Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              18    1482
XP_005266703                                                           18    1482
NP_001269607                                                           17    2528
NP_000457                                                              17    2528
XP_005250490                                                           17    2528
XP_005250486                                                           17    2528
NP_001128643                                                           17    4312
NP_001128642                                                           17    4312
NP_114117                                                              17    4312
NP_056326                                                              17    4312
NP_001258803                                                           17    4312
XP_006723833                                                           17    4312
XP_005260442                                                           17    4312
NP_116196                                                              16    7355
NP_835363                                                              16    7355
NP_001245381                                                           16    7355
NP_001245382                                                           16    7355
NP_055273                                                              16    7355
NP_001193723                                                           16    7355
NP_112739                                                              16    7355
NP_057458                                                              16    7355
XP_006717580                                                           16    7355
XP_006717579                                                           16    7355
XP_005273217                                                           16    7355
XP_006711844                                                           16    7355
XP_005245150                                                           16    7355
XP_006711340                                                           16    7355
NP_064592                                                              15    9605
NP_001599                                                              15    9605
NP_001273433                                                           15    9605
NP_001273432                                                           15    9605
NP_006635                                                              15    9605
NP_001273434                                                           15    9605
NP_004614                                                              15    9605
NP_037528                                                              15    9605
NP_001269970                                                           15    9605
NP_001269971                                                           15    9605
NP_001274143                                                           15    9605
NP_001274145                                                           15    9605
NP_001625                                                              15    9605
NP_056175                                                              15    9605
NP_001239049                                                           15    9605
NP_055963                                                              15    9605
NP_001239053                                                           15    9605
NP_001239051                                                           15    9605
NP_001239048                                                           15    9605
XP_005261006                                                           15    9605
XP_006724055                                                           15    9605
XP_006719820                                                           15    9605
XP_005266293                                                           15    9605
XP_005252384                                                           15    9605
XP_005246574                                                           15    9605
XP_005247048                                                           15    9605
XP_005247047                                                           15    9605
>NP_443179
          Length = 2170

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   KTLEVFF 7
           KTLEVFF
Sbjct: 858 KTLEVFF 864
>XP_005266703
          Length = 1501

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   KTLEVFF 7
           KTLEVFF
Sbjct: 189 KTLEVFF 195
>NP_001269607
          Length = 1075

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KTLEVFFSD 9
           KTLEV FS+
Sbjct: 434 KTLEVAFSE 442
>NP_000457
          Length = 1283

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KTLEVFFSD 9
           KTLEV FS+
Sbjct: 642 KTLEVAFSE 650
>XP_005250490
          Length = 700

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  KTLEVFFSD 9
          KTLEV FS+
Sbjct: 59 KTLEVAFSE 67
>XP_005250486
          Length = 1243

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KTLEVFFSD 9
           KTLEV FS+
Sbjct: 602 KTLEVAFSE 610
>NP_001128643
          Length = 289

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LEVFFSD 9
           LE+FF+D
Sbjct: 247 LEIFFTD 253
>NP_001128642
          Length = 296

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LEVFFSD 9
           LE+FF+D
Sbjct: 254 LEIFFTD 260
>NP_114117
          Length = 289

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LEVFFSD 9
           LE+FF+D
Sbjct: 247 LEIFFTD 253
>NP_056326
          Length = 384

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TLEVFFS 8
           TL+VFFS
Sbjct: 327 TLQVFFS 333
>NP_001258803
          Length = 384

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TLEVFFS 8
           TL+VFFS
Sbjct: 327 TLQVFFS 333
>XP_006723833
          Length = 384

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TLEVFFS 8
           TL+VFFS
Sbjct: 327 TLQVFFS 333
>XP_005260442
          Length = 384

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TLEVFFS 8
           TL+VFFS
Sbjct: 327 TLQVFFS 333
>NP_116196
          Length = 1094

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KTLEVFFS 8
           KTLE FF+
Sbjct: 609 KTLENFFA 616
>NP_835363
          Length = 1043

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KTLEVFFS 8
           KTLE FF+
Sbjct: 558 KTLENFFA 565
>NP_001245381
          Length = 986

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KTLEVFFS 8
           KTLE FF+
Sbjct: 484 KTLENFFA 491
>NP_001245382
          Length = 969

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KTLEVFFS 8
           KTLE FF+
Sbjct: 484 KTLENFFA 491
>NP_055273
          Length = 609

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTLEVFFSD 9
           KT+EVF  D
Sbjct: 569 KTIEVFDPD 577
>NP_001193723
          Length = 1312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTLEVFFSD 9
           KTL+  FSD
Sbjct: 938 KTLKELFSD 946
>NP_112739
          Length = 1226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTLEVFFSD 9
           KTL+  FSD
Sbjct: 852 KTLKELFSD 860
>NP_057458
          Length = 1312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTLEVFFSD 9
           KTL+  FSD
Sbjct: 938 KTLKELFSD 946
>XP_006717580
          Length = 1043

