Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_057502                                                              20     390
NP_861969                                                              20     390
NP_000259                                                              20     390
NP_861968                                                              20     390
NP_861966                                                              20     390
NP_861970                                                              20     390
NP_861546                                                              20     390
NP_861967                                                              20     390
NP_060862                                                              18    1135
XP_005263172                                                           18    1135
NP_002559                                                              17    2528
XP_005250918                                                           17    2528
NP_112241                                                              17    2528
NP_036228                                                              17    3301
NP_620688                                                              16    5631
NP_055812                                                              16    5631
NP_001035519                                                           16    5631
NP_005073                                                              16    5631
XP_005254929                                                           16    5631
XP_005266415                                                           16    5631
XP_005266414                                                           16    5631
XP_005250290                                                           16    5631
NP_055968                                                              16    7355
NP_598375                                                              16    7355
NP_001277188                                                           16    7355
NP_055455                                                              16    7355
XP_006715490                                                           16    7355
XP_005248760                                                           16    7355
XP_005248759                                                           16    7355
XP_006715489                                                           16    7355
XP_005248758                                                           16    7355
XP_005262773                                                           16    7355
XP_006714140                                                           16    7355
XP_006714139                                                           16    7355
XP_005262771                                                           16    7355
XP_005262770                                                           16    7355
XP_005262769                                                           16    7355
XP_005262768                                                           16    7355
XP_005247035                                                           16    7355
XP_006712939                                                           16    7355
XP_006712938                                                           16    7355
XP_006712937                                                           16    7355
XP_006712936                                                           16    7355
XP_005247034                                                           16    7355
NP_001082                                                              15    9605
NP_001259001                                                           15    9605
NP_056957                                                              15    9605
NP_009058                                                              15    9605
NP_001138422                                                           15    9605
XP_006719261                                                           15    9605
XP_005250024                                                           15    9605
XP_006715981                                                           15    9605
XP_006713248                                                           15    9605
XP_005265249                                                           15    9605
XP_006713247                                                           15    9605
XP_006713246                                                           15    9605
XP_005265248                                                           15    9605
NP_006567                                                              15    9605
NP_001182196                                                           15    9605
>NP_057502
          Length = 590

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LEIATKPMY 9
           LEIATKP Y
Sbjct: 473 LEIATKPTY 481
>NP_861969
          Length = 507

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LEIATKPMY 9
           LEIATKP Y
Sbjct: 390 LEIATKPTY 398
>NP_000259
          Length = 595

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LEIATKPMY 9
           LEIATKP Y
Sbjct: 473 LEIATKPTY 481
>NP_861968
          Length = 507

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LEIATKPMY 9
           LEIATKP Y
Sbjct: 390 LEIATKPTY 398
>NP_861966
          Length = 548

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LEIATKPMY 9
           LEIATKP Y
Sbjct: 431 LEIATKPTY 439
>NP_861970
          Length = 590

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LEIATKPMY 9
           LEIATKP Y
Sbjct: 473 LEIATKPTY 481
>NP_861546
          Length = 590

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LEIATKPMY 9
           LEIATKP Y
Sbjct: 473 LEIATKPTY 481
>NP_861967
          Length = 549

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LEIATKPMY 9
           LEIATKP Y
Sbjct: 432 LEIATKPTY 440
>NP_060862
          Length = 2104

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LEIATKPMY 9
           L+IATKP Y
Sbjct: 287 LKIATKPKY 295
>XP_005263172
          Length = 2104

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   LEIATKPMY 9
           L+IATKP Y
Sbjct: 287 LKIATKPKY 295
>NP_002559
          Length = 636

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IATKPMY 9
           +ATKP+Y
Sbjct: 358 VATKPLY 364
>XP_005250918
          Length = 636

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IATKPMY 9
           +ATKP+Y
Sbjct: 358 VATKPLY 364
>NP_112241
          Length = 631

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IATKPMY 9
           +ATKP+Y
Sbjct: 358 VATKPLY 364
>NP_036228
          Length = 709

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LEIATKPMY 9
           LE+A+ P+Y
Sbjct: 254 LEVASDPLY 262
>NP_620688
          Length = 1095

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IATKPMY 9
           +AT+P+Y
Sbjct: 898 VATRPLY 904
>NP_055812
          Length = 442

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EIATKP 7
           EIATKP
Sbjct: 301 EIATKP 306
>NP_001035519
          Length = 1159

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IATKPMY 9
           +AT PMY
Sbjct: 791 LATSPMY 797
>NP_005073
          Length = 630

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IATKPMY 9
           I+TKP+Y
Sbjct: 317 ISTKPVY 323
>XP_005254929
          Length = 1122

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IATKPMY 9
           +AT+P+Y
Sbjct: 925 VATRPLY 931
>XP_005266415
          Length = 1158

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IATKPMY 9
           +AT PMY
Sbjct: 791 LATSPMY 797
>XP_005266414
          Length = 1159

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   IATKPMY 9
           +AT PMY
Sbjct: 791 LATSPMY 797
>XP_005250290
          Length = 413

