Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245202                                                           20     509
NP_001245200                                                           20     509
NP_001161091                                                           20     509
NP_000240                                                              20     509
NP_001161090                                                           20     509
NP_001161089                                                           20     509
NP_001245203                                                           20     509
XP_005265221                                                           20     509
XP_005265220                                                           20     509
NP_078831                                                              18    1935
NP_036294                                                              18    1935
NP_065228                                                              17    4312
NP_001164278                                                           17    4312
XP_006715676                                                           17    4312
NP_775922                                                              16    5631
NP_005110                                                              16    5631
NP_003629                                                              16    7355
NP_001278423                                                           16    7355
NP_065816                                                              16    7355
NP_001257430                                                           16    7355
NP_001257429                                                           16    7355
NP_001092002                                                           16    7355
NP_001092001                                                           16    7355
NP_006096                                                              16    7355
NP_001257431                                                           16    7355
NP_758872                                                              16    7355
NP_078948                                                              16    7355
NP_001206                                                              16    7355
NP_002229                                                              16    7355
XP_005268628                                                           16    7355
XP_005268627                                                           16    7355
XP_005268626                                                           16    7355
XP_005263278                                                           16    7355
XP_005263277                                                           16    7355
XP_006710573                                                           16    7355
XP_006710572                                                           16    7355
XP_006710571                                                           16    7355
XP_006710570                                                           16    7355
XP_006710569                                                           16    7355
XP_006710568                                                           16    7355
XP_006710567                                                           16    7355
XP_006710566                                                           16    7355
XP_005245859                                                           16    7355
NP_036304                                                              16    7355
NP_001156971                                                           16    7355
NP_003189                                                              16    7355
NP_277041                                                              16    7355
NP_277047                                                              15    9605
NP_056044                                                              15    9605
NP_002449                                                              15    9605
NP_001019554                                                           15    9605
NP_001018098                                                           15    9605
NP_060154                                                              15    9605
NP_060550                                                              15    9605
NP_065872                                                              15    9605
NP_653320                                                              15    9605
NP_775885                                                              15    9605
NP_055718                                                              15    9605
NP_001004060                                                           15    9605
NP_001004067                                                           15    9605
XP_006725258                                                           15    9605
XP_005259798                                                           15    9605
XP_006722711                                                           15    9605
XP_005256625                                                           15    9605
XP_005256624                                                           15    9605
XP_005256622                                                           15    9605
XP_006721555                                                           15    9605
XP_006721554                                                           15    9605
XP_005255375                                                           15    9605
XP_006719740                                                           15    9605
XP_006719739                                                           15    9605
XP_006719738                                                           15    9605
XP_005269272                                                           15    9605
XP_005264955                                                           15    9605
NP_055102                                                              15    9605
NP_001290                                                              15    9605
>NP_001245202
          Length = 515

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  INHSLVEST 9
          INH LVEST
Sbjct: 21 INHRLVEST 29
>NP_001245200
          Length = 687

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   INHSLVEST 9
           INH LVEST
Sbjct: 262 INHRLVEST 270
>NP_001161091
          Length = 515

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  INHSLVEST 9
          INH LVEST
Sbjct: 21 INHRLVEST 29
>NP_000240
          Length = 756

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   INHSLVEST 9
           INH LVEST
Sbjct: 262 INHRLVEST 270
>NP_001161090
          Length = 515

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  INHSLVEST 9
          INH LVEST
Sbjct: 21 INHRLVEST 29
>NP_001161089
          Length = 658

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   INHSLVEST 9
           INH LVEST
Sbjct: 164 INHRLVEST 172
>NP_001245203
          Length = 515

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  INHSLVEST 9
          INH LVEST
Sbjct: 21 INHRLVEST 29
>XP_005265221
          Length = 515

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  INHSLVEST 9
          INH LVEST
Sbjct: 21 INHRLVEST 29
>XP_005265220
          Length = 515

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  INHSLVEST 9
          INH LVEST
Sbjct: 21 INHRLVEST 29
>NP_078831
          Length = 533

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   INHSLVEST 9
           + HS+VEST
Sbjct: 247 LQHSMVEST 255
>NP_036294
          Length = 539

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   INHSLVEST 9
           + HS+VEST
Sbjct: 253 LQHSMVEST 261
>NP_065228
          Length = 284

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  NHSLVE 7
          NHSLVE
Sbjct: 73 NHSLVE 78
>NP_001164278
          Length = 284

