Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000537                                                              19     869
NP_001263689                                                           19     869
NP_001119584                                                           19     869
NP_001119586                                                           19     869
NP_001263625                                                           19     869
NP_001119590                                                           19     869
NP_001263690                                                           19     869
NP_001119585                                                           19     869
NP_001263624                                                           19     869
NP_001119588                                                           19     869
NP_001119587                                                           19     869
NP_001119589                                                           19     869
NP_001263627                                                           19     869
NP_001263628                                                           19     869
NP_001263626                                                           19     869
NP_065186                                                              17    2528
XP_006714087                                                           17    2528
XP_005248177                                                           17    2528
XP_005248176                                                           17    2528
XP_005248175                                                           17    2528
NP_001093321                                                           16    7355
NP_001038945                                                           16    7355
XP_006713573                                                           16    7355
XP_006713572                                                           16    7355
NP_620170                                                              16    7355
NP_060119                                                              15    9605
NP_951058                                                              15    9605
NP_004577                                                              15    9605
NP_055311                                                              15    9605
NP_066958                                                              15    9605
NP_001006933                                                           15    9605
NP_062873                                                              15    9605
NP_002944                                                              15    9605
NP_001006666                                                           15    9605
NP_062874                                                              15    9605
XP_005262180                                                           15    9605
XP_005274634                                                           15    9605
XP_006724570                                                           15    9605
XP_005274633                                                           15    9605
XP_005274632                                                           15    9605
XP_006724569                                                           15    9605
XP_005274630                                                           15    9605
XP_006724568                                                           15    9605
XP_005267149                                                           15    9605
XP_006715612                                                           15    9605
XP_005246024                                                           15    9605
XP_005246023                                                           15    9605
NP_000863                                                              15    9605
>NP_000537
          Length = 393

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLKD 9
           ILTIITL+D
Sbjct: 251 ILTIITLED 259
>NP_001263689
          Length = 354

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLKD 9
           ILTIITL+D
Sbjct: 212 ILTIITLED 220
>NP_001119584
          Length = 393

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLKD 9
           ILTIITL+D
Sbjct: 251 ILTIITLED 259
>NP_001119586
          Length = 341

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLKD 9
           ILTIITL+D
Sbjct: 251 ILTIITLED 259
>NP_001263625
          Length = 302

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLKD 9
           ILTIITL+D
Sbjct: 212 ILTIITLED 220
>NP_001119590
          Length = 354

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLKD 9
           ILTIITL+D
Sbjct: 212 ILTIITLED 220
>NP_001263690
          Length = 354

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLKD 9
           ILTIITL+D
Sbjct: 212 ILTIITLED 220
>NP_001119585
          Length = 346

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLKD 9
           ILTIITL+D
Sbjct: 251 ILTIITLED 259
>NP_001263624
          Length = 307

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLKD 9
           ILTIITL+D
Sbjct: 212 ILTIITLED 220
>NP_001119588
          Length = 209

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLKD 9
           ILTIITL+D
Sbjct: 119 ILTIITLED 127
>NP_001119587
          Length = 261

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLKD 9
           ILTIITL+D
Sbjct: 119 ILTIITLED 127
>NP_001119589
          Length = 214

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLKD 9
           ILTIITL+D
Sbjct: 119 ILTIITLED 127
>NP_001263627
          Length = 182

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLKD 9
           ILTIITL+D
Sbjct: 92  ILTIITLED 100
>NP_001263628
          Length = 187

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLKD 9
           ILTIITL+D
Sbjct: 92  ILTIITLED 100
>NP_001263626
          Length = 234

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILTIITLKD 9
           ILTIITL+D
Sbjct: 92  ILTIITLED 100
>NP_065186
          Length = 1426

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ILTIITLKD 9
           +LTII +KD
Sbjct: 130 VLTIIAIKD 138
>XP_006714087
          Length = 1337

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  ILTIITLKD 9
          +LTII +KD
Sbjct: 41 VLTIIAIKD 49
>XP_005248177
          Length = 1399

