Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000360                                                              21     229
XP_005268094                                                           21     229
NP_006454                                                              18    1135
NP_998787                                                              18    1135
NP_964010                                                              18    1135
NP_065850                                                              18    1135
XP_006717993                                                           18    1135
XP_006717992                                                           18    1135
XP_006717991                                                           18    1135
XP_005264148                                                           18    1135
XP_005264145                                                           18    1135
XP_006711984                                                           18    1135
XP_006711983                                                           18    1135
NP_078891                                                              16    5631
NP_001171526                                                           16    5631
NP_001171527                                                           16    5631
NP_828847                                                              16    5631
NP_006368                                                              16    5631
XP_006716779                                                           16    5631
XP_005248654                                                           16    5631
XP_005248653                                                           16    5631
NP_996885                                                              16    7355
NP_057646                                                              16    7355
NP_775960                                                              16    7355
NP_115992                                                              16    7355
NP_001276093                                                           16    7355
NP_001276094                                                           16    7355
XP_006717211                                                           16    7355
XP_005251991                                                           16    7355
NP_006436                                                              15    9605
NP_942133                                                              15    9605
NP_942131                                                              15    9605
NP_942134                                                              15    9605
NP_942135                                                              15    9605
NP_942136                                                              15    9605
NP_056261                                                              15    9605
NP_777358                                                              15    9605
NP_004126                                                              15    9605
XP_006725385                                                           15    9605
XP_006725384                                                           15    9605
XP_006725383                                                           15    9605
XP_005257325                                                           15    9605
XP_005257324                                                           15    9605
XP_005257323                                                           15    9605
XP_006721916                                                           15    9605
XP_006719430                                                           15    9605
XP_006719429                                                           15    9605
XP_006719428                                                           15    9605
XP_005253933                                                           15    9605
XP_006711822                                                           15    9605
XP_006711821                                                           15    9605
NP_001167579                                                           15    9605
NP_001084                                                              15    9605
>NP_000360
          Length = 764

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ITSVDLYTH 9
           I SVDLYTH
Sbjct: 470 IASVDLYTH 478
>XP_005268094
          Length = 764

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ITSVDLYTH 9
           I SVDLYTH
Sbjct: 470 IASVDLYTH 478
>NP_006454
          Length = 424

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ITSVDLYTH 9
           ++SVDL+TH
Sbjct: 344 LSSVDLHTH 352
>NP_998787
          Length = 424

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ITSVDLYTH 9
           ++SVDL+TH
Sbjct: 344 LSSVDLHTH 352
>NP_964010
          Length = 424

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ITSVDLYTH 9
           ++SVDL+TH
Sbjct: 344 LSSVDLHTH 352
>NP_065850
          Length = 436

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ITSVDLYTH 9
           ++SVDL+TH
Sbjct: 356 LSSVDLHTH 364
>XP_006717993
          Length = 436

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ITSVDLYTH 9
           ++SVDL+TH
Sbjct: 356 LSSVDLHTH 364
>XP_006717992
          Length = 436

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ITSVDLYTH 9
           ++SVDL+TH
Sbjct: 356 LSSVDLHTH 364
>XP_006717991
          Length = 436

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ITSVDLYTH 9
           ++SVDL+TH
Sbjct: 356 LSSVDLHTH 364
>XP_005264148
          Length = 289

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ITSVDLYTH 9
           ++SVDL+TH
Sbjct: 209 LSSVDLHTH 217
>XP_005264145
          Length = 424

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ITSVDLYTH 9
           ++SVDL+TH
Sbjct: 344 LSSVDLHTH 352
>XP_006711984
          Length = 457

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ITSVDLYTH 9
           ++SVDL+TH
Sbjct: 391 LSSVDLHTH 399
>XP_006711983
          Length = 471

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   ITSVDLYTH 9
           ++SVDL+TH
Sbjct: 391 LSSVDLHTH 399
>NP_078891
          Length = 854

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ITSVDLYTH 9
           ITS DL+ H
Sbjct: 794 ITSSDLHKH 802
>NP_001171526
          Length = 854

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ITSVDLYTH 9
           ITS DL+ H
Sbjct: 794 ITSSDLHKH 802
>NP_001171527
          Length = 812

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ITSVDLYTH 9
           ITS DL+ H
Sbjct: 752 ITSSDLHKH 760
>NP_828847
          Length = 509

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TSVDLYTH 9
           TSV++Y H
Sbjct: 176 TSVEVYEH 183
>NP_006368
          Length = 1591

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    VDLYTH 9
            VDL+TH
Sbjct: 1427 VDLFTH 1432
>XP_006716779
          Length = 2399

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    VDLYTH 9
            VDL+TH
Sbjct: 2235 VDLFTH 2240
>XP_005248654
          Length = 607

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ITSVDLYTH 9
           ITS DL+ H
Sbjct: 547 ITSSDLHKH 555
>XP_005248653
          Length = 895

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   ITSVDLYTH 9
           ITS DL+ H
Sbjct: 835 ITSSDLHKH 843
>NP_996885
          Length = 112

