Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005219                                                              19     869
NP_001887                                                              17    3301
XP_005255858                                                           17    3301
XP_005255857                                                           17    3301
XP_005255856                                                           17    3301
NP_066566                                                              17    4312
NP_955452                                                              17    4312
NP_004568                                                              17    4312
XP_006715824                                                           17    4312
XP_005271834                                                           17    4312
XP_005271833                                                           17    4312
XP_005271832                                                           17    4312
XP_005271831                                                           17    4312
XP_006715823                                                           17    4312
XP_005271830                                                           17    4312
XP_006713543                                                           17    4312
NP_919268                                                              17    4312
NP_001073953                                                           16    5631
NP_002103                                                              16    5631
XP_006711061                                                           16    5631
XP_006711060                                                           16    5631
XP_005244868                                                           16    5631
NP_808227                                                              16    7355
NP_808228                                                              16    7355
NP_001886                                                              16    7355
NP_055855                                                              16    7355
NP_079330                                                              16    7355
NP_004565                                                              16    7355
NP_536340                                                              16    7355
NP_536341                                                              16    7355
NP_001243711                                                           16    7355
NP_001185642                                                           16    7355
NP_001243751                                                           16    7355
NP_001094891                                                           16    7355
XP_006723611                                                           16    7355
XP_006722018                                                           16    7355
XP_006722017                                                           16    7355
XP_006722016                                                           16    7355
XP_006722015                                                           16    7355
XP_006722014                                                           16    7355
XP_006722013                                                           16    7355
XP_006722012                                                           16    7355
XP_006712425                                                           16    7355
XP_006712424                                                           16    7355
NP_001231800                                                           15    9605
NP_001334                                                              15    9605
NP_001092284                                                           15    9605
NP_060633                                                              15    9605
NP_775899                                                              15    9605
NP_775922                                                              15    9605
NP_001243615                                                           15    9605
XP_006716232                                                           15    9605
XP_006716231                                                           15    9605
NP_061755                                                              15    9605
>NP_005219
          Length = 1210

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   LAKLLGVEE 9
           LAKLLG EE
Sbjct: 858 LAKLLGAEE 866
>NP_001887
          Length = 350

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LAKLLGVEE 9
           +AK+LG EE
Sbjct: 246 IAKVLGTEE 254
>XP_005255858
          Length = 213

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LAKLLGVEE 9
           +AK+LG EE
Sbjct: 109 IAKVLGTEE 117
>XP_005255857
          Length = 299

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LAKLLGVEE 9
           +AK+LG EE
Sbjct: 195 IAKVLGTEE 203
>XP_005255856
          Length = 322

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LAKLLGVEE 9
           +AK+LG EE
Sbjct: 218 IAKVLGTEE 226
>NP_066566
          Length = 555

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  AKLLGVEE 9
          AKL+G++E
Sbjct: 44 AKLIGIDE 51
>NP_955452
          Length = 2590

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LAKLLGVEE 9
           +A+L+GVEE
Sbjct: 683 VAELVGVEE 691
>NP_004568
          Length = 225

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LAKLLGVEE 9
          LAK+ GVE+
Sbjct: 34 LAKICGVED 42
>XP_006715824
          Length = 180

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LAKLLGVEE 9
          LAK+ GVE+
Sbjct: 34 LAKICGVED 42
>XP_005271834
          Length = 225

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LAKLLGVEE 9
          LAK+ GVE+
Sbjct: 34 LAKICGVED 42
>XP_005271833
          Length = 225

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LAKLLGVEE 9
          LAK+ GVE+
Sbjct: 34 LAKICGVED 42
>XP_005271832
          Length = 225

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LAKLLGVEE 9
          LAK+ GVE+
Sbjct: 34 LAKICGVED 42
>XP_005271831
          Length = 225

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LAKLLGVEE 9
          LAK+ GVE+
Sbjct: 34 LAKICGVED 42
>XP_006715823
          Length = 225

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LAKLLGVEE 9
          LAK+ GVE+
Sbjct: 34 LAKICGVED 42
>XP_005271830
          Length = 225

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  LAKLLGVEE 9
          LAK+ GVE+
Sbjct: 34 LAKICGVED 42
>XP_006713543
          Length = 2591

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   LAKLLGVEE 9
           +A+L+GVEE
Sbjct: 684 VAELVGVEE 692
>NP_919268
          Length = 657

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   AKLLGVEE 9
           AKL GVEE
Sbjct: 280 AKLSGVEE 287
>NP_001073953
          Length = 762

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KLLGVEE 9
           KL+GVEE
Sbjct: 550 KLVGVEE 556
>NP_002103
          Length = 662

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   LAKLLGVEE 9
           LAK+LG+ E
Sbjct: 123 LAKMLGLPE 131
>XP_006711061
          Length = 1553

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KLLGVEE 9
           KL+GVEE
Sbjct: 464 KLVGVEE 470
>XP_006711060
          Length = 1595

