Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006715                                                              19     665
NP_005913                                                              19     665
XP_005267046                                                           19     665
XP_005267045                                                           19     665
NP_071332                                                              17    4312
NP_001182036                                                           16    7355
NP_112218                                                              16    7355
NP_001182035                                                           16    7355
NP_001017388                                                           16    7355
NP_001182037                                                           16    7355
NP_060736                                                              16    7355
NP_001275677                                                           16    7355
NP_079514                                                              16    7355
NP_001011885                                                           16    7355
NP_060267                                                              16    7355
NP_878907                                                              16    7355
NP_055646                                                              16    7355
XP_005259650                                                           16    7355
XP_006720636                                                           16    7355
XP_005273981                                                           16    7355
XP_006714095                                                           16    7355
XP_006714094                                                           16    7355
XP_005247635                                                           16    7355
XP_005247634                                                           16    7355
XP_006713750                                                           16    7355
XP_006713495                                                           16    7355
NP_001259017                                                           15    9605
NP_001261                                                              15    9605
NP_001259016                                                           15    9605
NP_057664                                                              15    9605
NP_001262                                                              15    9605
NP_005062                                                              15    9605
XP_005276813                                                           15    9605
XP_006722907                                                           15    9605
XP_006722906                                                           15    9605
XP_006722905                                                           15    9605
XP_005271924                                                           15    9605
XP_005271923                                                           15    9605
XP_005248455                                                           15    9605
NP_001790                                                              15    9605
>NP_006715
          Length = 1558

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   INAYLLLTK 9
           I+AYLLLTK
Sbjct: 897 IDAYLLLTK 905
>NP_005913
          Length = 1608

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   INAYLLLTK 9
           I+AYLLLTK
Sbjct: 897 IDAYLLLTK 905
>XP_005267046
          Length = 1554

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   INAYLLLTK 9
           I+AYLLLTK
Sbjct: 897 IDAYLLLTK 905
>XP_005267045
          Length = 1604

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   INAYLLLTK 9
           I+AYLLLTK
Sbjct: 897 IDAYLLLTK 905
>NP_071332
          Length = 384

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   INAYLLLTK 9
           +N YLL+T+
Sbjct: 136 LNRYLLITR 144
>NP_001182036
          Length = 811

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   YLLLTK 9
           YLLLTK
Sbjct: 320 YLLLTK 325
>NP_112218
          Length = 811

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   YLLLTK 9
           YLLLTK
Sbjct: 320 YLLLTK 325
>NP_001182035
          Length = 811

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   YLLLTK 9
           YLLLTK
Sbjct: 320 YLLLTK 325
>NP_001017388
          Length = 811

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   YLLLTK 9
           YLLLTK
Sbjct: 320 YLLLTK 325
>NP_001182037
          Length = 797

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   YLLLTK 9
           YLLLTK
Sbjct: 306 YLLLTK 311
>NP_060736
          Length = 488

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   INAYLLLT 8
           INA+++LT
Sbjct: 327 INAFVMLT 334
>NP_001275677
          Length = 604

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   NAYLLL 7
           NAYLLL
Sbjct: 329 NAYLLL 334
>NP_079514
          Length = 482

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NAYLLLTK 9
           NA++LLT+
Sbjct: 179 NAFMLLTQ 186
>NP_001011885
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NAYLLLTK 9
           NA++LLT+
Sbjct: 179 NAFMLLTQ 186
>NP_060267
          Length = 525

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NAYLLLTK 9
           NA++LLT+
Sbjct: 221 NAFMLLTQ 228
>NP_878907
          Length = 544

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   NAYLLL 7
           NAYLLL
Sbjct: 329 NAYLLL 334
>NP_055646
          Length = 2925

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   AYLLLTK 9
           A+LLLTK
Sbjct: 480 AFLLLTK 486
>XP_005259650
          Length = 377

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  NAYLLLTK 9
          NA++LLT+
Sbjct: 73 NAFMLLTQ 80
>XP_006720636
          Length = 354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NAYLLLTK 9
           NA++LLT+
Sbjct: 179 NAFMLLTQ 186
>XP_005273981
          Length = 400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   NAYLLL 7
           NAYLLL
Sbjct: 329 NAYLLL 334
>XP_006714095
          Length = 797

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   YLLLTK 9
           YLLLTK
Sbjct: 306 YLLLTK 311
>XP_006714094
          Length = 797

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   YLLLTK 9
           YLLLTK
Sbjct: 306 YLLLTK 311
>XP_005247635
          Length = 377

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   INAYLLLT 8
           INA+++LT
Sbjct: 327 INAFVMLT 334
>XP_005247634
          Length = 380

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   INAYLLLT 8
           INA+++LT
Sbjct: 327 INAFVMLT 334
>XP_006713750
          Length = 488

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   INAYLLLT 8
           INA+++LT
Sbjct: 327 INAFVMLT 334
>XP_006713495
          Length = 2969

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   AYLLLTK 9
           A+LLLTK
Sbjct: 524 AFLLLTK 530
>NP_001259017
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  NAYLLLT 8
          NA++LLT
Sbjct: 56 NAFILLT 62
>NP_001261
          Length = 1710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   INAYLLLTK 9
           +N Y L+TK
Sbjct: 907 VNIYRLVTK 915
>NP_001259016
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  NAYLLLT 8
          NA++LLT
Sbjct: 56 NAFILLT 62
>NP_057664
          Length = 1184

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   NAYLLLT 8
           N Y+LLT
Sbjct: 408 NTYMLLT 414
>NP_001262
          Length = 1828

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   INAYLLLTK 9
           +N Y L+TK
Sbjct: 910 VNIYRLVTK 918
>NP_005062
          Length = 564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  NAYLLLT 8
          NA++LLT
Sbjct: 56 NAFILLT 62
>XP_005276813
          Length = 289

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  INAYLLLT 8
          I AY+L+T
Sbjct: 57 IKAYMLMT 64
>XP_006722907
          Length = 564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  NAYLLLT 8
          NA++LLT
Sbjct: 56 NAFILLT 62
>XP_006722906
          Length = 564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  NAYLLLT 8
          NA++LLT
Sbjct: 56 NAFILLT 62
>XP_006722905
          Length = 564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  NAYLLLT 8
          NA++LLT
Sbjct: 56 NAFILLT 62
>XP_005271924
          Length = 1710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   INAYLLLTK 9
           +N Y L+TK
Sbjct: 907 VNIYRLVTK 915
>XP_005271923
          Length = 1798

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   INAYLLLTK 9
           +N Y L+TK
Sbjct: 907 VNIYRLVTK 915
>XP_005248455
          Length = 289

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  INAYLLLT 8
          I AY+L+T
Sbjct: 57 IKAYMLMT 64
>NP_001790
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   INAYLLLT 8
           I AY+L+T
Sbjct: 114 IKAYMLMT 121
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.328    0.143    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 403,708
Number of extensions: 498
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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