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KTLEVFFS 8
           KTLE FF+
Sbjct: 558 KTLENFFA 565
>XP_006717579
          Length = 1180

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KTLEVFFS 8
           KTLE FF+
Sbjct: 695 KTLENFFA 702
>XP_005273217
          Length = 1141

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTLEVFFSD 9
           KTL+  FSD
Sbjct: 938 KTLKELFSD 946
>XP_006711844
          Length = 1276

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTLEVFFSD 9
           KTL+  FSD
Sbjct: 902 KTLKELFSD 910
>XP_005245150
          Length = 609

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTLEVFFSD 9
           KT+EVF  D
Sbjct: 569 KTIEVFDPD 577
>XP_006711340
          Length = 684

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTLEVFFSD 9
           KT+EVF  D
Sbjct: 644 KTIEVFDPD 652
>NP_064592
          Length = 1561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    EVFFSD 9
            EVFF+D
Sbjct: 1359 EVFFND 1364
>NP_001599
          Length = 430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   TLEVFFSD 9
           T E+FF D
Sbjct: 258 TAELFFED 265
>NP_001273433
          Length = 860

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LEVFFSD 9
           LE F+SD
Sbjct: 444 LEAFYSD 450
>NP_001273432
          Length = 814

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LEVFFSD 9
           LE F+SD
Sbjct: 442 LEAFYSD 448
>NP_006635
          Length = 858

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LEVFFSD 9
           LE F+SD
Sbjct: 442 LEAFYSD 448
>NP_001273434
          Length = 782

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LEVFFSD 9
           LE F+SD
Sbjct: 366 LEAFYSD 372
>NP_004614
          Length = 387

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LEVFFSD 9
           LEV+F D
Sbjct: 325 LEVYFED 331
>NP_037528
          Length = 1055

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KTLEVFFSD 9
           +T+E+ +SD
Sbjct: 575 RTIELMYSD 583
>NP_001269970
          Length = 1125

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KTLEVFFSD 9
           +T+E+ +SD
Sbjct: 575 RTIELMYSD 583
>NP_001269971
          Length = 1087

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KTLEVFFSD 9
           +T+E+ +SD
Sbjct: 575 RTIELMYSD 583
>NP_001274143
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  KTLEVFFS 8
          K LEV+FS
Sbjct: 12 KLLEVWFS 19
>NP_001274145
          Length = 214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  KTLEVFFS 8
          K LEV+FS
Sbjct: 12 KLLEVWFS 19
>NP_001625
          Length = 334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  KTLEVFFS 8
          K LEV+FS
Sbjct: 12 KLLEVWFS 19
>NP_056175
          Length = 1042

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KTLEVFFSD 9
           +T+E+ FS+
Sbjct: 465 ETIEILFSE 473
>NP_001239049
          Length = 1323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EVFFSD 9
           E+FFSD
Sbjct: 745 ELFFSD 750
>NP_055963
          Length = 1323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EVFFSD 9
           E+FFSD
Sbjct: 745 ELFFSD 750
>NP_001239053
          Length = 1143

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EVFFSD 9
           E+FFSD
Sbjct: 745 ELFFSD 750
>NP_001239051
          Length = 1288

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EVFFSD 9
           E+FFSD
Sbjct: 710 ELFFSD 715
>NP_001239048
          Length = 1330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EVFFSD 9
           E+FFSD
Sbjct: 745 ELFFSD 750
>XP_005261006
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KTLEVFFSD 9
           +T+E+ +SD
Sbjct: 171 RTIELMYSD 179
>XP_006724055
          Length = 826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KTLEVFFSD 9
           +T+E+ +SD
Sbjct: 276 RTIELMYSD 284
>XP_006719820
          Length = 913

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LEVFFSD 9
           LE F+SD
Sbjct: 497 LEAFYSD 503
>XP_005266293
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LEVFFSD 9
           LE F+SD
Sbjct: 444 LEAFYSD 450
>XP_005252384
          Length = 841

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EVFFSD 9
           EVFF+D
Sbjct: 639 EVFFND 644
>XP_005246574
          Length = 409

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   TLEVFFSD 9
           T E+FF D
Sbjct: 237 TAELFFED 244
>XP_005247048
          Length = 1107

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EVFFSD 9
           E+FFSD
Sbjct: 529 ELFFSD 534
>XP_005247047
          Length = 1137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EVFFSD 9
           E+FFSD
Sbjct: 559 ELFFSD 564
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.141    0.383 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 411,686
Number of extensions: 678
Number of successful extensions: 54
Number of sequences better than 10000.0: 54
Number of HSP's gapped: 54
Number of HSP's successfully gapped: 54
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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