Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000843                                                              17    4312
NP_005245                                                              16    5631
NP_852092                                                              16    5631
NP_002032                                                              16    5631
NP_057739                                                              16    5631
NP_057738                                                              16    5631
XP_006720521                                                           16    5631
XP_006720520                                                           16    5631
XP_005254331                                                           16    5631
XP_005254330                                                           16    5631
XP_006720519                                                           16    5631
XP_006720518                                                           16    5631
NP_065928                                                              16    7355
XP_005256527                                                           16    7355
NP_001137292                                                           15    9605
NP_005229                                                              15    9605
NP_653219                                                              15    9605
NP_640337                                                              15    9605
NP_001121187                                                           15    9605
NP_001073904                                                           15    9605
NP_055907                                                              15    9605
NP_001273429                                                           15    9605
NP_001018170                                                           15    9605
NP_001018169                                                           15    9605
NP_001607                                                              15    9605
NP_003896                                                              15    9605
NP_000373                                                              15    9605
NP_001265509                                                           15    9605
NP_001265508                                                           15    9605
NP_938020                                                              15    9605
XP_006724543                                                           15    9605
XP_006724542                                                           15    9605
XP_005274533                                                           15    9605
XP_005274532                                                           15    9605
XP_006724541                                                           15    9605
XP_005274531                                                           15    9605
XP_006724540                                                           15    9605
XP_005274530                                                           15    9605
XP_005256272                                                           15    9605
XP_005255242                                                           15    9605
XP_005255241                                                           15    9605
XP_005255240                                                           15    9605
XP_005255239                                                           15    9605
XP_005272481                                                           15    9605
XP_005272478                                                           15    9605
XP_005271485                                                           15    9605
XP_006715402                                                           15    9605
XP_006711216                                                           15    9605
XP_005244942                                                           15    9605
XP_005244941                                                           15    9605
XP_005244940                                                           15    9605
XP_006711215                                                           15    9605
XP_005244939                                                           15    9605
XP_006711214                                                           15    9605
XP_005244938                                                           15    9605
XP_005244937                                                           15    9605
NP_001026976                                                           15    9605
>NP_000843
          Length = 210

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  KQEVVTVIT 9
          K+EVVTV T
Sbjct: 30 KEEVVTVET 38
>NP_005245
          Length = 395

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   QEVVTVIT 9
           Q+V+T++T
Sbjct: 270 QQVITIVT 277
>NP_852092
          Length = 348

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   QEVVTVIT 9
           Q+V+T++T
Sbjct: 258 QQVITIVT 265
>NP_002032
          Length = 360

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   QEVVTVIT 9
           Q+V+T++T
Sbjct: 270 QQVITIVT 277
>NP_057739
          Length = 348

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   QEVVTVIT 9
           Q+V+T++T
Sbjct: 258 QQVITIVT 265
>NP_057738
          Length = 383

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   QEVVTVIT 9
           Q+V+T++T
Sbjct: 258 QQVITIVT 265
>XP_006720521
          Length = 387

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   QEVVTVIT 9
           Q+V+T++T
Sbjct: 262 QQVITIVT 269
>XP_006720520
          Length = 388

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   QEVVTVIT 9
           Q+V+T++T
Sbjct: 263 QQVITIVT 270
>XP_005254331
          Length = 395

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   QEVVTVIT 9
           Q+V+T++T
Sbjct: 270 QQVITIVT 277
>XP_005254330
          Length = 395

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   QEVVTVIT 9
           Q+V+T++T
Sbjct: 270 QQVITIVT 277
>XP_006720519
          Length = 399

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   QEVVTVIT 9
           Q+V+T++T
Sbjct: 274 QQVITIVT 281
>XP_006720518
          Length = 400

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   QEVVTVIT 9
           Q+V+T++T
Sbjct: 275 QQVITIVT 282
>NP_065928
          Length = 4427

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QEVVTVIT 9
           Q+VVT++T
Sbjct: 797 QDVVTIMT 804
>XP_005256527
          Length = 4427

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QEVVTVIT 9
           Q+VVT++T
Sbjct: 797 QDVVTIMT 804
>NP_001137292
          Length = 485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   KQEVVT 6
           KQEVVT
Sbjct: 271 KQEVVT 276
>NP_005229
          Length = 441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   KQEVVT 6
           KQEVVT
Sbjct: 227 KQEVVT 232
>NP_653219
          Length = 448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   QEVVTVIT 9
           Q V+T++T
Sbjct: 270 QRVITIVT 277
>NP_640337
          Length = 1115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KQEVVTVI 8
           KQEV+T +
Sbjct: 532 KQEVITEV 539
>NP_001121187
          Length = 1151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KQEVVTVI 8
           KQEV+T +
Sbjct: 532 KQEVITEV 539
>NP_001073904
          Length = 809

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QEVVTVIT 9
           QE+VTV T
Sbjct: 229 QELVTVAT 236
>NP_055907
          Length = 3661

