Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              16    5631
XP_005266703                                                           16    5631
NP_001188412                                                           16    7355
NP_001419                                                              16    7355
NP_219482                                                              16    7355
NP_001137251                                                           16    7355
NP_054774                                                              16    7355
NP_056107                                                              16    7355
NP_001171725                                                           16    7355
XP_006710496                                                           16    7355
NP_002408                                                              15    9605
NP_001139438                                                           15    9605
NP_005214                                                              15    9605
NP_060564                                                              15    9605
NP_001123479                                                           15    9605
NP_001123478                                                           15    9605
NP_510882                                                              15    9605
NP_114146                                                              15    9605
NP_001019552                                                           15    9605
NP_001019551                                                           15    9605
NP_002085                                                              15    9605
NP_919274                                                              15    9605
NP_001230131                                                           15    9605
NP_036548                                                              15    9605
XP_005255332                                                           15    9605
XP_005255331                                                           15    9605
XP_005255205                                                           15    9605
XP_006720916                                                           15    9605
XP_006720915                                                           15    9605
XP_006717927                                                           15    9605
XP_006716471                                                           15    9605
XP_005273714                                                           15    9605
XP_005247838                                                           15    9605
NP_079044                                                              15    9605
NP_001004758                                                           15    9605
>NP_443179
          Length = 2170

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    KTAIGKVLQ 9
            KTAI +VLQ
Sbjct: 1488 KTAIWQVLQ 1496
>XP_005266703
          Length = 1501

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KTAIGKVLQ 9
           KTAI +VLQ
Sbjct: 819 KTAIWQVLQ 827
>NP_001188412
          Length = 341

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   KTAIGK 6
           KTAIGK
Sbjct: 135 KTAIGK 140
>NP_001419
          Length = 434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   KTAIGK 6
           KTAIGK
Sbjct: 228 KTAIGK 233
>NP_219482
          Length = 477

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KTAIGKVLQ 9
           + A+G+VLQ
Sbjct: 416 RKAVGRVLQ 424
>NP_001137251
          Length = 676

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KTAIGKVLQ 9
           +T+IG+V+Q
Sbjct: 659 QTSIGQVIQ 667
>NP_054774
          Length = 676

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KTAIGKVLQ 9
           +T+IG+V+Q
Sbjct: 659 QTSIGQVIQ 667
>NP_056107
          Length = 1104

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTAIGKVLQ 9
           K  +GKVLQ
Sbjct: 417 KLDVGKVLQ 425
>NP_001171725
          Length = 1114

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTAIGKVLQ 9
           K  +GKVLQ
Sbjct: 417 KLDVGKVLQ 425
>XP_006710496
          Length = 434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   KTAIGK 6
           KTAIGK
Sbjct: 228 KTAIGK 233
>NP_002408
          Length = 3256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    KTAIGKV 7
            KT++GKV
Sbjct: 1634 KTSLGKV 1640
>NP_001139438
          Length = 2896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    KTAIGKV 7
            KT++GKV
Sbjct: 1274 KTSLGKV 1280
>NP_005214
          Length = 282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TAIGKVL 8
          TA+GK+L
Sbjct: 68 TAVGKLL 74
>NP_060564
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   AIGKVLQ 9
           AIGKVL+
Sbjct: 616 AIGKVLK 622
>NP_001123479
          Length = 499

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   AIGKVLQ 9
           AIGKVL+
Sbjct: 487 AIGKVLK 493
>NP_001123478
          Length = 636

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   AIGKVLQ 9
           AIGKVL+
Sbjct: 624 AIGKVLK 630
>NP_510882
          Length = 214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TAIGKVL 8
           TA+GK+L
Sbjct: 175 TAVGKLL 181
>NP_114146
          Length = 171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TAIGKVL 8
           TA+GK+L
Sbjct: 132 TAVGKLL 138
>NP_001019552
          Length = 171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TAIGKVL 8
           TA+GK+L
Sbjct: 132 TAVGKLL 138
>NP_001019551
          Length = 171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TAIGKVL 8
           TA+GK+L
Sbjct: 132 TAVGKLL 138
>NP_002085
          Length = 637

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   AIGKVLQ 9
           AIGKVL+
Sbjct: 625 AIGKVLK 631
>NP_919274
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TAIGKVL 8
           TA+GK+L
Sbjct: 353 TAVGKLL 359
>NP_001230131
          Length = 753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TAIGKVLQ 9
           +AIGK+L+
Sbjct: 630 SAIGKILK 637
>NP_036548
          Length = 1105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TAIGKVLQ 9
           +AIGK+L+
Sbjct: 982 SAIGKILK 989
>XP_005255332
          Length = 529

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   AIGKVLQ 9
           AIGKVL+
Sbjct: 517 AIGKVLK 523
>XP_005255331
          Length = 530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   AIGKVLQ 9
           AIGKVL+
Sbjct: 518 AIGKVLK 524
>XP_005255205
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TAIGKVL 8
          TA+GK+L
Sbjct: 68 TAVGKLL 74
>XP_006720916
          Length = 282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TAIGKVL 8
          TA+GK+L
Sbjct: 68 TAVGKLL 74
>XP_006720915
          Length = 282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TAIGKVL 8
          TA+GK+L
Sbjct: 68 TAVGKLL 74
>XP_006717927
          Length = 2406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KTAIGKV 7
           KT++GKV
Sbjct: 784 KTSLGKV 790
>XP_006716471
          Length = 171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TAIGKVL 8
           TA+GK+L
Sbjct: 132 TAVGKLL 138
>XP_005273714
          Length = 171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TAIGKVL 8
           TA+GK+L
Sbjct: 132 TAVGKLL 138
>XP_005247838
          Length = 599

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KTAIGKVL 8
           K A+GK+L
Sbjct: 535 KRALGKIL 542
>NP_079044
          Length = 598

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KTAIGKVL 8
           K A+GK+L
Sbjct: 534 KRALGKIL 541
>NP_001004758
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IGKVLQ 9
           IGKVLQ
Sbjct: 228 IGKVLQ 233
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.131    0.326 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 366,154
Number of extensions: 429
Number of successful extensions: 35
Number of sequences better than 10000.0: 35
Number of HSP's gapped: 35
Number of HSP's successfully gapped: 35
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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