Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004963                                                              19     869
XP_005251512                                                           19     869
NP_009017                                                              18    1482
XP_006720075                                                           18    1482
NP_116295                                                              17    2528
NP_149106                                                              17    3301
XP_006726589                                                           17    3301
XP_006718462                                                           17    3301
XP_006710010                                                           17    3301
NP_443182                                                              16    5631
XP_006719827                                                           16    5631
NP_006351                                                              16    7355
NP_757364                                                              16    7355
NP_757363                                                              16    7355
NP_757365                                                              16    7355
NP_001185550                                                           16    7355
NP_006540                                                              16    7355
NP_001271236                                                           16    7355
NP_001271235                                                           16    7355
NP_071918                                                              16    7355
NP_001257415                                                           16    7355
NP_001257414                                                           16    7355
NP_919269                                                              16    7355
XP_005254649                                                           16    7355
XP_005254648                                                           16    7355
XP_005253880                                                           16    7355
XP_005253879                                                           16    7355
XP_005264966                                                           16    7355
NP_001058                                                              15    9605
NP_001182502                                                           15    9605
NP_001258211                                                           15    9605
NP_056417                                                              15    9605
NP_001254507                                                           15    9605
NP_085124                                                              15    9605
NP_803187                                                              15    9605
NP_005637                                                              15    9605
NP_008832                                                              15    9605
NP_001103132                                                           15    9605
NP_001177962                                                           15    9605
NP_001073996                                                           15    9605
NP_065931                                                              15    9605
NP_055468                                                              15    9605
NP_001161713                                                           15    9605
XP_006725355                                                           15    9605
XP_006723257                                                           15    9605
XP_006723256                                                           15    9605
XP_005257689                                                           15    9605
XP_006720603                                                           15    9605
XP_006720602                                                           15    9605
XP_006719767                                                           15    9605
XP_006719766                                                           15    9605
XP_006719765                                                           15    9605
XP_006712602                                                           15    9605
XP_006712014                                                           15    9605
XP_005273291                                                           15    9605
NP_002236                                                              15    9605
NP_149420                                                              15    9605
NP_001004750                                                           15    9605
>NP_004963
          Length = 1132

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ILTRKPIRY 9
           ILTRK IRY
Sbjct: 223 ILTRKRIRY 231
>XP_005251512
          Length = 1132

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ILTRKPIRY 9
           ILTRK IRY
Sbjct: 223 ILTRKRIRY 231
>NP_009017
          Length = 1129

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  TRKPIRY 9
          TRKP+RY
Sbjct: 4  TRKPMRY 10
>XP_006720075
          Length = 1127

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  TRKPIRY 9
          TRKP+RY
Sbjct: 4  TRKPMRY 10
>NP_116295
          Length = 114

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LTRKPIRY 9
          L++KP+RY
Sbjct: 62 LSKKPLRY 69
>NP_149106
          Length = 830

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  RKPIRY 9
          RKP+RY
Sbjct: 85 RKPVRY 90
>XP_006726589
          Length = 931

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ILTRKPI 7
           +LTRKP+
Sbjct: 276 VLTRKPV 282
>XP_006718462
          Length = 4966

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    ILTRKPI 7
            +LTRKP+
Sbjct: 4301 VLTRKPV 4307
>XP_006710010
          Length = 1103

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ILTRKPI 7
           +LTRKP+
Sbjct: 497 VLTRKPV 503
>NP_443182
          Length = 400

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  LTRKPI 7
          LTRKPI
Sbjct: 10 LTRKPI 15
>XP_006719827
          Length = 290

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  LTRKPI 7
          LTRKPI
Sbjct: 10 LTRKPI 15
>NP_006351
          Length = 374

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ILTRKPIRY 9
           +LT KP+++
Sbjct: 223 LLTLKPVKF 231
>NP_757364
          Length = 490

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ILTRKPIR 8
           +LT+KP R
Sbjct: 473 LLTKKPTR 480
>NP_757363
          Length = 533

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ILTRKPIR 8
           +LT+KP R
Sbjct: 516 LLTKKPTR 523
>NP_757365
          Length = 545

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ILTRKPIR 8
           +LT+KP R
Sbjct: 473 LLTKKPTR 480
>NP_001185550
          Length = 1121

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RKPIRY 9
           R+P+RY
Sbjct: 677 RRPVRY 682
>NP_006540
          Length = 588

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ILTRKPIR 8
           +LT+KP R
Sbjct: 516 LLTKKPTR 523
>NP_001271236
          Length = 1111

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ILTRKPIR 8
           +LT KP+R
Sbjct: 604 VLTVKPVR 611
>NP_001271235
          Length = 1068

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ILTRKPIR 8
           +LT KP+R
Sbjct: 561 VLTVKPVR 568
>NP_071918
          Length = 1883

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    ILTRKPIR 8
            +LT KP+R
Sbjct: 1376 VLTVKPVR 1383
>NP_001257415
          Length = 556

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ILTRKPIR 8
           +LT+KP R
Sbjct: 516 LLTKKPTR 523
>NP_001257414
          Length = 588

