Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_958441                                                              19     665
NP_958439                                                              19     665
NP_958440                                                              19     665
NP_005219                                                              19     665
NP_001257449                                                           17    2528
NP_055807                                                              17    2528
XP_005267488                                                           17    2528
XP_005267487                                                           17    2528
NP_001010872                                                           17    4312
XP_006715085                                                           17    4312
XP_005245394                                                           17    4312
NP_982258                                                              17    4312
NP_001008895                                                           16    5631
NP_001265442                                                           16    5631
NP_001265443                                                           16    5631
NP_003580                                                              16    5631
NP_001073341                                                           16    5631
NP_001008781                                                           16    5631
NP_003579                                                              16    5631
XP_006724848                                                           16    5631
XP_006724847                                                           16    5631
XP_005262538                                                           16    5631
XP_006718827                                                           16    5631
NP_001165689                                                           16    7355
NP_036368                                                              16    7355
NP_001165691                                                           16    7355
NP_001165690                                                           16    7355
NP_001026864                                                           16    7355
NP_001165692                                                           16    7355
NP_001165693                                                           16    7355
XP_006710533                                                           16    7355
XP_006710532                                                           16    7355
XP_006710531                                                           16    7355
XP_006710530                                                           16    7355
XP_006710529                                                           16    7355
XP_006710528                                                           16    7355
XP_005270696                                                           16    7355
XP_006710527                                                           16    7355
XP_006710526                                                           16    7355
XP_006710525                                                           16    7355
NP_443191                                                              16    7355
NP_113584                                                              15    9605
NP_001264044                                                           15    9605
NP_001243657                                                           15    9605
NP_001243656                                                           15    9605
NP_001243655                                                           15    9605
NP_001243654                                                           15    9605
NP_006581                                                              15    9605
XP_005262029                                                           15    9605
XP_005262028                                                           15    9605
XP_005262026                                                           15    9605
XP_006724637                                                           15    9605
XP_005262025                                                           15    9605
XP_005262024                                                           15    9605
XP_005262023                                                           15    9605
XP_005262022                                                           15    9605
XP_005259796                                                           15    9605
XP_006710290                                                           15    9605
NP_660299                                                              15    9605
>NP_958441
          Length = 705

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  LEITYVLRN 9
          LEITYV RN
Sbjct: 65 LEITYVQRN 73
>NP_958439
          Length = 628

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  LEITYVLRN 9
          LEITYV RN
Sbjct: 65 LEITYVQRN 73
>NP_958440
          Length = 405

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  LEITYVLRN 9
          LEITYV RN
Sbjct: 65 LEITYVQRN 73
>NP_005219
          Length = 1210

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  LEITYVLRN 9
          LEITYV RN
Sbjct: 65 LEITYVQRN 73
>NP_001257449
          Length = 1068

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  EITYVLRN 9
          EITY LRN
Sbjct: 25 EITYRLRN 32
>NP_055807
          Length = 1078

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  EITYVLRN 9
          EITY LRN
Sbjct: 25 EITYRLRN 32
>XP_005267488
          Length = 1078

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  EITYVLRN 9
          EITY LRN
Sbjct: 25 EITYRLRN 32
>XP_005267487
          Length = 1078

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  EITYVLRN 9
          EITY LRN
Sbjct: 25 EITYRLRN 32
>NP_001010872
          Length = 1011

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  EITYVLRN 9
          EI Y+L+N
Sbjct: 60 EINYILKN 67
>XP_006715085
          Length = 1011

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  EITYVLRN 9
          EI Y+L+N
Sbjct: 60 EINYILKN 67
>XP_005245394
          Length = 1741

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    LEITYVL 7
            LE+TY+L
Sbjct: 1705 LEVTYIL 1711
>NP_982258
          Length = 404

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LEITYVLRN 9
          L ++YVLRN
Sbjct: 34 LLVSYVLRN 42
>NP_001008895
          Length = 759

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEITYVLRN 9
           L+ TYVL+N
Sbjct: 156 LDRTYVLQN 164
>NP_001265442
          Length = 659

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LEITYVLRN 9
          L+ TYVL+N
Sbjct: 56 LDRTYVLQN 64
>NP_001265443
          Length = 667

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LEITYVLRN 9
          L+ TYVL+N
Sbjct: 56 LDRTYVLQN 64
>NP_003580
          Length = 659

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LEITYVLRN 9
          L+ TYVL+N
Sbjct: 56 LDRTYVLQN 64
>NP_001073341
          Length = 895

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEITYVLRN 9
           L+ TYVL+N
Sbjct: 292 LDRTYVLQN 300
>NP_001008781
          Length = 4557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    EITYVLRN 9
            E+TYVL++
Sbjct: 2118 EVTYVLQD 2125
>NP_003579
          Length = 913

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEITYVLRN 9
           L+ TYVL+N
Sbjct: 310 LDRTYVLQN 318
>XP_006724848
          Length = 900

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEITYVLRN 9
           L+ TYVL+N
Sbjct: 297 LDRTYVLQN 305
>XP_006724847
          Length = 902

