Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_037440                                                              20     390
XP_005247460                                                           20     390
XP_005247459                                                           20     390
NP_001245340                                                           17    3301
NP_001245342                                                           17    3301
NP_443176                                                              17    3301
NP_001245341                                                           17    3301
NP_005758                                                              17    3301
NP_001155969                                                           17    3301
NP_001245343                                                           17    3301
XP_005255139                                                           17    3301
XP_006721078                                                           17    3301
XP_005255138                                                           17    3301
XP_006721077                                                           17    3301
XP_005255137                                                           17    3301
NP_001155970                                                           17    3301
NP_036471                                                              17    4312
NP_775760                                                              17    4312
XP_006714502                                                           17    4312
NP_001077430                                                           16    5631
NP_775907                                                              16    5631
NP_000903                                                              16    5631
NP_001269833                                                           16    5631
NP_775099                                                              16    5631
NP_056472                                                              16    5631
XP_005258866                                                           16    5631
XP_005251309                                                           16    5631
NP_001257906                                                           16    7355
NP_001257904                                                           16    7355
NP_001257905                                                           16    7355
NP_055576                                                              16    7355
NP_036423                                                              16    7355
NP_056996                                                              16    7355
NP_056542                                                              16    7355
NP_056280                                                              16    7355
NP_001049                                                              16    7355
NP_001239085                                                           16    7355
XP_006719768                                                           16    7355
XP_005250985                                                           16    7355
XP_006716634                                                           16    7355
NP_919227                                                              16    7355
NP_006436                                                              15    9605
NP_003741                                                              15    9605
NP_004358                                                              15    9605
NP_113597                                                              15    9605
NP_006662                                                              15    9605
NP_001274524                                                           15    9605
NP_001274526                                                           15    9605
NP_060717                                                              15    9605
NP_055032                                                              15    9605
NP_001017425                                                           15    9605
NP_003560                                                              15    9605
NP_001017424                                                           15    9605
NP_001137430                                                           15    9605
NP_001135780                                                           15    9605
>NP_037440
          Length = 319

 Score = 20.0 bits (40), Expect =   390
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   KIVSTVIWL 9
           K++STV+WL
Sbjct: 132 KMISTVVWL 140
>XP_005247460
          Length = 319

 Score = 20.0 bits (40), Expect =   390
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   KIVSTVIWL 9
           K++STV+WL
Sbjct: 132 KMISTVVWL 140
>XP_005247459
          Length = 319

 Score = 20.0 bits (40), Expect =   390
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   KIVSTVIWL 9
           K++STV+WL
Sbjct: 132 KMISTVVWL 140
>NP_001245340
          Length = 640

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   KIVSTVIWL 9
           K+V  ++WL
Sbjct: 581 KVVKAILWL 589
>NP_001245342
          Length = 611

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   KIVSTVIWL 9
           K+V  ++WL
Sbjct: 552 KVVKAILWL 560
>NP_443176
          Length = 675

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   KIVSTVIWL 9
           K+V  ++WL
Sbjct: 616 KVVKAILWL 624
>NP_001245341
          Length = 605

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   KIVSTVIWL 9
           K+V  ++WL
Sbjct: 546 KVVKAILWL 554
>NP_005758
          Length = 344

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KIVSTVIWL 9
           KIV T +WL
Sbjct: 134 KIVCTGVWL 142
>NP_001155969
          Length = 344

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KIVSTVIWL 9
           KIV T +WL
Sbjct: 134 KIVCTGVWL 142
>NP_001245343
          Length = 519

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   KIVSTVIWL 9
           K+V  ++WL
Sbjct: 460 KVVKAILWL 468
>XP_005255139
          Length = 514

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   KIVSTVIWL 9
           K+V  ++WL
Sbjct: 455 KVVKAILWL 463
>XP_006721078
          Length = 576

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   KIVSTVIWL 9
           K+V  ++WL
Sbjct: 517 KVVKAILWL 525
>XP_005255138
          Length = 583

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   KIVSTVIWL 9
           K+V  ++WL
Sbjct: 524 KVVKAILWL 532
>XP_006721077
          Length = 655

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   KIVSTVIWL 9
           K+V  ++WL
Sbjct: 596 KVVKAILWL 604
>XP_005255137
          Length = 675

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   KIVSTVIWL 9
           K+V  ++WL
Sbjct: 616 KVVKAILWL 624
>NP_001155970
          Length = 344

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KIVSTVIWL 9
           KIV T +WL
Sbjct: 134 KIVCTGVWL 142
>NP_036471
          Length = 294

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  IVSTVIWL 9
          I STV WL
Sbjct: 26 IYSTVFWL 33
>NP_775760
          Length = 1585

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KIVSTVIW 8
           K +STV+W
Sbjct: 563 KNISTVLW 570
>XP_006714502
          Length = 1064

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KIVSTVIW 8
          K +STV+W
Sbjct: 46 KNISTVLW 53
>NP_001077430
          Length = 1523

