
>XP_006715966
          Length = 856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LELAASTP 8
           L LAA TP
Sbjct: 551 LNLAAQTP 558
>XP_006715965
          Length = 872

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LELAASTP 8
           L LAA TP
Sbjct: 551 LNLAAQTP 558
>XP_006715964
          Length = 964

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LELAASTP 8
           L LAA TP
Sbjct: 551 LNLAAQTP 558
>XP_006715963
          Length = 975

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   LELAASTP 8
           L LAA TP
Sbjct: 551 LNLAAQTP 558
>XP_006715794
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LELAASTPS 9
           LEL  +TPS
Sbjct: 211 LELILNTPS 219
>XP_006715793
          Length = 456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LELAASTPS 9
           LEL  +TPS
Sbjct: 211 LELILNTPS 219
>XP_005262923
          Length = 1018

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ELAASTP 8
           ELAA TP
Sbjct: 317 ELAACTP 323
>XP_005262922
          Length = 1276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ELAASTP 8
           ELAA TP
Sbjct: 699 ELAACTP 705
>XP_005262921
          Length = 1309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ELAASTP 8
           ELAA TP
Sbjct: 699 ELAACTP 705
>XP_005262920
          Length = 1347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ELAASTP 8
           ELAA TP
Sbjct: 699 ELAACTP 705
>XP_005262919
          Length = 1383

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ELAASTP 8
           ELAA TP
Sbjct: 699 ELAACTP 705
>XP_005262918
          Length = 1400

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ELAASTP 8
           ELAA TP
Sbjct: 699 ELAACTP 705
>XP_005247987
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LELAASTPS 9
           ++LAA TP+
Sbjct: 115 VQLAAETPT 123
>XP_006713918
          Length = 830

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LELAASTPS 9
           ++LAA TP+
Sbjct: 463 VQLAAETPT 471
>XP_005247986
          Length = 842

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LELAASTPS 9
           ++LAA TP+
Sbjct: 475 VQLAAETPT 483
>XP_005264496
          Length = 739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LELAASTP 8
           LEL AS+P
Sbjct: 721 LELEASSP 728
>XP_005264309
          Length = 1324

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    ELAASTPS 9
            +LAA+TP+
Sbjct: 1166 DLAAATPA 1173
>XP_005264308
          Length = 1218

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    ELAASTPS 9
            +LAA+TP+
Sbjct: 1060 DLAAATPA 1067
>XP_006712048
          Length = 1249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    ELAASTPS 9
            +LAA+TP+
Sbjct: 1091 DLAAATPA 1098
>NP_001091105
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  LELAASTPS 9
          LELA   PS
Sbjct: 46 LELAGENPS 54
>NP_001004320
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LELAASTPS 9
           LEL  +TPS
Sbjct: 211 LELILNTPS 219
>NP_001481
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  LELAASTPS 9
          LELA   PS
Sbjct: 46 LELAGENPS 54
>NP_001091103
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  LELAASTPS 9
          LELA   PS
Sbjct: 46 LELAGENPS 54
>NP_001091104
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  LELAASTPS 9
          LELA   PS
Sbjct: 46 LELAGENPS 54
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.295    0.108    0.260 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 595,248
Number of extensions: 942
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package