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  NHSLVE 7
          NHSLVE
Sbjct: 73 NHSLVE 78
>XP_006715676
          Length = 284

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  NHSLVE 7
          NHSLVE
Sbjct: 73 NHSLVE 78
>NP_775922
          Length = 6996

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    INHSLVES 8
            I+HSLV+S
Sbjct: 3932 ISHSLVKS 3939
>NP_005110
          Length = 955

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NHSLVEST 9
           NHS VES+
Sbjct: 165 NHSRVESS 172
>NP_003629
          Length = 1063

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   INHSLVEST 9
           +N+SL EST
Sbjct: 604 LNYSLDEST 612
>NP_001278423
          Length = 1048

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   INHSLVEST 9
           +N+SL EST
Sbjct: 589 LNYSLDEST 597
>NP_065816
          Length = 5183

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   NHSLVES 8
           NHSLV S
Sbjct: 714 NHSLVTS 720
>NP_001257430
          Length = 248

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   INHSLVES 8
           +NH +VES
Sbjct: 209 LNHRVVES 216
>NP_001257429
          Length = 313

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   INHSLVES 8
           +NH +VES
Sbjct: 269 LNHRVVES 276
>NP_001092002
          Length = 881

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NHSLVES 8
           NH+LVE+
Sbjct: 787 NHTLVEN 793
>NP_001092001
          Length = 923

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NHSLVES 8
           NH+LVE+
Sbjct: 829 NHTLVEN 835
>NP_006096
          Length = 881

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NHSLVES 8
           NH+LVE+
Sbjct: 787 NHTLVEN 793
>NP_001257431
          Length = 180

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   INHSLVES 8
           +NH +VES
Sbjct: 141 LNHRVVES 148
>NP_758872
          Length = 989

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NHSLVEST 9
           NHSLV+++
Sbjct: 779 NHSLVKAS 786
>NP_078948
          Length = 903

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   INHSLVES 8
           INH L+E+
Sbjct: 543 INHVLIEA 550
>NP_001206
          Length = 308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   INHSLVES 8
           +NH +VES
Sbjct: 269 LNHRVVES 276
>NP_002229
          Length = 962

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NHSLVEST 9
           NHSLV+++
Sbjct: 752 NHSLVKAS 759
>XP_005268628
          Length = 495

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NHSLVES 8
           NH+LVE+
Sbjct: 401 NHTLVEN 407
>XP_005268627
          Length = 779

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NHSLVES 8
           NH+LVE+
Sbjct: 685 NHTLVEN 691
>XP_005268626
          Length = 779

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NHSLVES 8
           NH+LVE+
Sbjct: 685 NHTLVEN 691
>XP_005263278
          Length = 620

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   INHSLVES 8
           INH L+E+
Sbjct: 260 INHVLIEA 267
>XP_005263277
          Length = 759

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   INHSLVES 8
           INH L+E+
Sbjct: 399 INHVLIEA 406
>XP_006710573
          Length = 5177

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   NHSLVES 8
           NHSLV S
Sbjct: 714 NHSLVTS 720
>XP_006710572
          Length = 5188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   NHSLVES 8
           NHSLV S
Sbjct: 714 NHSLVTS 720
>XP_006710571
          Length = 5194

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   NHSLVES 8
           NHSLV S
Sbjct: 714 NHSLVTS 720
>XP_006710570
          Length = 5195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   NHSLVES 8
           NHSLV S
Sbjct: 714 NHSLVTS 720
>XP_006710569
          Length = 5212

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   NHSLVES 8
           NHSLV S
Sbjct: 714 NHSLVTS 720
>XP_006710568
          Length = 5221

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   NHSLVES 8
           NHSLV S
Sbjct: 714 NHSLVTS 720
>XP_006710567
          Length = 5222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   NHSLVES 8
           NHSLV S
Sbjct: 714 NHSLVTS 720
>XP_006710566
          Length = 5222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   NHSLVES 8
           NHSLV S
Sbjct: 714 NHSLVTS 720
>XP_005245859
          Length = 5223

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   NHSLVES 8
           NHSLV S
Sbjct: 714 NHSLVTS 720
>NP_036304
          Length = 618

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   INHSLVES 8
           +NHSLV S
Sbjct: 454 LNHSLVLS 461
>NP_001156971
          Length = 568

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   INHSLVES 8
           +NHSLV S
Sbjct: 404 LNHSLVLS 411
>NP_003189
          Length = 798

