Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              20     390
NP_671714                                                              20     390
XP_006715890                                                           20     390
XP_005250160                                                           20     390
XP_005250159                                                           20     390
NP_001254500                                                           18    1482
NP_001254501                                                           18    1482
NP_060891                                                              18    1482
NP_001265371                                                           17    2528
NP_004508                                                              17    2528
NP_001014795                                                           17    2528
NP_001014794                                                           17    2528
NP_001265370                                                           17    2528
XP_005252962                                                           17    2528
XP_005252961                                                           17    2528
NP_068761                                                              16    5631
NP_951008                                                              16    5631
NP_892006                                                              16    7355
NP_149062                                                              16    7355
XP_006715488                                                           16    7355
XP_006715487                                                           16    7355
XP_006715486                                                           16    7355
XP_006715485                                                           16    7355
XP_006715484                                                           16    7355
XP_006715483                                                           16    7355
XP_006715482                                                           16    7355
XP_006715481                                                           16    7355
XP_006715480                                                           16    7355
XP_006715479                                                           16    7355
XP_006715478                                                           16    7355
XP_006715477                                                           16    7355
XP_006715476                                                           16    7355
XP_006715475                                                           16    7355
XP_006715474                                                           16    7355
XP_006715473                                                           16    7355
XP_006715472                                                           16    7355
XP_006715471                                                           16    7355
XP_006715470                                                           16    7355
NP_057937                                                              15    9605
NP_057941                                                              15    9605
NP_065813                                                              15    9605
NP_057936                                                              15    9605
NP_000793                                                              15    9605
XP_005269099                                                           15    9605
>NP_005742
          Length = 3907

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLMNVAMNE 9
           KLMNVA+NE
Sbjct: 489 KLMNVAINE 497
>NP_671714
          Length = 3899

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLMNVAMNE 9
           KLMNVA+NE
Sbjct: 489 KLMNVAINE 497
>XP_006715890
          Length = 3860

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLMNVAMNE 9
           KLMNVA+NE
Sbjct: 489 KLMNVAINE 497
>XP_005250160
          Length = 3939

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLMNVAMNE 9
           KLMNVA+NE
Sbjct: 489 KLMNVAINE 497
>XP_005250159
          Length = 3952

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLMNVAMNE 9
           KLMNVA+NE
Sbjct: 489 KLMNVAINE 497
>NP_001254500
          Length = 928

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLMNVAMNE 9
           KLMN+A N+
Sbjct: 861 KLMNIAFND 869
>NP_001254501
          Length = 468

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLMNVAMNE 9
           KLMN+A N+
Sbjct: 401 KLMNIAFND 409
>NP_060891
          Length = 917

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLMNVAMNE 9
           KLMN+A N+
Sbjct: 850 KLMNIAFND 858
>NP_001265371
          Length = 318

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLMNVAMNE 9
           KLM + MNE
Sbjct: 289 KLMKICMNE 297
>NP_004508
          Length = 452

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLMNVAMNE 9
           KLM + MNE
Sbjct: 423 KLMKICMNE 431
>NP_001014795
          Length = 452

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLMNVAMNE 9
           KLM + MNE
Sbjct: 423 KLMKICMNE 431
>NP_001014794
          Length = 452

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLMNVAMNE 9
           KLM + MNE
Sbjct: 423 KLMKICMNE 431
>NP_001265370
          Length = 391

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLMNVAMNE 9
           KLM + MNE
Sbjct: 362 KLMKICMNE 370
>XP_005252962
          Length = 318

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLMNVAMNE 9
           KLM + MNE
Sbjct: 289 KLMKICMNE 297
>XP_005252961
          Length = 452

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLMNVAMNE 9
           KLM + MNE
Sbjct: 423 KLMKICMNE 431
>NP_068761
          Length = 1133

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LMNVAMNE 9
           L+NV MNE
Sbjct: 538 LINVLMNE 545
>NP_951008
          Length = 1086

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LMNVAMNE 9
           L+NV MNE
Sbjct: 538 LINVLMNE 545
>NP_892006
          Length = 8797

