Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              22     103
XP_006718908                                                           22     103
XP_005271621                                                           22     103
XP_006718907                                                           22     103
XP_006718906                                                           22     103
XP_005271619                                                           22     103
XP_005271618                                                           22     103
NP_004949                                                              18    1135
XP_005263496                                                           18    1135
XP_005263495                                                           18    1135
NP_055907                                                              18    1935
XP_005255242                                                           18    1935
XP_005255241                                                           18    1935
XP_005255240                                                           18    1935
XP_005255239                                                           18    1935
NP_008835                                                              17    2528
NP_001075109                                                           17    2528
NP_001231509                                                           17    2528
NP_003487                                                              17    2528
NP_001175                                                              17    3301
NP_115892                                                              17    3301
NP_001035269                                                           17    3301
NP_004740                                                              17    3301
NP_004175                                                              17    3301
NP_776049                                                              17    3301
NP_998811                                                              17    3301
NP_998810                                                              17    3301
NP_001248763                                                           17    3301
XP_006720312                                                           17    3301
XP_005268101                                                           17    3301
XP_006720311                                                           17    3301
NP_002556                                                              17    4312
NP_689603                                                              17    4312
XP_005264201                                                           17    4312
NP_005447                                                              16    5631
NP_037522                                                              16    5631
NP_001129292                                                           16    5631
NP_000765                                                              16    5631
XP_006723116                                                           16    5631
XP_006723115                                                           16    5631
XP_005251926                                                           16    5631
XP_005249801                                                           16    5631
NP_861456                                                              16    5631
NP_006209                                                              16    7355
NP_001888                                                              16    7355
NP_060832                                                              16    7355
NP_003807                                                              16    7355
XP_006713721                                                           16    7355
NP_689574                                                              16    7355
NP_689677                                                              16    7355
NP_001269596                                                           15    9605
NP_001269595                                                           15    9605
NP_001025025                                                           15    9605
NP_008940                                                              15    9605
NP_001153350                                                           15    9605
NP_001025022                                                           15    9605
NP_001660                                                              15    9605
NP_003710                                                              15    9605
NP_001025023                                                           15    9605
XP_005274573                                                           15    9605
XP_005274572                                                           15    9605
XP_005274571                                                           15    9605
XP_005253308                                                           15    9605
XP_005248681                                                           15    9605
XP_005248680                                                           15    9605
XP_006714790                                                           15    9605
XP_005248678                                                           15    9605
XP_006714789                                                           15    9605
XP_006714788                                                           15    9605
NP_002018                                                              15    9605
>NP_000042
          Length = 3056

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IPFRLTRDI 9
            +PFRLTRDI
Sbjct: 2906 VPFRLTRDI 2914
>XP_006718908
          Length = 1708

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IPFRLTRDI 9
            +PFRLTRDI
Sbjct: 1558 VPFRLTRDI 1566
>XP_005271621
          Length = 2708

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IPFRLTRDI 9
            +PFRLTRDI
Sbjct: 2558 VPFRLTRDI 2566
>XP_006718907
          Length = 3050

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IPFRLTRDI 9
            +PFRLTRDI
Sbjct: 2900 VPFRLTRDI 2908
>XP_006718906
          Length = 3056

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IPFRLTRDI 9
            +PFRLTRDI
Sbjct: 2906 VPFRLTRDI 2914
>XP_005271619
          Length = 3056

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IPFRLTRDI 9
            +PFRLTRDI
Sbjct: 2906 VPFRLTRDI 2914
>XP_005271618
          Length = 3056

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IPFRLTRDI 9
            +PFRLTRDI
Sbjct: 2906 VPFRLTRDI 2914
>NP_004949
          Length = 2549

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    IPFRLTR 7
            IPFRLTR
Sbjct: 2375 IPFRLTR 2381
>XP_005263496
          Length = 2322

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    IPFRLTR 7
            IPFRLTR
Sbjct: 2148 IPFRLTR 2154
>XP_005263495
          Length = 2549

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    IPFRLTR 7
            IPFRLTR
Sbjct: 2375 IPFRLTR 2381
>NP_055907
          Length = 3661