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KLLGVEE 9
           KL+GVEE
Sbjct: 506 KLVGVEE 512
>XP_005244868
          Length = 1639

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KLLGVEE 9
           KL+GVEE
Sbjct: 550 KLVGVEE 556
>NP_808227
          Length = 391

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LAKLLGVEE 9
           +AK+LG E+
Sbjct: 245 IAKVLGTED 253
>NP_808228
          Length = 255

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LAKLLGVEE 9
           +AK+LG E+
Sbjct: 109 IAKVLGTED 117
>NP_001886
          Length = 391

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LAKLLGVEE 9
           +AK+LG E+
Sbjct: 245 IAKVLGTED 253
>NP_055855
          Length = 2098

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LAKLLGV 7
            LAK+LGV
Sbjct: 1910 LAKILGV 1916
>NP_079330
          Length = 1222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  KLLGVEE 9
          +LLGVEE
Sbjct: 81 QLLGVEE 87
>NP_004565
          Length = 478

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KLLGVEE 9
           KLLG EE
Sbjct: 174 KLLGAEE 180
>NP_536340
          Length = 274

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KLLGVEE 9
           KLLG EE
Sbjct: 155 KLLGAEE 161
>NP_536341
          Length = 459

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KLLGVEE 9
           KLLG EE
Sbjct: 155 KLLGAEE 161
>NP_001243711
          Length = 493

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KLLGVEE 9
           KLLG EE
Sbjct: 189 KLLGAEE 195
>NP_001185642
          Length = 470

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KLLGVEE 9
           KLLG EE
Sbjct: 166 KLLGAEE 172
>NP_001243751
          Length = 331

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  KLLGVEE 9
          KLLG EE
Sbjct: 27 KLLGAEE 33
>NP_001094891
          Length = 1022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   LAKLLGV 7
           +AKLLGV
Sbjct: 303 IAKLLGV 309
>XP_006723611
          Length = 391

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   LAKLLGVEE 9
           +AK+LG E+
Sbjct: 245 IAKVLGTED 253
>XP_006722018
          Length = 331

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  KLLGVEE 9
          KLLG EE
Sbjct: 27 KLLGAEE 33
>XP_006722017
          Length = 331

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  KLLGVEE 9
          KLLG EE
Sbjct: 27 KLLGAEE 33
>XP_006722016
          Length = 331

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  KLLGVEE 9
          KLLG EE
Sbjct: 27 KLLGAEE 33
>XP_006722015
          Length = 360

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  KLLGVEE 9
          KLLG EE
Sbjct: 56 KLLGAEE 62
>XP_006722014
          Length = 379

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  KLLGVEE 9
          KLLG EE
Sbjct: 75 KLLGAEE 81
>XP_006722013
          Length = 384

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  KLLGVEE 9
          KLLG EE
Sbjct: 80 KLLGAEE 86
>XP_006722012
          Length = 483

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KLLGVEE 9
           KLLG EE
Sbjct: 179 KLLGAEE 185
>XP_006712425
          Length = 1349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LAKLLGV 7
            LAK+LGV
Sbjct: 1161 LAKILGV 1167
>XP_006712424
          Length = 1376

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    LAKLLGV 7
            LAK+LGV
Sbjct: 1188 LAKILGV 1194
>NP_001231800
          Length = 749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  AKLLGVEE 9
          AKL+G+++
Sbjct: 52 AKLIGIDD 59
>NP_001334
          Length = 770

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2  AKLLGVEE 9
          AKL+G+++
Sbjct: 52 AKLIGIDD 59
>NP_001092284
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   LAKLLGVE 8
           L KL+G+E
Sbjct: 170 LEKLIGIE 177
>NP_060633
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  LAKLLGVEE 9
          L  LLG+EE
Sbjct: 12 LYALLGIEE 20
>NP_775899
          Length = 4462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  AKLLGVEE 9
          +KL+G EE
Sbjct: 28 SKLIGAEE 35
>NP_775922
          Length = 6996

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    LAKLLGVE 8
            LAKL GV+
Sbjct: 1581 LAKLCGVD 1588
>NP_001243615
          Length = 391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   LAKLLGVEE 9
           +AK LG E+
Sbjct: 245 IAKFLGTED 253
>XP_006716232
          Length = 2753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    KLLGVEE 9
            K+LG+EE
Sbjct: 1799 KILGMEE 1805
>XP_006716231
          Length = 2753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    KLLGVEE 9
            K+LG+EE
Sbjct: 1799 KILGMEE 1805
>NP_061755
          Length = 795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  LAKLLGVE 8
          LAK LG+E
Sbjct: 48 LAKTLGLE 55
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.139    0.339 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 499,107
Number of extensions: 739
Number of successful extensions: 54
Number of sequences better than 10000.0: 54
Number of HSP's gapped: 54
Number of HSP's successfully gapped: 54
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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