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   EIATKP 7
           EIATKP
Sbjct: 272 EIATKP 277
>NP_055968
          Length = 2039

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LEIATKPM 8
            LE+A KP+
Sbjct: 1457 LELANKPL 1464
>NP_598375
          Length = 1101

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEIATKPM 8
           LE+ TKP+
Sbjct: 732 LELITKPL 739
>NP_001277188
          Length = 1951

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LEIATKPM 8
            LE+A KP+
Sbjct: 1369 LELANKPL 1376
>NP_055455
          Length = 1199

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEIATKPM 8
           +EI TKP+
Sbjct: 557 MEILTKPL 564
>XP_006715490
          Length = 1181

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEIATKPM 8
           LE+A KP+
Sbjct: 599 LELANKPL 606
>XP_005248760
          Length = 1308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEIATKPM 8
           LE+A KP+
Sbjct: 726 LELANKPL 733
>XP_005248759
          Length = 1951

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LEIATKPM 8
            LE+A KP+
Sbjct: 1369 LELANKPL 1376
>XP_006715489
          Length = 2039

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LEIATKPM 8
            LE+A KP+
Sbjct: 1457 LELANKPL 1464
>XP_005248758
          Length = 2039

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    LEIATKPM 8
            LE+A KP+
Sbjct: 1457 LELANKPL 1464
>XP_005262773
          Length = 557

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEIATKPM 8
           LE+ TKP+
Sbjct: 188 LELITKPL 195
>XP_006714140
          Length = 729

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEIATKPM 8
           LE+ TKP+
Sbjct: 360 LELITKPL 367
>XP_006714139
          Length = 950

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEIATKPM 8
           LE+ TKP+
Sbjct: 732 LELITKPL 739
>XP_005262771
          Length = 995

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEIATKPM 8
           LE+ TKP+
Sbjct: 626 LELITKPL 633
>XP_005262770
          Length = 995

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEIATKPM 8
           LE+ TKP+
Sbjct: 626 LELITKPL 633
>XP_005262769
          Length = 1034

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEIATKPM 8
           LE+ TKP+
Sbjct: 665 LELITKPL 672
>XP_005262768
          Length = 1064

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEIATKPM 8
           LE+ TKP+
Sbjct: 695 LELITKPL 702
>XP_005247035
          Length = 971

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEIATKPM 8
           +EI TKP+
Sbjct: 557 MEILTKPL 564
>XP_006712939
          Length = 972

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEIATKPM 8
           +EI TKP+
Sbjct: 557 MEILTKPL 564
>XP_006712938
          Length = 1138

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEIATKPM 8
           +EI TKP+
Sbjct: 557 MEILTKPL 564
>XP_006712937
          Length = 1199

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEIATKPM 8
           +EI TKP+
Sbjct: 557 MEILTKPL 564
>XP_006712936
          Length = 1199

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEIATKPM 8
           +EI TKP+
Sbjct: 557 MEILTKPL 564
>XP_005247034
          Length = 1199

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEIATKPM 8
           +EI TKP+
Sbjct: 557 MEILTKPL 564
>NP_001082
          Length = 751

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LEIATKPMY 9
           L+ ATKP++
Sbjct: 155 LQEATKPLH 163
>NP_001259001
          Length = 770

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LEIATKPMY 9
           L+ ATKP++
Sbjct: 155 LQEATKPLH 163
>NP_056957
          Length = 856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEIATKPM 8
           LE+AT P+
Sbjct: 266 LELATPPL 273
>NP_009058
          Length = 827

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   EIATKPM 8
           E+AT+P+
Sbjct: 269 EVATRPL 275
>NP_001138422
          Length = 1573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   EIATKP 7
           E+ATKP
Sbjct: 599 ELATKP 604
>XP_006719261
          Length = 819

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   EIATKPM 8
           E+AT+P+
Sbjct: 266 EVATRPL 272
>XP_005250024
          Length = 751

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LEIATKPMY 9
           L+ ATKP++
Sbjct: 155 LQEATKPLH 163
>XP_006715981
          Length = 770

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LEIATKPMY 9
           L+ ATKP++
Sbjct: 155 LQEATKPLH 163
>XP_006713248
          Length = 686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEIATKPM 8
           LE+AT P+
Sbjct: 96  LELATPPL 103
>XP_005265249
          Length = 856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEIATKPM 8
           LE+AT P+
Sbjct: 266 LELATPPL 273
>XP_006713247
          Length = 856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEIATKPM 8
           LE+AT P+
Sbjct: 266 LELATPPL 273
>XP_006713246
          Length = 856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEIATKPM 8
           LE+AT P+
Sbjct: 266 LELATPPL 273
>XP_005265248
          Length = 856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LEIATKPM 8
           LE+AT P+
Sbjct: 266 LELATPPL 273
>NP_006567
          Length = 819

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   EIATKPM 8
           E+AT+P+
Sbjct: 266 EVATRPL 272
>NP_001182196
          Length = 951

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   EIATKP 7
           E+ATKP
Sbjct: 599 ELATKP 604
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.319    0.134    0.377 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 657,165
Number of extensions: 956
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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