Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_065114                                                              17    2528
NP_001272378                                                           17    3301
NP_001272376                                                           17    3301
NP_001272374                                                           17    3301
NP_001272373                                                           17    3301
NP_055842                                                              17    3301
NP_001272377                                                           17    3301
NP_001272379                                                           17    3301
XP_006726664                                                           17    3301
XP_006726663                                                           17    3301
XP_006726662                                                           17    3301
XP_006726661                                                           17    3301
XP_006726660                                                           17    3301
XP_006726659                                                           17    3301
XP_006726658                                                           17    3301
XP_006725292                                                           17    3301
XP_006725291                                                           17    3301
XP_006725290                                                           17    3301
XP_006725289                                                           17    3301
XP_006725288                                                           17    3301
XP_006725287                                                           17    3301
XP_006725286                                                           17    3301
XP_006720929                                                           17    3301
XP_005255233                                                           17    3301
XP_006720928                                                           17    3301
XP_005255231                                                           17    3301
XP_005255230                                                           17    3301
NP_001035902                                                           17    4312
NP_003887                                                              17    4312
XP_005264687                                                           17    4312
XP_006712190                                                           17    4312
NP_001273707                                                           16    5631
NP_113649                                                              16    5631
NP_001273706                                                           16    5631
XP_006716544                                                           16    5631
NP_055429                                                              16    7355
NP_001129673                                                           15    9605
NP_694551                                                              15    9605
NP_078986                                                              15    9605
NP_077816                                                              15    9605
NP_001026915                                                           15    9605
NP_078905                                                              15    9605
NP_001253982                                                           15    9605
XP_005262047                                                           15    9605
XP_005262046                                                           15    9605
XP_005262045                                                           15    9605
XP_005268318                                                           15    9605
XP_005263275                                                           15    9605

>NP_065114
          Length = 399

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LAKTCRAAV 9
           LAK+C+AA+
Sbjct: 259 LAKSCQAAM 267



>NP_001272378
          Length = 498

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK CR A+
Sbjct: 146 LAKICRLAI 154



>NP_001272376
          Length = 773

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK CR A+
Sbjct: 131 LAKICRLAI 139



>NP_001272374
          Length = 760

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK CR A+
Sbjct: 118 LAKICRLAI 126



>NP_001272373
          Length = 761

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK CR A+
Sbjct: 119 LAKICRLAI 127



>NP_055842
          Length = 788

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK CR A+
Sbjct: 146 LAKICRLAI 154



>NP_001272377
          Length = 697

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LAKTCRAAV 9
          LAK CR A+
Sbjct: 55 LAKICRLAI 63



>NP_001272379
          Length = 429

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK CR A+
Sbjct: 146 LAKICRLAI 154



>XP_006726664
          Length = 516

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK CR A+
Sbjct: 164 LAKICRLAI 172



>XP_006726663
          Length = 761

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK CR A+
Sbjct: 119 LAKICRLAI 127



>XP_006726662
          Length = 773

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK CR A+
Sbjct: 131 LAKICRLAI 139



>XP_006726661
          Length = 779

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK CR A+
Sbjct: 137 LAKICRLAI 145



>XP_006726660
          Length = 788

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK CR A+
Sbjct: 146 LAKICRLAI 154



>XP_006726659
          Length = 797

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK CR A+
Sbjct: 155 LAKICRLAI 163



>XP_006726658
          Length = 806

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK CR A+
Sbjct: 164 LAKICRLAI 172



>XP_006725292
          Length = 516

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK CR A+
Sbjct: 164 LAKICRLAI 172



>XP_006725291
          Length = 761

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK CR A+
Sbjct: 119 LAKICRLAI 127



>XP_006725290
          Length = 773

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK CR A+
Sbjct: 131 LAKICRLAI 139



>XP_006725289
          Length = 779

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK CR A+
Sbjct: 137 LAKICRLAI 145



>XP_006725288
          Length = 788

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK CR A+
Sbjct: 146 LAKICRLAI 154



>XP_006725287
          Length = 797

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK CR A+
Sbjct: 155 LAKICRLAI 163



>XP_006725286
          Length = 806

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK CR A+
Sbjct: 164 LAKICRLAI 172



>XP_006720929
          Length = 516

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK CR A+
Sbjct: 164 LAKICRLAI 172



>XP_005255233
          Length = 773

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK CR A+
Sbjct: 131 LAKICRLAI 139



>XP_006720928
          Length = 779

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK CR A+
Sbjct: 137 LAKICRLAI 145



>XP_005255231
          Length = 797

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK CR A+
Sbjct: 155 LAKICRLAI 163



>XP_005255230
          Length = 806

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK CR A+
Sbjct: 164 LAKICRLAI 172



>NP_001035902
          Length = 395

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   AKTCRAAV 9
           AKTCR  V
Sbjct: 166 AKTCRRCV 173



>NP_003887
          Length = 418

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   AKTCRAAV 9
           AKTCR  V
Sbjct: 189 AKTCRRCV 196



>XP_005264687
          Length = 365

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   AKTCRAAV 9
           AKTCR  V
Sbjct: 189 AKTCRRCV 196



>XP_006712190
          Length = 378

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   AKTCRAAV 9
           AKTCR  V
Sbjct: 149 AKTCRRCV 156



>NP_001273707
          Length = 312

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           L+  CRAAV
Sbjct: 253 LSSICRAAV 261



>NP_113649
          Length = 500

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           L+  CRAAV
Sbjct: 441 LSSICRAAV 449



>NP_001273706
          Length = 314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           L+  CRAAV
Sbjct: 255 LSSICRAAV 263



>XP_006716544
          Length = 416

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           L+  CRAAV
Sbjct: 357 LSSICRAAV 365



>NP_055429
          Length = 1843

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           +A  CRAAV
Sbjct: 627 VADMCRAAV 635



>NP_001129673
          Length = 205

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LAKTCRAAV 9
          LAKTC + V
Sbjct: 80 LAKTCFSMV 88



>NP_694551
          Length = 534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LAKTCRAAV 9
           LAK+C+  V
Sbjct: 196 LAKSCKVLV 204



>NP_078986
          Length = 221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LAKTCRAAV 9
          LAKTC + V
Sbjct: 80 LAKTCFSMV 88



>NP_077816
          Length = 1499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LAKTCRAAV 9
            LAK CR+ +
Sbjct: 994  LAKQCRSVL 1002



>NP_001026915
          Length = 379

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LAKTCRAAV 9
           L ++CRAA+
Sbjct: 202 LEESCRAAM 210



>NP_078905
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   AKTCRAAV 9
           +K C+AA+
Sbjct: 271 SKVCKAAI 278



>NP_001253982
          Length = 238

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LAKTCRAAV 9
          L ++CRAA+
Sbjct: 87 LEESCRAAM 95



>XP_005262047
          Length = 264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  LAKTCRAAV 9
          L ++CRAA+
Sbjct: 87 LEESCRAAM 95



>XP_005262046
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LAKTCRAAV 9
           L ++CRAA+
Sbjct: 132 LEESCRAAM 140



>XP_005262045
          Length = 379

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LAKTCRAAV 9
           L ++CRAA+
Sbjct: 202 LEESCRAAM 210



>XP_005268318
          Length = 1499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    LAKTCRAAV 9
            LAK CR+ +
Sbjct: 994  LAKQCRSVL 1002



>XP_005263275
          Length = 389

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   AKTCRAAV 9
           +K C+AA+
Sbjct: 242 SKVCKAAI 249



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.124    0.372 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 481,402
Number of extensions: 330
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)