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    IPFRLTRDI 9
            +PFR+T++I
Sbjct: 2371 VPFRMTQNI 2379
>XP_005255242
          Length = 3609

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    IPFRLTRDI 9
            +PFR+T++I
Sbjct: 2319 VPFRMTQNI 2327
>XP_005255241
          Length = 3637

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    IPFRLTRDI 9
            +PFR+T++I
Sbjct: 2347 VPFRMTQNI 2355
>XP_005255240
          Length = 3663

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    IPFRLTRDI 9
            +PFR+T++I
Sbjct: 2373 VPFRMTQNI 2381
>XP_005255239
          Length = 3689

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    IPFRLTRDI 9
            +PFR+T++I
Sbjct: 2399 VPFRMTQNI 2407
>NP_008835
          Length = 4128

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    IPFRLTR 7
            +PFRLTR
Sbjct: 3959 MPFRLTR 3965
>NP_001075109
          Length = 4097

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    IPFRLTR 7
            +PFRLTR
Sbjct: 3928 MPFRLTR 3934
>NP_001231509
          Length = 3859

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    IPFRLTRDI 9
            +PFRLT +I
Sbjct: 3727 VPFRLTPNI 3735
>NP_003487
          Length = 3830

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    IPFRLTRDI 9
            +PFRLT +I
Sbjct: 3698 VPFRLTPNI 3706
>NP_001175
          Length = 2644

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    IPFRLTRDI 9
            +PFRLT ++
Sbjct: 2511 VPFRLTHNM 2519
>NP_115892
          Length = 340

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PFRLTR 7
           PFRLTR
Sbjct: 138 PFRLTR 143
>NP_001035269
          Length = 340

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PFRLTR 7
           PFRLTR
Sbjct: 138 PFRLTR 143
>NP_004740
          Length = 631

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PFRLTRDI 9
           PF LT+D+
Sbjct: 287 PFSLTKDV 294
>NP_004175
          Length = 471

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FRLTRDI 9
           FR+TRD+
Sbjct: 317 FRMTRDV 323
>NP_776049
          Length = 471

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FRLTRDI 9
           FR+TRD+
Sbjct: 317 FRMTRDV 323
>NP_998811
          Length = 430

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FRLTRDI 9
           FR+TRD+
Sbjct: 276 FRMTRDV 282
>NP_998810
          Length = 430

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FRLTRDI 9
           FR+TRD+
Sbjct: 276 FRMTRDV 282
>NP_001248763
          Length = 642

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PFRLTRDI 9
           PF LT+D+
Sbjct: 298 PFSLTKDV 305
>XP_006720312
          Length = 471

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FRLTRDI 9
           FR+TRD+
Sbjct: 317 FRMTRDV 323
>XP_005268101
          Length = 471

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FRLTRDI 9
           FR+TRD+
Sbjct: 317 FRMTRDV 323
>XP_006720311
          Length = 471

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   FRLTRDI 9
           FR+TRD+
Sbjct: 317 FRMTRDV 323
>NP_002556
          Length = 365

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IPFRLTRDI 9
           +PF +TR I
Sbjct: 259 VPFHITRTI 267
>NP_689603
          Length = 297

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IPFRLTRDI 9
           IPF LT+ I
Sbjct: 155 IPFNLTKTI 163
>XP_005264201
          Length = 251

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IPFRLTRDI 9
           IPF LT+ I
Sbjct: 155 IPFNLTKTI 163
>NP_005447
          Length = 711

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  FRLTRDI 9
          FRLT DI
Sbjct: 33 FRLTHDI 39
>NP_037522
          Length = 1383

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    IPFRLT 6
            +PFRLT
Sbjct: 1255 VPFRLT 1260
>NP_001129292
          Length = 1320

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    IPFRLT 6
            +PFRLT
Sbjct: 1192 VPFRLT 1197
>NP_000765
          Length = 491

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IPFRLTRD 8
           +P R+TRD
Sbjct: 367 LPHRVTRD 374
>XP_006723116
          Length = 447

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IPFRLTRD 8
           +P R+TRD
Sbjct: 367 LPHRVTRD 374
>XP_006723115
          Length = 498

