Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005219                                                              20     390
NP_004323                                                              18    1482
NP_001554                                                              17    2528
NP_001269297                                                           17    2528
XP_006714694                                                           17    3301
NP_001008398                                                           17    3301
NP_056080                                                              17    4312
NP_001165980                                                           17    4312
NP_001165988                                                           17    4312
NP_001156806                                                           17    4312
NP_620135                                                              17    4312
NP_001156807                                                           17    4312
XP_005246453                                                           17    4312
XP_006712435                                                           17    4312
NP_001091846                                                           16    5631
NP_001010890                                                           16    5631
NP_001009611                                                           16    5631
NP_001139816                                                           16    5631
NP_001013425                                                           16    5631
NP_001276866                                                           16    5631
NP_004439                                                              16    5631
NP_001276865                                                           16    5631
NP_001005862                                                           16    5631
NP_078954                                                              16    5631
NP_001026862                                                           16    5631
NP_005815                                                              16    5631
XP_005276181                                                           16    5631
XP_005276180                                                           16    5631
XP_005276179                                                           16    5631
XP_006725019                                                           16    5631
XP_005257197                                                           16    5631
XP_006721828                                                           16    5631
XP_006720644                                                           16    5631
XP_005254542                                                           16    5631
XP_005254541                                                           16    5631
XP_005254540                                                           16    5631
XP_005254538                                                           16    5631
XP_005250165                                                           16    5631
XP_006711146                                                           16    5631
XP_006711145                                                           16    5631
XP_006711143                                                           16    5631
XP_006710315                                                           16    5631
NP_001010889                                                           16    5631
NP_001104262                                                           16    7355
NP_001973                                                              16    7355
NP_065816                                                              16    7355
NP_004983                                                              16    7355
NP_981953                                                              16    7355
XP_005274738                                                           16    7355
XP_006710573                                                           16    7355
XP_006710572                                                           16    7355
XP_006710571                                                           16    7355
XP_006710570                                                           16    7355
XP_006710569                                                           16    7355
XP_006710568                                                           16    7355
XP_006710567                                                           16    7355
XP_006710566                                                           16    7355
XP_005245859                                                           16    7355
NP_001093322                                                           15    9605
NP_000148                                                              15    9605
NP_001005742                                                           15    9605
NP_001165282                                                           15    9605
NP_001005741                                                           15    9605
NP_057160                                                              15    9605
NP_079357                                                              15    9605
NP_001182209                                                           15    9605
XP_006726274                                                           15    9605
XP_006711333                                                           15    9605
>NP_005219
          Length = 1210

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KFKKIKVLG 9
           +FKKIKVLG
Sbjct: 711 EFKKIKVLG 719
>NP_004323
          Length = 291

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KFKKIKVLG 9
           KFKK+ +LG
Sbjct: 129 KFKKVSLLG 137
>NP_001554
          Length = 797

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   FKKIKVLG 9
           FKKI VLG
Sbjct: 280 FKKIHVLG 287
>NP_001269297
          Length = 719

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   FKKIKVLG 9
           FKKI VLG
Sbjct: 202 FKKIHVLG 209
>XP_006714694
          Length = 210

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FKKIKVLG 9
           F KIK+LG
Sbjct: 138 FHKIKILG 145
>NP_001008398
          Length = 209

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FKKIKVLG 9
           F KIK+LG
Sbjct: 137 FHKIKILG 144
>NP_056080
          Length = 733

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KFKKIKV 7
           K+KKIKV
Sbjct: 228 KYKKIKV 234
>NP_001165980
          Length = 733

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KFKKIKV 7
           K+KKIKV
Sbjct: 228 KYKKIKV 234
>NP_001165988
          Length = 733

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KFKKIKV 7
           K+KKIKV
Sbjct: 228 KYKKIKV 234
>NP_001156806
          Length = 752

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KFKKIKVLG 9
           +FK++ VLG
Sbjct: 127 RFKQVNVLG 135
>NP_620135
          Length = 730

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KFKKIKVLG 9
           +FK++ VLG
Sbjct: 127 RFKQVNVLG 135
>NP_001156807
          Length = 730