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    KIVSTVIWL 9
            ++VST +W+
Sbjct: 1454 ELVSTFLWI 1462
>NP_775907
          Length = 1518

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    KIVSTVIWL 9
            ++VST +W+
Sbjct: 1449 ELVSTFLWI 1457
>NP_000903
          Length = 380

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KIVSTVIWL 9
           KI++  IWL
Sbjct: 176 KIINICIWL 184
>NP_001269833
          Length = 291

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  KIVSTVIWL 9
          KI++  IWL
Sbjct: 87 KIINICIWL 95
>NP_775099
          Length = 2595

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KIVSTVIWL 9
           +I+S V WL
Sbjct: 594 EIISQVFWL 602
>NP_056472
          Length = 2277

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KIVSTVIWL 9
           +I+S V WL
Sbjct: 276 EIISQVFWL 284
>XP_005258866
          Length = 1486

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    KIVSTVIWL 9
            ++VST +W+
Sbjct: 1417 ELVSTFLWI 1425
>XP_005251309
          Length = 366

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KIVSTVIWL 9
           KI++  IWL
Sbjct: 162 KIINICIWL 170
>NP_001257906
          Length = 335

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VSTVIW 8
           VST+IW
Sbjct: 100 VSTLIW 105
>NP_001257904
          Length = 366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VSTVIW 8
           VST+IW
Sbjct: 100 VSTLIW 105
>NP_001257905
          Length = 379

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VSTVIW 8
           VST+IW
Sbjct: 113 VSTLIW 118
>NP_055576
          Length = 360

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VSTVIW 8
           VST+IW
Sbjct: 100 VSTLIW 105
>NP_036423
          Length = 2120

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   STVIWL 9
           STV+W+
Sbjct: 432 STVVWM 437
>NP_056996
          Length = 1406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    IVSTVIWL 9
            +VST +WL
Sbjct: 1260 LVSTGLWL 1267
>NP_056542
          Length = 311

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KIVSTVIWL 9
           K+V  VIW+
Sbjct: 148 KVVICVIWV 156
>NP_056280
          Length = 1508

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   KIVSTVIW 8
           K+V+T+ W
Sbjct: 579 KLVNTISW 586
>NP_001049
          Length = 407

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KIVSTVIWL 9
           K+V  VIW+
Sbjct: 148 KVVICVIWV 156
>NP_001239085
          Length = 1507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   KIVSTVIW 8
           K+V+T+ W
Sbjct: 578 KLVNTISW 585
>XP_006719768
          Length = 2120

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   STVIWL 9
           STV+W+
Sbjct: 432 STVVWM 437
>XP_005250985
          Length = 1406

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    IVSTVIWL 9
            +VST +WL
Sbjct: 1260 LVSTGLWL 1267
>XP_006716634
          Length = 1420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    IVSTVIWL 9
            +VST +WL
Sbjct: 1274 LVSTGLWL 1281
>NP_919227
          Length = 419

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IVSTVIWL 9
           I+S ++WL
Sbjct: 257 IISALLWL 264
>NP_006436
          Length = 2335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1    KIVSTVIW 8
            KI+ T +W
Sbjct: 1820 KIIHTSVW 1827
>NP_003741
          Length = 1382

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   VSTVIW 8
           VSTV W
Sbjct: 279 VSTVFW 284
>NP_004358
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   KIVSTVIW 8
           KI+  V+W
Sbjct: 165 KIICLVVW 172
>NP_113597
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   KIVSTVIW 8
           KI+  V+W
Sbjct: 165 KIICLVVW 172
>NP_006662
          Length = 560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   KIVSTVIW 8
           KIV+  +W
Sbjct: 259 KIVAVAVW 266
>NP_001274524
          Length = 619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   KIVSTVIW 8
           KIV+  +W
Sbjct: 259 KIVAVAVW 266
>NP_001274526
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1   KIVSTVIW 8
           KIV+  +W
Sbjct: 187 KIVAVAVW 194
>NP_060717
          Length = 361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IVSTVIWL 9
           I+ST+ W+
Sbjct: 311 ILSTISWM 318
>NP_055032
          Length = 411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KIVSTVIWL 9
           +I+ST+I++
Sbjct: 207 RIISTIIFI 215
>NP_001017425
          Length = 426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KIVSTVIWL 9
           +I+ST+I++
Sbjct: 222 RIISTIIFI 230
>NP_003560
          Length = 261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   IVSTVIW 8
           I+S +IW
Sbjct: 251 IISLIIW 257
>NP_001017424
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KIVSTVIWL 9
           +I+ST+I++
Sbjct: 218 RIISTIIFI 226
>NP_001137430
          Length = 325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IVSTVIWL 9
           I+ST+ W+
Sbjct: 275 ILSTISWM 282
>NP_001135780
          Length = 2156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   STVIW 8
           STVIW
Sbjct: 760 STVIW 764
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.137    0.463 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 467,425
Number of extensions: 518
Number of successful extensions: 55
Number of sequences better than 10000.0: 55
Number of HSP's gapped: 55
Number of HSP's successfully gapped: 55
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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