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    KQEVVTV 7
            KQE VTV
Sbjct: 2729 KQEAVTV 2735
>NP_001273429
          Length = 537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QEVVTVIT 9
           QEV+ +IT
Sbjct: 506 QEVIKIIT 513
>NP_001018170
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QEVVTVIT 9
           QEV+ +IT
Sbjct: 414 QEVIKIIT 421
>NP_001018169
          Length = 528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QEVVTVIT 9
           QEV+ +IT
Sbjct: 497 QEVIKIIT 504
>NP_001607
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   QEVVTVIT 9
           +++VTV+T
Sbjct: 492 EDIVTVVT 499
>NP_003896
          Length = 534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QEVVTVIT 9
           QEV+ +IT
Sbjct: 503 QEVIKIIT 510
>NP_000373
          Length = 485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  QEVVTVI 8
          QEV+TV+
Sbjct: 59 QEVITVL 65
>NP_001265509
          Length = 405

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   QEVVTVIT 9
           +++VTV+T
Sbjct: 384 EDIVTVVT 391
>NP_001265508
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   QEVVTVIT 9
           +++VTV+T
Sbjct: 492 EDIVTVVT 499
>NP_938020
          Length = 682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QEVVTVI 8
           QE++T+I
Sbjct: 473 QEIITII 479
>XP_006724543
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QEVVTVI 8
           QE++T+I
Sbjct: 473 QEIITII 479
>XP_006724542
          Length = 600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QEVVTVI 8
           QE++T+I
Sbjct: 473 QEIITII 479
>XP_005274533
          Length = 652

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QEVVTVI 8
           QE++T+I
Sbjct: 473 QEIITII 479
>XP_005274532
          Length = 681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QEVVTVI 8
           QE++T+I
Sbjct: 473 QEIITII 479
>XP_006724541
          Length = 682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QEVVTVI 8
           QE++T+I
Sbjct: 473 QEIITII 479
>XP_005274531
          Length = 691

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QEVVTVI 8
           QE++T+I
Sbjct: 453 QEIITII 459
>XP_006724540
          Length = 703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QEVVTVI 8
           QE++T+I
Sbjct: 473 QEIITII 479
>XP_005274530
          Length = 711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   QEVVTVI 8
           QE++T+I
Sbjct: 473 QEIITII 479
>XP_005256272
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QEVVTVIT 9
           QEV+ +IT
Sbjct: 414 QEVIKIIT 421
>XP_005255242
          Length = 3609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    KQEVVTV 7
            KQE VTV
Sbjct: 2677 KQEAVTV 2683
>XP_005255241
          Length = 3637

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    KQEVVTV 7
            KQE VTV
Sbjct: 2705 KQEAVTV 2711
>XP_005255240
          Length = 3663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    KQEVVTV 7
            KQE VTV
Sbjct: 2731 KQEAVTV 2737
>XP_005255239
          Length = 3689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    KQEVVTV 7
            KQE VTV
Sbjct: 2757 KQEAVTV 2763
>XP_005272481
          Length = 507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QEVVTVIT 9
           QE+VTV T
Sbjct: 229 QELVTVAT 236
>XP_005272478
          Length = 596

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  QEVVTVIT 9
          QE+VTV T
Sbjct: 16 QELVTVAT 23
>XP_005271485
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   KQEVVT 6
           KQEVVT
Sbjct: 204 KQEVVT 209
>XP_006715402
          Length = 1135

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KQEVVTVI 8
           KQEV+T +
Sbjct: 532 KQEVITEV 539
>XP_006711216
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   QEVVTVIT 9
           Q V+T++T
Sbjct: 214 QRVITIVT 221
>XP_005244942
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   QEVVTVIT 9
           Q V+T++T
Sbjct: 214 QRVITIVT 221
>XP_005244941
          Length = 410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   QEVVTVIT 9
           Q V+T++T
Sbjct: 232 QRVITIVT 239
>XP_005244940
          Length = 426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   QEVVTVIT 9
           Q V+T++T
Sbjct: 248 QRVITIVT 255
>XP_006711215
          Length = 448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   QEVVTVIT 9
           Q V+T++T
Sbjct: 270 QRVITIVT 277
>XP_005244939
          Length = 448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   QEVVTVIT 9
           Q V+T++T
Sbjct: 270 QRVITIVT 277
>XP_006711214
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   QEVVTVIT 9
           Q V+T++T
Sbjct: 286 QRVITIVT 293
>XP_005244938
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   QEVVTVIT 9
           Q V+T++T
Sbjct: 286 QRVITIVT 293
>XP_005244937
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   QEVVTVIT 9
           Q V+T++T
Sbjct: 286 QRVITIVT 293
>NP_001026976
          Length = 508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  QEVVTVI 8
          QEV+TV+
Sbjct: 59 QEVITVL 65
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.312    0.124    0.284 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 407,718
Number of extensions: 707
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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