Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005219                                                              19     869
NP_776175                                                              17    4312
NP_001137307                                                           17    4312
NP_057232                                                              17    4312
NP_006156                                                              17    4312
XP_006723297                                                           17    4312
XP_006723296                                                           17    4312
XP_005259020                                                           17    4312
XP_005254368                                                           17    4312
XP_006720536                                                           17    4312
XP_006720120                                                           17    4312
XP_006720119                                                           17    4312
XP_005271626                                                           17    4312
XP_005271625                                                           17    4312
XP_005271624                                                           17    4312
XP_005271623                                                           17    4312
XP_005271622                                                           17    4312
NP_689659                                                              17    4312
NP_060220                                                              16    5631
NP_061927                                                              16    5631
XP_006717968                                                           16    5631
XP_006717967                                                           16    5631
XP_006717966                                                           16    5631
XP_006717965                                                           16    5631
NP_001274420                                                           16    7355
NP_001121685                                                           16    7355
NP_001121684                                                           16    7355
NP_001275896                                                           16    7355
NP_001275894                                                           16    7355
NP_077817                                                              16    7355
NP_001275893                                                           16    7355
XP_005247863                                                           16    7355
XP_006712405                                                           16    7355
XP_006712404                                                           16    7355
XP_005246413                                                           16    7355
XP_005264244                                                           16    7355
NP_689741                                                              16    7355
NP_061853                                                              15    9605
NP_036473                                                              15    9605
XP_006725006                                                           15    9605
XP_006717500                                                           15    9605
NP_005859                                                              15    9605
>NP_005219
          Length = 1210

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KKIKVLSSG 9
           KKIKVL SG
Sbjct: 713 KKIKVLGSG 721
>NP_776175
          Length = 1150

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  KKIKVLSSG 9
          K+I+VLS+G
Sbjct: 83 KRIEVLSNG 91
>NP_001137307
          Length = 1299

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   IKVLSSG 9
           IKVLSSG
Sbjct: 695 IKVLSSG 701
>NP_057232
          Length = 2161

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KKIKVLSSG 9
           +KIKVLS G
Sbjct: 579 EKIKVLSIG 587
>NP_006156
          Length = 1324

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   IKVLSSG 9
           IKVLSSG
Sbjct: 720 IKVLSSG 726
>XP_006723297
          Length = 2152

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KKIKVLSSG 9
           +KIKVLS G
Sbjct: 579 EKIKVLSIG 587
>XP_006723296
          Length = 2161

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KKIKVLSSG 9
           +KIKVLS G
Sbjct: 579 EKIKVLSIG 587
>XP_005259020
          Length = 2169

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KKIKVLSSG 9
           +KIKVLS G
Sbjct: 579 EKIKVLSIG 587
>XP_005254368
          Length = 712

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  KKIKVLSSG 9
          K+I+VLS+G
Sbjct: 83 KRIEVLSNG 91
>XP_006720536
          Length = 1072

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  KKIKVLSSG 9
          K+I+VLS+G
Sbjct: 5  KRIEVLSNG 13
>XP_006720120
          Length = 1055

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KKIKVLSSG 9
           +K+KV SSG
Sbjct: 809 EKLKVFSSG 817
>XP_006720119
          Length = 1094

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KKIKVLSSG 9
           +K+KV SSG
Sbjct: 848 EKLKVFSSG 856
>XP_005271626
          Length = 1294

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   IKVLSSG 9
           IKVLSSG
Sbjct: 779 IKVLSSG 785
>XP_005271625
          Length = 1311

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   IKVLSSG 9
           IKVLSSG
Sbjct: 707 IKVLSSG 713
>XP_005271624
          Length = 1311

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   IKVLSSG 9
           IKVLSSG
Sbjct: 707 IKVLSSG 713
>XP_005271623
          Length = 1371

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   IKVLSSG 9
           IKVLSSG
Sbjct: 767 IKVLSSG 773
>XP_005271622
          Length = 1383

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   IKVLSSG 9
           IKVLSSG
Sbjct: 779 IKVLSSG 785
>NP_689659
          Length = 1094

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KKIKVLSSG 9
           +K+KV SSG
Sbjct: 848 EKLKVFSSG 856
>NP_060220
          Length = 610

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KKIKVLSSG 9
           K +KV+SSG
Sbjct: 196 KLVKVVSSG 204
>NP_061927
          Length = 835

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KKIKVLSSG 9
           KK+K++S+G
Sbjct: 400 KKMKLISNG 408
>XP_006717968
          Length = 952

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KKIKVLSSG 9
           KK+K++S+G
Sbjct: 400 KKMKLISNG 408
>XP_006717967
          Length = 952

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KKIKVLSSG 9
           KK+K++S+G
Sbjct: 400 KKMKLISNG 408
>XP_006717966
          Length = 952

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KKIKVLSSG 9
           KK+K++S+G
Sbjct: 400 KKMKLISNG 408
>XP_006717965
          Length = 958

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KKIKVLSSG 9
           KK+K++S+G
Sbjct: 406 KKMKLISNG 414
>NP_001274420
          Length = 1795

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KKIKVLSSG 9
           K+IK+ SSG
Sbjct: 755 KQIKIESSG 763
>NP_001121685
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KIKVLSSG 9
           K+K LSSG
Sbjct: 396 KVKSLSSG 403
>NP_001121684
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KIKVLSSG 9
           K+K LSSG
Sbjct: 396 KVKSLSSG 403
>NP_001275896
          Length = 445

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KKIKVLS 7
           KK+KVLS
Sbjct: 438 KKLKVLS 444
>NP_001275894
          Length = 577

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KKIKVLS 7
           KK+KVLS
Sbjct: 570 KKLKVLS 576
>NP_077817
          Length = 597

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KKIKVLS 7
           KK+KVLS
Sbjct: 590 KKLKVLS 596
>NP_001275893
          Length = 579

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KKIKVLS 7
           KK+KVLS
Sbjct: 572 KKLKVLS 578
>XP_005247863
          Length = 597

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KKIKVLS 7
           KK+KVLS
Sbjct: 590 KKLKVLS 596
>XP_006712405
          Length = 238

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KIKVLSSG 9
           K+K LSSG
Sbjct: 158 KVKSLSSG 165
>XP_006712404
          Length = 307

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KIKVLSSG 9
           K+K LSSG
Sbjct: 227 KVKSLSSG 234
>XP_005246413
          Length = 384

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KIKVLSSG 9
           K+K LSSG
Sbjct: 304 KVKSLSSG 311
>XP_005264244
          Length = 1795

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KKIKVLSSG 9
           K+IK+ SSG
Sbjct: 755 KQIKIESSG 763
>NP_689741
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KIKVLSSG 9
           K+K LSSG
Sbjct: 396 KVKSLSSG 403
>NP_061853
          Length = 299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KKIKVLSSG 9
           KK+KV S+G
Sbjct: 200 KKMKVHSAG 208
>NP_036473
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KKIKVLSS 8
           KK+K+L S
Sbjct: 491 KKLKILES 498
>XP_006725006
          Length = 570

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KKIKVLSS 8
           KK+K+L S
Sbjct: 444 KKLKILQS 451
>XP_006717500
          Length = 539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KKIKVLSS 8
           KK+K+L S
Sbjct: 396 KKLKILES 403
>NP_005859
          Length = 118

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KIKVLSSG 9
          K+K+LS G
Sbjct: 84 KLKILSRG 91
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.304    0.126    0.296 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 400,129
Number of extensions: 450
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package