Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_776159                                                              18    1935
NP_001273494                                                           17    3301
NP_001273495                                                           17    3301
NP_055547                                                              17    3301
NP_068776                                                              17    3301
XP_005256324                                                           17    3301
XP_005256322                                                           17    3301
XP_006719126                                                           17    3301
XP_005253411                                                           17    3301
XP_005253410                                                           17    3301
XP_006719125                                                           17    3301
XP_005253409                                                           17    3301
NP_000229                                                              17    4312
NP_001191727                                                           17    4312
NP_742053                                                              17    4312
NP_742054                                                              17    4312
NP_004981                                                              17    4312
NP_038476                                                              17    4312
NP_872589                                                              17    4312
XP_006719461                                                           17    4312
XP_006716040                                                           17    4312
NP_001019831                                                           16    5631
NP_004336                                                              16    5631
NP_003938                                                              16    5631
NP_079089                                                              16    5631
XP_006713880                                                           16    5631
XP_006713879                                                           16    5631
XP_006713878                                                           16    5631
XP_006713877                                                           16    5631
XP_006713876                                                           16    5631
XP_006713875                                                           16    5631
XP_006713874                                                           16    5631
XP_006713873                                                           16    5631
XP_005271280                                                           16    5631
XP_006710968                                                           16    5631
NP_000512                                                              16    7355
NP_005575                                                              16    7355
NP_065385                                                              16    7355
NP_619651                                                              16    7355
NP_001185797                                                           15    9605
NP_005177                                                              15    9605
NP_001185798                                                           15    9605
NP_001229342                                                           15    9605
NP_009049                                                              15    9605
NP_150375                                                              15    9605
NP_787954                                                              15    9605
NP_059130                                                              15    9605
NP_001096045                                                           15    9605
NP_001136248                                                           15    9605
NP_006248                                                              15    9605
NP_001269574                                                           15    9605
NP_001269573                                                           15    9605
NP_077016                                                              15    9605
NP_997719                                                              15    9605
NP_110406                                                              15    9605
NP_001265848                                                           15    9605
NP_001265849                                                           15    9605
NP_775115                                                              15    9605
NP_775185                                                              15    9605
XP_005261913                                                           15    9605
XP_005261910                                                           15    9605
XP_005261905                                                           15    9605
XP_005254520                                                           15    9605
XP_005254442                                                           15    9605
XP_006718761                                                           15    9605
XP_005252554                                                           15    9605
XP_006717528                                                           15    9605
XP_005252553                                                           15    9605
XP_006714558                                                           15    9605
NP_002364                                                              15    9605
NP_004852                                                              15    9605
>NP_776159
          Length = 402

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KLRIRDFMR 9
           +LR++DF+R
Sbjct: 189 RLRLKDFLR 197
>NP_001273494
          Length = 411

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LRIRDFMR 9
           L +RDFMR
Sbjct: 93  LALRDFMR 100
>NP_001273495
          Length = 401

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LRIRDFMR 9
           L +RDFMR
Sbjct: 93  LALRDFMR 100
>NP_055547
          Length = 411

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LRIRDFMR 9
           L +RDFMR
Sbjct: 93  LALRDFMR 100
>NP_068776
          Length = 703

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLRIRDFMR 9
           K RI+DF+R
Sbjct: 301 KARIQDFVR 309
>XP_005256324
          Length = 301

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LRIRDFMR 9
           L +RDFMR
Sbjct: 93  LALRDFMR 100
>XP_005256322
          Length = 411

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LRIRDFMR 9
           L +RDFMR
Sbjct: 93  LALRDFMR 100
>XP_006719126
          Length = 626

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLRIRDFMR 9
           K RI+DF+R
Sbjct: 224 KARIQDFVR 232
>XP_005253411
          Length = 630

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLRIRDFMR 9
           K RI+DF+R
Sbjct: 228 KARIQDFVR 236
>XP_005253410
          Length = 686

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLRIRDFMR 9
           K RI+DF+R
Sbjct: 284 KARIQDFVR 292
>XP_006719125
          Length = 703

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLRIRDFMR 9
           K RI+DF+R
Sbjct: 301 KARIQDFVR 309
>XP_005253409
          Length = 703

