Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006197                                                              20     390
XP_006714104                                                           20     390
XP_005265800                                                           20     390
XP_006714103                                                           20     390
XP_006714102                                                           20     390
NP_055521                                                              18    1935
XP_005269298                                                           18    1935
NP_620279                                                              16    7355
NP_055625                                                              16    7355
NP_001186776                                                           16    7355
NP_001183949                                                           16    7355
NP_065162                                                              16    7355
NP_851994                                                              16    7355
XP_005268297                                                           16    7355
XP_006716309                                                           16    7355
XP_005272429                                                           16    7355
XP_006716125                                                           16    7355
XP_006716124                                                           16    7355
XP_005250564                                                           16    7355
XP_006711734                                                           16    7355
XP_006711733                                                           16    7355
XP_006711732                                                           16    7355
XP_006711731                                                           16    7355
XP_006711730                                                           16    7355
XP_006711729                                                           16    7355
XP_005245695                                                           16    7355
NP_001098                                                              16    7355
NP_940866                                                              16    7355
NP_001110                                                              15    9605
NP_054909                                                              15    9605
NP_001158213                                                           15    9605
NP_054908                                                              15    9605
NP_789771                                                              15    9605
NP_001657                                                              15    9605
NP_997698                                                              15    9605
NP_001597                                                              15    9605
NP_954974                                                              15    9605
NP_001157934                                                           15    9605
XP_003960384                                                           15    9605
XP_006722160                                                           15    9605
XP_006717059                                                           15    9605
XP_003118572                                                           15    9605
XP_006712017                                                           15    9605
XP_003119970                                                           15    9605
>NP_006197
          Length = 1089

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   DRSTVEGR 9
           DRSTVEGR
Sbjct: 480 DRSTVEGR 487
>XP_006714104
          Length = 832

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   DRSTVEGR 9
           DRSTVEGR
Sbjct: 505 DRSTVEGR 512
>XP_005265800
          Length = 1089

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   DRSTVEGR 9
           DRSTVEGR
Sbjct: 480 DRSTVEGR 487
>XP_006714103
          Length = 1111

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   DRSTVEGR 9
           DRSTVEGR
Sbjct: 502 DRSTVEGR 509
>XP_006714102
          Length = 1114

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   DRSTVEGR 9
           DRSTVEGR
Sbjct: 505 DRSTVEGR 512
>NP_055521
          Length = 963

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LDRSTVEGR 9
           +DR +VEGR
Sbjct: 765 MDRKSVEGR 773
>XP_005269298
          Length = 981

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LDRSTVEGR 9
           +DR +VEGR
Sbjct: 783 MDRKSVEGR 791
>NP_620279
          Length = 269

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   STVEGR 9
           STVEGR
Sbjct: 259 STVEGR 264
>NP_055625
          Length = 3117

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DRSTVEGR 9
            D+S +EGR
Sbjct: 2046 DQSDIEGR 2053
>NP_001186776
          Length = 728

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RSTVEGR 9
           RSTV GR
Sbjct: 289 RSTVSGR 295
>NP_001183949
          Length = 276

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  DRSTVEGR 9
          DRS  EGR
Sbjct: 55 DRSIFEGR 62
>NP_065162
          Length = 757

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RSTVEGR 9
           RSTV GR
Sbjct: 315 RSTVSGR 321
>NP_851994
          Length = 731

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RSTVEGR 9
           RSTV GR
Sbjct: 289 RSTVSGR 295
>XP_005268297
          Length = 129

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DRSTVEGR 9
          DR TV+G+
Sbjct: 74 DRGTVQGQ 81
>XP_006716309
          Length = 177

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  DRSTVEGR 9
          DRS  EGR
Sbjct: 55 DRSIFEGR 62
>XP_005272429
          Length = 256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  DRSTVEGR 9
          DRS  EGR
Sbjct: 55 DRSIFEGR 62
>XP_006716125
          Length = 735

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RSTVEGR 9
           RSTV GR
Sbjct: 293 RSTVSGR 299
>XP_006716124
          Length = 743