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEITYVLRN 9
           L+ TYVL+N
Sbjct: 297 LDRTYVLQN 305
>XP_005262538
          Length = 915

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LEITYVLRN 9
           L+ TYVL+N
Sbjct: 310 LDRTYVLQN 318
>XP_006718827
          Length = 3479

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    EITYVLRN 9
            E+TYVL++
Sbjct: 1008 EVTYVLQD 1015
>NP_001165689
          Length = 577

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ITYVLR 8
           ITYVLR
Sbjct: 382 ITYVLR 387
>NP_036368
          Length = 591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ITYVLR 8
           ITYVLR
Sbjct: 396 ITYVLR 401
>NP_001165691
          Length = 577

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ITYVLR 8
           ITYVLR
Sbjct: 382 ITYVLR 387
>NP_001165690
          Length = 648

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ITYVLR 8
           ITYVLR
Sbjct: 453 ITYVLR 458
>NP_001026864
          Length = 660

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ITYVLR 8
           ITYVLR
Sbjct: 443 ITYVLR 448
>NP_001165692
          Length = 599

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ITYVLR 8
           ITYVLR
Sbjct: 382 ITYVLR 387
>NP_001165693
          Length = 480

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ITYVLR 8
           ITYVLR
Sbjct: 285 ITYVLR 290
>XP_006710533
          Length = 496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ITYVLR 8
           ITYVLR
Sbjct: 453 ITYVLR 458
>XP_006710532
          Length = 514

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ITYVLR 8
           ITYVLR
Sbjct: 453 ITYVLR 458
>XP_006710531
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ITYVLR 8
           ITYVLR
Sbjct: 352 ITYVLR 357
>XP_006710530
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ITYVLR 8
           ITYVLR
Sbjct: 352 ITYVLR 357
>XP_006710529
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ITYVLR 8
           ITYVLR
Sbjct: 352 ITYVLR 357
>XP_006710528
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ITYVLR 8
           ITYVLR
Sbjct: 352 ITYVLR 357
>XP_005270696
          Length = 599

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ITYVLR 8
           ITYVLR
Sbjct: 382 ITYVLR 387
>XP_006710527
          Length = 599

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ITYVLR 8
           ITYVLR
Sbjct: 382 ITYVLR 387
>XP_006710526
          Length = 613

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ITYVLR 8
           ITYVLR
Sbjct: 396 ITYVLR 401
>XP_006710525
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   ITYVLR 8
           ITYVLR
Sbjct: 453 ITYVLR 458
>NP_443191
          Length = 392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LEITYVLRN 9
           L  TY+LRN
Sbjct: 205 LVATYLLRN 213
>NP_113584
          Length = 4374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    EITYVLR 8
            EI Y+LR
Sbjct: 1866 EINYILR 1872
>NP_001264044
          Length = 4516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    ITYVLRN 9
            +TY LRN
Sbjct: 3892 MTYALRN 3898
>NP_001243657
          Length = 462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  EITYVLR 8
          +ITYVL+
Sbjct: 85 DITYVLK 91
>NP_001243656
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EITYVLR 8
           +ITYVL+
Sbjct: 110 DITYVLK 116
>NP_001243655
          Length = 488

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EITYVLR 8
           +ITYVL+
Sbjct: 188 DITYVLK 194
>NP_001243654
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EITYVLR 8
           +ITYVL+
Sbjct: 188 DITYVLK 194
>NP_006581
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EITYVLR 8
           +ITYVL+
Sbjct: 188 DITYVLK 194
>XP_005262029
          Length = 4240

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    EITYVLR 8
            EI Y+LR
Sbjct: 1866 EINYILR 1872
>XP_005262028
          Length = 4341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    EITYVLR 8
            EI Y+LR
Sbjct: 1866 EINYILR 1872
>XP_005262026
          Length = 4359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    EITYVLR 8
            EI Y+LR
Sbjct: 1866 EINYILR 1872
>XP_006724637
          Length = 4365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    EITYVLR 8
            EI Y+LR
Sbjct: 1857 EINYILR 1863
>XP_005262025
          Length = 4373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    EITYVLR 8
            EI Y+LR
Sbjct: 1866 EINYILR 1872
>XP_005262024
          Length = 4374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    EITYVLR 8
            EI Y+LR
Sbjct: 1866 EINYILR 1872
>XP_005262023
          Length = 4374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    EITYVLR 8
            EI Y+LR
Sbjct: 1866 EINYILR 1872
>XP_005262022
          Length = 4374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    EITYVLR 8
            EI Y+LR
Sbjct: 1866 EINYILR 1872
>XP_005259796
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LEITYVLRN 9
          LE+  VLRN
Sbjct: 87 LEVLNVLRN 95
>XP_006710290
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ITYVLRN 9
           IT+V+RN
Sbjct: 117 ITFVVRN 123
>NP_660299
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LEITYVLRN 9
          LE+  VLRN
Sbjct: 87 LEVLNVLRN 95
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.328    0.146    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 393,360
Number of extensions: 520
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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