Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005148                                                              20     390
NP_009297                                                              20     390
NP_001161710                                                           18    1935
NP_001161709                                                           18    1935
NP_001161708                                                           18    1935
NP_009298                                                              18    1935
NP_001129473                                                           18    1935
NP_005149                                                              18    1935
NP_001161711                                                           18    1935
XP_005245145                                                           18    1935
NP_001129472                                                           18    1935
NP_055535                                                              17    3301
XP_005270358                                                           17    3301
NP_001243084                                                           16    5631
NP_065816                                                              16    5631
NP_937870                                                              16    5631
NP_937872                                                              16    5631
XP_006713969                                                           16    5631
XP_006713968                                                           16    5631
XP_006710573                                                           16    5631
XP_006710572                                                           16    5631
XP_006710571                                                           16    5631
XP_006710570                                                           16    5631
XP_006710569                                                           16    5631
XP_006710568                                                           16    5631
XP_006710567                                                           16    5631
XP_006710566                                                           16    5631
XP_005245859                                                           16    5631
NP_002917                                                              16    5631
NP_002936                                                              16    7355
NP_001005739                                                           16    7355
NP_057600                                                              16    7355
XP_006712092                                                           16    7355
NP_001073280                                                           15    9605
NP_005210                                                              15    9605
NP_001547                                                              15    9605
NP_001229707                                                           15    9605
NP_001177649                                                           15    9605
NP_005786                                                              15    9605
NP_001258680                                                           15    9605
NP_002218                                                              15    9605
NP_115729                                                              15    9605
NP_001122089                                                           15    9605
NP_001273540                                                           15    9605
NP_001030                                                              15    9605
NP_005101                                                              15    9605
XP_005255526                                                           15    9605
XP_005273556                                                           15    9605
XP_005273555                                                           15    9605
XP_005273553                                                           15    9605
XP_005273552                                                           15    9605
XP_005273551                                                           15    9605
XP_005273550                                                           15    9605
XP_005273549                                                           15    9605
XP_005273548                                                           15    9605
XP_005273547                                                           15    9605
XP_005267235                                                           15    9605
XP_006715650                                                           15    9605
XP_005267234                                                           15    9605
XP_006715005                                                           15    9605
XP_005268441                                                           15    9605
XP_005246291                                                           15    9605
XP_005246289                                                           15    9605
XP_005246288                                                           15    9605
XP_005270898                                                           15    9605
XP_006710687                                                           15    9605
NP_002513                                                              15    9605
>NP_005148
          Length = 1130

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   INTVSDGKL 9
           INT SDGKL
Sbjct: 176 INTASDGKL 184
>NP_009297
          Length = 1149

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   INTVSDGKL 9
           INT SDGKL
Sbjct: 195 INTASDGKL 203
>NP_001161710
          Length = 1058

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   INTVSDGKL 9
           INT +DGK+
Sbjct: 201 INTTADGKV 209
>NP_001161709
          Length = 1079

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   INTVSDGKL 9
           INT +DGK+
Sbjct: 222 INTTADGKV 230
>NP_001161708
          Length = 1161

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   INTVSDGKL 9
           INT +DGK+
Sbjct: 201 INTTADGKV 209
>NP_009298
          Length = 1182

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   INTVSDGKL 9
           INT +DGK+
Sbjct: 222 INTTADGKV 230
>NP_001129473
          Length = 542

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   INTVSDGKL 9
           INT +DGK+
Sbjct: 201 INTTADGKV 209
>NP_005149
          Length = 1167

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   INTVSDGKL 9
           INT +DGK+
Sbjct: 207 INTTADGKV 215
>NP_001161711
          Length = 1043

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   INTVSDGKL 9
           INT +DGK+
Sbjct: 186 INTTADGKV 194
>XP_005245145
          Length = 1146

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   INTVSDGKL 9
           INT +DGK+
Sbjct: 186 INTTADGKV 194
>NP_001129472
          Length = 1064

