Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005219                                                              20     299
NP_001036064                                                           18    1135
NP_005226                                                              18    1135
NP_001276866                                                           18    1135
NP_004439                                                              18    1135
NP_001276865                                                           18    1135
NP_001005862                                                           18    1135
XP_005257197                                                           18    1135
XP_006721828                                                           18    1135
XP_005246434                                                           18    1135
XP_005246433                                                           18    1135
XP_005246432                                                           18    1135
XP_006712427                                                           18    1135
NP_079463                                                              17    4312
XP_005256234                                                           17    4312
XP_005256235                                                           17    4312
XP_006721347                                                           17    4312
NP_004422                                                              16    5631
NP_775926                                                              16    5631
NP_001265229                                                           16    5631
NP_001073917                                                           16    5631
NP_490595                                                              16    5631
NP_001258652                                                           16    5631
NP_110420                                                              16    5631
XP_006714860                                                           16    5631
XP_006714859                                                           16    5631
XP_005268570                                                           16    5631
XP_006713657                                                           16    5631
XP_006713656                                                           16    5631
XP_006713655                                                           16    5631
XP_005263889                                                           16    5631
XP_006712890                                                           16    5631
XP_005263888                                                           16    5631
XP_005263887                                                           16    5631
XP_005245809                                                           16    5631
XP_005245808                                                           16    5631
NP_001232                                                              16    5631
NP_937784                                                              16    7355
NP_001788                                                              16    7355
XP_005255824                                                           16    7355
XP_005255823                                                           16    7355
XP_005255821                                                           16    7355
XP_005255820                                                           16    7355
XP_005255819                                                           16    7355
XP_005255818                                                           16    7355
NP_001268695                                                           15    9605
NP_872272                                                              15    9605
NP_001787                                                              15    9605
NP_004430                                                              15    9605
NP_001268694                                                           15    9605
NP_001268696                                                           15    9605
XP_005255817                                                           15    9605
XP_005255816                                                           15    9605
XP_005265710                                                           15    9605
>NP_005219
          Length = 1210

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KVKIPIAIK 9
           KVKIP+AIK
Sbjct: 737 KVKIPVAIK 745
>NP_001036064
          Length = 1292

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   VKIPIAIK 9
           VKIP+AIK
Sbjct: 744 VKIPVAIK 751
>NP_005226
          Length = 1308

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   VKIPIAIK 9
           VKIP+AIK
Sbjct: 744 VKIPVAIK 751
>NP_001276866
          Length = 1055

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   VKIPIAIK 9
           VKIP+AIK
Sbjct: 746 VKIPVAIK 753
>NP_004439
          Length = 1255

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   VKIPIAIK 9
           VKIP+AIK
Sbjct: 746 VKIPVAIK 753
>NP_001276865
          Length = 1240

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   VKIPIAIK 9
           VKIP+AIK
Sbjct: 731 VKIPVAIK 738
>NP_001005862
          Length = 1225

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   VKIPIAIK 9
           VKIP+AIK
Sbjct: 716 VKIPVAIK 723
>XP_005257197
          Length = 1225

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   VKIPIAIK 9
           VKIP+AIK
Sbjct: 716 VKIPVAIK 723
>XP_006721828
          Length = 1336

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   VKIPIAIK 9
           VKIP+AIK
Sbjct: 827 VKIPVAIK 834
>XP_005246434
          Length = 1282

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   VKIPIAIK 9
           VKIP+AIK
Sbjct: 734 VKIPVAIK 741
>XP_005246433
          Length = 1298

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   VKIPIAIK 9
           VKIP+AIK
Sbjct: 734 VKIPVAIK 741
>XP_005246432
          Length = 1307

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   VKIPIAIK 9
           VKIP+AIK
Sbjct: 759 VKIPVAIK 766
>XP_006712427
          Length = 1323

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   VKIPIAIK 9
           VKIP+AIK
Sbjct: 759 VKIPVAIK 766
>NP_079463
          Length = 422

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KIPIAIK 9
           KIP+AIK
Sbjct: 328 KIPLAIK 334
>XP_005256234
          Length = 422

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KIPIAIK 9
           KIP+AIK
Sbjct: 328 KIPLAIK 334
>XP_005256235
          Length = 422

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KIPIAIK 9
           KIP+AIK
Sbjct: 328 KIPLAIK 334
>XP_006721347
          Length = 519

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KIPIAIK 9
           KIP+AIK
Sbjct: 425 KIPLAIK 431
>NP_004422
          Length = 976

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVKIPIAIK 9
           K ++P+AIK
Sbjct: 638 KKEVPVAIK 646
>NP_775926
          Length = 334

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KVKIPIAIK 9
           K +IP+AIK
Sbjct: 141 KREIPVAIK 149
>NP_001265229
          Length = 398

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KVKIPIAIK 9
           K +IP+AIK
Sbjct: 141 KREIPVAIK 149
>NP_001073917
          Length = 1130

