Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

XP_006710281                                                           18    1935
XP_005263754                                                           17    2528
NP_005180                                                              17    3301
XP_006722203                                                           17    3301
NP_612486                                                              17    4312
NP_001271135                                                           17    4312
NP_001271137                                                           17    4312
NP_003852                                                              17    4312
NP_001034749                                                           17    4312
NP_001007562                                                           17    4312
NP_001034748                                                           17    4312
NP_001271136                                                           17    4312
NP_071398                                                              17    4312
XP_005258838                                                           17    4312
XP_005258573                                                           17    4312
XP_005258572                                                           17    4312
XP_005254235                                                           17    4312
XP_005254233                                                           17    4312
XP_005254234                                                           17    4312
XP_006720363                                                           17    4312
XP_006720362                                                           17    4312
XP_006720361                                                           17    4312
XP_006720360                                                           17    4312
XP_005273762                                                           17    4312
NP_001138529                                                           17    4312
NP_775904                                                              17    4312
NP_766630                                                              17    4312
NP_003039                                                              16    5631
NP_004949                                                              16    7355
NP_006477                                                              16    7355
NP_003728                                                              16    7355
NP_001138820                                                           16    7355
NP_079049                                                              16    7355
NP_665697                                                              16    7355
XP_006721155                                                           16    7355
XP_005253264                                                           16    7355
XP_006716747                                                           16    7355
XP_005272414                                                           16    7355
XP_005263496                                                           16    7355
XP_005263495                                                           16    7355
NP_006152                                                              16    7355
NP_061844                                                              16    7355
NP_001166969                                                           15    9605
NP_000519                                                              15    9605
NP_061985                                                              15    9605
NP_065861                                                              15    9605
NP_001893                                                              15    9605
NP_714964                                                              15    9605
NP_001177392                                                           15    9605
NP_066279                                                              15    9605
NP_079157                                                              15    9605
NP_786951                                                              15    9605
XP_005259970                                                           15    9605
XP_006722681                                                           15    9605
XP_006722680                                                           15    9605
XP_006722679                                                           15    9605
XP_005267973                                                           15    9605
XP_005264216                                                           15    9605
XP_006710661                                                           15    9605
XP_006710659                                                           15    9605
XP_006710658                                                           15    9605
XP_006710657                                                           15    9605
NP_570603                                                              15    9605
NP_055018                                                              15    9605
>XP_006710281
          Length = 1303

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    LALRAVLPP 9
            L+LRA LPP
Sbjct: 1172 LSLRAPLPP 1180
>XP_005263754
          Length = 1133

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LRAVLPP 9
           +RAVLPP
Sbjct: 966 MRAVLPP 972
>NP_005180
          Length = 532

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LALRAVLPP 9
           LA RAV PP
Sbjct: 414 LASRAVAPP 422
>XP_006722203
          Length = 447

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LALRAVLPP 9
           LA RAV PP
Sbjct: 329 LASRAVAPP 337
>NP_612486
          Length = 1227

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LALRAVLPP 9
           LALR+ +PP
Sbjct: 664 LALRSQVPP 672
>NP_001271135
          Length = 941

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LALRAVLPP 9
           LALR  LPP
Sbjct: 248 LALRRRLPP 256
>NP_001271137
          Length = 326

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LALRAVLPP 9
           LALR  LPP
Sbjct: 249 LALRRRLPP 257
>NP_003852
          Length = 942

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LALRAVLPP 9
           LALR  LPP
Sbjct: 249 LALRRRLPP 257
>NP_001034749
          Length = 194

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LRAVLPP 9
           LRA LPP
Sbjct: 172 LRATLPP 178
>NP_001007562
          Length = 623

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ALRAVLPP 9
           ALR +LPP
Sbjct: 174 ALRRLLPP 181
>NP_001034748
          Length = 194

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LRAVLPP 9
           LRA LPP
Sbjct: 172 LRATLPP 178
>NP_001271136
          Length = 860

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LALRAVLPP 9
           LALR  LPP
Sbjct: 167 LALRRRLPP 175
>NP_071398
          Length = 1507

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LALRAVLPP 9
          +ALRA  PP
Sbjct: 74 IALRAARPP 82
>XP_005258838
          Length = 563

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ALRAVLPP 9
          ALR +LPP
Sbjct: 8  ALRRLLPP 15
>XP_005258573
          Length = 623

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ALRAVLPP 9
           ALR +LPP
Sbjct: 174 ALRRLLPP 181
>XP_005258572
          Length = 623

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ALRAVLPP 9
           ALR +LPP
Sbjct: 174 ALRRLLPP 181
>XP_005254235
          Length = 1017

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LALRAVLPP 9
           LALR+ +PP
Sbjct: 665 LALRSQVPP 673
>XP_005254233
          Length = 1228

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LALRAVLPP 9
           LALR+ +PP
Sbjct: 665 LALRSQVPP 673
>XP_005254234
          Length = 1076

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LALRAVLPP 9
           LALR+ +PP
Sbjct: 665 LALRSQVPP 673
>XP_006720363
          Length = 894

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LALRAVLPP 9
           LALR  LPP
Sbjct: 166 LALRRRLPP 174
>XP_006720362
          Length = 895

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LALRAVLPP 9
           LALR  LPP
Sbjct: 167 LALRRRLPP 175
>XP_006720361
          Length = 976

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LALRAVLPP 9
           LALR  LPP
Sbjct: 248 LALRRRLPP 256
>XP_006720360
          Length = 977

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   LALRAVLPP 9
           LALR  LPP
Sbjct: 249 LALRRRLPP 257
>XP_005273762
          Length = 194

