Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000312                                                              21     229
NP_000057                                                              18    1482
NP_001265472                                                           18    1482
XP_005271223                                                           18    1482
XP_006710936                                                           18    1482
NP_001188358                                                           18    1935
NP_036427                                                              18    1935
NP_001186210                                                           18    1935
XP_006724246                                                           18    1935
XP_006724245                                                           18    1935
XP_006724244                                                           18    1935
XP_006724243                                                           18    1935
XP_005261477                                                           18    1935
XP_005261476                                                           18    1935
XP_005261474                                                           18    1935
XP_006724242                                                           18    1935
XP_005261473                                                           18    1935
XP_005261472                                                           18    1935
NP_036203                                                              17    4312
NP_001012985                                                           16    5631
NP_078800                                                              16    5631
XP_005259175                                                           16    5631
XP_005259174                                                           16    5631
XP_006723374                                                           16    5631
XP_005259173                                                           16    5631
XP_006723373                                                           16    5631
XP_006723372                                                           16    5631
XP_005259172                                                           16    5631
XP_005259171                                                           16    5631
XP_006723371                                                           16    5631
XP_005263404                                                           16    5631
XP_005263403                                                           16    5631
XP_006714474                                                           16    5631
XP_006714473                                                           16    5631
XP_006714472                                                           16    5631
XP_005263402                                                           16    5631
XP_005263401                                                           16    5631
XP_005263399                                                           16    5631
XP_005263400                                                           16    5631
XP_006714471                                                           16    5631
XP_005263398                                                           16    5631
XP_006713805                                                           16    5631
XP_005269417                                                           16    5631
XP_005269415                                                           16    5631
XP_005269414                                                           16    5631
NP_067008                                                              16    5631
NP_000431                                                              16    7355
NP_000274                                                              16    7355
NP_001138763                                                           16    7355
NP_036298                                                              16    7355
NP_072050                                                              16    7355
NP_002050                                                              16    7355
NP_072052                                                              16    7355
NP_072051                                                              16    7355
XP_005251496                                                           16    7355
NP_079465                                                              15    9605
NP_001166142                                                           15    9605
NP_775802                                                              15    9605
XP_006726298                                                           15    9605
XP_006726297                                                           15    9605
XP_006726296                                                           15    9605
XP_006726295                                                           15    9605
XP_006722972                                                           15    9605
XP_005260139                                                           15    9605
XP_005260138                                                           15    9605
XP_005259842                                                           15    9605
XP_006722726                                                           15    9605
XP_006722725                                                           15    9605
XP_005259841                                                           15    9605
XP_005259840                                                           15    9605
XP_006716994                                                           15    9605
>NP_000312
          Length = 928

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KKMYRLAYL 9
           KK+YRLAYL
Sbjct: 652 KKVYRLAYL 660
>NP_000057
          Length = 591

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  KKMYRLAYL 9
          KK YR AYL
Sbjct: 81 KKRYRYAYL 89
>NP_001265472
          Length = 539

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  KKMYRLAYL 9
          KK YR AYL
Sbjct: 29 KKRYRYAYL 37
>XP_005271223
          Length = 628

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   KKMYRLAYL 9
           KK YR AYL
Sbjct: 118 KKRYRYAYL 126
>XP_006710936
          Length = 630

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   KKMYRLAYL 9
           KK YR AYL
Sbjct: 120 KKRYRYAYL 128
>NP_001188358
          Length = 2170

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KKMYRLAYL 9
            K +YRLA+L
Sbjct: 1478 KSLYRLAFL 1486
>NP_036427
          Length = 2220

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KKMYRLAYL 9
            K +YRLA+L
Sbjct: 1528 KSLYRLAFL 1536
>NP_001186210
          Length = 2220

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KKMYRLAYL 9
            K +YRLA+L
Sbjct: 1528 KSLYRLAFL 1536
>XP_006724246
          Length = 2103

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KKMYRLAYL 9
            K +YRLA+L
Sbjct: 1558 KSLYRLAFL 1566
>XP_006724245
          Length = 2191

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KKMYRLAYL 9
            K +YRLA+L
Sbjct: 1499 KSLYRLAFL 1507
>XP_006724244
          Length = 2191

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KKMYRLAYL 9
            K +YRLA+L
Sbjct: 1528 KSLYRLAFL 1536
>XP_006724243
          Length = 2196