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RSTVEGR 9
           RSTV GR
Sbjct: 301 RSTVSGR 307
>XP_005250564
          Length = 754

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RSTVEGR 9
           RSTV GR
Sbjct: 315 RSTVSGR 321
>XP_006711734
          Length = 3136

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DRSTVEGR 9
            D+S +EGR
Sbjct: 2065 DQSDIEGR 2072
>XP_006711733
          Length = 3137

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DRSTVEGR 9
            D+S +EGR
Sbjct: 2066 DQSDIEGR 2073
>XP_006711732
          Length = 3154

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DRSTVEGR 9
            D+S +EGR
Sbjct: 2083 DQSDIEGR 2090
>XP_006711731
          Length = 3157

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DRSTVEGR 9
            D+S +EGR
Sbjct: 2086 DQSDIEGR 2093
>XP_006711730
          Length = 3157

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DRSTVEGR 9
            D+S +EGR
Sbjct: 2086 DQSDIEGR 2093
>XP_006711729
          Length = 3158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DRSTVEGR 9
            D+S +EGR
Sbjct: 2087 DQSDIEGR 2094
>XP_005245695
          Length = 3158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DRSTVEGR 9
            D+S +EGR
Sbjct: 2087 DQSDIEGR 2094
>NP_001098
          Length = 99

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DRSTVEGR 9
          DR TV+G+
Sbjct: 44 DRGTVQGQ 51
>NP_940866
          Length = 352

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  DRSTVEGR 9
          DRS  EGR
Sbjct: 55 DRSIFEGR 62
>NP_001110
          Length = 737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LDRSTVEG 8
           +DRS V+G
Sbjct: 529 MDRSLVQG 536
>NP_054909
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LDRSTVEG 8
           +DRS V+G
Sbjct: 529 MDRSLVQG 536
>NP_001158213
          Length = 986

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LDRSTVE 7
           LDR T+E
Sbjct: 409 LDRQTIE 415
>NP_054908
          Length = 768

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LDRSTVEG 8
           +DRS V+G
Sbjct: 560 MDRSLVQG 567
>NP_789771
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LDRSTVEG 8
           +DRS V+G
Sbjct: 560 MDRSLVQG 567
>NP_001657
          Length = 946

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   LDRSTVE 7
           LDR T+E
Sbjct: 369 LDRQTIE 375
>NP_997698
          Length = 2466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LDRSTV 6
           LDRSTV
Sbjct: 172 LDRSTV 177
>NP_001597
          Length = 2436

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LDRSTV 6
           LDRSTV
Sbjct: 142 LDRSTV 147
>NP_954974
          Length = 1019

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RSTVEGR 9
           RST++GR
Sbjct: 754 RSTLQGR 760
>NP_001157934
          Length = 5335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   DRSTVEGR 9
           D ST+ GR
Sbjct: 426 DSSTISGR 433
>XP_003960384
          Length = 884

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LDRSTVEGR 9
           L RST +GR
Sbjct: 481 LQRSTDQGR 489
>XP_006722160
          Length = 733

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LDRSTVEGR 9
           L+ STV GR
Sbjct: 664 LELSTVRGR 672
>XP_006717059
          Length = 2435

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   LDRSTV 6
           LDRSTV
Sbjct: 141 LDRSTV 146
>XP_003118572
          Length = 884

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LDRSTVEGR 9
           L RST +GR
Sbjct: 481 LQRSTDQGR 489
>XP_006712017
          Length = 1028

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RSTVEGR 9
           RST++GR
Sbjct: 763 RSTLQGR 769
>XP_003119970
          Length = 884

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LDRSTVEGR 9
           L RST +GR
Sbjct: 481 LQRSTDQGR 489
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.312    0.133    0.347 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 503,832
Number of extensions: 905
Number of successful extensions: 44
Number of sequences better than 10000.0: 44
Number of HSP's gapped: 44
Number of HSP's successfully gapped: 44
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package