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LRAVLPP 9
           LRA LPP
Sbjct: 172 LRATLPP 178
>NP_001138529
          Length = 194

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LRAVLPP 9
           LRA LPP
Sbjct: 172 LRATLPP 178
>NP_775904
          Length = 493

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ALRAVLPP 9
          ALR +LPP
Sbjct: 8  ALRRLLPP 15
>NP_766630
          Length = 194

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LRAVLPP 9
           LRA LPP
Sbjct: 172 LRATLPP 178
>NP_003039
          Length = 812

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  ALRAVLPP 9
          +LRA LPP
Sbjct: 9  SLRAPLPP 16
>NP_004949
          Length = 2549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LRAVLPP 9
           +RA LPP
Sbjct: 459 IRAALPP 465
>NP_006477
          Length = 703

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LRAVLPP 9
           LRA+ PP
Sbjct: 618 LRAITPP 624
>NP_003728
          Length = 3298

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    ALRAVLPP 9
            A RA+ PP
Sbjct: 3225 AARAIFPP 3232
>NP_001138820
          Length = 454

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  ALRAVLP 8
          ALRA+LP
Sbjct: 59 ALRALLP 65
>NP_079049
          Length = 416

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  ALRAVLP 8
          ALRA+LP
Sbjct: 21 ALRALLP 27
>NP_665697
          Length = 838

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LALRAVLPP 9
           L LRA  PP
Sbjct: 606 LTLRAASPP 614
>XP_006721155
          Length = 427

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  ALRAVLP 8
          ALRA+LP
Sbjct: 32 ALRALLP 38
>XP_005253264
          Length = 3443

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    ALRAVLPP 9
            A RA+ PP
Sbjct: 3370 AARAIFPP 3377
>XP_006716747
          Length = 763

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LALRAVLPP 9
           L LRA  PP
Sbjct: 531 LTLRAASPP 539
>XP_005272414
          Length = 791

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LALRAVLPP 9
           L LRA  PP
Sbjct: 606 LTLRAASPP 614
>XP_005263496
          Length = 2322

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LRAVLPP 9
           +RA LPP
Sbjct: 232 IRAALPP 238
>XP_005263495
          Length = 2549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LRAVLPP 9
           +RA LPP
Sbjct: 459 IRAALPP 465
>NP_006152
          Length = 237

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   ALRAVLP 8
           ALR+VLP
Sbjct: 114 ALRSVLP 120
>NP_061844
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LALRAVLPP 9
           LAL A  PP
Sbjct: 150 LALAAAFPP 158
>NP_001166969
          Length = 1010

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  ALRAVLPP 9
          ALR  LPP
Sbjct: 27 ALRPPLPP 34
>NP_000519
          Length = 1011

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  ALRAVLPP 9
          ALR  LPP
Sbjct: 27 ALRPPLPP 34
>NP_061985
          Length = 2146

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    LRAVLPP 9
            LRA LPP
Sbjct: 1495 LRAHLPP 1501
>NP_065861
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LRAVLP 8
           LRAVLP
Sbjct: 186 LRAVLP 191
>NP_001893
          Length = 405

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  RAVLPP 9
          RAV+PP
Sbjct: 35 RAVVPP 40
>NP_714964
          Length = 361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  RAVLPP 9
          RAV+PP
Sbjct: 35 RAVVPP 40
>NP_001177392
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  RAVLPP 9
          RAV+PP
Sbjct: 35 RAVVPP 40
>NP_066279
          Length = 214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   ALRAVLP 8
           ALR VLP
Sbjct: 105 ALRGVLP 111
>NP_079157
          Length = 410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  LALRAVLPP 9
          LAL A LPP
Sbjct: 67 LALCAGLPP 75
>NP_786951
          Length = 214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LALRAVLP 8
           LAL+A LP
Sbjct: 97  LALQAALP 104
>XP_005259970
          Length = 1012

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  ALRAVLPP 9
          ALR  LPP
Sbjct: 27 ALRPPLPP 34
>XP_006722681
          Length = 1365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LRAVLPP 9
           LRA LPP
Sbjct: 714 LRAHLPP 720
>XP_006722680
          Length = 1636

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    LRAVLPP 9
            LRA LPP
Sbjct: 1495 LRAHLPP 1501
>XP_006722679
          Length = 2128

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    LRAVLPP 9
            LRA LPP
Sbjct: 1495 LRAHLPP 1501
>XP_005267973
          Length = 537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LRAVLP 8
           LRAVLP
Sbjct: 214 LRAVLP 219
>XP_005264216
          Length = 210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   LALRAVLP 8
           LAL+A LP
Sbjct: 97  LALQAALP 104
>XP_006710661
          Length = 4057

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    ALRAVLPP 9
            ALRA  PP
Sbjct: 1535 ALRAAPPP 1542
>XP_006710659
          Length = 4556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    ALRAVLPP 9
            ALRA  PP
Sbjct: 1511 ALRAAPPP 1518
>XP_006710658
          Length = 4563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    ALRAVLPP 9
            ALRA  PP
Sbjct: 1518 ALRAAPPP 1525
>XP_006710657
          Length = 4579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    ALRAVLPP 9
            ALRA  PP
Sbjct: 1534 ALRAAPPP 1541
>NP_570603
          Length = 955

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LALRAVLPP 9
           L LRA  PP
Sbjct: 661 LGLRAAPPP 669
>NP_055018
          Length = 977

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   LALRAVLPP 9
           L LRA  PP
Sbjct: 661 LGLRAAPPP 669
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.147    0.438 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 539,074
Number of extensions: 880
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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