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KKMYRLAYL 9
            K +YRLA+L
Sbjct: 1499 KSLYRLAFL 1507
>XP_005261477
          Length = 2200

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KKMYRLAYL 9
            K +YRLA+L
Sbjct: 1558 KSLYRLAFL 1566
>XP_005261476
          Length = 2210

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KKMYRLAYL 9
            K +YRLA+L
Sbjct: 1513 KSLYRLAFL 1521
>XP_005261474
          Length = 2225

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KKMYRLAYL 9
            K +YRLA+L
Sbjct: 1528 KSLYRLAFL 1536
>XP_006724242
          Length = 2226

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KKMYRLAYL 9
            K +YRLA+L
Sbjct: 1558 KSLYRLAFL 1566
>XP_005261473
          Length = 2250

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KKMYRLAYL 9
            K +YRLA+L
Sbjct: 1558 KSLYRLAFL 1566
>XP_005261472
          Length = 2255

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KKMYRLAYL 9
            K +YRLA+L
Sbjct: 1558 KSLYRLAFL 1566
>NP_036203
          Length = 195

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KMYRLAYL 9
           +MYR AYL
Sbjct: 143 RMYRPAYL 150
>NP_001012985
          Length = 1706

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KKMYRLAYL 9
            KK+YR  Y+
Sbjct: 1178 KKVYRAEYI 1186
>NP_078800
          Length = 1226

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KMYRLAYL 9
           K+YR AYL
Sbjct: 405 KLYRDAYL 412
>XP_005259175
          Length = 595

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KMYRLAYL 9
          K+Y+L YL
Sbjct: 22 KLYQLVYL 29
>XP_005259174
          Length = 799

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KMYRLAYL 9
           K+Y+L YL
Sbjct: 226 KLYQLVYL 233
>XP_006723374
          Length = 1159

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KMYRLAYL 9
           K+Y+L YL
Sbjct: 586 KLYQLVYL 593
>XP_005259173
          Length = 1099

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KMYRLAYL 9
           K+Y+L YL
Sbjct: 526 KLYQLVYL 533
>XP_006723373
          Length = 1120

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KMYRLAYL 9
           K+Y+L YL
Sbjct: 547 KLYQLVYL 554
>XP_006723372
          Length = 1159

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KMYRLAYL 9
           K+Y+L YL
Sbjct: 586 KLYQLVYL 593
>XP_005259172
          Length = 1159

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KMYRLAYL 9
           K+Y+L YL
Sbjct: 586 KLYQLVYL 593
>XP_005259171
          Length = 1159

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KMYRLAYL 9
           K+Y+L YL
Sbjct: 586 KLYQLVYL 593
>XP_006723371
          Length = 1159

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KMYRLAYL 9
           K+Y+L YL
Sbjct: 586 KLYQLVYL 593
>XP_005263404
          Length = 1308

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KKMYRLAYL 9
            KK+YR  Y+
Sbjct: 1179 KKVYRAEYI 1187
>XP_005263403
          Length = 1672

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KKMYRLAYL 9
            KK+YR  Y+
Sbjct: 1179 KKVYRAEYI 1187
>XP_006714474
          Length = 1674

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KKMYRLAYL 9
            KK+YR  Y+
Sbjct: 1146 KKVYRAEYI 1154
>XP_006714473
          Length = 1675

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KKMYRLAYL 9
            KK+YR  Y+
Sbjct: 1147 KKVYRAEYI 1155
>XP_006714472
          Length = 1706

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KKMYRLAYL 9
            KK+YR  Y+
Sbjct: 1178 KKVYRAEYI 1186
>XP_005263402
          Length = 1707

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KKMYRLAYL 9
            KK+YR  Y+
Sbjct: 1179 KKVYRAEYI 1187
>XP_005263401
          Length = 1707

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KKMYRLAYL 9
            KK+YR  Y+
Sbjct: 1179 KKVYRAEYI 1187
>XP_005263399
          Length = 1707

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KKMYRLAYL 9
            KK+YR  Y+
Sbjct: 1179 KKVYRAEYI 1187
>XP_005263400
          Length = 1707

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KKMYRLAYL 9
            KK+YR  Y+
Sbjct: 1179 KKVYRAEYI 1187
>XP_006714471
          Length = 1707

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KKMYRLAYL 9
            KK+YR  Y+
Sbjct: 1179 KKVYRAEYI 1187
>XP_005263398
          Length = 1707

