Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              20     509
XP_006718908                                                           20     509
XP_005271621                                                           20     509
XP_006718907                                                           20     509
XP_006718906                                                           20     509
XP_005271619                                                           20     509
XP_005271618                                                           20     509
NP_001136070                                                           17    2528
NP_001136071                                                           17    2528
NP_001017973                                                           17    2528
NP_001017974                                                           17    2528
NP_004190                                                              17    2528
XP_005272179                                                           17    2528
XP_006714794                                                           17    2528
XP_006714793                                                           17    2528
XP_006714792                                                           17    2528
XP_006714791                                                           17    2528
XP_005272177                                                           17    2528
XP_005272176                                                           17    2528
XP_005272175                                                           17    2528
XP_005272174                                                           17    2528
XP_005272173                                                           17    2528
NP_001138584                                                           17    4312
NP_114153                                                              17    4312
NP_006333                                                              16    5631
NP_005528                                                              16    5631
XP_006713918                                                           16    5631
XP_005247986                                                           16    5631
NP_006002                                                              16    7355
NP_002903                                                              15    9605
NP_001273361                                                           15    9605
NP_001273360                                                           15    9605
NP_073739                                                              15    9605
NP_690042                                                              15    9605
NP_056456                                                              15    9605
XP_005250571                                                           15    9605
XP_005250570                                                           15    9605
XP_005250315                                                           15    9605
XP_005267148                                                           15    9605
XP_005267147                                                           15    9605
XP_006715607                                                           15    9605
XP_006715606                                                           15    9605
XP_005272109                                                           15    9605
XP_005263256                                                           15    9605
NP_001103447                                                           15    9605
NP_065930                                                              15    9605
>NP_000042
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KQMIKQLDA 9
            KQMIK+LDA
Sbjct: 2313 KQMIKKLDA 2321
>XP_006718908
          Length = 1708

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KQMIKQLDA 9
           KQMIK+LDA
Sbjct: 965 KQMIKKLDA 973
>XP_005271621
          Length = 2708

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KQMIKQLDA 9
            KQMIK+LDA
Sbjct: 1965 KQMIKKLDA 1973
>XP_006718907
          Length = 3050

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KQMIKQLDA 9
            KQMIK+LDA
Sbjct: 2307 KQMIKKLDA 2315
>XP_006718906
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KQMIKQLDA 9
            KQMIK+LDA
Sbjct: 2313 KQMIKKLDA 2321
>XP_005271619
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KQMIKQLDA 9
            KQMIK+LDA
Sbjct: 2313 KQMIKKLDA 2321
>XP_005271618
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KQMIKQLDA 9
            KQMIK+LDA
Sbjct: 2313 KQMIKKLDA 2321
>NP_001136070
          Length = 533

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   KQMIKQLDA 9
           +Q++KQLDA
Sbjct: 190 EQVLKQLDA 198
>NP_001136071
          Length = 535

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   KQMIKQLDA 9
           +Q++KQLDA
Sbjct: 190 EQVLKQLDA 198
>NP_001017973
          Length = 533

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   KQMIKQLDA 9
           +Q++KQLDA
Sbjct: 190 EQVLKQLDA 198
>NP_001017974
          Length = 533

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   KQMIKQLDA 9
           +Q++KQLDA
Sbjct: 190 EQVLKQLDA 198
>NP_004190
          Length = 535

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   KQMIKQLDA 9
           +Q++KQLDA
Sbjct: 190 EQVLKQLDA 198
>XP_005272179
          Length = 466

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   KQMIKQLDA 9
           +Q++KQLDA
Sbjct: 190 EQVLKQLDA 198
>XP_006714794
          Length = 507

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   KQMIKQLDA 9
           +Q++KQLDA
Sbjct: 190 EQVLKQLDA 198
>XP_006714793
          Length = 533

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   KQMIKQLDA 9
           +Q++KQLDA
Sbjct: 190 EQVLKQLDA 198
>XP_006714792
          Length = 533

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   KQMIKQLDA 9
           +Q++KQLDA
Sbjct: 190 EQVLKQLDA 198
>XP_006714791
          Length = 535

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   KQMIKQLDA 9
           +Q++KQLDA
Sbjct: 190 EQVLKQLDA 198
>XP_005272177
          Length = 535