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IPFRLTRD 8
           +P R+TRD
Sbjct: 367 LPHRVTRD 374
>XP_005251926
          Length = 1383

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    IPFRLT 6
            +PFRLT
Sbjct: 1255 VPFRLT 1260
>XP_005249801
          Length = 324

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  IPFRLT 6
          +PFRLT
Sbjct: 88 VPFRLT 93
>NP_861456
          Length = 305

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  IPFRLT 6
          +PFRLT
Sbjct: 69 VPFRLT 74
>NP_006209
          Length = 1068

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IPFRLTRD 8
           +PF LT+D
Sbjct: 952 VPFVLTQD 959
>NP_001888
          Length = 2322

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    IPFRLTR 7
            +P RLTR
Sbjct: 1839 VPLRLTR 1845
>NP_060832
          Length = 197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  PFRLTRDI 9
          P RL RDI
Sbjct: 7  PVRLERDI 14
>NP_003807
          Length = 819

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  PFRLTRD 8
          P+RLTR+
Sbjct: 48 PWRLTRE 54
>XP_006713721
          Length = 1068

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IPFRLTRD 8
           +PF LT+D
Sbjct: 952 VPFVLTQD 959
>NP_689574
          Length = 161

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   IPFRLTRD 8
           IP RL RD
Sbjct: 106 IPVRLLRD 113
>NP_689677
          Length = 208

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  IPFRLTRDI 9
          + FRL RD+
Sbjct: 55 VSFRLIRDL 63
>NP_001269596
          Length = 955

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   PFRLTRDI 9
           P RL RD+
Sbjct: 878 PLRLPRDL 885
>NP_001269595
          Length = 976

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   PFRLTRDI 9
           P RL RD+
Sbjct: 899 PLRLPRDL 906
>NP_001025025
          Length = 838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PFRLTRD 8
           P RLT+D
Sbjct: 124 PMRLTQD 130
>NP_008940
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  FRLTRD 8
          FRLT+D
Sbjct: 53 FRLTKD 58
>NP_001153350
          Length = 350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  FRLTRD 8
          FRLT+D
Sbjct: 53 FRLTKD 58
>NP_001025022
          Length = 788

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PFRLTRD 8
           P RLT+D
Sbjct: 124 PMRLTQD 130
>NP_001660
          Length = 593

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   IPFRLTRD 8
           +PF LT D
Sbjct: 176 MPFTLTND 183
>NP_003710
          Length = 885

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PFRLTRD 8
           P RLT+D
Sbjct: 124 PMRLTQD 130
>NP_001025023
          Length = 830

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PFRLTRD 8
           P RLT+D
Sbjct: 124 PMRLTQD 130
>XP_005274573
          Length = 382

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   IPFRLTRD 8
           +PF LT D
Sbjct: 176 MPFTLTND 183
>XP_005274572
          Length = 475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   IPFRLTRD 8
           +PF LT D
Sbjct: 176 MPFTLTND 183
>XP_005274571
          Length = 548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   IPFRLTRD 8
           +PF LT D
Sbjct: 176 MPFTLTND 183
>XP_005253308
          Length = 1012

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   PFRLTRDI 9
           P RL RD+
Sbjct: 935 PLRLPRDL 942
>XP_005248681
          Length = 783

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  PFRLTRD 8
          P RLT+D
Sbjct: 22 PMRLTQD 28
>XP_005248680
          Length = 784

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  PFRLTRD 8
          P RLT+D
Sbjct: 23 PMRLTQD 29
>XP_006714790
          Length = 859

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PFRLTRD 8
           P RLT+D
Sbjct: 145 PMRLTQD 151
>XP_005248678
          Length = 884

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PFRLTRD 8
           P RLT+D
Sbjct: 123 PMRLTQD 129
>XP_006714789
          Length = 905

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PFRLTRD 8
           P RLT+D
Sbjct: 144 PMRLTQD 150
>XP_006714788
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PFRLTRD 8
           P RLT+D
Sbjct: 145 PMRLTQD 151
>NP_002018
          Length = 379

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   FRLTRD 8
           F+LTRD
Sbjct: 117 FKLTRD 122
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.344    0.163    0.505 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 460,527
Number of extensions: 667
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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