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KKMYRLAYL 9
            KK+YR  Y+
Sbjct: 1179 KKVYRAEYI 1187
>XP_006713805
          Length = 1074

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KMYRLAYL 9
           K+YR AYL
Sbjct: 223 KLYRDAYL 230
>XP_005269417
          Length = 1104

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KMYRLAYL 9
           K+YR AYL
Sbjct: 405 KLYRDAYL 412
>XP_005269415
          Length = 1229

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KMYRLAYL 9
           K+YR AYL
Sbjct: 378 KLYRDAYL 385
>XP_005269414
          Length = 1256

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KMYRLAYL 9
           K+YR AYL
Sbjct: 405 KLYRDAYL 412
>NP_067008
          Length = 1159

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KMYRLAYL 9
           K+Y+L YL
Sbjct: 586 KLYQLVYL 593
>NP_000431
          Length = 860

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KMYRLAYL 9
           K+Y L+YL
Sbjct: 223 KVYHLSYL 230
>NP_000274
          Length = 854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KMYRLAYL 9
           K+Y L+YL
Sbjct: 221 KIYHLSYL 228
>NP_001138763
          Length = 853

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KMYRLAYL 9
           K+Y L+YL
Sbjct: 221 KIYHLSYL 228
>NP_036298
          Length = 956

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   MYRLAY 8
           MYRL+Y
Sbjct: 371 MYRLSY 376
>NP_072050
          Length = 202

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  KKMYRLAY 8
          +++Y+LAY
Sbjct: 44 RRLYQLAY 51
>NP_002050
          Length = 217

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  KKMYRLAY 8
          +++Y+LAY
Sbjct: 44 RRLYQLAY 51
>NP_072052
          Length = 245

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  KKMYRLAY 8
          +++Y+LAY
Sbjct: 44 RRLYQLAY 51
>NP_072051
          Length = 256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  KKMYRLAY 8
          +++Y+LAY
Sbjct: 44 RRLYQLAY 51
>XP_005251496
          Length = 653

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   MYRLAY 8
           MYRL+Y
Sbjct: 371 MYRLSY 376
>NP_079465
          Length = 570

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KKMYRLAYL 9
           K  YR +YL
Sbjct: 380 KAFYRFSYL 388
>NP_001166142
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KKMYRLAYL 9
           K  YR +YL
Sbjct: 379 KAFYRFSYL 387
>NP_775802
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KKMYRLAYL 9
           K  YR +YL
Sbjct: 380 KAFYRFSYL 388
>XP_006726298
          Length = 327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KKMYRLAYL 9
           K  YR +YL
Sbjct: 165 KAFYRFSYL 173
>XP_006726297
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KKMYRLAYL 9
           K  YR +YL
Sbjct: 317 KAFYRFSYL 325
>XP_006726296
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KKMYRLAYL 9
           K  YR +YL
Sbjct: 347 KAFYRFSYL 355
>XP_006726295
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KKMYRLAYL 9
           K  YR +YL
Sbjct: 379 KAFYRFSYL 387
>XP_006722972
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KKMYRLAYL 9
           K  YR +YL
Sbjct: 348 KAFYRFSYL 356
>XP_005260139
          Length = 514

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KKMYRLAYL 9
           K  YR +YL
Sbjct: 380 KAFYRFSYL 388
>XP_005260138
          Length = 539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KKMYRLAYL 9
           K  YR +YL
Sbjct: 349 KAFYRFSYL 357
>XP_005259842
          Length = 327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KKMYRLAYL 9
           K  YR +YL
Sbjct: 165 KAFYRFSYL 173
>XP_006722726
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KKMYRLAYL 9
           K  YR +YL
Sbjct: 317 KAFYRFSYL 325
>XP_006722725
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KKMYRLAYL 9
           K  YR +YL
Sbjct: 317 KAFYRFSYL 325
>XP_005259841
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KKMYRLAYL 9
           K  YR +YL
Sbjct: 347 KAFYRFSYL 355
>XP_005259840
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KKMYRLAYL 9
           K  YR +YL
Sbjct: 379 KAFYRFSYL 387
>XP_006716994
          Length = 534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KKMYRL 6
           KK+YRL
Sbjct: 481 KKLYRL 486
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.337    0.144    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 446,595
Number of extensions: 608
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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