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   INTVSDGKL 9
           INT +DGK+
Sbjct: 207 INTTADGKV 215
>NP_055535
          Length = 1235

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   INTVSDGK 8
           IN+VS+GK
Sbjct: 444 INSVSEGK 451
>XP_005270358
          Length = 1204

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   INTVSDGK 8
           IN+VS+GK
Sbjct: 444 INSVSEGK 451
>NP_001243084
          Length = 2290

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NTVSDGKL 9
           +T+SDGK+
Sbjct: 483 DTLSDGKI 490
>NP_065816
          Length = 5183

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    TVSDGKL 9
            T+SDGK+
Sbjct: 1771 TISDGKV 1777
>NP_937870
          Length = 799

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  TVSDGKL 9
          TVSDG+L
Sbjct: 21 TVSDGEL 27
>NP_937872
          Length = 1447

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TVSDGKL 9
           TVSDG+L
Sbjct: 669 TVSDGEL 675
>XP_006713969
          Length = 1157

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TVSDGKL 9
           TVSDG+L
Sbjct: 669 TVSDGEL 675
>XP_006713968
          Length = 1447

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TVSDGKL 9
           TVSDG+L
Sbjct: 669 TVSDGEL 675
>XP_006710573
          Length = 5177

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    TVSDGKL 9
            T+SDGK+
Sbjct: 1771 TISDGKV 1777
>XP_006710572
          Length = 5188

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    TVSDGKL 9
            T+SDGK+
Sbjct: 1771 TISDGKV 1777
>XP_006710571
          Length = 5194

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    TVSDGKL 9
            T+SDGK+
Sbjct: 1771 TISDGKV 1777
>XP_006710570
          Length = 5195

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    TVSDGKL 9
            T+SDGK+
Sbjct: 1771 TISDGKV 1777
>XP_006710569
          Length = 5212

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    TVSDGKL 9
            T+SDGK+
Sbjct: 1771 TISDGKV 1777
>XP_006710568
          Length = 5221

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    TVSDGKL 9
            T+SDGK+
Sbjct: 1771 TISDGKV 1777
>XP_006710567
          Length = 5222

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    TVSDGKL 9
            T+SDGK+
Sbjct: 1771 TISDGKV 1777
>XP_006710566
          Length = 5222

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    TVSDGKL 9
            T+SDGK+
Sbjct: 1771 TISDGKV 1777
>XP_005245859
          Length = 5223

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    TVSDGKL 9
            T+SDGK+
Sbjct: 1771 TISDGKV 1777
>NP_002917
          Length = 1376

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TVSDGKL 9
           TVSDG+L
Sbjct: 669 TVSDGEL 675
>NP_002936
          Length = 616

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  INTVSDGK 8
          +NT+ DG+
Sbjct: 84 VNTLKDGR 91
>NP_001005739
          Length = 965

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   INTVSDGKL 9
           ++++SDGK+
Sbjct: 693 VDSLSDGKI 701
>NP_057600
          Length = 977

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   INTVSDGKL 9
           ++++SDGK+
Sbjct: 705 VDSLSDGKI 713
>XP_006712092
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   INTVSDGKL 9
           ++++SDGK+
Sbjct: 669 VDSLSDGKI 677
>NP_001073280
          Length = 1263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   INTVSDGK 8
           +NTV D K
Sbjct: 389 LNTVKDSK 396
>NP_005210
          Length = 1272

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   INTVSDGK 8
           +NTV D K
Sbjct: 398 LNTVKDSK 405
>NP_001547
          Length = 756

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VSDGKL 9
           +SDGKL
Sbjct: 371 ISDGKL 376
>NP_001229707
          Length = 697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VSDGKL 9
           +SDGKL
Sbjct: 312 ISDGKL 317
>NP_001177649
          Length = 754