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KFKKIKVLG 9
           +FK++ VLG
Sbjct: 127 RFKQVNVLG 135
>XP_005246453
          Length = 675

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KFKKIKV 7
           K+KKIKV
Sbjct: 170 KYKKIKV 176
>XP_006712435
          Length = 733

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KFKKIKV 7
           K+KKIKV
Sbjct: 228 KYKKIKV 234
>NP_001091846
          Length = 478

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KKIKVLG 9
           KK+K+LG
Sbjct: 185 KKLKILG 191
>NP_001010890
          Length = 478

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KKIKVLG 9
           KK+K+LG
Sbjct: 185 KKLKILG 191
>NP_001009611
          Length = 478

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KKIKVLG 9
           KK+K+LG
Sbjct: 185 KKLKILG 191
>NP_001139816
          Length = 478

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KKIKVLG 9
           KK+K+LG
Sbjct: 185 KKLKILG 191
>NP_001013425
          Length = 476

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KKIKVLG 9
           KK+K+LG
Sbjct: 183 KKLKILG 189
>NP_001276866
          Length = 1055

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KFKKIKVLG 9
           + +K+KVLG
Sbjct: 719 ELRKVKVLG 727
>NP_004439
          Length = 1255

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KFKKIKVLG 9
           + +K+KVLG
Sbjct: 719 ELRKVKVLG 727
>NP_001276865
          Length = 1240

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KFKKIKVLG 9
           + +K+KVLG
Sbjct: 704 ELRKVKVLG 712
>NP_001005862
          Length = 1225

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KFKKIKVLG 9
           + +K+KVLG
Sbjct: 689 ELRKVKVLG 697
>NP_078954
          Length = 477

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KFKKIKVLG 9
           K +KIKV+G
Sbjct: 111 KAEKIKVIG 119
>NP_001026862
          Length = 441

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KFKKIKVL 8
           KFKK+K L
Sbjct: 103 KFKKLKSL 110
>NP_005815
          Length = 313

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KFKKIKVL 8
           KFKK+K L
Sbjct: 103 KFKKLKSL 110
>XP_005276181
          Length = 478

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KKIKVLG 9
           KK+K+LG
Sbjct: 185 KKLKILG 191
>XP_005276180
          Length = 478

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KKIKVLG 9
           KK+K+LG
Sbjct: 185 KKLKILG 191
>XP_005276179
          Length = 478

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KKIKVLG 9
           KK+K+LG
Sbjct: 185 KKLKILG 191
>XP_006725019
          Length = 478

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KKIKVLG 9
           KK+K+LG
Sbjct: 185 KKLKILG 191
>XP_005257197
          Length = 1225

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KFKKIKVLG 9
           + +K+KVLG
Sbjct: 689 ELRKVKVLG 697
>XP_006721828
          Length = 1336

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KFKKIKVLG 9
           + +K+KVLG
Sbjct: 800 ELRKVKVLG 808
>XP_006720644
          Length = 699

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  KFKKIKVLG 9
          KF+ +++LG
Sbjct: 28 KFRAVRILG 36
>XP_005254542
          Length = 756

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  KFKKIKVLG 9
          KF+ +++LG
Sbjct: 28 KFRAVRILG 36
>XP_005254541
          Length = 890

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  KFKKIKVLG 9
          KF+ +++LG
Sbjct: 28 KFRAVRILG 36
>XP_005254540
          Length = 924

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  KFKKIKVLG 9
          KF+ +++LG
Sbjct: 28 KFRAVRILG 36
>XP_005254538
          Length = 993

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  KFKKIKVLG 9
          KF+ +++LG
Sbjct: 28 KFRAVRILG 36
>XP_005250165
          Length = 441

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KFKKIKVL 8
           KFKK+K L
Sbjct: 103 KFKKLKSL 110
>XP_006711146
          Length = 478

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KKIKVLG 9
           KK+K+LG
Sbjct: 185 KKLKILG 191
>XP_006711145
          Length = 478