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LMNVAMNE 9
            LMN A NE
Sbjct: 2327 LMNCAQNE 2334
>NP_149062
          Length = 8749

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LMNVAMNE 9
            LMN A NE
Sbjct: 2334 LMNCAQNE 2341
>XP_006715488
          Length = 8721

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LMNVAMNE 9
            LMN A NE
Sbjct: 2334 LMNCAQNE 2341
>XP_006715487
          Length = 8744

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LMNVAMNE 9
            LMN A NE
Sbjct: 2334 LMNCAQNE 2341
>XP_006715486
          Length = 8758

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LMNVAMNE 9
            LMN A NE
Sbjct: 2334 LMNCAQNE 2341
>XP_006715485
          Length = 8793

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LMNVAMNE 9
            LMN A NE
Sbjct: 2281 LMNCAQNE 2288
>XP_006715484
          Length = 8794

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LMNVAMNE 9
            LMN A NE
Sbjct: 2334 LMNCAQNE 2341
>XP_006715483
          Length = 8795

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LMNVAMNE 9
            LMN A NE
Sbjct: 2334 LMNCAQNE 2341
>XP_006715482
          Length = 8797

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LMNVAMNE 9
            LMN A NE
Sbjct: 2327 LMNCAQNE 2334
>XP_006715481
          Length = 8799

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LMNVAMNE 9
            LMN A NE
Sbjct: 2287 LMNCAQNE 2294
>XP_006715480
          Length = 8799

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LMNVAMNE 9
            LMN A NE
Sbjct: 2334 LMNCAQNE 2341
>XP_006715479
          Length = 8804

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LMNVAMNE 9
            LMN A NE
Sbjct: 2334 LMNCAQNE 2341
>XP_006715478
          Length = 8809

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LMNVAMNE 9
            LMN A NE
Sbjct: 2334 LMNCAQNE 2341
>XP_006715477
          Length = 8822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LMNVAMNE 9
            LMN A NE
Sbjct: 2310 LMNCAQNE 2317
>XP_006715476
          Length = 8823

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LMNVAMNE 9
            LMN A NE
Sbjct: 2334 LMNCAQNE 2341
>XP_006715475
          Length = 8827

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LMNVAMNE 9
            LMN A NE
Sbjct: 2334 LMNCAQNE 2341
>XP_006715474
          Length = 8829

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LMNVAMNE 9
            LMN A NE
Sbjct: 2317 LMNCAQNE 2324
>XP_006715473
          Length = 8832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LMNVAMNE 9
            LMN A NE
Sbjct: 2334 LMNCAQNE 2341
>XP_006715472
          Length = 8839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LMNVAMNE 9
            LMN A NE
Sbjct: 2327 LMNCAQNE 2334
>XP_006715471
          Length = 8842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LMNVAMNE 9
            LMN A NE
Sbjct: 2334 LMNCAQNE 2341
>XP_006715470
          Length = 8846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LMNVAMNE 9
            LMN A NE
Sbjct: 2334 LMNCAQNE 2341
>NP_057937
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KLMNVAMN 8
          +L+NV MN
Sbjct: 32 ELLNVCMN 39
>NP_057941
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KLMNVAMN 8
          +L+NV MN
Sbjct: 32 ELLNVCMN 39
>NP_065813
          Length = 1085

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   MNVAMNE 9
           MN A+NE
Sbjct: 966 MNTALNE 972
>NP_057936
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KLMNVAMN 8
          +L+NV MN
Sbjct: 32 ELLNVCMN 39
>NP_000793
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KLMNVAMN 8
          +L+NV MN
Sbjct: 32 ELLNVCMN 39
>XP_005269099
          Length = 1062

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   MNVAMNE 9
           MN A+NE
Sbjct: 943 MNTALNE 949
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.120    0.293 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 264,311
Number of extensions: 340
Number of successful extensions: 44
Number of sequences better than 10000.0: 44
Number of HSP's gapped: 44
Number of HSP's successfully gapped: 44
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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