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ILTIITLKD 9
           +LTII +KD
Sbjct: 130 VLTIIAIKD 138
>XP_005248176
          Length = 1411

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ILTIITLKD 9
           +LTII +KD
Sbjct: 130 VLTIIAIKD 138
>XP_005248175
          Length = 1426

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   ILTIITLKD 9
           +LTII +KD
Sbjct: 130 VLTIIAIKD 138
>NP_001093321
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LTIITLKD 9
           L I+TLKD
Sbjct: 351 LEILTLKD 358
>NP_001038945
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LTIITLKD 9
           L I+TLKD
Sbjct: 351 LEILTLKD 358
>XP_006713573
          Length = 298

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ILTIITLKD 9
          ILT++ +KD
Sbjct: 25 ILTLVPVKD 33
>XP_006713572
          Length = 308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ILTIITLKD 9
          ILT++ +KD
Sbjct: 35 ILTLVPVKD 43
>NP_620170
          Length = 298

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  ILTIITLKD 9
          ILT++ +KD
Sbjct: 25 ILTLVPVKD 33
>NP_060119
          Length = 875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ILTIITLKD 9
           +L I+TL+D
Sbjct: 563 VLGIVTLED 571
>NP_951058
          Length = 853

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ILTIITLKD 9
           +L I+TL+D
Sbjct: 563 VLGIVTLED 571
>NP_004577
          Length = 740

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IITLKD 9
           IITLKD
Sbjct: 476 IITLKD 481
>NP_055311
          Length = 745

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IITLKD 9
           IITLKD
Sbjct: 480 IITLKD 485
>NP_066958
          Length = 733

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IITLKD 9
           IITLKD
Sbjct: 469 IITLKD 474
>NP_001006933
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IITLKD 9
           IITLKD
Sbjct: 477 IITLKD 482
>NP_062873
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  ILTIITL 7
          ILT+ITL
Sbjct: 87 ILTLITL 93
>NP_002944
          Length = 735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IITLKD 9
           IITLKD
Sbjct: 472 IITLKD 477
>NP_001006666
          Length = 744

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IITLKD 9
           IITLKD
Sbjct: 481 IITLKD 486
>NP_062874
          Length = 432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  ILTIITL 7
          ILT+ITL
Sbjct: 87 ILTLITL 93
>XP_005262180
          Length = 624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IITLKD 9
           IITLKD
Sbjct: 359 IITLKD 364
>XP_005274634
          Length = 710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IITLKD 9
           IITLKD
Sbjct: 446 IITLKD 451
>XP_006724570
          Length = 711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IITLKD 9
           IITLKD
Sbjct: 447 IITLKD 452
>XP_005274633
          Length = 711

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IITLKD 9
           IITLKD
Sbjct: 447 IITLKD 452
>XP_005274632
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IITLKD 9
           IITLKD
Sbjct: 448 IITLKD 453
>XP_006724569
          Length = 712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IITLKD 9
           IITLKD
Sbjct: 448 IITLKD 453
>XP_005274630
          Length = 739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IITLKD 9
           IITLKD
Sbjct: 475 IITLKD 480
>XP_006724568
          Length = 740

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IITLKD 9
           IITLKD
Sbjct: 476 IITLKD 481
>XP_005267149
          Length = 758

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IITLKD 9
           IITLKD
Sbjct: 494 IITLKD 499
>XP_006715612
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IITLKD 9
           IITLKD
Sbjct: 497 IITLKD 502
>XP_005246024
          Length = 643

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IITLKD 9
           IITLKD
Sbjct: 380 IITLKD 385
>XP_005246023
          Length = 719

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   IITLKD 9
           IITLKD
Sbjct: 456 IITLKD 461
>NP_000863
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  ILTIITL 7
          ILT+ITL
Sbjct: 87 ILTLITL 93
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.153    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 442,937
Number of extensions: 991
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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