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLRIRDFMR 9
           K RI+DF+R
Sbjct: 301 KARIQDFVR 309
>NP_000229
          Length = 1159

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LRIRDFMR 9
           LR+R+F+R
Sbjct: 678 LRVREFIR 685
>NP_001191727
          Length = 548

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LRIRDFMR 9
           LR+R+F+R
Sbjct: 338 LRVREFIR 345
>NP_742053
          Length = 888

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LRIRDFMR 9
           LR+R+F+R
Sbjct: 678 LRVREFIR 685
>NP_742054
          Length = 819

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LRIRDFMR 9
           LR+R+F+R
Sbjct: 338 LRVREFIR 345
>NP_004981
          Length = 900

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLRIRDFMR 9
           K+RIRD +R
Sbjct: 698 KVRIRDALR 706
>NP_038476
          Length = 1556

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KLRIRDFM 8
           +LR+RDF+
Sbjct: 976 ELRLRDFL 983
>NP_872589
          Length = 1524

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KLRIRDFM 8
           +LR+RDF+
Sbjct: 944 ELRLRDFL 951
>XP_006719461
          Length = 666

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLRIRDFMR 9
           K+RIRD +R
Sbjct: 464 KVRIRDALR 472
>XP_006716040
          Length = 1137

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LRIRDFMR 9
           LR+R+F+R
Sbjct: 656 LRVREFIR 663
>NP_001019831
          Length = 2986

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KLRIRDFMR 9
           ++RI+DF+R
Sbjct: 623 EVRIQDFVR 631
>NP_004336
          Length = 173

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RIRDFMR 9
           RI+DF+R
Sbjct: 159 RIKDFLR 165
>NP_003938
          Length = 1663

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KLRIRDFMR 9
           ++RI+DF+R
Sbjct: 623 EVRIQDFVR 631
>NP_079089
          Length = 612

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LRIRDFMR 9
           LRIR+F R
Sbjct: 461 LRIREFYR 468
>XP_006713880
          Length = 1530

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KLRIRDFMR 9
           ++RI+DF+R
Sbjct: 625 EVRIQDFVR 633
>XP_006713879
          Length = 1656

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KLRIRDFMR 9
           ++RI+DF+R
Sbjct: 625 EVRIQDFVR 633
>XP_006713878
          Length = 1665

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KLRIRDFMR 9
           ++RI+DF+R
Sbjct: 625 EVRIQDFVR 633
>XP_006713877
          Length = 2956

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KLRIRDFMR 9
           ++RI+DF+R
Sbjct: 625 EVRIQDFVR 633
>XP_006713876
          Length = 2966

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KLRIRDFMR 9
           ++RI+DF+R
Sbjct: 625 EVRIQDFVR 633
>XP_006713875
          Length = 2975

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KLRIRDFMR 9
           ++RI+DF+R
Sbjct: 625 EVRIQDFVR 633
>XP_006713874
          Length = 2979

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KLRIRDFMR 9
           ++RI+DF+R
Sbjct: 625 EVRIQDFVR 633
>XP_006713873
          Length = 2988

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KLRIRDFMR 9
           ++RI+DF+R
Sbjct: 625 EVRIQDFVR 633
>XP_005271280
          Length = 566

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LRIRDFMR 9
           LRIR+F R
Sbjct: 461 LRIREFYR 468
>XP_006710968
          Length = 579

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LRIRDFMR 9
           LRIR+F R
Sbjct: 461 LRIREFYR 468
>NP_000512
          Length = 556

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RIRDFMR 9
           +I+DFMR
Sbjct: 366 KIQDFMR 372
>NP_005575
          Length = 359

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   KLRIRD 6
           KLRIRD
Sbjct: 159 KLRIRD 164
>NP_065385
          Length = 731

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLRIRDFM 8
           +LR RDF+
Sbjct: 653 RLRFRDFV 660
>NP_619651
          Length = 384