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ILTRKPIR 8
           +LT+KP R
Sbjct: 516 LLTKKPTR 523
>NP_919269
          Length = 1843

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RKPIRY 9
           R+P+RY
Sbjct: 677 RRPVRY 682
>XP_005254649
          Length = 1819

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    ILTRKPIR 8
            +LT KP+R
Sbjct: 1312 VLTVKPVR 1319
>XP_005254648
          Length = 1906

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    ILTRKPIR 8
            +LT KP+R
Sbjct: 1399 VLTVKPVR 1406
>XP_005253880
          Length = 533

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ILTRKPIR 8
           +LT+KP R
Sbjct: 516 LLTKKPTR 523
>XP_005253879
          Length = 545

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   ILTRKPIR 8
           +LT+KP R
Sbjct: 473 LLTKKPTR 480
>XP_005264966
          Length = 1843

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RKPIRY 9
           R+P+RY
Sbjct: 677 RRPVRY 682
>NP_001058
          Length = 1531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    ILTRKPIRY 9
            +  +KPI+Y
Sbjct: 1513 VRAKKPIKY 1521
>NP_001182502
          Length = 1829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ILTRKPI 7
           ILT KPI
Sbjct: 804 ILTAKPI 810
>NP_001258211
          Length = 1922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ILTRKPI 7
           ILT KPI
Sbjct: 804 ILTAKPI 810
>NP_056417
          Length = 583

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LTRKPIRY 9
           L R P+RY
Sbjct: 193 LRRPPLRY 200
>NP_001254507
          Length = 584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LTRKPIRY 9
           L R P+RY
Sbjct: 194 LRRPPLRY 201
>NP_085124
          Length = 1922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ILTRKPI 7
           ILT KPI
Sbjct: 804 ILTAKPI 810
>NP_803187
          Length = 1922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   ILTRKPI 7
           ILT KPI
Sbjct: 804 ILTAKPI 810
>NP_005637
          Length = 1621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   LTRKPIRY 9
           LTRK  RY
Sbjct: 279 LTRKRARY 286
>NP_008832
          Length = 2548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   LTRKPIR 8
           +T+KP+R
Sbjct: 367 ITKKPLR 373
>NP_001103132
          Length = 4284

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    ILTRKPIRY 9
            ILT  PI Y
Sbjct: 3974 ILTPSPITY 3982
>NP_001177962
          Length = 664

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  RKPIRY 9
          R+P+RY
Sbjct: 20 REPVRY 25
>NP_001073996
          Length = 2116

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RKPIRY 9
           R+P+RY
Sbjct: 991 RRPLRY 996
>NP_065931
          Length = 599

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RKPIRY 9
           RKP++Y
Sbjct: 208 RKPLKY 213
>NP_055468
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  RKPIRY 9
          RKP+R+
Sbjct: 14 RKPVRF 19
>NP_001161713
          Length = 874

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RKPIRY 9
           R+P+RY
Sbjct: 97  REPVRY 102
>XP_006725355
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  RKPIRY 9
          R+P+RY
Sbjct: 8  RRPLRY 13
>XP_006723257
          Length = 332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RKPIRY 9
           RKP++Y
Sbjct: 208 RKPLKY 213
>XP_006723256
          Length = 459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RKPIRY 9
           RKP++Y
Sbjct: 208 RKPLKY 213
>XP_005257689
          Length = 1519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    ILTRKPIRY 9
            +  +KPI+Y
Sbjct: 1501 VRAKKPIKY 1509
>XP_006720603
          Length = 2619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   LTRKPIR 8
           +T+KP+R
Sbjct: 367 ITKKPLR 373
>XP_006720602
          Length = 2619

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   LTRKPIR 8
           +T+KP+R
Sbjct: 367 ITKKPLR 373
>XP_006719767
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  RKPIRY 9
          RKP+R+
Sbjct: 14 RKPVRF 19
>XP_006719766
          Length = 465

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  RKPIRY 9
          RKP+R+
Sbjct: 14 RKPVRF 19
>XP_006719765
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  RKPIRY 9
          RKP+R+
Sbjct: 14 RKPVRF 19
>XP_006712602
          Length = 2142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RKPIRY 9
           R+P+RY
Sbjct: 991 RRPLRY 996
>XP_006712014
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RKPIRY 9
           R+P+RY
Sbjct: 97  REPVRY 102
>XP_005273291
          Length = 1620

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   LTRKPIRY 9
           LTRK  RY
Sbjct: 279 LTRKRARY 286
>NP_002236
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   LTRKPIRY 9
           +TR+P+ Y
Sbjct: 160 VTRRPVLY 167
>NP_149420
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   ILTRKPIRY 9
           I  R P+RY
Sbjct: 122 IAIRNPLRY 130
>NP_001004750
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   ILTRKPIRY 9
           I  R P+RY
Sbjct: 122 ITIRSPLRY 130
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.154    0.463 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 649,124
Number of extensions: 1043
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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