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KVKIPIAIK 9
           K +IP+AIK
Sbjct: 749 KREIPVAIK 757
>NP_490595
          Length = 730

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KVKIPIA 7
           K+KIPIA
Sbjct: 483 KMKIPIA 489
>NP_001258652
          Length = 943

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KVKIPIAIK 9
           K+KIPI  K
Sbjct: 182 KLKIPIGAK 190
>NP_110420
          Length = 1113

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KVKIPIAIK 9
           K+KIPI  K
Sbjct: 182 KLKIPIGAK 190
>XP_006714860
          Length = 1146

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KVKIPIAIK 9
           K+KIPI  K
Sbjct: 182 KLKIPIGAK 190
>XP_006714859
          Length = 1188

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KVKIPIAIK 9
           K+KIPI  K
Sbjct: 182 KLKIPIGAK 190
>XP_005268570
          Length = 1188

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KVKIPIAIK 9
           K+KIPI  K
Sbjct: 182 KLKIPIGAK 190
>XP_006713657
          Length = 496

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KVKIPIAIK 9
           K +IP+AIK
Sbjct: 115 KREIPVAIK 123
>XP_006713656
          Length = 496

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KVKIPIAIK 9
           K +IP+AIK
Sbjct: 115 KREIPVAIK 123
>XP_006713655
          Length = 1146

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KVKIPIAIK 9
           K +IP+AIK
Sbjct: 765 KREIPVAIK 773
>XP_005263889
          Length = 555

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KVKIPIA 7
           K+KIPIA
Sbjct: 308 KMKIPIA 314
>XP_006712890
          Length = 586

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KVKIPIA 7
           K+KIPIA
Sbjct: 339 KMKIPIA 345
>XP_005263888
          Length = 586

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KVKIPIA 7
           K+KIPIA
Sbjct: 339 KMKIPIA 345
>XP_005263887
          Length = 709

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KVKIPIA 7
           K+KIPIA
Sbjct: 462 KMKIPIA 468
>XP_005245809
          Length = 922

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVKIPIAIK 9
           K ++P+AIK
Sbjct: 584 KKEVPVAIK 592
>XP_005245808
          Length = 965

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVKIPIAIK 9
           K ++P+AIK
Sbjct: 627 KKEVPVAIK 635
>NP_001232
          Length = 663

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KVKIPIA 7
           K+KIPIA
Sbjct: 483 KMKIPIA 489
>NP_937784
          Length = 914

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VKIPIAI 8
           VKIP+A+
Sbjct: 760 VKIPVAL 766
>NP_001788
          Length = 796

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KVKIPIAIK 9
           + K+P+AI+
Sbjct: 469 EAKVPVAIR 477
>XP_005255824
          Length = 560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KVKIPIAIK 9
           + K+P+AI+
Sbjct: 469 EAKVPVAIR 477
>XP_005255823
          Length = 565

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KVKIPIAIK 9
           + K+P+AI+
Sbjct: 469 EAKVPVAIR 477
>XP_005255821
          Length = 693

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KVKIPIAIK 9
           + K+P+AI+
Sbjct: 469 EAKVPVAIR 477
>XP_005255820
          Length = 796

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KVKIPIAIK 9
           + K+P+AI+
Sbjct: 469 EAKVPVAIR 477
>XP_005255819
          Length = 796

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KVKIPIAIK 9
           + K+P+AI+
Sbjct: 469 EAKVPVAIR 477
>XP_005255818
          Length = 796

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KVKIPIAIK 9
           + K+P+AI+
Sbjct: 469 EAKVPVAIR 477
>NP_001268695
          Length = 1016

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVKIPIAIK 9
           K ++P+AIK
Sbjct: 678 KRELPVAIK 686
>NP_872272
          Length = 1015

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVKIPIAIK 9
           K ++P+AIK
Sbjct: 677 KRELPVAIK 685
>NP_001787
          Length = 799

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   KIPIAIK 9
           ++P+AIK
Sbjct: 479 RVPVAIK 485
>NP_004430
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVKIPIAIK 9
           K ++P+AIK
Sbjct: 699 KRELPVAIK 707
>NP_001268694
          Length = 1038

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVKIPIAIK 9
           K ++P+AIK
Sbjct: 700 KRELPVAIK 708
>NP_001268696
          Length = 1004

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVKIPIAIK 9
           K ++P+AIK
Sbjct: 700 KRELPVAIK 708
>XP_005255817
          Length = 711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   KIPIAIK 9
           ++P+AIK
Sbjct: 479 RVPVAIK 485
>XP_005255816
          Length = 799

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   KIPIAIK 9
           ++P+AIK
Sbjct: 479 RVPVAIK 485
>XP_005265710
          Length = 874

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KVKIPIAIK 9
           K ++P+AIK
Sbjct: 536 KRELPVAIK 544
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.145    0.379 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 503,952
Number of extensions: 612
Number of successful extensions: 54
Number of sequences better than 10000.0: 54
Number of HSP's gapped: 54
Number of HSP's successfully gapped: 54
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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