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  TSVDLYTH 9
          T +DLY H
Sbjct: 90 TGLDLYGH 97
>NP_057646
          Length = 1049

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ITSVDLYT 8
           + S+DLYT
Sbjct: 825 VISLDLYT 832
>NP_775960
          Length = 1285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VDLYTH 9
           VDL+TH
Sbjct: 621 VDLWTH 626
>NP_115992
          Length = 753

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   SVDLYTH 9
           S+D++TH
Sbjct: 612 SMDIFTH 618
>NP_001276093
          Length = 608

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   SVDLYTH 9
           S+D++TH
Sbjct: 467 SMDIFTH 473
>NP_001276094
          Length = 392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   SVDLYTH 9
           S+D++TH
Sbjct: 251 SMDIFTH 257
>XP_006717211
          Length = 853

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  ITSVDLYT 8
          +TSVDL T
Sbjct: 84 VTSVDLET 91
>XP_005251991
          Length = 953

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VDLYTH 9
           VDL+TH
Sbjct: 289 VDLWTH 294
>NP_006436
          Length = 2335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ITSVDLYTH 9
           I  +DLY+H
Sbjct: 896 IEFMDLYSH 904
>NP_942133
          Length = 2346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1    ITSVDLYTH 9
            ++++D+Y H
Sbjct: 1105 LSAIDMYGH 1113
>NP_942131
          Length = 2383

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1    ITSVDLYTH 9
            ++++D+Y H
Sbjct: 1142 LSAIDMYGH 1150
>NP_942134
          Length = 2288

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1    ITSVDLYTH 9
            ++++D+Y H
Sbjct: 1047 LSAIDMYGH 1055
>NP_942135
          Length = 2268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1    ITSVDLYTH 9
            ++++D+Y H
Sbjct: 1027 LSAIDMYGH 1035
>NP_942136
          Length = 2346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1    ITSVDLYTH 9
            ++++D+Y H
Sbjct: 1105 LSAIDMYGH 1113
>NP_056261
          Length = 2275

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    ITSVDLYT 8
            +TSV+ YT
Sbjct: 1444 LTSVETYT 1451
>NP_777358
          Length = 380

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TSVDLYTH 9
           TS+DLY +
Sbjct: 137 TSLDLYAN 144
>NP_004126
          Length = 393

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   TSVDLYTH 9
           TS+DLY +
Sbjct: 137 TSLDLYAN 144
>XP_006725385
          Length = 2038

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   ITSVDLYTH 9
           ++++D+Y H
Sbjct: 797 LSAIDMYGH 805
>XP_006725384
          Length = 2268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1    ITSVDLYTH 9
            ++++D+Y H
Sbjct: 1027 LSAIDMYGH 1035
>XP_006725383
          Length = 2338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1    ITSVDLYTH 9
            ++++D+Y H
Sbjct: 1105 LSAIDMYGH 1113
>XP_005257325
          Length = 2038

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   ITSVDLYTH 9
           ++++D+Y H
Sbjct: 797 LSAIDMYGH 805
>XP_005257324
          Length = 2268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1    ITSVDLYTH 9
            ++++D+Y H
Sbjct: 1027 LSAIDMYGH 1035
>XP_005257323
          Length = 2268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1    ITSVDLYTH 9
            ++++D+Y H
Sbjct: 1027 LSAIDMYGH 1035
>XP_006721916
          Length = 2375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1    ITSVDLYTH 9
            ++++D+Y H
Sbjct: 1142 LSAIDMYGH 1150
>XP_006719430
          Length = 2256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1    ITSVDLYTH 9
            ++++D+Y H
Sbjct: 1046 LSAIDMYGH 1054
>XP_006719429
          Length = 2395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1    ITSVDLYTH 9
            ++++D+Y H
Sbjct: 1185 LSAIDMYGH 1193
>XP_006719428
          Length = 2458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1    ITSVDLYTH 9
            ++++D+Y H
Sbjct: 1248 LSAIDMYGH 1256
>XP_005253933
          Length = 2458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1    ITSVDLYTH 9
            ++++D+Y H
Sbjct: 1248 LSAIDMYGH 1256
>XP_006711822
          Length = 2266

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    ITSVDLYT 8
            +TSV+ YT
Sbjct: 1435 LTSVETYT 1442
>XP_006711821
          Length = 2301

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    ITSVDLYT 8
            +TSV+ YT
Sbjct: 1470 LTSVETYT 1477
>NP_001167579
          Length = 979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   SVDLYTH 9
           +VD++TH
Sbjct: 483 TVDIWTH 489
>NP_001084
          Length = 2458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1    ITSVDLYTH 9
            ++++D+Y H
Sbjct: 1248 LSAIDMYGH 1256
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.133    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 506,202
Number of extensions: 915
Number of successful extensions: 53
Number of sequences better than 10000.0: 53
Number of HSP's gapped: 53
Number of HSP's successfully gapped: 53
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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