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KKIKVLG 9
           KK+K+LG
Sbjct: 185 KKLKILG 191
>XP_006711143
          Length = 478

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KKIKVLG 9
           KK+K+LG
Sbjct: 185 KKLKILG 191
>XP_006710315
          Length = 287

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KKIKVLG 9
           KK+K+LG
Sbjct: 185 KKLKILG 191
>NP_001010889
          Length = 476

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KKIKVLG 9
           KK+K+LG
Sbjct: 183 KKLKILG 189
>NP_001104262
          Length = 498

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KFKKIK 6
          KFKK+K
Sbjct: 39 KFKKVK 44
>NP_001973
          Length = 1342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KFKKIKVLG 9
           + +K+KVLG
Sbjct: 708 ELRKLKVLG 716
>NP_065816
          Length = 5183

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KFKKIKVLG 9
            KF+  KVLG
Sbjct: 4846 KFQPTKVLG 4854
>NP_004983
          Length = 486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KFKKIK 6
          KFKK+K
Sbjct: 27 KFKKVK 32
>NP_981953
          Length = 791

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KFKKIK 6
           KFKK+K
Sbjct: 643 KFKKVK 648
>XP_005274738
          Length = 486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KFKKIK 6
          KFKK+K
Sbjct: 27 KFKKVK 32
>XP_006710573
          Length = 5177

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KFKKIKVLG 9
            KF+  KVLG
Sbjct: 4840 KFQPTKVLG 4848
>XP_006710572
          Length = 5188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KFKKIKVLG 9
            KF+  KVLG
Sbjct: 4851 KFQPTKVLG 4859
>XP_006710571
          Length = 5194

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KFKKIKVLG 9
            KF+  KVLG
Sbjct: 4857 KFQPTKVLG 4865
>XP_006710570
          Length = 5195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KFKKIKVLG 9
            KF+  KVLG
Sbjct: 4858 KFQPTKVLG 4866
>XP_006710569
          Length = 5212

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KFKKIKVLG 9
            KF+  KVLG
Sbjct: 4875 KFQPTKVLG 4883
>XP_006710568
          Length = 5221

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KFKKIKVLG 9
            KF+  KVLG
Sbjct: 4884 KFQPTKVLG 4892
>XP_006710567
          Length = 5222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KFKKIKVLG 9
            KF+  KVLG
Sbjct: 4885 KFQPTKVLG 4893
>XP_006710566
          Length = 5222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KFKKIKVLG 9
            KF+  KVLG
Sbjct: 4885 KFQPTKVLG 4893
>XP_005245859
          Length = 5223

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KFKKIKVLG 9
            KF+  KVLG
Sbjct: 4886 KFQPTKVLG 4894
>NP_001093322
          Length = 475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KKIKVLG 9
           KK+K+LG
Sbjct: 183 KKLKMLG 189
>NP_000148
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KFKKIKVLG 9
           KF+K+K  G
Sbjct: 113 KFQKVKGFG 121
>NP_001005742
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KFKKIKVLG 9
           KF+K+K  G
Sbjct: 113 KFQKVKGFG 121
>NP_001165282
          Length = 449

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  KFKKIKVLG 9
          KF+K+K  G
Sbjct: 26 KFQKVKGFG 34
>NP_001005741
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KFKKIKVLG 9
           KF+K+K  G
Sbjct: 113 KFQKVKGFG 121
>NP_057160
          Length = 194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  KFKKIKVLG 9
          KFK+  VLG
Sbjct: 68 KFKEAVVLG 76
>NP_079357
          Length = 1898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    FKKIKVLG 9
            +KK+++LG
Sbjct: 1563 YKKLRLLG 1570
>NP_001182209
          Length = 287

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KFKKIKVL 8
          +FKK+K L
Sbjct: 65 RFKKLKYL 72
>XP_006726274
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KFKKIKVLG 9
           KF+K+K  G
Sbjct: 113 KFQKVKGFG 121
>XP_006711333
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KFKKIKVLG 9
           KF+K+K  G
Sbjct: 113 KFQKVKGFG 121
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.327    0.151    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 427,999
Number of extensions: 713
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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