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  RIRDFMR 9
          RI+DF+R
Sbjct: 88 RIQDFLR 94
>NP_001185797
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LRIRDFMR 9
           +  RDFMR
Sbjct: 336 MSFRDFMR 343
>NP_005177
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LRIRDFMR 9
           +  RDFMR
Sbjct: 336 MSFRDFMR 343
>NP_001185798
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LRIRDFMR 9
           +  RDFMR
Sbjct: 336 MSFRDFMR 343
>NP_001229342
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLRIRDFM 8
           KL+I DF+
Sbjct: 374 KLKIEDFI 381
>NP_009049
          Length = 3097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RIRDFMR 9
           RI+DF+R
Sbjct: 655 RIQDFVR 661
>NP_150375
          Length = 1196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LRIRDFMR 9
           LR+++F+R
Sbjct: 681 LRVKEFIR 688
>NP_787954
          Length = 1551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KLRIRDFMR 9
           +LR+R+F R
Sbjct: 618 RLRMRNFKR 626
>NP_059130
          Length = 1551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KLRIRDFMR 9
           +LR+R+F R
Sbjct: 618 RLRMRNFKR 626
>NP_001096045
          Length = 624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   KLRIRDF 7
           ++R+RDF
Sbjct: 586 QIRVRDF 592
>NP_001136248
          Length = 219

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LRIRDFMR 9
           LR+ DFM+
Sbjct: 177 LRLADFMQ 184
>NP_006248
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLRIRDFM 8
           KL+I DF+
Sbjct: 374 KLKIEDFI 381
>NP_001269574
          Length = 581

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLRIRDFM 8
           KL+I DF+
Sbjct: 249 KLKIEDFI 256
>NP_001269573
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLRIRDFM 8
           KL+I DF+
Sbjct: 338 KLKIEDFI 345
>NP_077016
          Length = 264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LRIRDFMR 9
           LR+ DFM+
Sbjct: 222 LRLADFMQ 229
>NP_997719
          Length = 291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   KLRIRDFM 8
           KL++ DF+
Sbjct: 131 KLKVEDFL 138
>NP_110406
          Length = 994

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LRIRDFMR 9
           LR+++F+R
Sbjct: 530 LRVKEFIR 537
>NP_001265848
          Length = 958

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LRIRDFMR 9
           LR+++F+R
Sbjct: 530 LRVKEFIR 537
>NP_001265849
          Length = 835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LRIRDFMR 9
           LR+++F+R
Sbjct: 407 LRVKEFIR 414
>NP_775115
          Length = 905

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LRIRDFMR 9
           LR+++F+R
Sbjct: 477 LRVKEFIR 484
>NP_775185
          Length = 732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LRIRDFMR 9
           LR+++F+R
Sbjct: 674 LRVKEFIR 681
>XP_005261913
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IRDFMR 9
           IRDF+R
Sbjct: 417 IRDFLR 422
>XP_005261910
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IRDFMR 9
           IRDF+R
Sbjct: 417 IRDFLR 422
>XP_005261905
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IRDFMR 9
           IRDF+R
Sbjct: 417 IRDFLR 422
>XP_005254520
          Length = 1235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KLRIRDFMR 9
           +LR+R+F R
Sbjct: 302 RLRMRNFKR 310
>XP_005254442
          Length = 3041

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLRIRDFMR 9
           KLR  DF+R
Sbjct: 520 KLRHLDFLR 528
>XP_006718761
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LRIRDFMR 9
           +  RDFMR
Sbjct: 336 MSFRDFMR 343
>XP_005252554
          Length = 697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLRIRDFM 8
           KL+I DF+
Sbjct: 408 KLKIEDFI 415
>XP_006717528
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLRIRDFM 8
           KL+I DF+
Sbjct: 374 KLKIEDFI 381
>XP_005252553
          Length = 740

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLRIRDFM 8
           KL+I DF+
Sbjct: 408 KLKIEDFI 415
>XP_006714558
          Length = 2612

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   RIRDFMR 9
           RI+DF+R
Sbjct: 170 RIQDFVR 176
>NP_002364
          Length = 2803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLRIRDFMR 9
           KLR  DF+R
Sbjct: 282 KLRHLDFLR 290
>NP_004852
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   IRDFMR 9
           IRDF+R
Sbjct: 417 IRDFLR 422
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.355    0.162    0.466 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 476,267
Number of extensions: 854
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (17.0 bits)
S2: 28 (15.4 bits)

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