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VSDGKL 9
           +SDGKL
Sbjct: 369 ISDGKL 374
>NP_005786
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   INTVSDG 7
           ++T+SDG
Sbjct: 423 VSTISDG 429
>NP_001258680
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   INTVSDG 7
           ++T+SDG
Sbjct: 423 VSTISDG 429
>NP_002218
          Length = 1154

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    INTVSDGK 8
            +NT+ +GK
Sbjct: 1105 VNTLKEGK 1112
>NP_115729
          Length = 176

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   INTVSDGK 8
           I TVSDG+
Sbjct: 164 IITVSDGR 171
>NP_001122089
          Length = 769

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   NTVSDG 7
           NTV+DG
Sbjct: 480 NTVADG 485
>NP_001273540
          Length = 796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   NTVSDG 7
           NTV+DG
Sbjct: 507 NTVADG 512
>NP_001030
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NTVSDGK 8
           N+VS+GK
Sbjct: 144 NSVSEGK 150
>NP_005101
          Length = 682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   INTVSDGKL 9
           I  V+DGKL
Sbjct: 282 IAAVADGKL 290
>XP_005255526
          Length = 616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NTVSDGK 8
           N+VS+GK
Sbjct: 144 NSVSEGK 150
>XP_005273556
          Length = 595

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VSDGKL 9
           +SDGKL
Sbjct: 161 ISDGKL 166
>XP_005273555
          Length = 595

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VSDGKL 9
           +SDGKL
Sbjct: 161 ISDGKL 166
>XP_005273553
          Length = 595

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VSDGKL 9
           +SDGKL
Sbjct: 161 ISDGKL 166
>XP_005273552
          Length = 595

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VSDGKL 9
           +SDGKL
Sbjct: 161 ISDGKL 166
>XP_005273551
          Length = 674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VSDGKL 9
           +SDGKL
Sbjct: 371 ISDGKL 376
>XP_005273550
          Length = 700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VSDGKL 9
           +SDGKL
Sbjct: 266 ISDGKL 271
>XP_005273549
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VSDGKL 9
           +SDGKL
Sbjct: 371 ISDGKL 376
>XP_005273548
          Length = 746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VSDGKL 9
           +SDGKL
Sbjct: 312 ISDGKL 317
>XP_005273547
          Length = 805

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VSDGKL 9
           +SDGKL
Sbjct: 371 ISDGKL 376
>XP_005267235
          Length = 773

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   NTVSDG 7
           NTV+DG
Sbjct: 507 NTVADG 512
>XP_006715650
          Length = 775

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   NTVSDG 7
           NTV+DG
Sbjct: 486 NTVADG 491
>XP_005267234
          Length = 795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   NTVSDG 7
           NTV+DG
Sbjct: 506 NTVADG 511
>XP_006715005
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   INTVSDGKL 9
           I  V+DGKL
Sbjct: 282 IAAVADGKL 290
>XP_005268441
          Length = 1250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   INTVSDGK 8
           +NTV D K
Sbjct: 398 LNTVKDSK 405
>XP_005246291
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   INTVSDG 7
           ++T+SDG
Sbjct: 434 VSTISDG 440
>XP_005246289
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   INTVSDG 7
           ++T+SDG
Sbjct: 434 VSTISDG 440
>XP_005246288
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   INTVSDG 7
           ++T+SDG
Sbjct: 434 VSTISDG 440
>XP_005270898
          Length = 1154

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    INTVSDGK 8
            +NT+ +GK
Sbjct: 1105 VNTLKEGK 1112
>XP_006710687
          Length = 1154

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    INTVSDGK 8
            +NT+ +GK
Sbjct: 1105 VNTLKEGK 1112
>NP_002513
          Length = 432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   INTVSDGK 8
           +NT+ +GK
Sbjct: 181 VNTLEEGK 188
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.307    0.131    0.340 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 538,236
Number of extensions: 574
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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