Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055726                                                              19     869
NP_001032203                                                           19     869
NP_068579                                                              19     869
XP_005250580                                                           19     869
NP_065816                                                              17    3301
XP_006710573                                                           17    3301
XP_006710572                                                           17    3301
XP_006710571                                                           17    3301
XP_006710570                                                           17    3301
XP_006710569                                                           17    3301
XP_006710568                                                           17    3301
XP_006710567                                                           17    3301
XP_006710566                                                           17    3301
XP_005245859                                                           17    3301
NP_997320                                                              17    4312
XP_005253612                                                           17    4312
NP_004603                                                              16    5631
NP_055414                                                              16    5631
NP_055777                                                              16    5631
NP_056280                                                              16    5631
NP_957516                                                              16    5631
NP_001239085                                                           16    5631
NP_803182                                                              16    5631
NP_001026918                                                           16    5631
XP_006723613                                                           16    5631
NP_055861                                                              16    7355
NP_005309                                                              16    7355
NP_004970                                                              16    7355
NP_079089                                                              16    7355
XP_005272230                                                           16    7355
XP_005272229                                                           16    7355
XP_005272228                                                           16    7355
XP_005271280                                                           16    7355
XP_006710968                                                           16    7355
NP_150094                                                              15    9605
NP_002410                                                              15    9605
NP_758872                                                              15    9605
NP_001098028                                                           15    9605
NP_079206                                                              15    9605
NP_005457                                                              15    9605
NP_001123498                                                           15    9605
NP_002229                                                              15    9605
NP_001271140                                                           15    9605
NP_001271138                                                           15    9605
XP_006726518                                                           15    9605
XP_006719294                                                           15    9605
XP_006715991                                                           15    9605
XP_006715990                                                           15    9605
XP_005248664                                                           15    9605
XP_005248663                                                           15    9605
XP_006714758                                                           15    9605
NP_001138947                                                           15    9605
NP_775949                                                              15    9605
NP_001123497                                                           15    9605
>NP_055726
          Length = 961

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KLPETVKAS 9
           KLPE VKAS
Sbjct: 332 KLPEPVKAS 340
>NP_001032203
          Length = 473

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   KLPETVKA 8
           K+PETVKA
Sbjct: 291 KIPETVKA 298
>NP_068579
          Length = 974

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   KLPETVKA 8
           K+PETVKA
Sbjct: 291 KIPETVKA 298
>XP_005250580
          Length = 485

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   KLPETVKA 8
           K+PETVKA
Sbjct: 291 KIPETVKA 298
>NP_065816
          Length = 5183

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KLPETVK 7
           KLP+TVK
Sbjct: 159 KLPQTVK 165
>XP_006710573
          Length = 5177

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KLPETVK 7
           KLP+TVK
Sbjct: 159 KLPQTVK 165
>XP_006710572
          Length = 5188

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KLPETVK 7
           KLP+TVK
Sbjct: 159 KLPQTVK 165
>XP_006710571
          Length = 5194

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KLPETVK 7
           KLP+TVK
Sbjct: 159 KLPQTVK 165
>XP_006710570
          Length = 5195

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KLPETVK 7
           KLP+TVK
Sbjct: 159 KLPQTVK 165
>XP_006710569
          Length = 5212

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KLPETVK 7
           KLP+TVK
Sbjct: 159 KLPQTVK 165
>XP_006710568
          Length = 5221

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KLPETVK 7
           KLP+TVK
Sbjct: 159 KLPQTVK 165
>XP_006710567
          Length = 5222

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KLPETVK 7
           KLP+TVK
Sbjct: 159 KLPQTVK 165
>XP_006710566
          Length = 5222

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KLPETVK 7
           KLP+TVK
Sbjct: 159 KLPQTVK 165
>XP_005245859
          Length = 5223

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KLPETVK 7
           KLP+TVK
Sbjct: 159 KLPQTVK 165
>NP_997320
          Length = 4471

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    KLPETVKA 8
            +LPE+VKA
Sbjct: 1943 ELPESVKA 1950
>XP_005253612
          Length = 4589

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    KLPETVKA 8
            +LPE+VKA
Sbjct: 2061 ELPESVKA 2068
>NP_004603
          Length = 503

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLPETVKAS 9
           +LP TVK+S
Sbjct: 110 ELPTTVKSS 118
>NP_055414
          Length = 606

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  KLPETVKAS 9
          ++PET KAS
Sbjct: 38 EVPETPKAS 46
>NP_055777
          Length = 522

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  LPETVK 7
          LPETVK
Sbjct: 18 LPETVK 23
>NP_056280
          Length = 1508