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   NHSLVEST 9
           NH L+E T
Sbjct: 622 NHVLIEET 629
>NP_277041
          Length = 580

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   INHSLVES 8
           +NHSLV S
Sbjct: 416 LNHSLVLS 423
>NP_277047
          Length = 417

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   NHSLVES 8
           NHS +ES
Sbjct: 356 NHSSIES 362
>NP_056044
          Length = 1309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   INHSLVE 7
           ++HSLVE
Sbjct: 278 LSHSLVE 284
>NP_002449
          Length = 5762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   HSLVEST 9
           H+LV+ST
Sbjct: 275 HALVDST 281
>NP_001019554
          Length = 2385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   INHSLVEST 9
           I+HS +E+T
Sbjct: 708 ISHSTLETT 716
>NP_001018098
          Length = 3628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    INHSLVE 7
            I HSL+E
Sbjct: 2267 IEHSLIE 2273
>NP_060154
          Length = 3710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    INHSLVE 7
            I HSL+E
Sbjct: 2224 IEHSLIE 2230
>NP_060550
          Length = 3585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    INHSLVE 7
            I HSL+E
Sbjct: 2224 IEHSLIE 2230
>NP_065872
          Length = 3753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    INHSLVE 7
            I HSL+E
Sbjct: 2267 IEHSLIE 2273
>NP_653320
          Length = 715

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   INHSLVES 8
           + H+LVES
Sbjct: 509 LGHTLVES 516
>NP_775885
          Length = 1222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  INHSLVE 7
          IN+SL+E
Sbjct: 49 INYSLIE 55
>NP_055718
          Length = 2363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   INHSLVEST 9
           I+HS +E+T
Sbjct: 708 ISHSTLETT 716
>NP_001004060
          Length = 1267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  INHSLVE 7
          IN+SL+E
Sbjct: 49 INYSLIE 55
>NP_001004067
          Length = 1222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  INHSLVE 7
          IN+SL+E
Sbjct: 49 INYSLIE 55
>XP_006725258
          Length = 1267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  INHSLVE 7
          IN+SL+E
Sbjct: 49 INYSLIE 55
>XP_005259798
          Length = 247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  NHSLVEST 9
          NH+ V+ST
Sbjct: 66 NHTQVQST 73
>XP_006722711
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   NHSLVEST 9
           NH+ V+ST
Sbjct: 116 NHTQVQST 123
>XP_005256625
          Length = 1347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   INHSLVE 7
           ++HSLVE
Sbjct: 316 LSHSLVE 322
>XP_005256624
          Length = 1348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   INHSLVE 7
           ++HSLVE
Sbjct: 316 LSHSLVE 322
>XP_005256622
          Length = 1383

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   INHSLVE 7
           ++HSLVE
Sbjct: 351 LSHSLVE 357
>XP_006721555
          Length = 1444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   INHSLVE 7
           ++HSLVE
Sbjct: 413 LSHSLVE 419
>XP_006721554
          Length = 1445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   INHSLVE 7
           ++HSLVE
Sbjct: 413 LSHSLVE 419
>XP_005255375
          Length = 1267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  INHSLVE 7
          IN+SL+E
Sbjct: 49 INYSLIE 55
>XP_006719740
          Length = 1863

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   INHSLVEST 9
           I+HS +E+T
Sbjct: 208 ISHSTLETT 216
>XP_006719739
          Length = 2306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   INHSLVEST 9
           I+HS +E+T
Sbjct: 651 ISHSTLETT 659
>XP_006719738
          Length = 2340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   INHSLVEST 9
           I+HS +E+T
Sbjct: 685 ISHSTLETT 693
>XP_005269272
          Length = 2356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   INHSLVEST 9
           I+HS +E+T
Sbjct: 708 ISHSTLETT 716
>XP_005264955
          Length = 674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   INHSLVES 8
           + H+LVES
Sbjct: 509 LGHTLVES 516
>NP_055102
          Length = 1222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  INHSLVE 7
          IN+SL+E
Sbjct: 49 INYSLIE 55
>NP_001290
          Length = 297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   NHSLVEST 9
           NH+ V+ST
Sbjct: 116 NHTQVQST 123
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.304    0.117    0.294 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 517,654
Number of extensions: 665
Number of successful extensions: 76
Number of sequences better than 10000.0: 76
Number of HSP's gapped: 76
Number of HSP's successfully gapped: 76
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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