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   KQMIKQLDA 9
           +Q++KQLDA
Sbjct: 190 EQVLKQLDA 198
>XP_005272176
          Length = 535

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   KQMIKQLDA 9
           +Q++KQLDA
Sbjct: 190 EQVLKQLDA 198
>XP_005272175
          Length = 535

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   KQMIKQLDA 9
           +Q++KQLDA
Sbjct: 190 EQVLKQLDA 198
>XP_005272174
          Length = 535

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   KQMIKQLDA 9
           +Q++KQLDA
Sbjct: 190 EQVLKQLDA 198
>XP_005272173
          Length = 535

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   KQMIKQLDA 9
           +Q++KQLDA
Sbjct: 190 EQVLKQLDA 198
>NP_001138584
          Length = 543

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KQMIKQLDA 9
           KQ+++QL+A
Sbjct: 527 KQLVQQLEA 535
>NP_114153
          Length = 301

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KQMIKQLDA 9
           K M+KQL+A
Sbjct: 292 KMMMKQLEA 300
>NP_006333
          Length = 838

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KQMIKQLDA 9
           +Q+IK++DA
Sbjct: 103 QQLIKEVDA 111
>NP_005528
          Length = 422

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KQMIKQLD 8
           KQ++K+LD
Sbjct: 188 KQILKELD 195
>XP_006713918
          Length = 830

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KQMIKQLDA 9
           +Q+IK++DA
Sbjct: 103 QQLIKEVDA 111
>XP_005247986
          Length = 842

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KQMIKQLDA 9
           +Q+IK++DA
Sbjct: 103 QQLIKEVDA 111
>NP_006002
          Length = 375

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KQMIKQLDA 9
           KQ++K LDA
Sbjct: 98  KQILKFLDA 106
>NP_002903
          Length = 3130

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    QMIKQLD 8
            QM++QLD
Sbjct: 2529 QMLEQLD 2535
>NP_001273361
          Length = 3052

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    QMIKQLD 8
            QM++QLD
Sbjct: 2451 QMLEQLD 2457
>NP_001273360
          Length = 3052

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    QMIKQLD 8
            QM++QLD
Sbjct: 2451 QMLEQLD 2457
>NP_073739
          Length = 1430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QMIKQLDA 9
           QM+K +DA
Sbjct: 811 QMLKTIDA 818
>NP_690042
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KQMIKQLDA 9
           KQ+ KQL A
Sbjct: 139 KQLAKQLPA 147
>NP_056456
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KQMIKQLDA 9
           KQ+ KQL A
Sbjct: 148 KQLAKQLPA 156
>XP_005250571
          Length = 823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KQMIKQLD 8
           K+MI++LD
Sbjct: 619 KEMIQKLD 626
>XP_005250570
          Length = 904

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KQMIKQLD 8
           K+MI++LD
Sbjct: 700 KEMIQKLD 707
>XP_005250315
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  KQMIKQLDA 9
          KQ+ KQL A
Sbjct: 63 KQLAKQLPA 71
>XP_005267148
          Length = 2679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    QMIKQLD 8
            QM++QLD
Sbjct: 2529 QMLEQLD 2535
>XP_005267147
          Length = 2689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    QMIKQLD 8
            QM++QLD
Sbjct: 2529 QMLEQLD 2535
>XP_006715607
          Length = 3052

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    QMIKQLD 8
            QM++QLD
Sbjct: 2451 QMLEQLD 2457
>XP_006715606
          Length = 3130

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    QMIKQLD 8
            QM++QLD
Sbjct: 2529 QMLEQLD 2535
>XP_005272109
          Length = 1123

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QMIKQLDA 9
           QM+K +DA
Sbjct: 811 QMLKTIDA 818
>XP_005263256
          Length = 1040

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QMIKQLDA 9
           Q+IK+LD+
Sbjct: 757 QIIKELDS 764
>NP_001103447
          Length = 1040

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QMIKQLDA 9
           Q+IK+LD+
Sbjct: 757 QIIKELDS 764
>NP_065930
          Length = 955

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KQMIKQLD 8
           K+MI++LD
Sbjct: 751 KEMIQKLD 758
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.319    0.128    0.308 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 344,130
Number of extensions: 585
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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