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    KLPETVKA 8
            K PE++KA
Sbjct: 1447 KFPESIKA 1454
>NP_957516
          Length = 606

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  KLPETVKAS 9
          ++PET KAS
Sbjct: 38 EVPETPKAS 46
>NP_001239085
          Length = 1507

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    KLPETVKA 8
            K PE++KA
Sbjct: 1446 KFPESIKA 1453
>NP_803182
          Length = 606

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  KLPETVKAS 9
          ++PET KAS
Sbjct: 38 EVPETPKAS 46
>NP_001026918
          Length = 652

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  KLPETVK 7
          K+PETV+
Sbjct: 65 KIPETVR 71
>XP_006723613
          Length = 522

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  LPETVK 7
          LPETVK
Sbjct: 18 LPETVK 23
>NP_055861
          Length = 2677

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    PETVKA 8
            PET+KA
Sbjct: 1421 PETIKA 1426
>NP_005309
          Length = 194

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KLPETVKA 8
           K P+TVKA
Sbjct: 158 KKPKTVKA 165
>NP_004970
          Length = 647

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   PETVKAS 9
           PETVK S
Sbjct: 639 PETVKIS 645
>NP_079089
          Length = 612

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LPETVKAS 9
           LPE +KAS
Sbjct: 305 LPERLKAS 312
>XP_005272230
          Length = 2706

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    PETVKA 8
            PET+KA
Sbjct: 1421 PETIKA 1426
>XP_005272229
          Length = 2706

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    PETVKA 8
            PET+KA
Sbjct: 1421 PETIKA 1426
>XP_005272228
          Length = 2706

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3    PETVKA 8
            PET+KA
Sbjct: 1421 PETIKA 1426
>XP_005271280
          Length = 566

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LPETVKAS 9
           LPE +KAS
Sbjct: 305 LPERLKAS 312
>XP_006710968
          Length = 579

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LPETVKAS 9
           LPE +KAS
Sbjct: 305 LPERLKAS 312
>NP_150094
          Length = 3564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    LPETVKA 8
            LP T+KA
Sbjct: 1004 LPHTIKA 1010
>NP_002410
          Length = 847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   PETVKAS 9
           PE +KAS
Sbjct: 291 PEVIKAS 297
>NP_758872
          Length = 989

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   LPETVKAS 9
           LPE  KAS
Sbjct: 862 LPERTKAS 869
>NP_001098028
          Length = 281

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KLPETVK 7
           +LP+TVK
Sbjct: 266 RLPKTVK 272
>NP_079206
          Length = 281

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KLPETVK 7
           +LP+TVK
Sbjct: 266 RLPKTVK 272
>NP_005457
          Length = 246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LPETVK 7
           +PETVK
Sbjct: 214 IPETVK 219
>NP_001123498
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LPETVKA 8
           LP+T+KA
Sbjct: 229 LPQTLKA 235
>NP_002229
          Length = 962

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   LPETVKAS 9
           LPE  KAS
Sbjct: 835 LPERTKAS 842
>NP_001271140
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LPETVK 7
           +PETVK
Sbjct: 214 IPETVK 219
>NP_001271138
          Length = 253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LPETVK 7
           +PETVK
Sbjct: 221 IPETVK 226
>XP_006726518
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LPETVKA 8
           LP+T+KA
Sbjct: 360 LPQTLKA 366
>XP_006719294
          Length = 2348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LPETVKA 8
           LP+T+KA
Sbjct: 162 LPDTLKA 168
>XP_006715991
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LPETVKA 8
           LP+T+KA
Sbjct: 393 LPQTLKA 399
>XP_006715990
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LPETVKA 8
           LP+T+KA
Sbjct: 393 LPQTLKA 399
>XP_005248664
          Length = 268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KLPETVK 7
           +LP+TVK
Sbjct: 253 RLPKTVK 259
>XP_005248663
          Length = 281

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KLPETVK 7
           +LP+TVK
Sbjct: 266 RLPKTVK 272
>XP_006714758
          Length = 281

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KLPETVK 7
           +LP+TVK
Sbjct: 266 RLPKTVK 272
>NP_001138947
          Length = 2351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LPETVKA 8
           LP+T+KA
Sbjct: 162 LPDTLKA 168
>NP_775949
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LPETVKA 8
           LP+T+KA
Sbjct: 393 LPQTLKA 399
>NP_001123497
          Length = 845

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LPETVKA 8
           LP+T+KA
Sbjct: 393 LPQTLKA 399
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.296    0.113    0.280 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 764,035
Number of extensions: 1082
Number of successful extensions: 54
Number of sequences better than 10000.0: 54
Number of HSP's gapped: 54
Number of HSP's successfully gapped: 54
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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