Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              18    1135
NP_001075109                                                           18    1135
NP_775837                                                              16    5631
XP_006724284                                                           16    5631
XP_006724283                                                           16    5631
XP_006724282                                                           16    5631
XP_005261537                                                           16    5631
NP_065783                                                              16    7355
NP_059989                                                              16    7355
XP_006715590                                                           16    7355
XP_005267126                                                           16    7355
XP_006715589                                                           16    7355
XP_006715588                                                           16    7355
XP_006715587                                                           16    7355
XP_006715586                                                           16    7355
NP_001128251                                                           15    9605
NP_443187                                                              15    9605
>NP_008835
          Length = 4128

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    KMVSAVLN 8
            KMVSAVLN
Sbjct: 1591 KMVSAVLN 1598
>NP_001075109
          Length = 4097

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    KMVSAVLN 8
            KMVSAVLN
Sbjct: 1591 KMVSAVLN 1598
>NP_775837
          Length = 2151

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KMVSAVLNS 9
           KMV+ +LNS
Sbjct: 875 KMVAGLLNS 883
>XP_006724284
          Length = 1989

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KMVSAVLNS 9
           KMV+ +LNS
Sbjct: 713 KMVAGLLNS 721
>XP_006724283
          Length = 2151

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KMVSAVLNS 9
           KMV+ +LNS
Sbjct: 875 KMVAGLLNS 883
>XP_006724282
          Length = 2151

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KMVSAVLNS 9
           KMV+ +LNS
Sbjct: 875 KMVAGLLNS 883
>XP_005261537
          Length = 2151

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KMVSAVLNS 9
           KMV+ +LNS
Sbjct: 875 KMVAGLLNS 883
>NP_065783
          Length = 2249

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VSAVLNS 9
            +SAVLNS
Sbjct: 2227 ISAVLNS 2233
>NP_059989
          Length = 2236

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VSAVLNS 9
            +SAVLNS
Sbjct: 2214 ISAVLNS 2220
>XP_006715590
          Length = 2277

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VSAVLNS 9
            +SAVLNS
Sbjct: 2255 ISAVLNS 2261
>XP_005267126
          Length = 2316

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VSAVLNS 9
            +SAVLNS
Sbjct: 2294 ISAVLNS 2300
>XP_006715589
          Length = 2320

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VSAVLNS 9
            +SAVLNS
Sbjct: 2298 ISAVLNS 2304
>XP_006715588
          Length = 2330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VSAVLNS 9
            +SAVLNS
Sbjct: 2308 ISAVLNS 2314
>XP_006715587
          Length = 2359

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VSAVLNS 9
            +SAVLNS
Sbjct: 2337 ISAVLNS 2343
>XP_006715586
          Length = 2373

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VSAVLNS 9
            +SAVLNS
Sbjct: 2351 ISAVLNS 2357
>NP_001128251
          Length = 1015

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  KMVSAVLNS 9
          KMVS  LNS
Sbjct: 37 KMVSMDLNS 45
>NP_443187
          Length = 710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KMVSAVLNS 9
           ++VSA++NS
Sbjct: 224 RVVSAMINS 232
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.308    0.113    0.251 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 239,663
Number of extensions: 208
Number of successful extensions: 17
Number of sequences better than 10000.0: 17
Number of HSP's gapped: 17
Number of HSP's successfully gapped: 17
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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